Uniprot accession / id : Q60748  OR   Uniprot accession / id : Q13324
 
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Entry Information
Entry status  (1)
REL
(9)
 
Experimental methods  (3)
Electron Microscopy
(3)
Solution NMR
(3)
X-ray diffraction
(3)
 
Authors  (42)
Xu HE
(6)
DiGruccio MR
(3)
Grace CR
(3)
Mao C
(3)
Melcher K
(3)
Pal K
(3)
Perrin MH
(3)
Pioszak AA
(3)
Riek R
(3)
Rivier JE
(3)
Shen DD
(3)
Swaminathan K
(3)
Vale WW
(3)
Zhang Y
(3)
Zhao L-H
(3)
Zhao LH
(3)
Zhou XE
(3)
Cantle JP
(2)
Digruccio MR
(2)
Grace CRR
(2)
Gulyas J
(2)
He X
(2)
Ji S
(2)
Ji SY
(2)
Jozsef G
(2)
Lin J
(2)
Shen D
(2)
Sun J
(2)
Xiao P
(2)
Yu X
(2)
Bi P
(1)
Jiang Y
(1)
Li C
(1)
Ma S
(1)
Miller CL
(1)
Sexton PM
(1)
Shen D-D
(1)
Shen Q
(1)
Wang M-W
(1)
Wang MW
(1)
Wootten D
(1)
de Waal PW
(1)
 
Homo / hetero assembly  (2)
hetero
(7)
homo
(2)
 
Assembly composition  (2)
protein/protein complex
(7)
protein structure
(2)
 
Assembly polymer count  (5)
hexamer
(3)
monomer
(2)
trimer
(2)
dimer
(1)
tetramer
(1)
 
Resolution distribution
2.0 - 2.5
(1)
2.5 - 3
(4)
3.5 - 4
(1)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(5)
2010 - 2015
(3)
2015 - 2020
(1)
2020 - 2025
(3)
 
Journal  (4)
Proc Natl Acad Sci U S A
(3)
To be published
(3)
Nat Commun
(2)
Mol Cell
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(9)
 
Organism name  (2)
Homo sapiens
(6)
Mus musculus
(3)
 
Molecule name  (13)
CRF-R-2
(9)
CRF-R2
(9)
CRFR-2
(9)
CRH-R-2
(9)
CRH-R2
(9)
Corticotropin-releasing factor receptor 2
(9)
Corticotropin-releasing hormone receptor 2
(9)
CRF-RB
(3)
MBP
(3)
MMBP
(3)
Maltodextrin-binding protein
(3)
Maltose-binding protein
(3)
Maltose/maltodextrin-binding periplasmic protein
(3)
 
Molecule type  (1)
Protein
(9)
 
Gene names  (8)
CRF2R
(6)
CRH2R
(6)
CRHR2
(6)
Crf2r
(3)
Crhr2
(3)
JW3994
(3)
b4034
(3)
malE
(3)
 
Interacting Molecules  (13)
Urocortin
(4)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
(3)
Guanine nucleotide-binding protein subunit gamma
(2)
scFV16
(2)
ASTRESSIN
(1)
Dominant negative Go alpha subunit
(1)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(1)
Guanine nucleotide-binding protein G(i) subunit alpha-1
(1)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
(1)
Guanine nucleotide-binding protein subunit alpha-11
(1)
Nanobody 35
(1)
Urocortin-2
(1)
Urocortin-3
(1)
 
Interacting ligands  (5)
GLC : alpha-D-glucopyranose
(3)
PRD_900001 : alpha-maltose
(3)
CLR : CHOLESTEROL
(1)
GOL : GLYCEROL
(1)
PLM : PALMITIC ACID
(1)
 
Function and Biology
Biological function  (3)
G protein-coupled receptor activity
(9)
carbohydrate transmembrane transporter activity
(3)
transmembrane signaling receptor activity
(3)
 
Biological process  (4)
G protein-coupled receptor signaling pathway
(9)
carbohydrate transport
(3)
cell surface receptor signaling pathway
(3)
transmembrane transport
(3)
 
Biological cell component  (1)
membrane
(9)
 
Sequence and Structure classification
SCOP fold  (1)
Hormone receptor domain
(1)
 
SCOP family  (1)
Hormone receptor domain
(1)
 
CATH class  (2)
Few Secondary Structures
(6)
Alpha Beta
(3)
 
CATH topology  (2)
Hormone receptor fold
(6)
D-Maltodextrin-Binding Protein; domain 2
(3)
 
Pfam accession / name  (3)
PF02793 : HRM
(9)
PF00002 : 7tm_2
(3)
PF01547 : SBP_bac_1
(3)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(6)
 
Diffraction radiation source type  (1)
Synchrotron
(3)
 
Diffraction source  (2)
APS BEAMLINE 21-ID-F
(2)
APS BEAMLINE 21-ID-D
(1)
 
Synchrotron site  (1)
APS
(3)
 
