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Entry Information
Entry status
(1)
Experimental methods
(2)
X-ray diffraction
(8)
Electron Microscopy
(3)
Authors
(83)
Roth BL
(10)
Wacker D
(8)
McCorvy JD
(6)
Che T
(5)
Lansu K
(5)
Wang S
(5)
Agegnehu B
(4)
Dror RO
(4)
Jin J
(4)
Liu J
(4)
Nichols DE
(4)
Olsen RHJ
(4)
Tribo AR
(4)
Barros-Alvarez X
(3)
Barros-Álvarez X
(3)
Cao C
(3)
Cherezov V
(3)
Damgen MA
(3)
Dämgen MA
(3)
Fay JF
(3)
Gumpper RH
(3)
Han GW
(3)
Huttenhain R
(3)
Hüttenhain R
(3)
Katritch V
(3)
Kim K
(3)
Krogan NJ
(3)
Krumm BE
(3)
Liu W
(3)
Panova O
(3)
Robertson MJ
(3)
Seven AB
(3)
Skiniotis G
(3)
Stevens RC
(3)
Suomivuori CM
(3)
Zhang S
(3)
Zhong X
(3)
Basu S
(2)
Boutet S
(2)
GPCR Network (GPCR)
(2)
James D
(2)
Messerschmidt M
(2)
Wang C
(2)
Wang D
(2)
Weierstall U
(2)
Barty A
(1)
Betz RM
(1)
Beyerlein KR
(1)
Caffrey M
(1)
Chapman HN
(1)
Chu M
(1)
Fromme P
(1)
Fromme R
(1)
Gati C
(1)
Grotjohann I
(1)
Huang X
(1)
Huang XP
(1)
Ishchenko A
(1)
Jiang Y
(1)
Kapoor M
(1)
Kirian RA
(1)
Koglin JE
(1)
Kupitz C
(1)
Levit A
(1)
Li D
(1)
Nelson G
(1)
Patel N
(1)
Rendek KN
(1)
Schools ZL
(1)
Seibert MM
(1)
Shah ST
(1)
Shah STA
(1)
Shoichet BK
(1)
Siu FY
(1)
Spence JC
(1)
Spence JCH
(1)
Vardy E
(1)
Venkatakrishnan AJ
(1)
White TA
(1)
Williams GJ
(1)
Xu HE
(1)
Zatsepin NA
(1)
Zhang A
(1)
Homo / hetero assembly
(2)
homo
(8)
hetero
(3)
Assembly composition
(2)
protein structure
(8)
protein/protein complex
(3)
Assembly polymer count
(4)
monomer
(8)
hexamer
(1)
pentamer
(1)
trimer
(1)
Resolution distribution
2.5 - 3
(7)
3.0 - 3.5
(4)
Release year distribution
2010 - 2015
(2)
2015 - 2020
(6)
2020 - 2025
(3)
Journal
(5)
Nat Struct Mol Biol
(4)
Neuron
(3)
Science
(2)
Cell
(1)
Proc Natl Acad Sci U S A
(1)
Macromolecules
Organism superkingdom
(2)
Eukaryota
(11)
Bacteria
(8)
Organism name
(2)
Homo sapiens
(11)
Escherichia coli
(8)
Molecule name
(6)
5-HT-2B
(11)
5-HT2B
(11)
5-hydroxytryptamine receptor 2B
(11)
Serotonin receptor 2B
(11)
Cytochrome b-562
(8)
Soluble cytochrome b562
(8)
Molecule type
(1)
Protein
(11)
Gene names
(2)
HTR2B
(11)
cybC
(8)
Interacting Molecules
(11)
Anti-5-HT2B Fab heavy chain
(1)
Anti-5-HT2B Fab light chain
(1)
Anti-5HT2BR Fab heavy chain
(1)
Anti-5HT2BR Fab light chain
(1)
Beta-arrestin-1
(1)
Fab30 heavy chain
(1)
Fab30 light chain
(1)
G protein subunit q (Gi2-mini-Gq chimera)
(1)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(1)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
(1)
single-chain variable fragment 16 (scFv16)
(1)
Function and Biology
Biological function
(6)
G protein-coupled receptor activity
(11)
G protein-coupled serotonin receptor activity
(9)
electron transfer activity
(8)
heme binding
(8)
iron ion binding
(8)
metal ion binding
(8)
Biological process
(6)
G protein-coupled receptor signaling pathway
(11)
electron transport chain
(8)
heart development
(2)
regulation of behavior
(2)
smooth muscle contraction
(2)
vasoconstriction
(2)
Biological cell component
(3)
membrane
(11)
plasma membrane
(9)
periplasmic space
(8)
Sequence and Structure classification
CATH class
(1)
Mainly Alpha
(2)
CATH topology
(2)
Four Helix Bundle (Hemerythrin (Met), subunit A)
(2)
Rhopdopsin 7-helix transmembrane proteins
(2)
Pfam accession / name
(2)
PF00001 : 7tm_1
(11)
PF07361 : Cytochrom_B562
(8)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 11
Select all entries on this page
Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody
Ishchenko A, Wacker D, Kapoor M, Zhang A, Han GW, Basu S, Boutet S, James D, Wang D, Weierstall U, Liu W, Katritch V, Stevens RC, Cherezov V
Proc Natl Acad Sci U S A
(2017)
[PMID: 28716900 ]
