Uniprot accession / id : P43026  OR   Uniprot accession / id : E2R0W8  OR   Uniprot accession / id : Q9W6G0  OR   Uniprot accession / id : F1QK08
 
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Entry Information
Entry status  (1)
REL
(15)
 
Experimental methods  (1)
X-ray diffraction
(15)
 
Authors  (65)
Malinauskas T
(8)
Mueller TD
(8)
Siebold C
(8)
Muller TD
(6)
Bishop B
(5)
Peer TV
(5)
Ashe H
(3)
Ashe HL
(3)
Baldock C
(3)
Belnoue-Davis H
(3)
Belnoue-Davis HL
(3)
Duman R
(3)
Eggington H
(3)
El Omari K
(3)
Griffiths SC
(3)
Kotzsch A
(3)
Leedham SJ
(3)
Moore G
(3)
Nickel J
(3)
Rudolf AF
(3)
Sebald W
(3)
Wagner A
(3)
Woolley RE
(3)
Kattamuri C
(2)
Nolan K
(2)
Thompson TB
(2)
Zorn AM
(2)
Agricola Z
(1)
Brenneis C
(1)
Cowan KJ
(1)
Czepnik M
(1)
Edwards NA
(1)
Gigout A
(1)
Gipson GR
(1)
Guehring H
(1)
Guhring H
(1)
Gühring H
(1)
Hellmann TV
(1)
Henson F
(1)
Kenny AP
(1)
Klammert U
(1)
Kleinschmidt-Doerr K
(1)
Koyama M
(1)
Kruse M
(1)
Kuebler AC
(1)
Liesum A
(1)
Menges S
(1)
Michaelis M
(1)
Mullins MC
(1)
Musil D
(1)
Müller TD
(1)
Nolan KT
(1)
Pohl J
(1)
Rankin SA
(1)
Read RJ
(1)
Schliermann A
(1)
Schmitz W
(1)
Schreuder H
(1)
Seher A
(1)
Thudium C
(1)
Thudium CS
(1)
Wekmann D
(1)
Werkmann D
(1)
Wuerzler KK
(1)
Zinski J
(1)
 
Homo / hetero assembly  (2)
hetero
(12)
homo
(3)
 
Assembly composition  (2)
protein/protein complex
(12)
protein structure
(3)
 
Assembly polymer count  (3)
tetramer
(9)
dimer
(5)
decamer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(2)
2.0 - 2.5
(5)
2.5 - 3
(5)
3.0 - 3.5
(1)
5.5 - 6
(1)
 
Release year distribution
2000 - 2005
(2)
2005 - 2010
(3)
2010 - 2015
(1)
2015 - 2020
(6)
2020 - 2025
(10)
 
Journal  (8)
Proc Natl Acad Sci U S A
(5)
Nat Commun
(3)
BMC Biol
(2)
Arthritis Rheumatol
(1)
Biochem Biophys Res Commun
(1)
Cell Rep
(1)
EMBO J
(1)
J Mol Biol
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(15)
 
Organism name  (1)
Homo sapiens
(15)
 
Molecule name  (10)
BMP-14
(15)
Bone morphogenetic protein 14
(15)
CDMP-1
(15)
Cartilage-derived morphogenetic protein 1
(15)
GDF-5
(15)
Growth/differentiation factor 5
(15)
LAP-4
(15)
LPS-associated protein 4
(15)
Lipopolysaccharide-associated protein 4
(15)
Radotermin
(15)
 
Molecule type  (1)
Protein
(15)
 
Gene names  (3)
BMP14
(15)
CDMP1
(15)
GDF5
(15)
 
Interacting Molecules  (9)
Repulsive guidance molecule B
(3)
Twisted gastrulation protein homolog 1
(3)
Bone morphogenetic protein 2
(1)
Bone morphogenetic protein receptor type-1A
(1)
Bone morphogenetic protein receptor type-1B
(1)
Gremlin-2
(1)
Hemojuvelin
(1)
Neogenin
(1)
Repulsive guidance molecule A
(1)
 
Interacting ligands  (7)
CA : CALCIUM ION
(3)
CIT : CITRIC ACID
(1)
EDO : 1,2-ETHANEDIOL
(1)
GOL : GLYCEROL
(1)
IPA : ISOPROPYL ALCOHOL
(1)
MPD : (4S)-2-METHYL-2,4-PENTANEDIOL
(1)
SO4 : SULFATE ION
(1)
 
Function and Biology
Biological function  (1)
growth factor activity
(15)
 
Biological cell component  (1)
extracellular region
(15)
 
Sequence and Structure classification
CATH class  (1)
Mainly Beta
(5)
 
CATH topology  (1)
Cystine Knot Cytokines, subunit B
(5)
 
Pfam accession / name  (1)
PF00019 : TGF_beta
(15)
 
Experimental Information
Diffraction protocol  (2)
Single wavelength
(15)
MAD
(1)
 
Diffraction radiation source type  (2)
Synchrotron
(13)
Rotating anode
(2)
 
Diffraction source  (9)
DIAMOND BEAMLINE I03
(3)
DIAMOND BEAMLINE I04
(3)
SLS BEAMLINE X06SA
(3)
DIAMOND BEAMLINE I23
(2)
APS BEAMLINE 23-ID-B
(1)
APS BEAMLINE 23-ID-D
(1)
BESSY BEAMLINE 14.1
(1)
ENRAF-NONIUS FR571
(1)
RIGAKU MICROMAX-007
(1)
 
Synchrotron site  (4)
Diamond
(8)
SLS
(3)
APS
(2)
BESSY
(1)
 
Diffraction detector type  (3)
Pixel
(11)
CCD
(2)
Image plate
(2)
 
