Uniprot accession / id : P41145  OR   Uniprot accession / id : E2RMT3  OR   Uniprot accession / id : Q2KIP6  OR   Uniprot accession / id : P33534  OR   Uniprot accession / id : Q14AL5  OR   Uniprot accession / id : P34975  OR   Uniprot accession / id : E1C0V9  OR   Uniprot accession / id : Q98U14
 
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Entry Information
Entry status  (1)
REL
(25)
 
Experimental methods  (2)
Electron Microscopy
(21)
X-ray diffraction
(4)
 
Authors  (157)
Che T
(11)
Majumdar S
(10)
Katritch V
(7)
Krumm BE
(7)
Han GW
(6)
Bernhard SM
(5)
Fay JF
(5)
Han J
(5)
Meyerowitz JG
(5)
Panova O
(5)
Robertson MJ
(5)
Skiniotis G
(5)
Carroll FI
(4)
Gati C
(4)
Kenakin T
(4)
Khan S
(4)
Lam JH
(4)
Landaker D
(4)
Motiwala Z
(4)
Nazarova AL
(4)
Nichols DE
(4)
Ramos-Gonzalez N
(4)
Rangari VA
(4)
Ranjbar M
(4)
Roth BL
(4)
Shenvi R
(4)
Styrpejko D
(4)
Tyson AS
(4)
Villers K
(4)
Woo S
(4)
Yuan P
(4)
Zhang J
(4)
Zhang Z
(4)
Zhao L
(4)
He F
(3)
Papasergi-Scott MM
(3)
Peroto MC
(3)
Seven AB
(3)
Wacker D
(3)
Basbaum AI
(2)
Bhardwaj K
(2)
Billesbolle C
(2)
Billesbølle C
(2)
Borrelli K
(2)
Braz J
(2)
Chen Q
(2)
Cherezov V
(2)
Chiang YC
(2)
Ellman JA
(2)
Hu H
(2)
Hu HL
(2)
Huang XP
(2)
Irwin J
(2)
Jiao H
(2)
Jiao HZ
(2)
Kim JY
(2)
Kim K
(2)
Kweon OS
(2)
Liu W
(2)
Manglik A
(2)
Mosier PD
(2)
Ohno S
(2)
Olsen RHJ
(2)
Pan Q
(2)
Pang B
(2)
Pardon E
(2)
Ren R
(2)
Shoichet BK
(2)
Skinotis G
(2)
Stevens RC
(2)
Steyaert J
(2)
Vardy E
(2)
Vigneron SF
(2)
Wang S
(2)
Webb C
(2)
Appourchaux K
(1)
Baker D
(1)
Bhardwaj G
(1)
Carroll IF
(1)
Chen B
(1)
Chen BO
(1)
Chen Y
(1)
Craik DJ
(1)
Craven TW
(1)
Deibler K
(1)
DiBerto JF
(1)
Diberto J
(1)
Diberto JF
(1)
Dror RO
(1)
El Daibani A
(1)
English J
(1)
GPCR Network (GPCR)
(1)
Gruber CW
(1)
Hegazy L
(1)
Hellinger R
(1)
Hochrainer N
(1)
Hosseinzadeh P
(1)
Jadhav KB
(1)
Jain MK
(1)
Jiang Y
(1)
 
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Homo / hetero assembly  (2)
hetero
(23)
homo
(2)
 
