Uniprot accession / id : (Q61234)
 
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Entry Information
Entry status  (1)
REL
(6)
 
Experimental methods  (2)
Solution NMR
(4)
X-ray diffraction
(2)
 
Authors  (29)
Adams ME
(3)
Froehner SC
(3)
Long JF
(3)
Wen W
(3)
Xu W
(3)
Yan J
(3)
Zhang M
(3)
Ashurst J
(1)
Bredt DS
(1)
Christopherson KS
(1)
Harwood I
(1)
Harwood IM
(1)
Hillier BJ
(1)
Hoffmueller U
(1)
Hoffmuller U
(1)
Hoffmüller U
(1)
Karpiak J
(1)
Kortemme T
(1)
Krause G
(1)
Lim WA
(1)
Macias M
(1)
Macias MJ
(1)
Melero C
(1)
Ollikainen N
(1)
Oschkinat H
(1)
Prehoda KE
(1)
Schmieder P
(1)
Schneider-Mergener J
(1)
Schultz J
(1)
 
Homo / hetero assembly  (2)
hetero
(3)
homo
(3)
 
Assembly composition  (2)
protein structure
(3)
protein/protein complex
(3)
 
Assembly polymer count  (2)
dimer
(3)
monomer
(3)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(1)
 
Release year distribution
1995 - 2000
(2)
2005 - 2010
(3)
2010 - 2015
(1)
 
Journal  (4)
EMBO J
(3)
Nat Struct Biol
(1)
Proc Natl Acad Sci U S A
(1)
Science
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(6)
 
Organism name  (2)
Mus musculus
(6)
Rattus norvegicus
(2)
 
Molecule name  (13)
59 kDa dystrophin-associated protein A1 acidic component 1
(6)
Alpha-1-syntrophin
(6)
Syntrophin-1
(6)
Constitutive NOS
(2)
N-NOS
(2)
NC-NOS
(2)
NOS type I
(2)
Neuronal NOS
(2)
Nitric oxide synthase 1
(2)
Nitric oxide synthase, brain
(2)
Peptidyl-cysteine S-nitrosylase NOS1
(2)
bNOS
(2)
nNOS
(2)
 
Molecule type  (1)
Protein
(6)
 
Gene names  (4)
Snt1
(6)
Snta1
(6)
Bnos
(2)
Nos1
(2)
 
Interacting Molecules  (3)
Alpha-1-syntrophin
(2)
Nitric oxide synthase 1
(2)
PEPTIDE GVKESLV
(1)
 
Function and Biology
EC number / name  (1)
1.14.13.39 : Nitric-oxide synthase (NADPH)
(2)
 
Biological function  (1)
structural molecule activity
(6)
 
Sequence and Structure classification
SCOP fold  (2)
PDZ domain-like
(3)
PH domain-like barrel
(1)
 
SCOP family  (2)
PDZ domain
(3)
Pleckstrin-homology domain (PH domain)
(1)
 
CATH class  (1)
Mainly Beta
(6)
 
CATH topology  (2)
Pdz3 Domain
(5)
PH-domain like
(2)
 
Pfam accession / name  (2)
PF00595 : PDZ
(5)
PF18012 : PH_17
(2)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(2)
 
Diffraction radiation source type  (1)
Synchrotron
(2)
 
Diffraction source  (3)
ALS BEAMLINE 5.0.2
(1)
ALS BEAMLINE 8.3.1
(1)
SSRL BEAMLINE BL7-1
(1)
 
Synchrotron site  (2)
ALS
(2)
SSRL
(1)
 
Diffraction detector type  (2)
CCD
(2)
Image plate
(1)
 
Refinement software  (3)
CNS
(1)
REFMAC
(1)
X-PLOR
(1)
 
NMR
NMR software packages  (2)
CNS
(3)
X-PLOR
(1)
 
NMR Field Strength
500.0 - 600
(1)
600.0 - 700
(1)
700.0 - 800
(4)
 
Representative Structures
Representative Structures
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Entries 1 to 6 of 6
Entries 1 to 6 of 6
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Crystal structure of the computationally designed NNOS-Syntrophin complex
Harwood IM, Melero C, Ollikainen N, Kortemme T
Proc Natl Acad Sci U S A (2014) [PMID: 25313039  ]
Assembly composition: protein/protein complex
Assembly name: Nitric oxide synthase 1 and Alpha-1-syntrophin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-151519 (Preferred)   search this ID
PDBe-KB: P29476    Q61234   
X-ray diffraction
2.29Å resolution
Released: 6 Nov 2013
Model geometry
Fit model/data
4hop
4hop
4hop
Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of NNOS-Syntrophin Complex
Hillier BJ, Christopherson KS, Prehoda KE, Bredt DS, Lim WA
Science (1999) [PMID: 10221915  ]
Assembly composition: protein/protein complex
Assembly name: Nitric oxide synthase 1 and Alpha-1-syntrophin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-151519 (Preferred)   search this ID
PDBe-KB: P29476    Q61234   
X-ray diffraction
1.9Å resolution
Released: 4 May 1999
Model geometry
Fit model/data
Data not deposited
1qav
1qav
1qav
Solution structure of the PDZ domain of alpha-syntrophin
Yan J, Xu W, Wen W, Long JF, Adams ME, Froehner SC, Zhang M
EMBO J (2005) [PMID: 16252003  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Assembly name: Alpha-1-syntrophin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-178874 (Preferred)   search this ID
PDBe-KB: Q61234   
Solution NMR
Released: 24 Jan 2006
Model geometry
Fit model/data
Data not analysed
1z86
1z86
1z86
solution structure of the joined PH domain of alpha1-syntrophin
Yan J, Wen W, Xu W, Long JF, Adams ME, Froehner SC, Zhang M
EMBO J (2005) [PMID: 16252003  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Assembly name: Alpha-1-syntrophin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-178874 (Preferred)   search this ID
PDBe-KB: Q61234   
Solution NMR
Released: 24 Jan 2006
Model geometry
Fit model/data
Data not analysed
2adz
2adz
2adz
solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
Yan J, Xu W, Wen W, Long JF, Adams ME, Froehner SC, Zhang M
EMBO J (2005) [PMID: 16252003  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Assembly name: Alpha-1-syntrophin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-178874 (Preferred)   search this ID
PDBe-KB: Q61234   
Solution NMR
Released: 24 Jan 2006
Model geometry
Fit model/data
Data not analysed
1z87
1z87
1z87
SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES
Schultz J, Hoffmueller U, Ashurst J, Krause G, Schmieder P, Macias M, Schneider-Mergener J, Oschkinat H
Nat Struct Biol (1998) [PMID: 9437424  ]
Source organisms: Synthetic construct, Mus musculus  
Assembly composition: protein/protein complex
Assembly name: Alpha-1-syntrophin and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-163160 (Preferred)   search this ID
PDBe-KB: Q61234   
Solution NMR
Released: 30 Dec 1998
Model geometry
Fit model/data
Data not deposited
2pdz
2pdz
2pdz
Entries 1 to 6 of 6
Entries 1 to 6 of 6