Uniprot accession / id : P42858  OR   Uniprot accession / id : P42859  OR   Uniprot accession / id : G3X9H5  OR   Uniprot accession / id : O42269
 
Filter by :
Entry Information
Entry status  (1)
REL
(26)
 
Experimental methods  (3)
X-ray diffraction
(14)
Electron Microscopy
(9)
Solution NMR
(3)
 
Authors  (118)
Bezprozvanny I
(7)
Chelliah Y
(7)
Kim MW
(7)
Kim SW
(7)
Otwinowski Z
(7)
Kim M
(4)
Baumeister W
(3)
Cheng J
(3)
Engler T
(3)
Fernandez-Busnadiego R
(3)
Fernández-Busnadiego R
(3)
Guo Q
(3)
Kochanek S
(3)
Maurer M
(3)
Pautsch A
(3)
Aebersold R
(2)
Arrowsmith CH
(2)
Astorga-Wells J
(2)
Bechinger B
(2)
Boudet J
(2)
Dal Perraro M
(2)
Deme JC
(2)
Doherty E
(2)
Harding RJ
(2)
Hebert H
(2)
Huang B
(2)
Hutchinson A
(2)
Jung R
(2)
Jung T
(2)
Kim H
(2)
Lea SM
(2)
Leitner A
(2)
Loppnau P
(2)
Marcaida MJ
(2)
Michalek M
(2)
Niedermeier ML
(2)
Peraro MD
(2)
Poweleit N
(2)
Salnikov ES
(2)
Seitova A
(2)
Seong IS
(2)
Shin B
(2)
Song J
(2)
Song JJ
(2)
Stengel F
(2)
Structural Genomics Consortium (SGC)
(2)
Tamo G
(2)
Vijayvargia R
(2)
Werten S
(2)
Alqazzaz M
(1)
Alteen MG
(1)
Alvarez CP
(1)
Begeja N
(1)
Bianchi E
(1)
Bin H
(1)
Blaesse M
(1)
Butler DC
(1)
Cantle JP
(1)
Carroll JB
(1)
Ceccon A
(1)
Chandrasekaran R
(1)
Chatwell L
(1)
Chirgadze DY
(1)
Cicero DO
(1)
Clore GM
(1)
Colby DW
(1)
De Genst E
(1)
Di Marino S
(1)
Dobson CM
(1)
Doherty EM
(1)
Dominguez C
(1)
Dominguez L
(1)
Fan L
(1)
Finotto M
(1)
Gallo M
(1)
Ghirlando R
(1)
Goss S
(1)
Heck AJR
(1)
Hevler JF
(1)
Huston JS
(1)
Ingenito R
(1)
Klein FA
(1)
Korner J
(1)
Kotler SA
(1)
Körner J
(1)
Lee MR
(1)
Lemak A
(1)
Libich DS
(1)
Matak-Vinkovic D
(1)
Matak-Vinković D
(1)
Messer A
(1)
Monteagudo E
(1)
Moser F
(1)
Neudegger T
(1)
Neumaier I
(1)
Oeckl P
(1)
Otto M
(1)
Pfeifer G
(1)
Schapira M
(1)
Schiefner A
(1)
 
More...
 
Homo / hetero assembly  (2)
homo
(17)
hetero
(9)
 
Assembly composition  (2)
protein structure
(17)
protein/protein complex
(9)
 
Assembly polymer count  (5)
trimer
(11)
dimer
(8)
monomer
(5)
hexamer
(1)
tetramer
(1)
 
Resolution distribution
2.0 - 2.5
(1)
2.5 - 3
(8)
3.0 - 3.5
(4)
3.5 - 4
(7)
4.0 - 4.5
(1)
9.5 - 10
(1)
18.0 - 18.5
(1)
 
Release year distribution
2005 - 2010
(7)
2010 - 2015
(8)
2015 - 2020
(6)
2020 - 2025
(9)
 
Journal  (8)
Structure
(12)
Prion
(4)
To be published
(3)
Biophys J
(2)
J Mol Biol
(2)
Commun Biol
(1)
Nature
(1)
Proc Natl Acad Sci U S A
(1)
 
Macromolecules
Organism superkingdom  (2)
Eukaryota
(26)
Bacteria
(11)
 
Organism name  (4)
Homo sapiens
(26)
Escherichia coli K-12
(9)
Escherichia coli O157:H7
(2)
synthetic construct
(2)
 
Molecule name  (10)
HD protein
(26)
Huntingtin
(26)
Huntingtin, myristoylated N-terminal fragment
(26)
Huntington disease protein
(26)
Maltodextrin-binding protein
(12)
MBP
(11)
MMBP
(11)
Maltose-binding protein
(11)
Maltose/maltodextrin-binding periplasmic protein
(11)
Maltose-binding periplasmic protein,PigG
(1)
 
