Entry status  (1)

REL

(10)

Experimental methods  (2)

X-ray diffraction

(9)

Electron Microscopy

(1)

Authors  (45)

Walter MR

(5)

Logsdon NJ

(3)

Jones BC

(2)

Josephson K

(2)

Schalk-Hihi C

(2)

Wlodawer A

(2)

Yoon SI

(2)

Zdanov A

(2)

Abhiraman GC

(1)

Aduri NG

(1)

Bagger M

(1)

DeLarosa D

(1)

DiDonato M

(1)

DiGiacomo R

(1)

Donnelly RP

(1)

Fathman JW

(1)

Garcia KC

(1)

Gati C

(1)

Geierstanger B

(1)

Gustchina A

(1)

Henneberg LT

(1)

Indelicato SR

(1)

Jamontt J

(1)

Jones DH

(1)

Josepson K

(1)

Junt T

(1)

Knuth M

(1)

Kuenze G

(1)

Logsdon N

(1)

Meeusen S

(1)

Mohan K

(1)

Nagabhushan TL

(1)

Peters E

(1)

Picard D

(1)

Saxton RA

(1)

Sheikh F

(1)

Simpson CT

(1)

Sommer U

(1)

Spraggon G

(1)

Su LL

(1)

Tsang M

(1)

Tsutsumi N

(1)

Vo T

(1)

Walter LJ

(1)

Weatherbee J

(1)

Homo / hetero assembly  (2)

hetero

(5)

homo

(5)

Assembly composition  (2)

protein structure

(5)

protein/protein complex

(5)

Assembly polymer count  (4)

dimer

(6)

tetramer

(2)

hexamer

(1)

trimer

(1)

Resolution distribution

1.5 - 2

(5)

2.0 - 2.5

(2)

2.5 - 3

(2)

3.0 - 3.5

(1)

Release year distribution

1990 - 1995

(1)

1995 - 2000

(3)

2000 - 2005

(3)

2005 - 2010

(2)

2010 - 2015

(1)

2015 - 2020

(1)

2020 - 2025

(2)

Journal  (7)

Structure

(4)

Biochemistry

(1)

Immunity

(1)

J Biol Chem

(1)

Protein Sci

(1)

Science

(1)

To be published

(1)

Organism superkingdom  (1)

Eukaryota

(10)

Organism name  (2)

Homo sapiens

(9)

Mus musculus

(1)

Molecule name  (5)

CSIF

(10)

Cytokine synthesis inhibitory factor

(10)

IL-10

(10)

Interleukin-10

(10)

IG-light kappa chain

(1)

Molecule type  (1)

Protein

(10)

Gene names  (3)

IL10

(9)

Il-10

(1)

Il10

(1)

Interacting Molecules  (5)

Interleukin-10 receptor subunit alpha

(3)

Ig gamma-1 chain C region

(1)

Ig kappa chain C region, B allele

(1)

Immunoglobulin gamma-1 heavy chain

(1)

Interleukin-10 receptor subunit beta

(1)

Interacting ligands  (2)

EDO : 1,2-ETHANEDIOL

(1)

SO4 : SULFATE ION

(1)

Biological function  (5)

cytokine activity

(10)

interleukin-10 receptor binding

(8)

protein dimerization activity

(8)

growth factor activity

(7)

protein binding

(7)

Biological process  (74)

immune response

(10)

branching involved in labyrinthine layer morphogenesis

(8)

cellular response to estradiol stimulus

(8)

cellular response to hepatocyte growth factor stimulus

(8)

cellular response to lipopolysaccharide

(8)

chronic inflammatory response to antigenic stimulus

(8)

defense response to bacterium

(8)

defense response to protozoan

(8)

interleukin-10-mediated signaling pathway

(8)

liver regeneration

(8)

negative regulation of B cell proliferation

(8)

negative regulation of MHC class II biosynthetic process

(8)

negative regulation of apoptotic process

(8)

negative regulation of autophagy

(8)

negative regulation of cell population proliferation

(8)

negative regulation of chronic inflammatory response to antigenic stimulus

(8)

negative regulation of cytokine production

(8)

negative regulation of cytokine production involved in immune response

(8)

negative regulation of endothelial cell apoptotic process

(8)

negative regulation of heterotypic cell-cell adhesion

(8)

negative regulation of inflammatory response

(8)

negative regulation of interleukin-12 production

(8)

negative regulation of interleukin-6 production

(8)

negative regulation of membrane protein ectodomain proteolysis

(8)

negative regulation of myeloid dendritic cell activation

(8)

negative regulation of neuron apoptotic process

(8)

negative regulation of nitric oxide biosynthetic process

(8)

