Entry status  (1)

REL

(35)

Experimental methods  (3)

X-ray diffraction

(33)

Electron Microscopy

(1)

Solution NMR

(1)

Authors  (87)

Addlagatta A

(27)

Arya T

(18)

Gumpena R

(16)

Kishor C

(16)

Reddi R

(16)

Bhukya S

(12)

Drag M

(12)

Ganji RJ

(12)

Liu JO

(12)

McGowan S

(12)

Matthews BW

(7)

Chen X

(6)

Hu X

(6)

Ma D

(6)

Marapaka AK

(5)

Lu JP

(4)

Saddanapu V

(4)

Xu W

(4)

Ye QZ

(4)

Amzel LM

(2)

Bala S

(2)

Bhat S

(2)

Gabelli SB

(2)

Gundla R

(2)

Kadari A

(2)

Kattula B

(2)

Liu J

(2)

Lu J

(2)

Pillalamarri V

(2)

Ravinuthala VSU

(2)

Singh OV

(2)

Yellamanda KV

(2)

Zhang F

(2)

Bala SC

(1)

Ban N

(1)

Beavers WN

(1)

Caprioli RM

(1)

Chazin WJ

(1)

Cheng YL

(1)

Crews P

(1)

Deuerling E

(1)

Di Marchi R

(1)

DiMarchi RD

(1)

Diederichs K

(1)

Drury SL

(1)

Edmonds KA

(1)

Furlani M

(1)

Gamerdinger M

(1)

Giedroc DP

(1)

Haque N

(1)

Hunaeus G

(1)

Jaskolowski M

(1)

Jia M

(1)

Jomaa A

(1)

Jordan MR

(1)

Khakzar KM

(1)

Kruse ARS

(1)

Krystofiak ES

(1)

Meyers DJ

(1)

Miller M

(1)

Miller MS

(1)

Monteith AJ

(1)

Munneke MJ

(1)

Murdoch CC

(1)

Nacev BA

(1)

Perera YR

(1)

Petoletti AM

(1)

Rabl L

(1)

Rodriguez Nassif AM

(1)

Rodríguez Nassif AM

(1)

Sandeep CB

(1)

Scaiola A

(1)

Schloemer R

(1)

Shim JS

(1)

Skaar EP

(1)

Spraggins JM

(1)

Tenney K

(1)

Thalluri K

(1)

Ulusoy Z

(1)

Wallisch A

(1)

Wang R

(1)

Weiss A

(1)

Wu H

(1)

Yang X

(1)

Zhang P

(1)

Zhang Y

(1)

sandeep CB

(1)

Homo / hetero assembly  (2)

homo

(34)

hetero

(1)

Assembly composition  (2)

protein structure

(34)

RNA/protein complex

(1)

Assembly polymer count  (2)

monomer

(34)

88-mer

(1)

Resolution distribution

1.0 - 1.5

(9)

1.5 - 2

(22)

2.0 - 2.5

(2)

2.5 - 3

(1)

Release year distribution

2000 - 2005

(3)

2005 - 2010

(7)

2010 - 2015

(22)

2015 - 2020

(14)

2020 - 2025

(4)

Journal  (11)

J Med Chem

(21)

Biochemistry

(3)

Bioorg Chem

(2)

Proc Natl Acad Sci U S A

(2)

Angew Chem Int Ed Engl

(1)

Biochem J

(1)

Bioorg Med Chem

(1)

Cell

(1)

Protein Sci

(1)

Science

(1)

To be published

(1)

Organism superkingdom  (1)

Eukaryota

(35)

Organism name  (2)

Homo sapiens

(34)

Mus musculus

(1)

Molecule name  (7)

MAP 1

(35)

MetAP 1

(35)

Methionine aminopeptidase 1

(35)

Peptidase M 1

(35)

COBW domain-containing protein 1

(1)

Cobalamin synthase W domain-containing protein 1

(1)

Zinc-regulated GTPase metalloprotein activator 1

(1)

Molecule type  (1)

Protein

(35)

Gene names  (5)

KIAA0094

(34)

METAP1

(34)

Cbwd1

(1)

Metap1

(1)

Zng1

(1)

Interacting Molecules  (87)

18s rRNA

(1)

28S ribosomal RNA

(1)

40S ribosomal protein S24

(1)

40S ribosomal protein S26

(1)

5.8S ribosomal RNA

(1)

5S ribosomal RNA

(1)

E-site tRNA

(1)

Glucose-6-phosphate isomerase

(1)

Large ribosomal subunit protein eL13

(1)

Large ribosomal subunit protein eL14

(1)