Representative Structures
Representative Structures
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Entries 1 to 9 of 9
Entries 1 to 9 of 9
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Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 2 receptor in complex with Gs protein and Nb35
Ma S, Shen Q, Zhao L-H, Mao C, Zhou XE, Shen D-D, de Waal PW, Bi P, Li C, Jiang Y, Wang M-W, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE
Mol Cell (2020) [PMID: 32004470  ]
Assembly composition: protein/protein complex
Bound ligands: CLR    CLR    PLM   
PDBe complex ID: PDB-CPX-279969 (Preferred)   search this ID
PDBe-KB: Q13324    P55089    P63092    P62873    P63096    P59768   
Electron Microscopy
2.8Å resolution
Released: 12 Feb 2020
Model geometry
Fit model/data
Data not analysed
6pb1
6pb1
6pb1
Refined 3D NMR structure of ECD1 of mCRF-R2beta at pH 5
Grace CRR, Perrin MH, Jozsef G, DiGruccio MR, Cantle JP, Rivier JE, Vale WW, Riek R
Proc Natl Acad Sci U S A (2007) [PMID: 17360332  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Assembly name: Corticotropin-releasing factor receptor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-178812 (Preferred)   search this ID
PDBe-KB: Q60748    Q60748   
Solution NMR
Released: 13 Mar 2007
Model geometry
Fit model/data
Data not analysed
2jnc
2jnc
2jnc
3D NMR structure of ECD1 of mCRF-R2b in complex with Astressin
Grace CRR, Perrin MH, Jozsef G, DiGruccio MR, Cantle JP, Rivier JE, Vale WW, Riek R
Proc Natl Acad Sci U S A (2007) [PMID: 17360332  ]
Assembly composition: protein/protein complex
Modified residues: DPN    DPN    NLE    NH2    NH2    NLE   
Assembly name: Corticotropin-releasing factor receptor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-162781 (Preferred)   search this ID
PDBe-KB: Q60748    Q60748   
Solution NMR
Released: 13 Mar 2007
Model geometry
Fit model/data
Data not analysed
2jnd
2jnd
2jnd
Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein
Zhao L-H, Lin J, Mao C, Zhou XE, Ji S, Shen D, Xiao P, Melcher K, Zhang Y, Yu X, Xu HE
Nat Commun (2022) [PMID: 36335102  ]
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-288903 (Preferred)   search this ID
PDBe-KB: Q13324    P55089    A0A9X9ZA26    P54311   
Electron Microscopy
2.8Å resolution
Released: 9 Nov 2022
Model geometry
Fit model/data
Data not analysed
7ts0
7ts0
7ts0
Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein
Zhao L-H, Lin J, Mao C, Zhou XE, Ji S, Shen D, Xiao P, Melcher K, Zhang Y, Yu X, Xu HE
Nat Commun (2022) [PMID: 36335102  ]
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-288902 (Preferred)   search this ID
PDBe-KB: Q13324    P55089    A0A9X9ZA26    P54311    P29992   
Electron Microscopy
3.7Å resolution
Released: 9 Nov 2022
Model geometry
Fit model/data
Data not analysed
7try
7try
7try
Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 2
Pal K, Swaminathan K, Pioszak AA, Xu HE
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: NH2    NH2   
Carbohydrate polymer components:
Molecule 1 - GLC(2)
Assembly name: Urocortin-2 and Corticotropin-releasing factor receptor 2, Maltose/maltodextrin-binding periplasmic protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-238709 (Preferred)   search this ID
PDBe-KB: P0AEX9    Q13324    Q96RP3   
X-ray diffraction
2.72Å resolution
Released: 20 Oct 2010
Model geometry
Fit model/data
3n95
3n95
3n95
Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1
Pal K, Swaminathan K, Pioszak AA, Xu HE
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: NH2    NH2   
Carbohydrate polymer components:
Molecule 1 - GLC(2)
Assembly name: Urocortin and Corticotropin-releasing factor receptor 2, Maltose/maltodextrin-binding periplasmic protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-142560 (Preferred)   search this ID
PDBe-KB: P0AEX9    Q13324    P55089   
X-ray diffraction
2.75Å resolution
Released: 20 Oct 2010
Model geometry
Fit model/data
3n96
3n96
3n96
Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 3
Pal K, Swaminathan K, Pioszak AA, Xu HE
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GOL   
Modified residues: NH2    NH2   
Carbohydrate polymer components:
Molecule 1 - GLC(2)
Assembly name: Urocortin-3 and Corticotropin-releasing factor receptor 2, Maltose/maltodextrin-binding periplasmic protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-142561 (Preferred)   search this ID
PDBe-KB: P0AEX9    Q13324    Q969E3   
X-ray diffraction
2.5Å resolution
Released: 20 Oct 2010
Model geometry
Fit model/data
3n93
3n93
3n93
3D NMR structure of the first extracellular domain of CRFR-2beta, a type B1 G-protein coupled receptor
Grace CR, Perrin MH, DiGruccio MR, Miller CL, Rivier JE, Vale WW, Riek R
Proc Natl Acad Sci U S A (2004) [PMID: 15326300  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Assembly name: Corticotropin-releasing factor receptor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-178812 (Preferred)   search this ID
PDBe-KB: Q60748    Q60748   
Solution NMR
Released: 7 Sep 2004
Model geometry
Fit model/data
Data not analysed
1u34
1u34
1u34
Entries 1 to 9 of 9
Entries 1 to 9 of 9