Uniprot accession / id : (P35456)
 
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Entry Information
Entry status  (1)
REL
(2)
 
Experimental methods  (1)
X-ray diffraction
(2)
 
Authors  (14)
Huang M
(2)
Lin L
(2)
Ploug M
(2)
Gardsvoll H
(1)
Gårdsvoll H
(1)
Hoyer-Hansen G
(1)
Huai Q
(1)
Høyer-Hansen G
(1)
Jiang L
(1)
Li H
(1)
Li J
(1)
Liu M
(1)
Min L
(1)
Yuan C
(1)
 
Homo / hetero assembly  (2)
hetero
(1)
homo
(1)
 
Assembly composition  (2)
protein structure
(1)
protein/protein complex
(1)
 
Assembly polymer count  (2)
dimer
(1)
monomer
(1)
 
Resolution distribution
2.0 - 2.5
(1)
3.0 - 3.5
(1)
 
Release year distribution
2005 - 2010
(1)
2010 - 2015
(1)
2015 - 2020
(1)
 
Journal  (2)
FEBS Lett
(1)
J Biol Chem
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(2)
 
Organism name  (1)
Mus musculus
(2)
 
Molecule name  (9)
U-PAR
(2)
Urokinase plasminogen activator surface receptor
(2)
uPAR
(2)
U-plasminogen activator
(1)
Urokinase-type plasminogen activator
(1)
Urokinase-type plasminogen activator chain B
(1)
Urokinase-type plasminogen activator long chain A
(1)
Urokinase-type plasminogen activator short chain A
(1)
uPA
(1)
 
Molecule type  (1)
Protein
(2)
 
Gene names  (2)
Plaur
(2)
Plau
(1)
 
Interacting Molecules  (2)
Urokinase plasminogen activator surface receptor
(1)
Urokinase-type plasminogen activator long chain A
(1)
 
Interacting ligands  (1)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(2)
 
Function and Biology
EC number / name  (1)
3.4.21.73 : U-plasminogen activator
(1)
 
Biological function  (4)
enzyme binding
(2)
protein binding
(2)
protein domain specific binding
(2)
signaling receptor binding
(2)
 
Biological process  (9)
negative regulation of apoptotic process
(2)
negative regulation of intrinsic apoptotic signaling pathway
(2)
positive regulation of epidermal growth factor receptor signaling pathway
(2)
positive regulation of homotypic cell-cell adhesion
(2)
positive regulation of release of cytochrome c from mitochondria
(2)
regulation of cell adhesion
(2)
regulation of fibrinolysis
(2)
regulation of plasminogen activation
(2)
urokinase plasminogen activator signaling pathway
(2)
 
Biological cell component  (8)
cell surface
(2)
external side of plasma membrane
(2)
extracellular region
(2)
membrane
(2)
plasma membrane
(2)
protein complex involved in cell-matrix adhesion
(2)
serine-type endopeptidase complex
(2)
side of membrane
(2)
 
Sequence and Structure classification
CATH class  (1)
Mainly Beta
(1)
 
CATH topology  (3)
CD59
(1)
Laminin
(1)
Plasminogen Kringle 4
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 2 of 2
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Structure-based engineering of species selectivity in the uPA-uPAR interaction
Huang M
J Biol Chem (2010) [PMID: 20133942  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Assembly name: uPA-uPAR complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-139267 (Preferred)   search this ID
PDBe-KB: P06869    P35456   
X-ray diffraction
3.2Å resolution
Released: 2 Feb 2010
Model geometry
Fit model/data
3laq
3laq
3laq
Crystal structure of unoccupied murine uPAR
Min L, Huang M
FEBS Lett (2019) [PMID: 31044429  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Bound ligands: NAG    NAG   
Assembly name: Urokinase plasminogen activator surface receptor (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152924 (Preferred)   search this ID
PDBe-KB: P35456   
X-ray diffraction
2.393Å resolution
Released: 17 Jul 2019
Model geometry
Fit model/data
6aex
6aex
6aex
Entries 1 to 2 of 2
Entries 1 to 2 of 2