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Entry status
(1)
Experimental methods
(1)
X-ray diffraction
(2)
Authors
(21)
Arrowsmith C
(2)
Bountra C
(2)
Burgess-Brown N
(2)
Edwards A
(2)
Kopec J
(2)
Yue WW
(2)
von Delft F
(2)
Bezerra GA
(1)
Chalk R
(1)
Fairhead M
(1)
Fitzpatrick F
(1)
McCorvie T
(1)
McCorvie TJ
(1)
Patel D
(1)
Pey AL
(1)
Shrestha L
(1)
Strain-Damerell C
(1)
Structural Genomics Consortium (SGC)
(1)
Tallant C
(1)
Velupillai S
(1)
Zhang M
(1)
Homo / hetero assembly
(1)
homo
(2)
Assembly composition
(1)
protein structure
(2)
Assembly polymer count
(1)
dimer
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Resolution distribution
1.5 - 2
(2)
Release year distribution
2015 - 2020
(2)
Journal
(2)
Hum Mol Genet
(1)
To be published
(1)
Macromolecules
Organism superkingdom
(1)
Eukaryota
(2)
Organism name
(1)
Homo sapiens
(2)
Molecule name
(3)
Gal-1-P uridylyltransferase
(2)
Galactose-1-phosphate uridylyltransferase
(2)
UDP-glucose--hexose-1-phosphate uridylyltransferase
(2)
Molecule type
(1)
Protein
(2)
Gene names
(1)
GALT
(2)
Interacting ligands
(4)
EDO : 1,2-ETHANEDIOL
(2)
H2U : 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE
(2)
ZN : ZINC ION
(2)
G1P : 1-O-phosphono-alpha-D-glucopyranose
(1)
Function and Biology
EC number / name
(1)
2.7.7.12 : UDP-glucose--hexose-1-phosphate uridylyltransferase
(2)
Biological function
(6)
UDP-glucose:hexose-1-phosphate uridylyltransferase activity
(2)
metal ion binding
(2)
nucleotidyltransferase activity
(2)
protein binding
(2)
transferase activity
(2)
zinc ion binding
(2)
Biological process
(3)
UDP-alpha-D-glucose metabolic process
(2)
galactose catabolic process via UDP-galactose, Leloir pathway
(2)
galactose metabolic process
(2)
Biological cell component
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Golgi apparatus
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cytoplasm
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cytosol
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Sequence and Structure classification
CATH class
(1)
Alpha Beta
(2)
CATH topology
(1)
HIT family, subunit A
(2)
Pfam accession / name
(2)
PF01087 : GalP_UDP_transf
(2)
PF02744 : GalP_UDP_tr_C
(2)
Experimental Information
Diffraction protocol
(1)
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(2)
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Diffraction source
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DIAMOND BEAMLINE I02
(1)
DIAMOND BEAMLINE I04-1
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PHENIX
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Representative Structures
Representative Structures
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Entries 1 to 2 of 2
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Crystal structure of glucose-1-phosphate bound nucleotidylated human galactose-1-phosphate uridylyltransferase
Kopec J, McCorvie T, Tallant C, Velupillai S, Shrestha L, Fitzpatrick F, Patel D, Chalk R, Burgess-Brown N, von Delft F, Arrowsmith C, Edwards A, Bountra C, Yue WW
Hum Mol Genet
(2016)
[PMID: 27005423 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Galactose-1-phosphate uridylyltransferase
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139830 (Preferred)
search this ID
PDBe-KB:
P07902
Structure of human galactose-1-phosphate uridylyltransferase (GALT), with crystallization epitope mutations A21Y:A22T:T23P:R25L
Fairhead M, Strain-Damerell C, Kopec J, Bezerra GA, Zhang M, Burgess-Brown N, von Delft F, Arrowsmith C, Edwards A, Bountra C, Yue WW, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Galactose-1-phosphate uridylyltransferase
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139830 (Preferred)
search this ID
Entries 1 to 2 of 2