Uniprot accession / id : Q9UBU3  OR   Uniprot accession / id : Q9BEF8  OR   Uniprot accession / id : Q9BDJ6  OR   Uniprot accession / id : B9DQV0  OR   Uniprot accession / id : Q9EQX0  OR   Uniprot accession / id : A2RSS9  OR   Uniprot accession / id : Q9QYH7
 
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Entry Information
Entry status  (1)
REL
(7)
 
Experimental methods  (2)
Solution NMR
(4)
Electron Microscopy
(3)
 
Authors  (56)
Campiglia P
(3)
D'Ursi AM
(3)
Esposito C
(3)
Gomez-Monterrey I
(3)
Novellino E
(3)
Scrima M
(3)
Baneres JL
(2)
Damian M
(2)
Banères JL
(1)
Cai Y
(1)
Cantel S
(1)
Czaplicki G
(1)
Delort B
(1)
Demange P
(1)
Fehrentz JA
(1)
Ferre G
(1)
Ferré G
(1)
Floquet N
(1)
Gavara L
(1)
Guo J
(1)
Guo S
(1)
He X
(1)
Hirata K
(1)
Ji S
(1)
Ji SY
(1)
Jiang Y
(1)
Liu H
(1)
Louet M
(1)
M'Kadmi C
(1)
Ma Y
(1)
Mao C
(1)
Marie J
(1)
Milon A
(1)
Ming Q
(1)
Myasnikov A
(1)
Qin J
(1)
Renault P
(1)
Saurel O
(1)
Shao Z
(1)
Shen D
(1)
Shen DD
(1)
Sun D
(1)
Sun J
(1)
Wang Y
(1)
Wu C
(1)
Xie X
(1)
Xu HE
(1)
Xu P
(1)
Xu Z
(1)
Yan W
(1)
Yin W
(1)
Yun Y
(1)
Zhang C
(1)
Zhang H
(1)
Zhang Y
(1)
Zhuang Y
(1)
 
Homo / hetero assembly  (2)
homo
(4)
hetero
(3)
 
Assembly composition  (2)
protein structure
(4)
protein/protein complex
(3)
 
Assembly polymer count  (2)
monomer
(4)
hexamer
(3)
 
Resolution distribution
2.5 - 3
(3)
 
Release year distribution
2005 - 2010
(3)
2015 - 2020
(1)
2020 - 2025
(3)
 
Journal  (3)
Biochem Biophys Res Commun
(3)
Nat Commun
(3)
Proc Natl Acad Sci U S A
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(7)
 
Organism name  (2)
Homo sapiens
(4)
Mus musculus
(3)
 
Molecule name  (9)
Appetite-regulating hormone
(7)
Ghrelin
(7)
Growth hormone secretagogue
(7)
Growth hormone-releasing peptide
(7)
Motilin-related peptide
(7)
Obestatin
(7)
Protein M46
(7)
Ghrelin-27
(4)
Ghrelin-28
(4)
 
Molecule type  (1)
Protein
(7)
 
Gene names  (5)
GHRL
(4)
MTLRP
(4)
UNQ524/PRO1066
(4)
Ghrl
(3)
Mtlrp
(3)
 
Interacting Molecules  (10)
Growth hormone secretagogue receptor type 1
(3)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(3)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
(3)
Antibody fragment
(1)
Engineered G-alpha-q subunit
(1)
Guanine nucleotide-binding protein G(i) subunit alpha-1
(1)
Guanine nucleotide-binding protein G(o) subunit alpha
(1)
NB35
(1)
ScFv16
(1)
Soluble cytochrome b562
(1)
 
Interacting ligands  (2)
FKZ : octan-1-amine
(1)
OCA : OCTANOIC ACID (CAPRYLIC ACID)
(1)
 
Function and Biology
Biological function  (2)
hormone activity
(5)
growth hormone-releasing hormone activity
(1)
 
Biological cell component  (1)
extracellular region
(5)
 
Sequence and Structure classification
Pfam accession / name  (2)
PF04644 : Motilin_ghrelin
(4)
PF04643 : Motilin_assoc
(2)
 
Experimental Information
Refinement software  (1)
PHENIX
(1)
 
