Entry status  (1)

REL

(5)

Experimental methods  (2)

Solution NMR

(3)

X-ray diffraction

(2)

Authors  (24)

Byeon I-JL

(3)

Byeon IJ

(3)

Li J

(3)

Selby TL

(3)

Tsai M-D

(3)

Tsai MD

(3)

Ericson K

(2)

Kim H-J

(2)

Kim HJ

(2)

O'Maille P

(2)

Tevelev A

(2)

Burbidge O

(1)

Endicott JA

(1)

Hodder SL

(1)

Itzhaki L

(1)

Jeffrey PD

(1)

Lee JO

(1)

Noble MEM

(1)

Pastok MW

(1)

Pavletich NP

(1)

Russo AA

(1)

Tong L

(1)

Yuan C

(1)

Zenkeviciute G

(1)

Homo / hetero assembly  (2)

homo

(3)

hetero

(2)

Assembly composition  (2)

protein structure

(3)

protein/protein complex

(2)

Assembly polymer count  (3)

monomer

(3)

dimer

(1)

tetramer

(1)

Resolution distribution

1.5 - 2

(1)

3.0 - 3.5

(1)

Release year distribution

1995 - 2000

(4)

2020 - 2025

(1)

Journal  (4)

Mol Cell

(2)

Nature

(1)

Protein Sci

(1)

To be published

(1)

Organism superkingdom  (1)

Eukaryota

(5)

Organism name  (1)

Homo sapiens

(5)

Molecule name  (8)

CDK4I

(5)

Cyclin-dependent kinase 4 inhibitor A

(5)

Cyclin-dependent kinase inhibitor 2A

(5)

MTS-1

(5)

Multiple tumor suppressor 1

(5)

p16-INK4

(5)

p16-INK4a

(5)

p16INK4A

(5)

Molecule type  (1)

Protein

(5)

Gene names  (3)

CDKN2

(5)

CDKN2A

(5)

MTS1

(5)

Interacting Molecules  (2)

Camelid nanobody NB09

(1)

Cyclin-dependent kinase 6

(1)

Biological function  (5)

NF-kappaB binding

(5)

RNA binding

(5)

cyclin-dependent protein serine/threonine kinase inhibitor activity

(5)

protein binding

(5)

protein kinase binding

(5)

Biological process  (30)

Ras protein signal transduction

(5)

apoptotic process involved in mammary gland involution

(5)

cellular response to hydrogen peroxide

(5)

cellular senescence

(5)

epidermis development

(5)

glucose homeostasis

(5)

keratinocyte differentiation

(5)

keratinocyte proliferation

(5)

mammary gland epithelial cell proliferation

(5)

negative regulation of DNA-templated transcription

(5)

negative regulation of cell cycle

(5)

negative regulation of cell growth

(5)

negative regulation of cell population proliferation

(5)

negative regulation of cell-matrix adhesion

(5)

negative regulation of cyclin-dependent protein serine/threonine kinase activity

(5)

negative regulation of mammary gland epithelial cell proliferation

(5)

negative regulation of proteolysis involved in protein catabolic process

(5)

negative regulation of transcription by RNA polymerase II

(5)

negative regulation of ubiquitin-dependent protein catabolic process

(5)

oncogene-induced cell senescence

(5)

positive regulation of apoptotic process involved in mammary gland involution

(5)

positive regulation of macrophage apoptotic process

(5)

positive regulation of smooth muscle cell apoptotic process

(5)

rRNA transcription

(5)

regulation of G1/S transition of mitotic cell cycle

(5)

regulation of cell cycle

(5)

regulation of gene expression

(5)

regulation of nucleocytoplasmic transport

(5)

replicative senescence

(5)

somatic stem cell population maintenance

(5)

Biological cell component  (5)

cytoplasm

(5)

cytosol

(5)

nucleolus

(5)

nucleus

(5)

senescence-associated heterochromatin focus

(5)

SCOP fold  (1)

beta-hairpin-alpha-hairpin repeat

(4)

SCOP family  (1)

Ankyrin repeat

(4)

CATH class  (1)

Mainly Alpha

(4)

CATH topology  (1)

Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

(4)

Diffraction protocol  (1)

Single wavelength

(1)

Diffraction radiation source type  (1)

Synchrotron

(2)

Diffraction source  (2)

CHESS BEAMLINE A1

(1)

DIAMOND BEAMLINE I03

(1)

Synchrotron site  (2)

CHESS

(1)

Diamond

(1)

Diffraction detector type  (2)

CCD

(1)

Pixel

(1)

Refinement software  (2)

X-PLOR

(3)

REFMAC

(1)

NMR software packages  (3)

X-PLOR

(3)

Felix

(1)

XwinNMR

(1)

NMR Field Strength

500.0 - 600

(3)

600.0 - 700

(3)

700.0 - 800

(3)

800.0 - 900

(3)

Representative Structures

100%

95%

90%

70%

50%

40%

30%