Large ribosomal subunit protein eL15

(1)

Large ribosomal subunit protein eL19

(1)

Large ribosomal subunit protein eL20

(1)

Large ribosomal subunit protein eL21

(1)

Large ribosomal subunit protein eL22

(1)

Large ribosomal subunit protein eL24

(1)

Large ribosomal subunit protein eL27

(1)

Large ribosomal subunit protein eL28

(1)

Large ribosomal subunit protein eL29

(1)

Large ribosomal subunit protein eL30

(1)

Large ribosomal subunit protein eL31

(1)

Large ribosomal subunit protein eL32

(1)

Large ribosomal subunit protein eL33

(1)

Large ribosomal subunit protein eL34

(1)

Large ribosomal subunit protein eL36

(1)

Large ribosomal subunit protein eL37

(1)

Large ribosomal subunit protein eL38

(1)

Large ribosomal subunit protein eL39

(1)

Large ribosomal subunit protein eL42

(1)

Large ribosomal subunit protein eL43

(1)

Large ribosomal subunit protein eL6

(1)

Large ribosomal subunit protein eL8

(1)

Large ribosomal subunit protein uL1

(1)

Large ribosomal subunit protein uL10

(1)

Large ribosomal subunit protein uL11

(1)

Large ribosomal subunit protein uL13

(1)

Large ribosomal subunit protein uL14

(1)

Large ribosomal subunit protein uL15

(1)

Large ribosomal subunit protein uL15/eL18 domain-containing protein

(1)

Large ribosomal subunit protein uL16

(1)

Large ribosomal subunit protein uL18

(1)

Large ribosomal subunit protein uL2

(1)

Large ribosomal subunit protein uL22

(1)

Large ribosomal subunit protein uL23

(1)

Large ribosomal subunit protein uL24

(1)

Large ribosomal subunit protein uL29

(1)

Large ribosomal subunit protein uL3

(1)

Large ribosomal subunit protein uL30

(1)

Large ribosomal subunit protein uL4

(1)

Large ribosomal subunit protein uL5

(1)

Large ribosomal subunit protein uL6

(1)

Nascent polypeptide-associated complex subunit alpha

(1)

P-site Val-tRNA

(1)

Small ribosomal subunit protein RACK1

(1)

Small ribosomal subunit protein eS1

(1)

Small ribosomal subunit protein eS10

(1)

Small ribosomal subunit protein eS12

(1)

Small ribosomal subunit protein eS17

(1)

Small ribosomal subunit protein eS19

(1)

Small ribosomal subunit protein eS21

(1)

Small ribosomal subunit protein eS25

(1)

Small ribosomal subunit protein eS27

(1)

Small ribosomal subunit protein eS28

(1)

Small ribosomal subunit protein eS32

(1)

Small ribosomal subunit protein eS4

(1)

Small ribosomal subunit protein eS6

(1)

Small ribosomal subunit protein eS7

(1)

Small ribosomal subunit protein eS8

(1)

Small ribosomal subunit protein uS10

(1)

Small ribosomal subunit protein uS11

(1)

Small ribosomal subunit protein uS12

(1)

Small ribosomal subunit protein uS13

(1)

Small ribosomal subunit protein uS14

(1)

Small ribosomal subunit protein uS15

(1)

Small ribosomal subunit protein uS17

(1)

Small ribosomal subunit protein uS19

(1)

Small ribosomal subunit protein uS2

(1)

Small ribosomal subunit protein uS3

(1)

Small ribosomal subunit protein uS4

(1)

Small ribosomal subunit protein uS5

(1)

Small ribosomal subunit protein uS7

(1)

Small ribosomal subunit protein uS8

(1)

Small ribosomal subunit protein uS9

(1)

Transcription factor BTF3

(1)

Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

(1)

Ubiquitin-ribosomal protein eL40 fusion protein

(1)

Ubiquitin-ribosomal protein eS31 fusion protein

(1)

Interacting ligands  (36)

CO : COBALT (II) ION

(28)

K : POTASSIUM ION

(23)

GOL : GLYCEROL

(20)

NA : SODIUM ION

(7)

MN : MANGANESE (II) ION

(4)

MET : METHIONINE

(3)

MG : MAGNESIUM ION

(2)

OVA : 3,4-DIHYDROXY-2-METHOXY-4-METHYL-3-[2-METHYL-3-(3-METHYL-BUT-2-ENYL) -OXIRANYL]-CYCLOHEXANONE

(2)

Q02 : [(R)-amino(phenyl)methyl]phosphonic acid

(2)

Q07 : [(1R,2S)-1-amino-2-methylpentyl]phosphonic acid

(2)