Refinement software  (4)
PHENIX
(8)
REFMAC
(5)
BUSTER
(1)
X-PLOR
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 15
Entries 1 to 10 of 15
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Crystal structure of the GDF-5:BMP receptor IB complex.
Kotzsch A, Mueller TD
EMBO J (2009) [PMID: 19229295  ]
Assembly composition: protein/protein complex
Assembly name: Growth/differentiation factor 5 and Bone morphogenetic protein receptor type-1B (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153254 (Preferred)   search this ID
PDBe-KB: P43026    P36898   
X-ray diffraction
2.1Å resolution
Released: 10 Mar 2009
Model geometry
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3evs
3evs
3evs
Crystal structure of a TGF-beta ligand-receptor complex
Mueller TD, Nickel J, Sebald W
BMC Biol (2015) [PMID: 26385096  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Bone morphogenetic protein receptor type-1A and Growth/differentiation factor 5 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153247 (Preferred)   search this ID
PDBe-KB: P43026    P36894   
X-ray diffraction
2.28Å resolution
Released: 14 Mar 2012
Model geometry
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3qb4
3qb4
3qb4
Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation Factor 5 (GDF5) and calcium, long-wavelength X-ray dataset (4010 eV)
Malinauskas T, Rudolf AF, Moore G, Eggington H, Belnoue-Davis H, El Omari K, Woolley RE, Griffiths SC, Duman R, Wagner A, Leedham SJ, Baldock C, Ashe H, Siebold C
Nat Commun (2024) [PMID: 38862520  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CA    CA   
Assembly name: Growth/differentiation factor 5 and Twisted gastrulation protein homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-273754 (Preferred)   search this ID
PDBe-KB: P43026    Q9GZX9   
X-ray diffraction
2.57Å resolution
Released: 19 Jun 2024
Model geometry
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8bwn
8bwn
8bwn
Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium
Malinauskas T, Rudolf AF, Moore G, Eggington H, Belnoue-Davis H, El Omari K, Woolley RE, Griffiths SC, Duman R, Wagner A, Leedham SJ, Baldock C, Ashe H, Siebold C
Nat Commun (2024) [PMID: 38862520  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CA    CA   
Assembly name: Growth/differentiation factor 5 and Twisted gastrulation protein homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-273754 (Preferred)   search this ID
PDBe-KB: P43026    Q9GZX9   
X-ray diffraction
1.96Å resolution
Released: 19 Jun 2024
Model geometry
Fit model/data
8bwl
8bwl
8bwl
Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium, long-wavelength X-ray dataset (4042 eV)
Malinauskas T, Rudolf AF, Moore G, Eggington H, Belnoue-Davis H, El Omari K, Woolley RE, Griffiths SC, Duman R, Wagner A, Leedham SJ, Baldock C, Ashe H, Siebold C
Nat Commun (2024) [PMID: 38862520  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CA    CA   
Assembly name: Growth/differentiation factor 5 and Twisted gastrulation protein homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-273754 (Preferred)   search this ID
PDBe-KB: P43026    Q9GZX9   
X-ray diffraction
2.5Å resolution
Released: 19 Jun 2024
Model geometry
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8bwm
8bwm
8bwm
BMP2/GDF5 heterodimer
Gipson GR, Nolan KT, Thompson TB
BMC Biol (2023) [PMID: 36726183  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GOL   
Assembly name: Growth/differentiation factor 5 and Bone morphogenetic protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-273194 (Preferred)   search this ID
PDBe-KB: P43026    P12643   
X-ray diffraction
2.8Å resolution
Released: 15 Feb 2023
Model geometry
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8e3g
8e3g
8e3g
Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) (crystal form 2)
Malinauskas T, Peer TV, Bishop B, Muller TD, Siebold C
Proc Natl Acad Sci U S A (2020) [PMID: 32576689  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Growth/differentiation factor 5 and Repulsive guidance molecule B (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154936 (Preferred)   search this ID
PDBe-KB: P43026    Q6NW40   
X-ray diffraction
3.158Å resolution
Released: 1 Jul 2020
Model geometry
Fit model/data
6z3h
6z3h
6z3h
Repulsive Guidance Molecule C (RGMC, Hemojuvelin, HJV, HFE2) in complex with Growth Differentiation Factor 5 (GDF5)
Malinauskas T, Peer TV, Bishop B, Muller TD, Siebold C
Proc Natl Acad Sci U S A (2020) [PMID: 32576689  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Growth/differentiation factor 5 and Hemojuvelin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154937 (Preferred)   search this ID
PDBe-KB: P43026    Q6ZVN8   
X-ray diffraction
2.513Å resolution
Released: 1 Jul 2020
Model geometry
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6z3l
6z3l
6z3l
Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1).
Malinauskas T, Peer TV, Bishop B, Muller TD, Siebold C
Proc Natl Acad Sci U S A (2020) [PMID: 32576689  ]
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
PDBe complex ID: PDB-CPX-216334 (Preferred)   search this ID
PDBe-KB: P43026    P97798    Q6NW40   
X-ray diffraction
5.501Å resolution
Released: 1 Jul 2020
Model geometry
Fit model/data
6z3m
6z3m
6z3m
Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) (crystal form 1)
Malinauskas T, Peer TV, Bishop B, Muller TD, Siebold C
Proc Natl Acad Sci U S A (2020) [PMID: 32576689  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GOL    NAG    SO4    CL    NAG    EDO   
Assembly name: Growth/differentiation factor 5 and Repulsive guidance molecule B (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154936 (Preferred)   search this ID
PDBe-KB: P43026    Q6NW40   
X-ray diffraction
1.65Å resolution
Released: 1 Jul 2020
Model geometry
Fit model/data
6z3j
6z3j
6z3j
Entries 1 to 10 of 15
Entries 1 to 10 of 15