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

(8)

negative regulation of tumor necrosis factor production

(8)

negative regulation of type II interferon production

(8)

negative regulation of vascular associated smooth muscle cell proliferation

(8)

positive regulation of B cell apoptotic process

(8)

positive regulation of DNA-templated transcription

(8)

positive regulation of MHC class II biosynthetic process

(8)

positive regulation of cell cycle

(8)

positive regulation of cytokine production

(8)

positive regulation of endothelial cell proliferation

(8)

positive regulation of immunoglobulin production

(8)

positive regulation of macrophage activation

(8)

positive regulation of miRNA transcription

(8)

positive regulation of plasma cell differentiation

(8)

positive regulation of receptor signaling pathway via JAK-STAT

(8)

positive regulation of sprouting angiogenesis

(8)

positive regulation of transcription by RNA polymerase II

(8)

regulation of cytokine production

(8)

regulation of gene expression

(8)

regulation of response to wounding

(8)

regulation of synapse organization

(8)

response to activity

(8)

response to carbon monoxide

(8)

response to glucocorticoid

(8)

response to inactivity

(8)

response to insulin

(8)

response to lipopolysaccharide

(8)

response to molecule of bacterial origin

(8)

response to xenobiotic stimulus

(8)

B cell differentiation

(7)

B cell proliferation

(7)

endothelial cell apoptotic process

(7)

hemopoiesis

(7)

leukocyte chemotaxis

(7)

negative regulation of T cell proliferation

(7)

negative regulation of chemokine (C-C motif) ligand 5 production

(7)

negative regulation of cytokine activity

(7)

negative regulation of interferon-alpha production

(7)

negative regulation of interleukin-1 production

(7)

negative regulation of interleukin-18 production

(7)

negative regulation of interleukin-8 production

(7)

negative regulation of mitotic cell cycle

(7)

positive regulation of heterotypic cell-cell adhesion

(7)

positive regulation of vascular associated smooth muscle cell proliferation

(7)

regulation of complement-dependent cytotoxicity

(7)

regulation of isotype switching

(7)

type 2 immune response

(7)

Biological cell component  (2)

extracellular region

(10)

extracellular space

(8)

SCOP fold  (1)

4-helical cytokines

(7)

SCOP family  (1)

Interferons/interleukin-10 (IL-10)

(7)

CATH class  (1)

Mainly Alpha

(8)

CATH topology  (1)

Growth Hormone; Chain: A;

(8)

Pfam accession / name  (1)

PF00726 : IL10

(10)

Diffraction protocol  (1)

Single wavelength

(6)

Diffraction radiation source type  (1)

Synchrotron

(8)

Diffraction source  (6)

EMBL/DESY, HAMBURG BEAMLINE BW7B

(2)

SSRL BEAMLINE BL9-2

(2)

ALS BEAMLINE 5.0.3

(1)

BESSY BEAMLINE 14.1

(1)

NSLS BEAMLINE X4A

(1)

SSRL BEAMLINE BL9-1

(1)

Synchrotron site  (5)

SSRL

(3)

EMBL/DESY, Hamburg

(2)

ALS

(1)

BESSY

(1)

NSLS

(1)

Diffraction detector type  (2)

Image plate

(5)

CCD

(4)

Refinement software  (6)

CNS

(4)

PHENIX

(2)

PROFFT

(2)

X-PLOR

(2)

REFMAC

(1)

phenix.real_space_refine

(1)

EM microscope model  (1)

FEI TITAN KRIOS

(1)

EM detector name  (1)

GATAN K3 (6k x 4k)

(1)

Representative Structures

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