Uniprot accession / id : Q02152  OR   Uniprot accession / id : P41595
 
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Entry Information
Entry status  (1)
REL
(11)
 
Experimental methods  (2)
X-ray diffraction
(8)
Electron Microscopy
(3)
 
Authors  (83)
Roth BL
(10)
Wacker D
(8)
McCorvy JD
(6)
Che T
(5)
Lansu K
(5)
Wang S
(5)
Agegnehu B
(4)
Dror RO
(4)
Jin J
(4)
Liu J
(4)
Nichols DE
(4)
Olsen RHJ
(4)
Tribo AR
(4)
Barros-Alvarez X
(3)
Barros-Álvarez X
(3)
Cao C
(3)
Cherezov V
(3)
Damgen MA
(3)
Dämgen MA
(3)
Fay JF
(3)
Gumpper RH
(3)
Han GW
(3)
Huttenhain R
(3)
Hüttenhain R
(3)
Katritch V
(3)
Kim K
(3)
Krogan NJ
(3)
Krumm BE
(3)
Liu W
(3)
Panova O
(3)
Robertson MJ
(3)
Seven AB
(3)
Skiniotis G
(3)
Stevens RC
(3)
Suomivuori CM
(3)
Zhang S
(3)
Zhong X
(3)
Basu S
(2)
Boutet S
(2)
GPCR Network (GPCR)
(2)
James D
(2)
Messerschmidt M
(2)
Wang C
(2)
Wang D
(2)
Weierstall U
(2)
Barty A
(1)
Betz RM
(1)
Beyerlein KR
(1)
Caffrey M
(1)
Chapman HN
(1)
Chu M
(1)
Fromme P
(1)
Fromme R
(1)
Gati C
(1)
Grotjohann I
(1)
Huang X
(1)
Huang XP
(1)
Ishchenko A
(1)
Jiang Y
(1)
Kapoor M
(1)
Kirian RA
(1)
Koglin JE
(1)
Kupitz C
(1)
Levit A
(1)
Li D
(1)
Nelson G
(1)
Patel N
(1)
Rendek KN
(1)
Schools ZL
(1)
Seibert MM
(1)
Shah ST
(1)
Shah STA
(1)
Shoichet BK
(1)
Siu FY
(1)
Spence JC
(1)
Spence JCH
(1)
Vardy E
(1)
Venkatakrishnan AJ
(1)
White TA
(1)
Williams GJ
(1)
Xu HE
(1)
Zatsepin NA
(1)
Zhang A
(1)
 
Homo / hetero assembly  (2)
homo
(8)
hetero
(3)
 
Assembly composition  (2)
protein structure
(8)
protein/protein complex
(3)
 
Assembly polymer count  (4)
monomer
(8)
hexamer
(1)
pentamer
(1)
trimer
(1)
 
Resolution distribution
2.5 - 3
(7)
3.0 - 3.5
(4)
 
Release year distribution
2010 - 2015
(2)
2015 - 2020
(6)
2020 - 2025
(3)
 
Journal  (5)
Nat Struct Mol Biol
(4)
Neuron
(3)
Science
(2)
Cell
(1)
Proc Natl Acad Sci U S A
(1)
 
Macromolecules
Organism superkingdom  (2)
Eukaryota
(11)
Bacteria
(8)
 
Organism name  (2)
Homo sapiens
(11)
Escherichia coli
(8)
 
Molecule name  (6)
5-HT-2B
(11)
5-HT2B
(11)
5-hydroxytryptamine receptor 2B
(11)
Serotonin receptor 2B
(11)
Cytochrome b-562
(8)
Soluble cytochrome b562
(8)
 
Molecule type  (1)
Protein
(11)
 
Gene names  (2)
HTR2B
(11)
cybC
(8)
 
