Uniprot accession / id : Q811D0  OR   Uniprot accession / id : Q12959  OR   Uniprot accession / id : C9JCP6
 
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Entry Information
Entry status  (1)
REL
(14)
 
Experimental methods  (2)
X-ray diffraction
(12)
Solution NMR
(2)
 
Authors  (96)
Chen L
(3)
Arthanari H
(2)
Ballet S
(2)
Bazarbachi A
(2)
Blavier J
(2)
Brammerloo Y
(2)
Chi CN
(2)
Delvigne F
(2)
El Hajj H
(2)
Gianni S
(2)
Gorgulla C
(2)
Jemth P
(2)
Li H
(2)
Lin K
(2)
Lu X
(2)
Martin C
(2)
Maseko S
(2)
Maseko SB
(2)
Ntombela T
(2)
Olivet J
(2)
Plant E
(2)
Remaut H
(2)
Salehi-Ashtiani K
(2)
Selmer M
(2)
Sogues A
(2)
Twizere JC
(2)
Van Lint C
(2)
Van Molle I
(2)
Volkov A
(2)
Volkov AN
(2)
Wu G
(2)
Xu P
(2)
Zhang J
(2)
Zhang Z
(2)
Akiyama T
(1)
Arakawa A
(1)
Baleja JD
(1)
Byron O
(1)
Cabral JM
(1)
Carneiro L
(1)
Chishti AH
(1)
Cousido-Siah A
(1)
Dorr L
(1)
Ecsedi P
(1)
Elfstrom L
(1)
Elfström L
(1)
Engstrom A
(1)
Engström A
(1)
Gogl G
(1)
Gorlach M
(1)
Görlach M
(1)
Handa N
(1)
Haq SR
(1)
Hegde RS
(1)
Henry GD
(1)
Hortschansky P
(1)
Hultqvist G
(1)
Jurgens MC
(1)
Jürgens MC
(1)
Koh CS
(1)
Kostmann C
(1)
Lian L-Y
(1)
Liddington R
(1)
Liddington RC
(1)
Liu Y
(1)
Long J
(1)
Marfatia SM
(1)
Mayans O
(1)
Mischo A
(1)
Morais Cabral JH
(1)
Mori S
(1)
Morrone A
(1)
Nyitray L
(1)
Ohlenschlager O
(1)
Ohlenschläger O
(1)
Pandalaneni S
(1)
Petosa C
(1)
Poy F
(1)
Punekar AS
(1)
Ramachandran R
(1)
Raza S
(1)
Shen Y
(1)
Shirouzu M
(1)
Slep KC
(1)
Sutcliffe MJ
(1)
Tezuka Y
(1)
Tian C
(1)
Tian R
(1)
Trave G
(1)
Wang Z
(1)
Xie X
(1)
Yang X
(1)
Yokoyama S
(1)
Zhang R
(1)
Zhao W
(1)
Zhou H
(1)
 
Homo / hetero assembly  (2)
hetero
(9)
homo
(5)
 
Assembly composition  (2)
protein/protein complex
(9)
protein structure
(5)
 
Assembly polymer count  (4)
dimer
(9)
hexamer
(2)
monomer
(2)
24-mer
(1)
 
Resolution distribution
1.5 - 2
(3)
2.0 - 2.5
(6)
2.5 - 3
(3)
 
Release year distribution
1995 - 2000
(1)
2005 - 2010
(3)
2010 - 2015
(9)
2020 - 2025
(3)
 
Journal  (9)
PLoS One
(5)
Antiviral Res
(2)
Acta Crystallogr D Struct Biol
(1)
Biochem Biophys Res Commun
(1)
Biochemistry
(1)
FASEB J
(1)
J Biol Chem
(1)
Nature
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(14)
 
Organism name  (2)
Homo sapiens
(13)
Mus musculus
(1)
 
Molecule name  (25)
Disks large homolog 1
(14)
SAP-97
(14)
SAP97
(14)
Synapse-associated protein 97
(14)
hDlg
(13)
Annexin A2
(1)
Annexin II
(1)
Annexin-2
(1)
Calpactin I heavy chain
(1)
Calpactin-1 heavy chain
(1)
Chromobindin-8
(1)
E-dlg/SAP97
(1)
Embryo-dlg/synapse-associated protein 97
(1)
Lin-7C
(1)
Lipocortin II
(1)
MAGUK p55 subfamily member 7
(1)
MALS-3
(1)
Mammalian lin-seven protein 3
(1)
PAP-IV
(1)
Placental anticoagulant protein IV
(1)
Protein I
(1)
Protein lin-7 homolog C
(1)
Veli-3
(1)
Vertebrate lin-7 homolog 3
(1)
p36
(1)
 
Molecule type  (1)
Protein
(14)
 
Gene names  (12)
DLG1
(13)
ANX2
(1)
ANX2L4
(1)
ANXA2
(1)
CAL1H
(1)
Dlg1
(1)
Dlgh1
(1)
LIN7C
(1)
LPC2D
(1)
MALS3
(1)
MPP7
(1)
VELI3
(1)
 
Interacting Molecules  (5)
Adenomatous polyposis coli protein
(3)
Protein Tax-1
(3)
5-hydroxytryptamine receptor 2A
(1)
C-terminal HPV-18 E6 peptide
(1)
Protein E6
(1)
 
