Uniprot accession / id : P98170  OR   Uniprot accession / id : Q9R0I6  OR   Uniprot accession / id : Q8UVF8  OR   Uniprot accession / id : A2RV08  OR   Uniprot accession / id : Q7QJ54  OR   Uniprot accession / id : A0NBE1  OR   Uniprot accession / id : Q7PT86  OR   Uniprot accession / id : Q5TXN5
 
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Entry Information
Entry status  (1)
REL
(72)
 
Experimental methods  (3)
X-ray diffraction
(64)
Solution NMR
(7)
Electron Microscopy
(1)
 
Authors  (335)
Chessari G
(18)
Johnson CN
(18)
Lewis EJ
(18)
Martins V
(18)
Rich SJ
(18)
Ward GA
(18)
Williams PA
(18)
Wilsher NE
(18)
Buck IM
(17)
Day JEH
(17)
Reader M
(17)
Iqbal A
(15)
Tamanini E
(15)
Cossu F
(11)
Mastrangelo E
(11)
Milani M
(11)
Day JE
(10)
Day PJ
(10)
Miller D
(10)
Rees DC
(10)
Vitorino M
(10)
Williams G
(10)
Woolford AJ
(10)
Woolford AJ-A
(10)
Bolognesi M
(8)
Gao L
(8)
Goggin B
(8)
Janson CA
(8)
Li S
(8)
Chiarparin E
(7)
Lecis D
(7)
Lukacs CM
(7)
Peakman T
(7)
Seneci P
(7)
Belunis C
(6)
Crowther R
(6)
Danho W
(6)
Delia D
(6)
Fesik SW
(6)
Gosu R
(6)
Kamath AV
(6)
Kuglstatter A
(6)
Lukacs C
(6)
Pandey R
(6)
Remiszewski S
(6)
Schutt A
(6)
Shi Y
(6)
Singh SK
(6)
Sun C
(6)
Swaminathan S
(6)
Thakur MK
(6)
Tyagi R
(6)
Drago C
(5)
Frederickson M
(5)
Griffiths-Jones CM
(5)
Hearn K
(5)
Heightman TD
(5)
Manzoni L
(5)
Meadows RP
(5)
Riedl SJ
(5)
Scolastico C
(5)
Huang Y
(4)
Rizzo V
(4)
Sorrentino G
(4)
Wu H
(4)
Ahn JS
(3)
Betz SF
(3)
Borzilleri RM
(3)
Carter PH
(3)
Chai J
(3)
Condon SM
(3)
Connors WH
(3)
Corti A
(3)
Deshayes K
(3)
Elliott LO
(3)
Emanuel SL
(3)
Fairbrother WJ
(3)
Fargnoli J
(3)
Flygare JA
(3)
Fraley A
(3)
Grassi S
(3)
Hymowitz SG
(3)
Kim K
(3)
Lei M
(3)
Lin SC
(3)
Lo YC
(3)
Lu M
(3)
Malvezzi F
(3)
Maurer B
(3)
Munck JM
(3)
Naglich JG
(3)
Olejniczak ET
(3)
Pokross ME
(3)
Posy SL
(3)
Seigal BA
(3)
Shen H
(3)
Smyth T
(3)
Sun H
(3)
Surti N
(3)
Talbott R
(3)
 
More...
 
Homo / hetero assembly  (2)
homo
(50)
hetero
(22)
 
Assembly composition  (2)
protein structure
(50)
protein/protein complex
(22)
 
Assembly polymer count  (5)
monomer
(34)
dimer
(32)
tetramer
(3)
hexamer
(2)
trimer
(1)
 
Resolution distribution
1.0 - 1.5
(6)
1.5 - 2
(14)
2.0 - 2.5
(25)
2.5 - 3
(16)
3.0 - 3.5
(4)
 
Release year distribution
1995 - 2000
(1)
2000 - 2005
(11)
2005 - 2010
(16)
2010 - 2015
(31)
2015 - 2020
(26)
2020 - 2025
(4)
 
