Uniprot accession / id : Q92692  OR   Uniprot accession / id : Q5FVC5
 
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Entry Information
Entry status  (1)
REL
(6)
 
Experimental methods  (1)
X-ray diffraction
(6)
 
Authors  (35)
Gao GF
(3)
Liu J
(3)
Qi J
(3)
Zhang S
(3)
Almo SC
(2)
Atoms-to-Animals: The Immune Function Network (IFN)
(2)
Chen Z
(2)
Gao F
(2)
Nathenson SG
(2)
New York Structural Genomics Research Consortium (NYSGRC)
(2)
Qian X
(2)
Ramagopal UA
(2)
Samanta D
(2)
Xu X
(2)
Yan J
(2)
Zhang R
(2)
Berry R
(1)
Cao X
(1)
Chen Q
(1)
Deuss FA
(1)
Gully BS
(1)
Han P
(1)
Han Y
(1)
Hu S
(1)
Hu ST
(1)
Liu H
(1)
Miao K
(1)
Qi JX
(1)
Rossjohn J
(1)
Rubinstein R
(1)
Tan S
(1)
Vigdorovich V
(1)
Wang H
(1)
Wang M
(1)
Xiao J
(1)
 
Homo / hetero assembly  (2)
homo
(4)
hetero
(2)
 
Assembly composition  (2)
protein structure
(4)
protein/protein complex
(2)
 
Assembly polymer count  (2)
dimer
(5)
monomer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(4)
3.0 - 3.5
(1)
 
Release year distribution
2010 - 2015
(4)
2015 - 2020
(1)
2020 - 2025
(1)
 
Journal  (5)
J Immunol
(2)
J Biol Chem
(1)
Proc Natl Acad Sci U S A
(1)
Structure
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(6)
 
Organism name  (1)
Homo sapiens
(6)
 
Molecule name  (6)
Herpes virus entry mediator B
(6)
Herpesvirus entry mediator B
(6)
HveB
(6)
Nectin cell adhesion molecule 2
(6)
Nectin-2
(6)
Poliovirus receptor-related protein 2
(6)
 
Molecule type  (1)
Protein
(6)
 
Gene names  (4)
HVEB
(6)
NECTIN2
(6)
PRR2
(6)
PVRL2
(6)
 
Interacting Molecules  (2)
T-cell immunoreceptor with Ig and ITIM domains
(1)
Transmembrane protein PVRIG
(1)
 
Interacting ligands  (3)
CL : CHLORIDE ION
(1)
MG : MAGNESIUM ION
(1)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(1)
 
Sequence and Structure classification
CATH class  (1)
Mainly Beta
(5)
 
CATH topology  (1)
Immunoglobulin-like
(5)
 
Pfam accession / name  (1)
PF07686 : V-set
(6)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(6)
 
Diffraction radiation source type  (1)
Synchrotron
(6)
 
Diffraction source  (4)
NSLS BEAMLINE X29A
(2)
SSRF BEAMLINE BL17U
(2)
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
(1)
SSRF BEAMLINE BL02U1
(1)
 
Synchrotron site  (3)
SSRF
(3)
NSLS
(2)
Australian Synchrotron
(1)
 
Diffraction detector type  (3)
CCD
(3)
Image plate
(2)
Pixel
(1)
 
Refinement software  (3)
PHENIX
(3)
REFMAC
(2)
BUSTER
(1)
 
Representative Structures
Representative Structures
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90%
70%
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40%
30%
Entries 1 to 6 of 6
Entries 1 to 6 of 6
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Crystal structure of cell adhesion molecule nectin-2/CD112 mutant FAMP
Liu J, Qian X, Chen Z, Xu X, Gao F, Zhang S, Zhang R, Qi J, Gao GF, Yan J
J Immunol (2012) [PMID: 22547693  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Nectin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-187721 (Preferred)   search this ID
PDBe-KB: Q92692   
X-ray diffraction
1.8Å resolution
Released: 6 Jun 2012
Model geometry
Fit model/data
4dfi
4dfi
4dfi
Crystal Structure of the Immunoglobulin variable domain of Nectin-2 in monoclinic form
Ramagopal UA, Samanta D, Nathenson SG, Almo SC, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Nectin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-187722 (Preferred)   search this ID
PDBe-KB: Q92692   
X-ray diffraction
1.7Å resolution
Released: 30 Jan 2013
Model geometry
Fit model/data
4hza
4hza
4hza
Crystal structure of cell adhesion molecule nectin-2/CD112 variable domain
Liu J, Qian X, Chen Z, Xu X, Gao F, Zhang S, Zhang R, Qi J, Gao GF, Yan J
J Immunol (2012) [PMID: 22547693  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Nectin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-187722 (Preferred)   search this ID
PDBe-KB: Q92692   
X-ray diffraction
1.85Å resolution
Released: 6 Jun 2012
Model geometry
Fit model/data
4dfh
4dfh
4dfh
Crystal structure of immune receptor PVRIG in complex with ligand Nectin-2
Hu ST, Han P, Wang H, Qi JX
Structure (2024) [PMID: 38626767  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Assembly name: Nectin-2 and Transmembrane protein PVRIG (Preferred)   search this complex
PDBe complex ID: PDB-CPX-274864 (Preferred)   search this ID
PDBe-KB: Q92692    Q6DKI7   
X-ray diffraction
2Å resolution
Released: 24 Apr 2024
Model geometry
Fit model/data
8x6b
8x6b
8x6b
Structure of TIGIT bound to nectin-2 (CD112)
Deuss FA, Gully BS, Rossjohn J, Berry R
J Biol Chem (2017) [PMID: 28515320  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GOL    NAG    SO4    NAG   
Assembly name: T-cell immunoreceptor with Ig and ITIM domains and Nectin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-175399 (Preferred)   search this ID
PDBe-KB: Q92692    Q495A1   
X-ray diffraction
3.1Å resolution
Released: 24 May 2017
Model geometry
Fit model/data
5v52
5v52
5v52
Crystal Structure of the Immunoglobulin variable domain of Nectin-2
Ramagopal UA, Samanta D, Nathenson SG, Almo SC, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)
Proc Natl Acad Sci U S A (2012) [PMID: 22927415  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MG    CL    MG   
Assembly name: Nectin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-187722 (Preferred)   search this ID
PDBe-KB: Q92692   
X-ray diffraction
1.3Å resolution
Released: 27 Apr 2011
Model geometry
Fit model/data
3r0n
3r0n
3r0n
Entries 1 to 6 of 6
Entries 1 to 6 of 6