Entry status  (1)

REL

(38)

Experimental methods  (3)

X-ray diffraction

(33)

Electron Microscopy

(4)

Solution NMR

(1)

Authors  (220)

Garcia KC

(9)

Randal M

(9)

Wells JA

(9)

Arkin MR

(7)

Braisted AC

(7)

DeLano WL

(7)

Hyde J

(7)

Arkin MA

(6)

Luong TN

(6)

McDowell RS

(6)

Oslob JD

(6)

Raphael DR

(6)

Taylor L

(6)

Wang J

(6)

Jude KM

(5)

Boyman O

(4)

Kovar M

(4)

Ring AM

(4)

Spangler JB

(4)

Su L

(4)

Tomala J

(4)

Wang Y

(4)

Xiao J

(4)

Moraga I

(3)

Thanos CD

(3)

Allen KN

(2)

Bates DL

(2)

Bowman GR

(2)

Brenke R

(2)

Cao SD

(2)

Chu AE

(2)

Dong S

(2)

Fabilane CS

(2)

Fathman CG

(2)

Gao N

(2)

Gould JR

(2)

Henclova T

(2)

Hou S

(2)

Huang P-S

(2)

Huang PS

(2)

Huliciak M

(2)

Jehle S

(2)

Ji C

(2)

Johansen ER

(2)

Kare AJ

(2)

Khort HE

(2)

Kozakov D

(2)

Krieg C

(2)

Leff MI

(2)

Leonard EK

(2)

Leonard WJ

(2)

Levin AM

(2)

Li P

(2)

Li Y

(2)

Lin JT

(2)

Lin JX

(2)

Luca VC

(2)

Montano Romero A

(2)

Novick P

(2)

Pande VS

(2)

Pepper M

(2)

Picton LK

(2)

Porter MJ

(2)

Raeber ME

(2)

Raimondi G

(2)

Ren J

(2)

Rickert M

(2)

Sargunas PR

(2)

Schneider B

(2)

Shen H

(2)

Su C

(2)

Thompson L

(2)

Vajda S

(2)

Vanek O

(2)

Vaněk O

(2)

Votavova P

(2)

Wang G

(2)

Wang X

(2)

Wang YX

(2)

Xiao JY

(2)

Zhu Q

(2)

Acuff NV

(1)

Aerni HR

(1)

Alvarez JC

(1)

Arenas-Ramirez N

(1)

Artemiev I

(1)

Ast O

(1)

Bacac M

(1)

Baines BS

(1)

Benz J

(1)

Bessette PH

(1)

Birk M

(1)

Bluestone JA

(1)

Bolijn M

(1)

Boulanger MJ

(1)

Brandhuber BJ

(1)

Brannetti B

(1)

Brunker P

(1)

Brünker P

(1)

Caffaro CE

(1)

 

More...

Homo / hetero assembly  (2)

hetero

(19)

homo

(19)

Assembly composition  (2)

protein structure

(19)

protein/protein complex

(19)

Assembly polymer count  (7)

monomer

(17)

trimer

(9)

dimer

(6)

tetramer

(3)

dodecamer

(1)

heptamer

(1)

hexamer

(1)

Resolution distribution

1.5 - 2

(9)

2.0 - 2.5

(10)

2.5 - 3

(10)

3.0 - 3.5

(7)

3.5 - 4

(1)

Release year distribution

1990 - 1995

(2)

1995 - 2000

(1)

2000 - 2005

(12)

2005 - 2010

(4)

2010 - 2015

(6)

2015 - 2020

(9)

2020 - 2025

(14)

Journal  (17)

Proc Natl Acad Sci U S A

(10)

Nat Commun

(3)

Science

(3)

Cell Res

(2)

Immunity

(2)

J Am Chem Soc

(2)

JCI Insight

(2)

Nature

(2)

Oncoimmunology

(2)

Sci Transl Med

(2)

To be published

(2)

Biochemistry

(1)

J Immunother Cancer

(1)

J Mol Biol

(1)

Nat Med

(1)

Russ. J. Bioorganic Chem.