Journal  (20)
J Med Chem
(29)
Acta Crystallogr D Biol Crystallogr
(6)
To be published
(6)
J Mol Biol
(5)
Mol Cell
(4)
Cell
(3)
Nature
(3)
Biochem J
(2)
Bioorg Med Chem
(2)
ChemistryOpen
(2)
ACS Chem Biol
(1)
Biochem Biophys Res Commun
(1)
Biochemistry
(1)
Biomol NMR Assign
(1)
FEBS J
(1)
J Biol Chem
(1)
Life Sci Alliance
(1)
Mol Cancer Ther
(1)
PLoS One
(1)
Proteins
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(72)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 72
Entries 1 to 10 of 72
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Crystal structure of XIAP-BIR2 domain complexed with (S)-3-(4-methoxyphenyl)-2-((S)-2-((S)-1-((S)-2-((S)-2-(methylamino)propanamido)pent-4-ynoyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)propanoic acid
Pokross ME
J Med Chem (2015) [PMID: 25695766  ]
Source organisms: Synthetic construct, Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GOL    ZN    SO4    ZN   
Modified residues: MAA    4LZ    MAA    LPH    4LZ    LPH   
Assembly name: E3 ubiquitin-protein ligase XIAP and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161368 (Preferred)   search this ID
PDBe-KB: P98170   
X-ray diffraction
2.09Å resolution
Released: 6 May 2015
Model geometry
Fit model/data
4wvs
4wvs
4wvs
Smac mimic bound to BIR3-XIAP
Wist AD, Lu G, Riedl SJ, Shi Y, McLendon GL
Bioorg Med Chem (2007) [PMID: 17336535  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CO9    ZN    ZN    CO9   
Assembly name: E3 ubiquitin-protein ligase XIAP (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161372 (Preferred)   search this ID
PDBe-KB: P98170   
X-ray diffraction
2.8Å resolution
Released: 20 Feb 2007
Model geometry
Fit model/data
Data not deposited
2opy
2opy
2opy
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 18
Chessari G, Buck IM, Day JEH, Day PJ, Iqbal A, Johnson CN, Lewis EJ, Martins V, Miller D, Reader M, Rees DC, Rich SJ, Tamanini E, Vitorino M, Ward GA, Williams PA, Williams G, Wilsher NE, Woolford AJ-A
J Med Chem (2015) [PMID: 26218264  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 4YC    ZN    ZN    4YC   
Assembly name: E3 ubiquitin-protein ligase XIAP (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161361 (Preferred)   search this ID
PDBe-KB: P98170   
X-ray diffraction
2.32Å resolution
Released: 12 Aug 2015
Model geometry
Fit model/data
5c7c
5c7c
5c7c
Fragment Derived XIAP inhibitor
Williams PA
J Med Chem (2018) [PMID: 30091600  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: FUE    ZN    NA    ZN    NA   
Assembly name: E3 ubiquitin-protein ligase XIAP (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161361 (Preferred)   search this ID
PDBe-KB: P98170   
X-ray diffraction
2.03Å resolution
Released: 22 Aug 2018
Model geometry
Fit model/data
6h6r
6h6r
6h6r
AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-3 DOMAIN OF XIAP
Sun C, Cai M, Meadows RP, Fesik SW
J Biol Chem (2000) [PMID: 10934209  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: E3 ubiquitin-protein ligase XIAP (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161361 (Preferred)   search this ID
PDBe-KB: P98170   
Solution NMR
Released: 11 Jul 2001
Model geometry
Fit model/data
Data not deposited
1f9x
1f9x
1f9x
NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP
Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Zou H, Fesik SW
J Med Chem (2004) [PMID: 15317454  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN    998    998   
Assembly name: E3 ubiquitin-protein ligase XIAP (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161361 (Preferred)   search this ID
PDBe-KB: P98170   
Solution NMR
Released: 7 Sep 2004
Model geometry
Fit model/data
Data not deposited
1tfq
1tfq
1tfq
CRYSTAL STRUCTURE OF THE XIAP/CASPASE-7 COMPLEX
Huang Y, Park YC, Rich RL, Segal D, Myszka DG, Wu H
Cell (2001) [PMID: 11257231  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: E3 ubiquitin-protein ligase XIAP and Caspase-7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157230 (Preferred)   search this ID
PDBe-KB: P98170    P55210   
X-ray diffraction
2.4Å resolution
Released: 21 Mar 2001
Model geometry
Fit model/data
Data not deposited
1i4o
1i4o
1i4o
CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP
Chai J, Shi Y
Cell (2001) [PMID: 11257230  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Caspase-7 complex and E3 ubiquitin-protein ligase XIAP (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157235 (Preferred)   search this ID
PDBe-KB: P98170    P55210   
X-ray diffraction
2.45Å resolution
Released: 23 Feb 2002
Model geometry
Fit model/data
Data not deposited
1i51
1i51
1i51
STRUCTURE OF CASPASE-9 IN AN INHIBITORY COMPLEX WITH XIAP-BIR3
Shiozaki EN, Chai J, Rigotti DJ, Riedl SJ, Li P, Srinivasula SM, Alnemri ES, Fairman R, Shi Y
Mol Cell (2003) [PMID: 12620238  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Assembly name: Caspases (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157263 (Preferred)   search this ID
PDBe-KB: P98170    P55211   
X-ray diffraction
2.4Å resolution
Released: 25 Mar 2003
Model geometry
Fit model/data
Data not deposited
1nw9
1nw9
1nw9
Solution structure of the ring domain of the Baculoviral IAP repeat-containing protein 4 from Homo sapiens
Miyamoto K, Sato M, Koshiba S, Watanabe S, Harada T, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: E3 ubiquitin-protein ligase XIAP (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161361 (Preferred)   search this ID
PDBe-KB: P98170   
Solution NMR
Released: 18 Mar 2008
Model geometry
Fit model/data
Data not deposited
2ecg
2ecg
2ecg
...
Entries 1 to 10 of 72
Entries 1 to 10 of 72