Interacting Molecules  (11)
Anti-5-HT2B Fab heavy chain
(1)
Anti-5-HT2B Fab light chain
(1)
Anti-5HT2BR Fab heavy chain
(1)
Anti-5HT2BR Fab light chain
(1)
Beta-arrestin-1
(1)
Fab30 heavy chain
(1)
Fab30 light chain
(1)
G protein subunit q (Gi2-mini-Gq chimera)
(1)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(1)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
(1)
single-chain variable fragment 16 (scFv16)
(1)
 
Function and Biology
Biological function  (6)
G protein-coupled receptor activity
(11)
G protein-coupled serotonin receptor activity
(9)
electron transfer activity
(8)
heme binding
(8)
iron ion binding
(8)
metal ion binding
(8)
 
Biological process  (6)
G protein-coupled receptor signaling pathway
(11)
electron transport chain
(8)
heart development
(2)
regulation of behavior
(2)
smooth muscle contraction
(2)
vasoconstriction
(2)
 
Biological cell component  (3)
membrane
(11)
plasma membrane
(9)
periplasmic space
(8)
 
Sequence and Structure classification
CATH class  (1)
Mainly Alpha
(2)
 
CATH topology  (2)
Four Helix Bundle (Hemerythrin (Met), subunit A)
(2)
Rhopdopsin 7-helix transmembrane proteins
(2)
 
Pfam accession / name  (2)
PF00001 : 7tm_1
(11)
PF07361 : Cytochrom_B562
(8)
 