Assembly composition  (2)
protein/protein complex
(23)
protein structure
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 25
Entries 1 to 10 of 25
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Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor
Che T, Majumdar S, Zaidi SA, Kormos C, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll IF, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL
Cell (2018) [PMID: 29307491  ]
Assembly composition: protein/protein complex
Bound ligands: CLR    CLR    CVV    CVV    OLA    OLA   
Assembly name: Kappa-type opioid receptor, Soluble cytochrome b562 and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-230827 (Preferred)   search this ID
PDBe-KB: P41145    P0ABE7   
X-ray diffraction
3.1Å resolution
Released: 17 Jan 2018
Model geometry
Fit model/data
6b73
6b73
6b73
Structure of CXCR3 complexed with antagonist SCH546738
Jiao HZ, Hu HL
Nat Struct Mol Biol (2024) [PMID: 38177682  ]
Assembly composition: protein/protein complex
Bound ligands: CLR    CLR    43I   
Assembly name: C-X-C chemokine receptor type 3, Kappa-type opioid receptor, Soluble cytochrome b562 and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-276050 (Preferred)   search this ID
PDBe-KB: P41145    P0ABE7    P49682   
Electron Microscopy
3.6Å resolution
Released: 29 Nov 2023
Model geometry
Fit model/data
Data not analysed
8hnn
8hnn
8hnn
momSalB bound Kappa Opioid Receptor in complex with GoA
Fay JF, Che T
Nature (2023) [PMID: 37138078  ]
Assembly composition: protein/protein complex
Bound ligands: U99    U99   
PDBe complex ID: PDB-CPX-272486 (Preferred)   search this ID
PDBe-KB: P41145    P09471    P62873    P59768   
Electron Microscopy
2.82Å resolution
Released: 3 May 2023
Model geometry
Fit model/data
Data not analysed
8dzq
8dzq
8dzq
GR89,696 bound Kappa Opioid Receptor in complex with gustducin
Fay JF, Che T
Nature (2023) [PMID: 37138078  ]
Assembly composition: protein/protein complex
Bound ligands: U9I    U9I   
PDBe complex ID: PDB-CPX-273700 (Preferred)   search this ID
PDBe-KB: P41145    P62873    P59768   
Electron Microscopy
2.61Å resolution
Released: 3 May 2023
Model geometry
Fit model/data
Data not analysed
8dzr
8dzr
8dzr
Kappa opioid receptor:Galphai protein in complex with inverse agonist norBNI
Gati C, Motiwala Z, Tyson AS, Styrpejko D, Han GW, Khan S, Ramos-Gonzalez N, Shenvi R, Majumdar S
Nat Chem Biol (2025) [PMID: 39775170  ]
Assembly composition: protein/protein complex
Bound ligands: A1AD6   
PDBe complex ID: PDB-CPX-284580 (Preferred)   search this ID
PDBe-KB: P41145    P62873    P63096    P59768   
Electron Microscopy
3.3Å resolution
Released: 15 Jan 2025
Model geometry
Fit model/data
Data not analysed
8vve
8vve
8vve
Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic
Gati C, Motiwala Z, Tyson AS, Styrpejko D, Han GW, Khan S, Ramos-Gonzalez N, Shenvi R, Majumdar S
Nat Chem Biol (2025) [PMID: 39775170  ]
Assembly composition: protein/protein complex
Bound ligands: JDC    JDC   
PDBe complex ID: PDB-CPX-284581 (Preferred)   search this ID
PDBe-KB: P41145    P62873    P63096    P59768   
Electron Microscopy
3Å resolution
Released: 15 Jan 2025
Model geometry
Fit model/data
Data not analysed
8vvf
8vvf
8vvf
Kappa opioid receptor in complex with heterotrimerig Gi protein, bound to inverse agonist GB18
Gati C, Motiwala Z, Tyson AS, Styrpejko D, Han GW, Khan S, Ramos-Gonzalez N, Shenvi R, Majumdar S
Nat Chem Biol (2025) [PMID: 39775170  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: A1AD5   
PDBe complex ID: PDB-CPX-284582 (Preferred)   search this ID
PDBe-KB: P41145    P62873    P63096    P59768   
Electron Microscopy
3.3Å resolution
Released: 15 Jan 2025
Model geometry
Fit model/data
Data not analysed
8vvg
8vvg
8vvg
CryoEM structure of somatostatin receptor 2 in complex with somatostatin-14 and Gi3
Robertson MJ, Skinotis G
Nat Struct Mol Biol (2022) [PMID: 35210615  ]
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-209393 (Preferred)   search this ID
PDBe-KB: P41145    P30874    P08754    P62873    P59768    P61278   
Electron Microscopy
2.5Å resolution
Released: 9 Mar 2022
Model geometry
Fit model/data
Data not analysed
7t10
7t10
7t10
momSalB bound Kappa Opioid Receptor in complex with Gi1
Fay JF, Che T
Nature (2023) [PMID: 37138078  ]
Assembly composition: protein/protein complex
Bound ligands: U99    U99   
PDBe complex ID: PDB-CPX-273699 (Preferred)   search this ID
PDBe-KB: P41145    P62873    P63096    P59768   
Electron Microscopy
2.71Å resolution
Released: 3 May 2023
Model geometry
Fit model/data
Data not analysed
8dzp
8dzp
8dzp
GR89,696 bound Kappa Opioid Receptor in complex with Gz
Fay JF, Che T
Nature (2023) [PMID: 37138078  ]
Assembly composition: protein/protein complex
Bound ligands: U9I    U9I   
PDBe complex ID: PDB-CPX-276164 (Preferred)   search this ID
PDBe-KB: P41145    P19086    P62873    P59768   
Electron Microscopy
2.65Å resolution
Released: 3 May 2023
Model geometry
Fit model/data
Data not analysed
8dzs
8dzs
8dzs
Entries 1 to 10 of 25
Entries 1 to 10 of 25