Uniprot accession / id : Q92956  OR   Uniprot accession / id : Q80WM9  OR   Uniprot accession / id : Q5BK53  OR   Uniprot accession / id : B0V329  OR   Uniprot accession / id : Q0P402
 
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Entry Information
Entry status  (1)
REL
(9)
 
Experimental methods  (1)
X-ray diffraction
(9)
 
Authors  (45)
Almo SC
(5)
Bonanno JB
(5)
Liu W
(5)
Garforth SJ
(4)
Ramagopal UA
(4)
Cheroutre H
(3)
Chou TF
(3)
Fedorov E
(3)
Garrett-Thomson SC
(3)
Kakugawa K
(3)
Kim K
(3)
Kronenberg M
(3)
Seo GY
(3)
Wang Q
(3)
Atoms-to-Animals: The Immune Function Network (IFN)
(2)
Garrett-Thompson SC
(2)
Nathenson SG
(2)
Nemcovicova I
(2)
New York Structural Genomics Research Consortium (NYSGRC)
(2)
Ramagopal U
(2)
Zajonc DM
(2)
Bhosle RC
(1)
Bonanno J
(1)
Carfi A
(1)
Carfí A
(1)
Cohen GH
(1)
Compaan DM
(1)
Eaton D
(1)
Eisenberg RJ
(1)
Fedorov EV
(1)
Garrett SC
(1)
Gonzalez LC
(1)
Himmel D
(1)
Hymowitz SG
(1)
Krummenacher C
(1)
Krummenacker C
(1)
Loyet KM
(1)
Patskovsky Y
(1)
Ramagoal UA
(1)
Tom I
(1)
Vigdorovich V
(1)
Whitbeck JC
(1)
Wiley DC
(1)
Willis SH
(1)
Zhan C
(1)
 
Homo / hetero assembly  (2)
homo
(5)
hetero
(4)
 
Assembly composition  (2)
protein structure
(5)
protein/protein complex
(4)
 
Assembly polymer count  (4)
monomer
(5)
hexamer
(2)
dimer
(1)
tetramer
(1)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(4)
2.5 - 3
(3)
3.0 - 3.5
(1)
 
Release year distribution
2000 - 2005
(2)
2005 - 2010
(1)
2010 - 2015
(2)
2015 - 2020
(4)
2020 - 2025
(2)
 
Journal  (6)
J Exp Med
(3)
To be published
(2)
J Biol Chem
(1)
Mol Biotechnol
(1)
Mol Cell
(1)
Structure
(1)
 
Macromolecules
Organism superkingdom  (2)
Eukaryota
(8)
Viruses
(1)
 
Organism name  (3)
Homo sapiens
(7)
Human alphaherpesvirus 1
(1)
Mus musculus
(1)
 
Molecule name  (9)
Herpes virus entry mediator A
(9)
Herpesvirus entry mediator A
(9)
HveA
(9)
TR2
(9)
Tumor necrosis factor receptor superfamily member 14
(9)
Tumor necrosis factor receptor-like 2
(9)
CD160 antigen
(2)
CD160 antigen, soluble form
(2)
Natural killer cell receptor BY55
(2)
 
Molecule type  (1)
Protein
(9)
 
Gene names  (8)
HVEA
(8)
HVEM
(8)
TNFRSF14
(8)
UNQ329/PRO509
(8)
BY55
(2)
CD160
(2)
Tnfrsf14
(1)
hvem
(1)
 
Interacting Molecules  (3)
Tumor necrosis factor ligand superfamily member 14, soluble form
(2)
B- and T-lymphocyte attenuator
(1)
Envelope glycoprotein D
(1)
 
Interacting ligands  (6)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(4)
BMA : beta-D-mannopyranose
(2)
SO4 : SULFATE ION
(2)
CL : CHLORIDE ION
(1)
FUL : beta-L-fucopyranose
(1)
GOL : GLYCEROL
(1)
 
Function and Biology
Biological function  (1)
transmembrane signaling receptor activity
(2)
 
Biological process  (1)
regulation of adaptive immune response
(2)
 
Sequence and Structure classification
SCOP fold  (1)
TNF receptor-like
(2)
 
SCOP family  (1)
TNF receptor-like
(2)
 
CATH class  (1)
Mainly Beta
(6)
 
CATH topology  (1)
Tumor Necrosis Factor Receptor, subunit A; domain 2
(6)
 
Pfam accession / name  (1)
PF00020 : TNFR_c6
(9)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(9)
 
Diffraction radiation source type  (1)
Synchrotron
(9)
 
Diffraction source  (5)
APS BEAMLINE 31-ID
(3)
NSLS BEAMLINE X29A
(2)
SSRL BEAMLINE BL7-1
(2)
ALS BEAMLINE 5.0.1
(1)
CHESS BEAMLINE A1
(1)
 
Synchrotron site  (5)
APS
(3)
NSLS
(2)
SSRL
(2)
ALS
(1)
CHESS
(1)
 
Diffraction detector type  (1)
CCD
(9)
 