Representative Structures
Representative Structures
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30%
Entries 1 to 10 of 11
Entries 1 to 10 of 11
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Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody
Ishchenko A, Wacker D, Kapoor M, Zhang A, Han GW, Basu S, Boutet S, James D, Wang D, Weierstall U, Liu W, Katritch V, Stevens RC, Cherezov V
Proc Natl Acad Sci U S A (2017) [PMID: 28716900  ]
Assembly composition: protein/protein complex
Bound ligands: ERM   
Assembly name: 5-hydroxytryptamine receptor 2B, Soluble cytochrome b562 and IG-light kappa chain and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-230828 (Preferred)   search this ID
PDBe-KB: P0ABE7    P41595   
X-ray diffraction
3Å resolution
Released: 26 Jul 2017
Model geometry
Fit model/data
5tud
5tud
5tud
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL
Nat Struct Mol Biol (2018) [PMID: 30127358  ]
Assembly composition: protein only structure
Bound ligands: CLR    H8M    PEG    OLC    PEG    CLR    OLC    H8M   
Assembly name: 5-hydroxytryptamine receptor 2B, Soluble cytochrome b562 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-142091 (Preferred)   search this ID
PDBe-KB: P0ABE7    P41595   
X-ray diffraction
3.188Å resolution
Released: 29 Aug 2018
Model geometry
Fit model/data
6ds0
6ds0
6ds0
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL
Nat Struct Mol Biol (2018) [PMID: 30127358  ]
Assembly composition: protein only structure
Bound ligands: CLR    H8D    PEG    OLC    PEG    CLR    H8D    OLC    OLA    OLA    PO4   
Assembly name: 5-hydroxytryptamine receptor 2B, Soluble cytochrome b562 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-142091 (Preferred)   search this ID
PDBe-KB: P0ABE7    P41595   
X-ray diffraction
2.918Å resolution
Released: 29 Aug 2018
Model geometry
Fit model/data
6dry
6dry
6dry
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL
Nat Struct Mol Biol (2018) [PMID: 30127358  ]
Assembly composition: protein only structure
Bound ligands: CLR    H8G    OLC    CLR    OLC    H8G   
Assembly name: 5-hydroxytryptamine receptor 2B, Soluble cytochrome b562 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-142091 (Preferred)   search this ID
PDBe-KB: P0ABE7    P41595   
X-ray diffraction
3.1Å resolution
Released: 29 Aug 2018
Model geometry
Fit model/data
6drx
6drx
6drx
Crystal structure of the LSD-bound 5-HT2B receptor
Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL
Cell (2017) [PMID: 28129538  ]
Assembly composition: protein only structure
Bound ligands: CLR    PEG    OLC    PEG    CLR    OLC    7LD    7LD    PO4   
Assembly name: 5-hydroxytryptamine receptor 2B, Soluble cytochrome b562 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-142091 (Preferred)   search this ID
PDBe-KB: P0ABE7    P41595   
X-ray diffraction
2.9Å resolution
Released: 1 Feb 2017
Model geometry
Fit model/data
5tvn
5tvn
5tvn
5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM)
Barros-Alvarez X, Cao C, Panova O, Roth BL, Skiniotis G
Neuron (2022) [PMID: 36087581  ]
Assembly composition: protein/protein complex
Bound ligands: NAG    7LD    NAG    7LD   
Modified residues: SEP    SEP   
PDBe complex ID: PDB-CPX-279936 (Preferred)   search this ID
PDBe-KB: P41595    P49407   
Electron Microscopy
3.3Å resolution
Released: 21 Sep 2022
Model geometry
Fit model/data
Data not analysed
7srs
7srs
7srs
5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM)
Barros-Alvarez X, Kim K, Panova O, Cao C, Roth BL, Skiniotis G
Neuron (2022) [PMID: 36087581  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: 7LD    7LD   
PDBe complex ID: PDB-CPX-211201 (Preferred)   search this ID
PDBe-KB: P41595    P62873    P59768   
Electron Microscopy
2.9Å resolution
Released: 21 Sep 2022
Model geometry
Fit model/data
Data not analysed
7srr
7srr
7srr
5-HT2B receptor bound to LSD obtained by cryo-electron microscopy (cryoEM)
Barros-Alvarez X, Cao C, Panova O, Roth BL, Skiniotis G
Neuron (2022) [PMID: 36087581  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NAG    7LD    NAG    7LD   
Assembly name: 5-hydroxytryptamine receptor 2B (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154412 (Preferred)   search this ID
PDBe-KB: P41595   
Electron Microscopy
2.7Å resolution
Released: 21 Sep 2022
Model geometry
Fit model/data
Data not analysed
7srq
7srq
7srq
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL
Nat Struct Mol Biol (2018) [PMID: 30127358  ]
Assembly composition: protein only structure
Bound ligands: CLR    H8J    PEG    OLC    PEG    CLR    OLC    H8J    OLA    OLA    PO4   
Assembly name: 5-hydroxytryptamine receptor 2B, Soluble cytochrome b562 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-142091 (Preferred)   search this ID
PDBe-KB: P0ABE7    P41595   
X-ray diffraction
3.102Å resolution
Released: 29 Aug 2018
Model geometry
Fit model/data
6drz
6drz
6drz
Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase.
Liu W, Wacker D, Gati C, Han GW, James D, Wang D, Nelson G, Weierstall U, Katritch V, Barty A, Zatsepin NA, Li D, Messerschmidt M, Boutet S, Williams GJ, Koglin JE, Seibert MM, Wang C, Shah STA, Basu S, Fromme R, Kupitz C, Rendek KN, Grotjohann I, Fromme P, Kirian RA, Beyerlein KR, White TA, Chapman HN, Caffrey M, Spence JCH, Stevens RC, Cherezov V, GPCR Network (GPCR)
Science (2013) [PMID: 24357322  ]
Assembly composition: protein only structure
Bound ligands: CLR    ERM    PEG    OLC    PEG    CLR    DGA    OLC    PLM    TRS    TRS    DGA    OLA    OLA   
Assembly name: 5-hydroxytryptamine receptor 2B, Soluble cytochrome b562 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-142091 (Preferred)   search this ID
PDBe-KB: P0ABE7    P41595   
X-ray diffraction
2.8Å resolution
Released: 18 Dec 2013
Model geometry
Fit model/data
4nc3
4nc3
4nc3
Entries 1 to 10 of 11
Entries 1 to 10 of 11