Assembly composition: protein/protein complex
Bound ligands:
ERM
Assembly name:
5-hydroxytryptamine receptor 2B, Soluble cytochrome b562 and IG-light kappa chain and IG-heavy chain
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-230828 (Preferred)
search this ID
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL
Nat Struct Mol Biol
(2018)
[PMID: 30127358 ]
Source organisms: Escherichia coli , Homo sapiens
Assembly composition: protein only structure
Assembly name:
5-hydroxytryptamine receptor 2B, Soluble cytochrome b562
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-142091 (Preferred)
search this ID
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL
Nat Struct Mol Biol
(2018)
[PMID: 30127358 ]
Source organisms: Escherichia coli , Homo sapiens
Assembly composition: protein only structure
Assembly name:
5-hydroxytryptamine receptor 2B, Soluble cytochrome b562
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-142091 (Preferred)
search this ID
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL
Nat Struct Mol Biol
(2018)
[PMID: 30127358 ]
Source organisms: Escherichia coli , Homo sapiens
Assembly composition: protein only structure
Assembly name:
5-hydroxytryptamine receptor 2B, Soluble cytochrome b562
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-142091 (Preferred)
search this ID
Crystal structure of the LSD-bound 5-HT2B receptor
Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL
Cell
(2017)
[PMID: 28129538 ]
Source organisms: Escherichia coli , Homo sapiens
Assembly composition: protein only structure
Assembly name:
5-hydroxytryptamine receptor 2B, Soluble cytochrome b562
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-142091 (Preferred)
search this ID
5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM)
Barros-Alvarez X, Cao C, Panova O, Roth BL, Skiniotis G
Neuron
(2022)
[PMID: 36087581 ]
Source organisms: Mus musculus , Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-279936 (Preferred)
search this ID
5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM)
Barros-Alvarez X, Kim K, Panova O, Cao C, Roth BL, Skiniotis G
Neuron
(2022)
[PMID: 36087581 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-211201 (Preferred)
search this ID
5-HT2B receptor bound to LSD obtained by cryo-electron microscopy (cryoEM)
Barros-Alvarez X, Cao C, Panova O, Roth BL, Skiniotis G
Neuron
(2022)
[PMID: 36087581 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
5-hydroxytryptamine receptor 2B
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-154412 (Preferred)
search this ID

Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL
Nat Struct Mol Biol
(2018)
[PMID: 30127358 ]
Source organisms: Escherichia coli , Homo sapiens
Assembly composition: protein only structure
Assembly name:
5-hydroxytryptamine receptor 2B, Soluble cytochrome b562
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-142091 (Preferred)
search this ID
Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase.
Liu W, Wacker D, Gati C, Han GW, James D, Wang D, Nelson G, Weierstall U, Katritch V, Barty A, Zatsepin NA, Li D, Messerschmidt M, Boutet S, Williams GJ, Koglin JE, Seibert MM, Wang C, Shah STA, Basu S, Fromme R, Kupitz C, Rendek KN, Grotjohann I, Fromme P, Kirian RA, Beyerlein KR, White TA, Chapman HN, Caffrey M, Spence JCH, Stevens RC, Cherezov V, GPCR Network (GPCR)
Science
(2013)
[PMID: 24357322 ]
Source organisms: Escherichia coli , Homo sapiens
Assembly composition: protein only structure
Assembly name:
5-hydroxytryptamine receptor 2B, Soluble cytochrome b562
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-142091 (Preferred)
search this ID
Entries 1 to 10 of 11