Interacting ligands  (5)
GOL : GLYCEROL
(2)
CA : CALCIUM ION
(1)
IMD : IMIDAZOLE
(1)
SO4 : SULFATE ION
(1)
TRS : 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 14
Entries 1 to 10 of 14
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The second PDZ domain of DLG1 complexed with the PDZ-binding motif of HTLV1-TAX1
Cousido-Siah A, Trave G, Gogl G
Acta Crystallogr D Struct Biol (2022) [PMID: 35362473  ]
Assembly composition: protein/protein complex
Bound ligands: CA    GOL    CA    SO4   
Assembly name: Annexin A2, Disks large homolog 1 and Protein Tax-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-136965 (Preferred)   search this ID
PDBe-KB: P07355    Q12959    P03409   
X-ray diffraction
1.95Å resolution
Released: 20 Apr 2022
Model geometry
Fit model/data
7pc3
7pc3
7pc3
hDLG1-PDZ2 in complex with a TAX1 peptide from HTLV-1
Maseko S, Sogues A, Volkov A, Remaut H, Twizere JC
Antiviral Res (2023) [PMID: 37481039  ]
Assembly name: Disks large homolog 1 and Protein Tax-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-272201 (Preferred)   search this ID
PDBe-KB: Q12959    P03409   
X-ray diffraction
2.71Å resolution
Released: 2 Aug 2023
Model geometry
Fit model/data
8cn3
8cn3
8cn3
hDLG1-PDZ1 in complex with a TAX1 peptide from HTLV-1
Maseko S, Sogues A, Volkov A, Remaut H, Twizere JC
Antiviral Res (2023) [PMID: 37481039  ]
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Disks large homolog 1 and Protein Tax-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-272202 (Preferred)   search this ID
PDBe-KB: Q12959    P03409   
X-ray diffraction
2.09Å resolution
Released: 2 Aug 2023
Model geometry
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8cn1
8cn1
8cn1
Crystal structure of the human DLG1 guanylate kinase domain
Mori S, Tezuka Y, Arakawa A, Handa N, Shirouzu M, Akiyama T, Yokoyama S
Biochem Biophys Res Commun (2013) [PMID: 23624197  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Modified residues: MSE    MSE   
Assembly name: Disks large homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171455 (Preferred)   search this ID
PDBe-KB: Q12959   
X-ray diffraction
2.2Å resolution
Released: 26 Jun 2013
Model geometry
Fit model/data
3w9y
3w9y
3w9y
Structure of the hDLG/SAP97 PDZ2 in complex with HPV-18 papillomavirus E6 peptide
Liu Y, Baleja JD, Henry GD, Hegde RS
Biochemistry (2007) [PMID: 17713926  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Disks large homolog 1 and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-163125 (Preferred)   search this ID
PDBe-KB: Q12959   
Solution NMR
Released: 4 Sep 2007
Model geometry
Fit model/data
Data not analysed
2oqs
2oqs
2oqs
CRYSTAL STRUCTURE OF THE THIRD PDZ DOMAIN FROM THE HUMAN HOMOLOG OF DISCS LARGE PROTEIN
Cabral JM, Liddington R
Nature (1996) [PMID: 8757139  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Disks large homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171457 (Preferred)   search this ID
PDBe-KB: Q12959   
X-ray diffraction
2.8Å resolution
Released: 23 Jul 1997
Model geometry
Fit model/data
1pdr
1pdr
1pdr
Influence of circular permutation on the folding pathway of a PDZ domain
Hultqvist G, Punekar AS, Chi CN, Selmer M, Gianni S, Jemth P
PLoS One (2012) [PMID: 23185531  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    TRS    TRS   
Assembly name: Disks large homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171456 (Preferred)   search this ID
PDBe-KB: Q12959   
X-ray diffraction
2.3Å resolution
Released: 5 Dec 2012
Model geometry
Fit model/data
4amh
4amh
4amh
Crystal structure of the complex between SAP97 PDZ2 and 5HT2A receptor peptide
Pandalaneni S, Dorr L, Mayans O, Lian L-Y
To be published
Assembly composition: protein/protein complex
Assembly name: Disks large homolog 1 and 5-hydroxytryptamine receptor 2A (Preferred)   search this complex
PDBe complex ID: PDB-CPX-147105 (Preferred)   search this ID
PDBe-KB: Q811D0    P14842   
X-ray diffraction
2.3Å resolution
Released: 29 Jan 2014
Model geometry
Fit model/data
4oaj
4oaj
4oaj
Structure of the Human Discs Large 1 PDZ2 - Adenomatous Polyposis Coli Cytoskeletal Polarity Complex
Slep KC
PLoS One (2012) [PMID: 23185543  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Adenomatous polyposis coli protein and Disks large homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150352 (Preferred)   search this ID
PDBe-KB: Q12959    P25054   
X-ray diffraction
2Å resolution
Released: 12 Dec 2012
Model geometry
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4g69
4g69
4g69
Crystal Structure of the SAP97 PDZ2 I342W C378A mutant protein domain
Haq SR, Jurgens MC, Chi CN, Elfstrom L, Koh CS, Selmer M, Gianni S, Jemth P
J Biol Chem (2010) [PMID: 20356847  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: IMD    IMD    NH4    NH4   
Assembly name: Disks large homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171456 (Preferred)   search this ID
PDBe-KB: Q12959   
X-ray diffraction
2Å resolution
Released: 31 Mar 2010
Model geometry
Fit model/data
2x7z
2x7z
2x7z
Entries 1 to 10 of 14
Entries 1 to 10 of 14