Refinement software  (3)
REFMAC
(7)
CNS
(1)
PHENIX
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 9 of 9
Entries 1 to 9 of 9
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Unliganded Human HVEM at 2.1A in P 21 21 21
Nemcovicova I, Zajonc DM
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Tumor necrosis factor receptor superfamily member 14 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-187821 (Preferred)   search this ID
PDBe-KB: Q92956   
X-ray diffraction
2.1Å resolution
Released: 24 Oct 2018
Model geometry
Fit model/data
5t2r
5t2r
5t2r
Crystal structure of human CD160 and HVEM complex
Liu W, Bonanno J, Almo SC
Structure (2019) [PMID: 31230945  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MG    MG   
Carbohydrate polymer components:
Molecule 1 - BMA(2), NAG(2)
Molecule 2 - NAG(2)
Assembly name: CD160 antigen, Tumor necrosis factor receptor superfamily member 14 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132092 (Preferred)   search this ID
PDBe-KB: O95971    Q92956   
X-ray diffraction
2.88Å resolution
Released: 3 Jul 2019
Model geometry
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6ng3
6ng3
6ng3
The crystal structure of LIGHT in complex with HVEM and CD160
Liu W, Ramagopal U, Garrett-Thompson SC, Fedorov E, Bonanno JB, Almo SC
J Exp Med (2021) [PMID: 34709351  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Molecule 2 - BMA(1), NAG(2)
Assembly name: Tumor necrosis factor ligand superfamily member 14, soluble form and CD160 antigen, Tumor necrosis factor receptor superfamily member 14 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-128992 (Preferred)   search this ID
PDBe-KB: O95971    Q92956    O43557   
X-ray diffraction
3.5Å resolution
Released: 27 Oct 2021
Model geometry
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7msg
7msg
7msg
The crystal structure of mouse HVEM
Liu W, Ramagopal U, Garrett-Thompson SC, Fedorov E, Bonanno JB, Almo SC
J Exp Med (2021) [PMID: 34709351  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Bound ligands: SO4   
Assembly name: Tumor necrosis factor receptor superfamily member 14 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-182402 (Preferred)   search this ID
PDBe-KB: Q80WM9   
X-ray diffraction
2.1Å resolution
Released: 27 Oct 2021
Model geometry
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7msj
7msj
7msj
CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS GLYCOPROTEIN D BOUND TO THE CELLULAR RECEPTOR HVEA/HVEM
Carfi A, Willis SH, Whitbeck JC, Krummenacker C, Cohen GH, Eisenberg RJ, Wiley DC
Mol Cell (2001) [PMID: 11511370  ]
Assembly composition: protein/protein complex
Bound ligands: SO4   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Assembly name: Envelope glycoprotein D and Tumor necrosis factor receptor superfamily member 14 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157600 (Preferred)   search this ID
PDBe-KB: Q92956    P57083   
X-ray diffraction
2.65Å resolution
Released: 26 Sep 2001
Model geometry
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1jma
1jma
1jma
Crystal structure of the human BTLA-HVEM complex
Compaan DM, Gonzalez LC, Tom I, Loyet KM, Eaton D, Hymowitz SG
J Biol Chem (2005) [PMID: 16169851  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NI    NI   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Molecule 2 - FUL(1), NAG(1)
Assembly name: B- and T-lymphocyte attenuator and Tumor necrosis factor receptor superfamily member 14 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-182287 (Preferred)   search this ID
PDBe-KB: Q92956    Q7Z6A9   
X-ray diffraction
2.8Å resolution
Released: 27 Sep 2005
Model geometry
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2aw2
2aw2
2aw2
Unliganded Human HVEM at 1.9A in P 1 21 1
Nemcovicova I, Zajonc DM
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Tumor necrosis factor receptor superfamily member 14 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-187821 (Preferred)   search this ID
PDBe-KB: Q92956   
X-ray diffraction
1.9Å resolution
Released: 24 Oct 2018
Model geometry
Fit model/data
5t2q
5t2q
5t2q
Crystal structure of the light and hvem complex
Liu W, Ramagoal UA, Himmel D, Bonanno JB, Nathenson SG, Almo SC, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC)
J Exp Med (2021) [PMID: 34709351  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GOL    NAG    CL    NAG   
Assembly name: TNFSF14-TNFRSF14 receptor complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-128993 (Preferred)   search this ID
PDBe-KB: Q92956    O43557   
X-ray diffraction
2.3Å resolution
Released: 4 Feb 2015
Model geometry
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4rsu
4rsu
4rsu
Crystal Structure of HVEM
Liu W, Zhan C, Patskovsky Y, Bhosle RC, Nathenson SG, Almo SC, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC)
Mol Biotechnol (2015) [PMID: 26202493  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Tumor necrosis factor receptor superfamily member 14 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-187821 (Preferred)   search this ID
PDBe-KB: Q92956   
X-ray diffraction
2.251Å resolution
Released: 18 Jul 2012
Model geometry
Fit model/data
4fhq
4fhq
4fhq
Entries 1 to 9 of 9
Entries 1 to 9 of 9