Entry status  (1)

REL

(53)

Experimental methods  (1)

X-ray diffraction

(53)

Authors  (140)

Christianson DW

(39)

Decroos C

(26)

Fierke CA

(16)

Bowman CM

(15)

Deardorff MA

(14)

Dowling DP

(12)

Christianson KE

(11)

Gattis SG

(11)

Bowman CB

(8)

Moser J-AS

(8)

Moser JA

(8)

Porter NJ

(8)

Christianson NH

(7)

Gantt SL

(7)

Gullett LE

(7)

Lee MS

(7)

Arvai A

(4)

Buggy JJ

(4)

Chi E

(4)

Dougan DR

(4)

Gantt SM

(4)

Ho JD

(4)

Jennings AJ

(4)

Katz BA

(4)

Knuth MW

(4)

Leahy EM

(4)

Luong C

(4)

McRee DE

(4)

Mol C

(4)

Navre M

(4)

Sang B-C

(4)

Sang BC

(4)

Skene RJ

(4)

Snell G

(4)

Somoza JR

(4)

Swanson RV

(4)

Tang J

(4)

Tari LW

(4)

Verner E

(4)

Wynands R

(4)

Bair K

(3)

Barczak N

(3)

Caravella J

(3)

Clausen DJ

(3)

Conti C

(3)

De Francesco R

(3)

Di Marco S

(3)

Gallinari P

(3)

Garcia-Dancey R

(3)

Haines BE

(3)

Han B

(3)

Hardy C

(3)

Krantz ID

(3)

Lahdenranta J

(3)

Lancia Jr D

(3)

Lee M

(3)

Leng C

(3)

Li P

(3)

Liu C

(3)

Martin M

(3)

Ng PY

(3)

Osko JD

(3)

Pardo E

(3)

Raible SE

(3)

Rudnitskaya A

(3)

Saldahna A

(3)

Steinkühler C

(3)

Tan T

(3)

Thomason JJ

(3)

Toms AV

(3)

Vannini A

(3)

Volpari C

(3)

Watson PR

(3)

Wiest O

(3)

Williams RM

(3)

Yao L

(3)

Zablocki M-M

(3)

Zhang C

(3)

Zheng X

(3)

Atadja PW

(2)

Carfi A

(2)

Carfí A

(2)

Claiborne T

(2)

Cole KE

(2)

Defrancesco R

(2)

Dobler MR

(2)

Grob JE

(2)

Jones P

(2)

Mattu M

(2)

McRiner A

(2)

Pancost MR

(2)

Patnaik A

(2)

Radetich B

(2)

Shao W

(2)

Shultz M

(2)

Stams T

(2)

Steinkuhler C

(2)

Tichkule R

(2)

Tommasi RA

(2)

Vash B

(2)

 

More...

Homo / hetero assembly  (2)

homo

(40)

hetero

(13)

Assembly composition  (2)

protein structure

(40)

protein/protein complex

(13)

Assembly polymer count  (3)

monomer

(38)

dimer

(14)

trimer

(1)

Resolution distribution

1.0 - 1.5

(3)

1.5 - 2

(20)

2.0 - 2.5

(17)

2.5 - 3

(11)

3.0 - 3.5

(2)

Release year distribution

2000 - 2005

(5)

2005 - 2010

(13)

2010 - 2015

(21)

2015 - 2020

(24)

2020 - 2025

(6)

Journal  (10)

Biochemistry

(26)

ACS Chem Biol

(9)

J Struct Biol

(4)

Structure

(4)

To be published

(3)

Bioorg Med Chem

(2)

EMBO Rep

(2)

J Am Chem Soc

(1)

J Med Chem

(1)

Proc Natl Acad Sci U S A

(1)

Organism superkingdom  (1)

Eukaryota

(53)

Organism name  (1)

Homo sapiens

(53)

Molecule name  (4)

HD8

(53)

Histone deacetylase 8

(53)

Protein deacetylase HDAC8

(53)

Protein decrotonylase HDAC8

(53)

Molecule type  (1)

Protein

(53)

Gene names  (3)

CDA07

(53)

HDAC8

(53)

HDACL1

(53)

Interacting Molecules  (9)

Fluor-de-Lys tetrapeptide assay substrate

(3)

tetrapeptide substrate

(3)

HDAC8 Fluor de Lys tetrapeptide substrate

(2)

ACE-ARG-HIS-ALY-ALY-MCM

(1)

Cellular tumor antigen p53

(1)

GLYCYL-GLYCYL-GLYCINE

(1)

Largazole

(1)

PEPTIDIC SUBSTRATE

(1)

Trapoxin A

(1)

Interacting ligands  (35)

K : POTASSIUM ION

(49)

ZN : ZINC ION

(49)

GOL : GLYCEROL

(21)

B3N : 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide

(17)

EDO : 1,2-ETHANEDIOL

(7)

BME : BETA-MERCAPTOETHANOL

(4)

MCM : 7-AMINO-4-METHYL-CHROMEN-2-ONE

(4)

SHH : OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE

(4)

TSN : TRICHOSTATIN A

(4)

NA : SODIUM ION

(3)

CO : COBALT (II) ION

(2)

IMD : IMIDAZOLE

(2)