(1)

Sci Immunol

(1)

Organism superkingdom  (1)

Eukaryota

(38)

Organism name  (2)

Homo sapiens

(36)

Mus musculus

(2)

Molecule name  (26)

IL-2

(38)

Interleukin-2

(38)

T-cell growth factor

(38)

TCGF

(38)

Apoptosis inhibitor expressed by macrophages

(2)

CD5 antigen-like

(2)

CT-2

(2)

Ig alpha-1 chain C region

(2)

Ig alpha-1 chain C region BUR

(2)

Ig alpha-1 chain C region TRO

(2)

Ig mu chain C region

(2)

Ig mu chain C region BOT

(2)

Ig mu chain C region GAL

(2)

Ig mu chain C region OU

(2)

IgM-associated peptide

(2)

Immunoglobulin heavy constant alpha 1

(2)

Immunoglobulin heavy constant mu

(2)

SP-alpha

(2)

hAIM

(2)

IL-2 receptor subunit alpha

(1)

IL-2-RA

(1)

IL-2R subunit alpha

(1)

IL2-RA

(1)

Interleukin-2 receptor subunit alpha

(1)

TAC antigen

(1)

p55

(1)

Molecule type  (1)

Protein

(38)

Gene names  (9)

IL2

(36)

API6

(2)

CD5L

(2)

IGHA1

(2)

IGHM

(2)

Il-2

(2)

Il2

(2)

UNQ203/PRO229

(2)

IL2RA

(1)

Interacting Molecules  (24)

Cytokine receptor common subunit gamma

(4)

Immunoglobulin J chain

(4)

Interleukin-2 receptor subunit alpha

(4)

Interleukin-2 receptor subunit beta

(4)

CD5 antigen-like

(2)

Immunoglobulin heavy constant mu

(2)

Interleukin-2

(2)

Secretory component

(2)

602 single chain fragment variable

(1)

Chains: A,D,G

(1)

Chains: B,E,H

(1)

F10 single chain fragment variable

(1)

Heavy chain of FAB fragment

(1)

Ig-like domain-containing protein

(1)

JES6-1 VH domain

(1)

JES6-1 VL domain

(1)

Light chain of FAB fragment

(1)

S4B6 Fab heavy chain

(1)

S4B6 Fab light chain

(1)

SigA binding protein

(1)

anti-hIL2 FAB fragment heavy chain

(1)

anti-hIL2 FAB fragment light chain

(1)

anti-human IL-2 antibody, mouse Ig G, heavy chain

(1)

anti-human IL-2 antibody, mouse Ig G, kappa chain

(1)

Interacting ligands  (18)

SO4 : SULFATE ION

(5)

CA : CALCIUM ION

(2)

GOL : GLYCEROL

(2)

NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose

(2)

ZN : ZINC ION

(2)

2JY : 5-[(2,3-dichlorophenoxy)methyl]furan-2-carboxylic acid

(1)

2K1 : 5-methylfuran-2-carboxylic acid

(1)

CMM : 2-[2-(1-CARBAMIMIDOYL-PIPERIDIN-3-YL)-ACETYLAMINO]-3-{4-[2-(3-OXALYL-1H-INDOL-7-YL)ETHYL]-PHENYL}-PROPIONIC ACID METHYL ESTER

(1)

EPE : 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID

(1)

FRB : 2-CYCLOHEXYL-N-(2-{4-[5-(2,3-DICHLORO-PHENYL)-2H-PYRAZOL-3-YL]-PIPERIDIN-1-YL}-2-OXO-ETHYL)-2-GUANIDINO-ACETAMIDE

(1)

FRG : 2-[3-METHYL-4-(N-METHYL-GUANIDINO)-BUTYRYLAMINO]-3-(4-PHENYLETHYNYL-PHENYL)-PROPIONIC ACID METHYL ESTER

(1)

FRH : 5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-PENTANOYLAMINO)-ACETYL]-PIPERIDIN-4-YL}-1-METHYL-1H-PYRAZOL-3-YL)-PHENOXYMETHYL]-FURAN-2-CARBOXYLIC ACID

(1)

FRI : 2-GUANIDINO-4-METHYL-PENTANOIC ACID [2-(4-{5-[4-(4-ACETYLAMINO-BENZYLOXY)-2,3-DICHLORO-PHENYL]-2-METHYL-2H-PYRAZOL-3-YL}-PIPERIDIN-1-YL)-2-OXO-ETHYL]-AMIDE

(1)

MG : MAGNESIUM ION

(1)

MHC : 3-MERCAPTO-1-(1,3,4,9-TETRAHYDRO-B-CARBOLIN-2-YL)-PROPAN-1-ONE

(1)

MPE : (1H-INDOL-3-YL)-(2-MERCAPTO-ETHOXYIMINO)-ACETIC ACID

(1)

NMP : 2-[2-(2-CYCLOHEXYL-2-GUANIDINO-ACETYLAMINO)-ACETYLAMINO]-N-(3-MERCAPTO-PROPYL)-PROPIONAMIDE

(1)

PO4 : PHOSPHATE ION

(1)

Biological function  (10)

growth factor activity

(33)

interleukin-2 receptor binding

(33)

carbohydrate binding

(26)

cytokine activity

(26)

glycosphingolipid binding

(26)

kappa-type opioid receptor binding

(26)

kinase activator activity

(26)

protein binding

(26)

interleukin-2 binding

(1)

interleukin-2 receptor activity

(1)