Molecule type  (1)
Protein
(26)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
50%
40%
30%
Entries 1 to 10 of 26
Entries 1 to 10 of 26
 Select all entries on this page
Huntingtin-Q17, 1-66, N-MBP fusion
Toledo-Sherman L, Dominguez C
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Carbohydrate polymer components:
Molecule 1 - GLC(2)
Assembly name: Huntingtin, Maltodextrin-binding protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-269351 (Preferred)   search this ID
PDBe-KB: P42858    A0A4P1LXE0   
X-ray diffraction
3.23Å resolution
Released: 18 Sep 2024
Model geometry
Fit model/data
8r2o
8r2o
8r2o
Structure of the Huntingtin tetramer/dimer mixture determined by paramagnetic NMR
Schwieters CD, Kotler SA, Schmidt T, Ceccon A, Ghirlando R, Libich DS, Clore GM
Proc Natl Acad Sci U S A (2019) [PMID: 30808748  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Huntingtin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154900 (Preferred)   search this ID
PDBe-KB: P42858   
Solution NMR
Released: 13 Feb 2019
Model geometry
Fit model/data
Data not analysed
6n8c
6n8c
6n8c
Human 46QHuntingtin-HAP40 complex structure
Guo Q, Fernandez-Busnadiego R
Structure (2021) [PMID: 33909994  ]
Assembly composition: protein/protein complex
Assembly name: Huntingtin and 40-kDa huntingtin-associated protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150024 (Preferred)   search this ID
PDBe-KB: P42858    P23610   
Electron Microscopy
3.6Å resolution
Released: 24 Mar 2021
Model geometry
Fit model/data
Data not analysed
7dxj
7dxj
7dxj
HTT in complex with HAP40 in the apo state.
Poweleit N, Boudet J, Doherty E
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Huntingtin and 40-kDa huntingtin-associated protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150024 (Preferred)   search this ID
PDBe-KB: P42858    P23610   
Electron Microscopy
2.72Å resolution
Released: 13 Mar 2024
Model geometry
Fit model/data
Data not analysed
8w15
8w15
8w15
HTT in complex with HAP40 and a small molecule.
Poweleit N, Boudet J, Doherty E
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: A1ACS    A1ACS   
Assembly name: Huntingtin and 40-kDa huntingtin-associated protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150024 (Preferred)   search this ID
PDBe-KB: P42858    P23610   
Electron Microscopy
2.6Å resolution
Released: 6 Mar 2024
Model geometry
Fit model/data
Data not analysed
8vlx
8vlx
8vlx
Cryo-EM structure of the Full-length disease type human Huntingtin
Tame G, Jung T, Dal Perraro M, Hebert H, Song J
Structure (2020) [PMID: 32668197  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Huntingtin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154897 (Preferred)   search this ID
PDBe-KB: P42858   
Electron Microscopy
18.2Å resolution
Released: 16 Dec 2020
Model geometry
Fit model/data
Data not analysed
6yej
6yej
6yej
Human Huntingtin-HAP40 complex structure
Guo Q, Bin H, Cheng J, Pfeifer G, Baumeister W, Fernandez-Busnadiego R, Kochanek S
Nature (2018) [PMID: 29466333  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Huntingtin and 40-kDa huntingtin-associated protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150024 (Preferred)   search this ID
PDBe-KB: P42858    P23610   
Electron Microscopy
4Å resolution
Released: 21 Feb 2018
Model geometry
Fit model/data
Data not analysed
6ez8
6ez8
6ez8
Human 128QHuntingtin-HAP40 complex structure
Guo Q, Fernandez-Busnadiego R
Structure (2021) [PMID: 33909994  ]
Assembly composition: protein/protein complex
Assembly name: Huntingtin and 40-kDa huntingtin-associated protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150024 (Preferred)   search this ID
PDBe-KB: P42858    P23610   
Electron Microscopy
4.1Å resolution
Released: 24 Mar 2021
Model geometry
Fit model/data
Data not analysed
7dxk
7dxk
7dxk
The Rigid-body refined model of the normal Huntingtin.
Jung T, Tamo G, Dal Perraro M, Hebert H, Song J
Structure (2020) [PMID: 32668197  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Huntingtin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154897 (Preferred)   search this ID
PDBe-KB: P42858   
Electron Microscopy
9.6Å resolution
Released: 3 Jun 2020
Model geometry
Fit model/data
Data not analysed
6rmh
6rmh
6rmh
High resolution cryoEM structure of huntingtin in complex with HAP40
Harding RJ, Deme JC, Lea SM, Arrowsmith CH, Structural Genomics Consortium (SGC)
Commun Biol (2021) [PMID: 34880419  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Huntingtin and 40-kDa huntingtin-associated protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150024 (Preferred)   search this ID
PDBe-KB: P42858    P23610   
Electron Microscopy
2.6Å resolution
Released: 17 Jun 2020
Model geometry
Fit model/data
Data not analysed
6x9o
6x9o
6x9o
Entries 1 to 10 of 26
Entries 1 to 10 of 26