Q08 : [(1R)-1-amino-2-propylpentyl]phosphonic acid

(2)

SO4 : SULFATE ION

(2)

1AY : (1R)-N~2~-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N~1~-(4-phenylbutyl)ethane-1,2-diamine

(1)

ACT : ACETATE ION

(1)

ACY : ACETIC ACID

(1)

CA : CALCIUM ION

(1)

CL : CHLORIDE ION

(1)

EPE : 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID

(1)

EYF : 1-[(3-methoxyphenyl)methyl]-~{N}-oxidanyl-pyrrolo[2,3-b]pyridine-5-carboxamide

(1)

EYL : ~{N}-oxidanyl-1-(phenylmethyl)pyrrolo[2,3-b]pyridine-4-carboxamide

(1)

FZ1 : 4-[4-(4-methoxyphenyl)piperazin-1-yl]-2-(pyridin-2-yl)quinazoline

(1)

HM2 : 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE

(1)

HM4 : TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATE

(1)

HM5 : 3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE

(1)

PVP : 2-{4-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]piperazin-1-yl}ethanol

(1)

Q03 : [(R)-amino(cyclohexyl)methyl]phosphonic acid

(1)

Q04 : [(1R)-1-amino-2-cyclohexylethyl]phosphonic acid

(1)

Q06 : [(1R)-1-amino-3-cyclopentylpropyl]phosphonic acid

(1)

SHX : Nalpha-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-D-phenylalaninamide

(1)

TFD : N-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-N'-[6-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine

(1)

TFV : N-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-N'-[5-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine

(1)

Y08 : (E,2R,3R,4S,5R)-N-[[(3S)-1-cyclopropylcarbonylpiperidin-3-yl]methyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide

(1)

Y10 : (E,2R,3R,4S,5R)-N-(2,3-dihydro-1H-inden-2-yl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide

(1)

Y16 : (E,2R,3R,4S,5R)-N-(2-azanyl-2-oxidanylidene-ethyl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide

(1)

YZ6 : (E,2R,3R,4S,5R)-N-[(3R)-3-(furan-2-yl)-3-phenyl-propyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide

(1)

ZN : ZINC ION

(1)

EC number / name  (1)

3.4.11.18 : Methionyl aminopeptidase

(35)

Biological function  (9)

metalloaminopeptidase activity

(34)

aminopeptidase activity

(2)

hydrolase activity

(2)

initiator methionyl aminopeptidase activity

(2)

metal ion binding

(2)

metalloexopeptidase activity

(2)

peptidase activity

(2)

protein binding

(2)

zinc ion binding

(2)

Biological process  (4)

proteolysis

(34)

platelet aggregation

(2)

protein maturation

(2)

regulation of translation

(2)

Biological cell component  (3)

cytoplasm

(2)

cytosol

(2)

cytosolic ribosome

(2)

CATH class  (1)

Alpha Beta

(31)

CATH topology  (1)

Creatine Amidinohydrolase

(31)

Pfam accession / name  (2)

PF00557 : Peptidase_M24

(34)

PF15801 : zf-C6H2

(3)

Diffraction protocol  (1)

Single wavelength

(33)

Diffraction radiation source type  (2)

Synchrotron

(17)

Rotating anode

(16)

Diffraction source  (6)

RIGAKU MICROMAX-007 HF

(14)

ALS BEAMLINE 8.2.2

(8)

APS BEAMLINE 19-BM

(4)

ALS BEAMLINE 8.2.1

(3)

ELETTRA BEAMLINE 11.2C

(2)

RIGAKU FR-E+ DW

(2)

Synchrotron site  (3)

ALS

(11)

APS

(4)

ELETTRA

(2)

Diffraction detector type  (3)

Image plate

(16)

CCD

(15)

Pixel

(2)

Refinement software  (7)

REFMAC

(25)

CNS

(4)

PHENIX

(2)

SHELX

(2)

SHELXL

(2)

SHELXL-97

(1)

phenix.real_space_refine

(1)

EM microscope model  (1)

FEI TITAN KRIOS

(1)

EM detector name  (1)

GATAN K3 (6k x 4k)

(1)

NMR software packages  (7)

CARA

(1)

CYANA

(1)

NMRFAM-SPARKY

(1)

NMRPipe

(1)

TopSpin

(1)

VnmrJ

(1)

hmsIST

(1)

NMR Field Strength

500.0 - 600

(1)

600.0 - 700

(1)

700.0 - 800

(1)

800.0 - 900

(1)

Representative Structures

100%

95%

90%

70%

50%

40%

30%