Biological process  (49)

immune response

(33)

immune system process

(28)

G protein-coupled receptor signaling pathway

(26)

T cell differentiation

(26)

T cell proliferation

(26)

activated T cell proliferation

(26)

adaptive immune response

(26)

cell adhesion

(26)

cell surface receptor signaling pathway via STAT

(26)

cell-cell signaling

(26)

extrinsic apoptotic signaling pathway in absence of ligand

(26)

gene expression

(26)

interleukin-2-mediated signaling pathway

(26)

leukocyte activation involved in immune response

(26)

lymphocyte proliferation

(26)

natural killer cell activation

(26)

negative regulation of B cell apoptotic process

(26)

negative regulation of T-helper 17 cell differentiation

(26)

negative regulation of apoptotic process

(26)

negative regulation of inflammatory response

(26)

negative regulation of lymphocyte proliferation

(26)

phospholipase C-activating G protein-coupled receptor signaling pathway

(26)

positive regulation of B cell proliferation

(26)

positive regulation of T cell differentiation

(26)

positive regulation of T cell proliferation

(26)

positive regulation of activated T cell proliferation

(26)

positive regulation of cell growth

(26)

positive regulation of cell population proliferation

(26)

positive regulation of cytosolic calcium ion concentration

(26)

positive regulation of dendritic spine development

(26)

positive regulation of immunoglobulin production

(26)

positive regulation of inflammatory response

(26)

positive regulation of interleukin-17 production

(26)

positive regulation of isotype switching to IgG isotypes

(26)

positive regulation of plasma cell differentiation

(26)

positive regulation of regulatory T cell differentiation

(26)

positive regulation of tissue remodeling

(26)

positive regulation of transcription by RNA polymerase II

(26)

positive regulation of type II interferon production

(26)

regulation of CD4-positive, alpha-beta T cell proliferation

(26)

regulation of T cell homeostatic proliferation

(26)

response to ethanol

(26)

response to tacrolimus

(26)

transcription by RNA polymerase II

(26)

apoptotic process

(2)

cellular defense response

(2)

inflammatory response

(2)

positive regulation of complement-dependent cytotoxicity

(2)

regulation of complement activation

(2)

Biological cell component  (7)

extracellular region

(35)

extracellular space

(28)

blood microparticle

(2)

cell surface

(2)

cytoplasm

(2)

membrane

(2)

plasma membrane

(2)

SCOP fold  (1)

4-helical cytokines

(14)

SCOP family  (1)

Short-chain cytokines

(14)

CATH class  (1)

Mainly Alpha

(24)

CATH topology  (1)

Growth Hormone; Chain: A;

(24)

Pfam accession / name  (5)

PF00715 : IL2

(33)

PF07654 : C1-set

(4)

PF00047 : ig

(2)

PF00530 : SRCR

(2)

PF00084 : Sushi

(1)

Diffraction protocol  (1)

Single wavelength

(32)

Diffraction radiation source type  (2)

Synchrotron

(24)

Rotating anode

(8)

Diffraction source  (17)

RIGAKU

(7)

SLS BEAMLINE X10SA

(3)

SSRL BEAMLINE BL11-1

(3)

SSRL BEAMLINE BL7-1

(3)

ALS BEAMLINE 8.2.1

(2)

ALS BEAMLINE 8.2.2

(2)

NSLS BEAMLINE X29A

(2)

ALS BEAMLINE 4.2.2

(1)

ALS BEAMLINE 8.3.1

(1)

APS BEAMLINE 23-ID-B

(1)

DIAMOND BEAMLINE I03

(1)

MACSCIENCE M06X

(1)

NSLS-II BEAMLINE 17-ID-1

(1)

PAL/PLS BEAMLINE 11C

(1)

SLS BEAMLINE X06DA

(1)

SSRL BEAMLINE BL12-1

(1)

SSRL BEAMLINE BL12-2

(1)

Synchrotron site  (8)

SSRL

(8)

ALS

(6)

SLS

(4)

NSLS

(2)

APS

(1)

Diamond

(1)

NSLS-II

(1)

PAL/PLS

(1)

Diffraction detector type  (4)

CCD

(11)

Pixel

(11)

Image plate

(9)

CMOS

(1)

Refinement software  (5)

PHENIX

(17)

REFMAC

(16)

BUSTER

(1)

CNS

(1)

X-PLOR

(1)

EM microscope model  (1)

FEI TITAN KRIOS

(4)

EM detector name  (3)

GATAN K2 QUANTUM (4k x 4k)

(2)

GATAN K3 (6k x 4k)

(2)

GATAN K2 SUMMIT (4k x 4k)

(1)

Representative Structures

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