0DI : (2R)-2-amino-3-(3-chlorophenyl)-1-[4-(2,5-difluorobenzoyl)piperazin-1-yl]propan-1-one

(1)

1DI : (2R)-2-amino-3-(2,4-dichlorophenyl)-1-(1,3-dihydro-2H-isoindol-2-yl)propan-1-one

(1)

5YA : 4-naphthalen-1-yl-~{N}-oxidanyl-benzamide

(1)

ACT : ACETATE ION

(1)

AGE : (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide

(1)

C7 : N-{2-[3-(hydroxyamino)-3-oxopropyl]phenyl}-3-(trifluoromethyl)benzamide

(1)

CA : CALCIUM ION

(1)

CRI : 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE

(1)

DIO : 1,4-DIETHYLENE DIOXIDE

(1)

FE2 : FE (II) ION

(1)

GGG : glycylglycylglycine

(1)

GOK : 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide

(1)

L6G : (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3,17-dithia-7,10,14,19,20-pentaazatricyclo[14.2.1.1~2,5~]icosa-1(18),2(20),16(19)-triene-6,9,13-trione

(1)

L7G : (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3-thia-7,10,14,17,21-pentaazatricyclo[14.3.1.1~2,5~]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione

(1)

L8G : (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3-thia-7,10,14,20,21-pentaazatricyclo[14.3.1.1~2,5~]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione

(1)

M7Y : (2E)-3-[2-(3-cyclopentyl-5,5-dimethyl-2-oxoimidazolidin-1-yl)phenyl]-N-hydroxyprop-2-enamide

(1)

M8G : N-{2-[(1E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]phenyl}-2-phenoxybenzamide

(1)

MG : MAGNESIUM ION

(1)

MN : MANGANESE (II) ION

(1)

NHB : N-HYDROXY-4-(METHYL{[5-(2-PYRIDINYL)-2-THIENYL]SULFONYL}AMINO)BENZAMIDE

(1)

P6G : HEXAETHYLENE GLYCOL

(1)

V5X : (2R)-N~8~-HYDROXY-2-{[(5-METHOXY-2-METHYL-1H-INDOL-3-YL)ACETYL]AMINO}-N~1~-[2-(2-PHENYL-1H-INDOL-3-YL)ETHYL]OCTANEDIAMIDE

(1)

XCH : Droxinostat

(1)

EC number / name  (1)

3.5.1.98 : Histone deacetylase

(53)

Biological function  (11)

DNA-binding transcription factor binding

(53)

Hsp70 protein binding

(53)

Hsp90 protein binding

(53)

histone deacetylase activity

(53)

histone deacetylase activity, hydrolytic mechanism

(53)

histone decrotonylase activity

(53)

hydrolase activity

(53)

metal ion binding

(53)

protein binding

(53)

protein decrotonylase activity

(53)

protein lysine deacetylase activity

(53)

Biological process  (7)

chromatin organization

(53)

heterochromatin formation

(53)

mitotic sister chromatid cohesion

(53)

negative regulation of protein ubiquitination

(53)

negative regulation of transcription by RNA polymerase II

(53)

regulation of protein stability

(53)

regulation of telomere maintenance

(53)

Biological cell component  (6)

chromosome

(53)

cytoplasm

(53)

histone deacetylase complex

(53)

nuclear chromosome

(53)

nucleoplasm

(53)

nucleus

(53)

SCOP fold  (1)

Arginase/deacetylase

(5)

SCOP family  (1)

Histone deacetylase, HDAC

(5)

CATH class  (1)

Alpha Beta

(47)

CATH topology  (1)

Arginase; Chain A

(47)

Pfam accession / name  (1)

PF00850 : Hist_deacetyl

(53)

Diffraction protocol  (1)

Single wavelength

(53)

Diffraction radiation source type  (2)

Synchrotron

(51)

Rotating anode

(2)

Diffraction source  (17)

NSLS BEAMLINE X29A

(19)

APS BEAMLINE 24-ID-C

(9)

APS BEAMLINE 24-ID-E

(7)

ALS BEAMLINE 5.0.3

(3)

ESRF BEAMLINE ID14-3

(3)

SSRL BEAMLINE BL14-1

(2)

APS BEAMLINE 17-BM

(1)

APS BEAMLINE 21-ID-D

(1)

CHESS BEAMLINE F1

(1)

NSLS BEAMLINE X12B

(1)

NSLS BEAMLINE X25

(1)

RIGAKU FR-E SUPERBRIGHT

(1)

RIGAKU RUH3R

(1)

SOLEIL BEAMLINE PROXIMA 1

(1)

SSRF BEAMLINE BL17U

(1)

SSRF BEAMLINE BL18U1

(1)

SSRL BEAMLINE BL9-2

(1)

Synchrotron site  (8)

NSLS

(21)

APS

(17)

ALS

(3)

ESRF

(3)

SSRL

(3)

SSRF

(2)

CHESS

(1)

SOLEIL

(1)

Diffraction detector type  (3)

CCD

(45)

Pixel

(7)

Image plate

(1)

Refinement software  (6)

PHENIX

(30)

REFMAC

(11)

CNS

(8)

CNX

(2)

BUSTER

(1)

X-PLOR

(1)

Representative Structures

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