Uniprot accession / id : Q5TBB1  OR   Uniprot accession / id : Q8N451  OR   Uniprot accession / id : Q80ZV0  OR   Uniprot accession / id : Q5XI96  OR   Uniprot accession / id : Q5ZK59  OR   Uniprot accession / id : Q7ZUH0  OR   Uniprot accession / id : Q9VYA4  OR   Uniprot accession / id : A0NF47
 
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Entry Information
Entry status  (1)
REL
(6)
 
Experimental methods  (2)
X-ray diffraction
(5)
Electron Microscopy
(1)
 
Authors  (23)
Bubeck D
(3)
Graham SC
(3)
Jackson AP
(3)
Jones EY
(3)
Reijns MA
(3)
Baillie GS
(2)
Gibson LC
(2)
Astell KR
(1)
Cerritelli SM
(1)
Chon H
(1)
Crouch RJ
(1)
Cybulska M
(1)
Figiel M
(1)
Gao N
(1)
Harvey S
(1)
Hollis T
(1)
Li N
(1)
Li Q
(1)
Nowotny M
(1)
Perrino FW
(1)
Shaban N
(1)
Shaban NM
(1)
Tian Y
(1)
 
Homo / hetero assembly  (1)
hetero
(6)
 
Assembly composition  (2)
protein/protein complex
(5)
DNA/protein complex
(1)
 
Assembly polymer count  (3)
trimer
(4)
decamer
(1)
hexamer
(1)
 
Resolution distribution
2.5 - 3
(3)
3.0 - 3.5
(1)
4.0 - 4.5
(1)
5.0 - 5.5
(1)
 
Release year distribution
2005 - 2010
(4)
2010 - 2015
(4)
2020 - 2025
(1)
 
Journal  (3)
J Biol Chem
(4)
EMBO J
(1)
Nucleic Acids Res
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(6)
 
Organism name  (2)
Homo sapiens
(4)
Mus musculus
(2)
 
Molecule name  (7)
RNase H2 subunit B
(6)
Ribonuclease H2 subunit B
(6)
Ribonuclease HI subunit B
(6)
AGS2
(4)
Aicardi-Goutieres syndrome 2 protein
(4)
Deleted in lymphocytic leukemia 8
(4)
Deleted in lymphocytic leukemia 8 homolog
(2)
 
Molecule type  (1)
Protein
(6)
 
Gene names  (4)
DLEU8
(4)
RNASEH2B
(4)
Dleu8
(2)
Rnaseh2b
(2)
 
Interacting Molecules  (7)
Ribonuclease H2 subunit A
(5)
Ribonuclease H2 subunit C
(5)
Proliferating cell nuclear antigen
(2)
Flap endonuclease 1
(1)
downstream DNA
(1)
parent strand DNA
(1)
upstream DNA
(1)
 
Function and Biology
EC number / name  (1)
3.1.26.4 : Ribonuclease H
(1)
 
Biological function  (1)
protein binding
(1)
 
Biological process  (10)
RNA catabolic process
(3)
fibroblast proliferation
(3)
gene expression
(3)
in utero embryonic development
(3)
mismatch repair
(3)
negative regulation of gene expression
(3)
positive regulation of fibroblast proliferation
(3)
regulation of DNA damage checkpoint
(3)
regulation of G2/M transition of mitotic cell cycle
(3)
ribonucleotide metabolic process
(3)
 
Biological cell component  (3)
ribonuclease H2 complex
(5)
nucleoplasm
(3)
nucleus
(3)
 
Sequence and Structure classification
CATH class  (2)
Mainly Alpha
(1)
Mainly Beta
(1)
 
CATH topology  (2)
Histone, subunit A
(1)
N-terminal domain of TfIIb
(1)
 
Pfam accession / name  (2)
PF09468 : RNase_H2-Ydr279
(5)
PF17745 : Ydr279_N
(5)
 
Experimental Information
Diffraction protocol  (2)
Single wavelength
(3)
MAD
(1)
 
Diffraction radiation source type  (1)
Synchrotron
(4)
 
Diffraction source  (4)
DIAMOND BEAMLINE I03
(1)
DIAMOND BEAMLINE I04
(1)
ESRF BEAMLINE ID23-2
(1)
NSLS BEAMLINE X29A
(1)
 
Synchrotron site  (3)
Diamond
(2)
ESRF
(1)
NSLS
(1)
 
Diffraction detector type  (1)
CCD
(4)
 
Refinement software  (3)
BUSTER
(4)
BUSTER-TNT
(1)
PHENIX
(1)
 
EM microscope model  (1)
FEI TITAN KRIOS
(1)
 
EM detector name  (1)
GATAN K3 (6k x 4k)
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 6 of 6
Entries 1 to 6 of 6
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Structure of the human endogenous PCNA-FEN1-RNase H2 complex - State D
Tian Y, Gao N
EMBO J (2024) [PMID: 39578540  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: PCNA homotrimer and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-281327 (Preferred)   search this ID
PDBe-KB: Q5TBB1    P12004    O75792    Q8TDP1    P39748   
Electron Microscopy
5.15Å resolution
Released: 4 Dec 2024
Model geometry
Fit model/data
Data not analysed
8yjz
8yjz
8yjz
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease
Bubeck D, Graham SC, Jones EY
J Biol Chem (2011) [PMID: 21177854  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Assembly name: RNase H2 complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-182412 (Preferred)   search this ID
PDBe-KB: Q80ZV0    Q9CQ18    Q9CWY8   
X-ray diffraction
2.9Å resolution
Released: 17 Nov 2010
Model geometry
Fit model/data
3p5j
3p5j
3p5j
Structure of human PCNA bound to RNASEH2B PIP box peptide
Bubeck D, Reijns MA, Graham SC, Astell KR, Jones EY, Jackson AP
Nucleic Acids Res (2011) [PMID: 21245041  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: PCNA homotrimer and Ribonuclease H2 subunit B (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146061 (Preferred)   search this ID
PDBe-KB: Q5TBB1    P12004   
X-ray diffraction
2.99Å resolution
Released: 2 Feb 2011
Model geometry
Fit model/data
3p87
3p87
3p87
mouse RNase H2 complex
Shaban N, Harvey S, Perrino FW, Hollis T
J Biol Chem (2010) [PMID: 19923215  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Modified residues: MSE    MSE   
Assembly name: RNase H2 complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-182412 (Preferred)   search this ID
PDBe-KB: Q80ZV0    Q9CQ18    Q9CWY8   
X-ray diffraction
2.9Å resolution
Released: 17 Nov 2009
Model geometry
Fit model/data
3kio
3kio
3kio
Crystal structure of human RNase H2 complex
Figiel M, Chon H, Cerritelli SM, Cybulska M, Crouch RJ, Nowotny M
J Biol Chem (2011) [PMID: 21177858  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: RNase H2 complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-131120 (Preferred)   search this ID
PDBe-KB: Q5TBB1    O75792    Q8TDP1   
X-ray diffraction
3.1Å resolution
Released: 22 Dec 2010
Model geometry
Fit model/data
3puf
3puf
3puf
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease
Bubeck D, Graham SC, Jones EY
J Biol Chem (2011) [PMID: 21177854  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: RNase H2 complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-131120 (Preferred)   search this ID
PDBe-KB: Q5TBB1    O75792    Q8TDP1   
X-ray diffraction
4.06Å resolution
Released: 17 Nov 2010
Model geometry
Fit model/data
3p56
3p56
3p56
Entries 1 to 6 of 6
Entries 1 to 6 of 6