EM microscope model  (1)
FEI TITAN KRIOS
(3)
 
EM detector name  (2)
GATAN K3 (6k x 4k)
(2)
GATAN K2 SUMMIT (4k x 4k)
(1)
 
NMR
NMR software packages  (4)
DYANA
(3)
Amber
(1)
Sparky
(1)
TopSpin
(1)
 
NMR Field Strength
500.0 - 600
(3)
600.0 - 700
(4)
700.0 - 800
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 7 of 7
Entries 1 to 7 of 7
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Receptor-bound Ghrelin conformation
Ferre G, Damian M, M'Kadmi C, Saurel O, Czaplicki G, Demange P, Marie J, Fehrentz JA, Baneres JL, Milon A
Proc Natl Acad Sci U S A (2019) [PMID: 31416915  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: FKZ   
Modified residues: NH2    NH2   
Assembly name: Ghrelin-27 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-193676 (Preferred)   search this ID
PDBe-KB: Q9UBU3   
Solution NMR
Released: 24 Jul 2019
Model geometry
Fit model/data
Data not analysed
6h3e
6h3e
6h3e
Cryo-EM structure of the ghrelin-bound human ghrelin receptor-Go complex
Qin J, Ming Q, Ji S, Mao C, Shen D, Zhang Y
Nat Commun (2022) [PMID: 35027551  ]
Assembly composition: protein/protein complex
Bound ligands: CLR    CLR   
Modified residues: K4Q   
PDBe complex ID: PDB-CPX-209412 (Preferred)   search this ID
PDBe-KB: Q9UBU3    P09471    P62873    P59768    Q92847   
Electron Microscopy
2.8Å resolution
Released: 19 Jan 2022
Model geometry
Fit model/data
Data not analysed
7w2z
7w2z
7w2z
Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist
Liu H, Sun D, Sun J, Zhang C
Nat Commun (2021)
Assembly composition: protein/protein complex
Bound ligands: CLR    CLR   
Modified residues: 1IC    1IC   
PDBe complex ID: PDB-CPX-211371 (Preferred)   search this ID
PDBe-KB: Q9UBU3    P62873    P63096    P59768    Q92847   
Electron Microscopy
2.7Å resolution
Released: 15 Dec 2021
Model geometry
Fit model/data
Data not analysed
7na7
7na7
7na7
ghrelin-bound ghrelin receptor in complex with Gq
Wang Y, Zhuang Y, Xu P, Xu HE, Jiang Y
Nat Commun (2021) [PMID: 34417468  ]
Source organisms: Lama glama  , Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CLR    OCA    CLR   
PDBe complex ID: PDB-CPX-209564 (Preferred)   search this ID
PDBe-KB: Q9UBU3    P0ABE7    P62873    P59768    Q92847   
Electron Microscopy
2.9Å resolution
Released: 18 Aug 2021
Model geometry
Fit model/data
Data not analysed
7f9y
7f9y
7f9y
11-23 obestatin fragment in DPC/SDS micellar solution
D'Ursi AM, Scrima M, Esposito C, Campiglia P
Biochem Biophys Res Commun (2007) [PMID: 17904104  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Modified residues: NH2    NH2   
Assembly name: Obestatin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-190165 (Preferred)   search this ID
PDBe-KB: Q9EQX0   
Solution NMR
Released: 21 Oct 2008
Model geometry
Fit model/data
Data not deposited
2jsi
2jsi
2jsi
Obestatin in water solution
D'Ursi AM, Scrima M, Esposito C, Campiglia P
Biochem Biophys Res Commun (2007) [PMID: 17904104  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Modified residues: NH2    NH2   
Assembly name: Obestatin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-190165 (Preferred)   search this ID
PDBe-KB: Q9EQX0   
Solution NMR
Released: 21 Oct 2008
Model geometry
Fit model/data
Data not deposited
2jsj
2jsj
2jsj
obestatin NMR structure in SDS/DPC micellar solution
D'Ursi AM, Scrima M, Esposito C, Campiglia P
Biochem Biophys Res Commun (2007) [PMID: 17904104  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Modified residues: NH2    NH2   
Assembly name: Obestatin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-190165 (Preferred)   search this ID
PDBe-KB: Q9EQX0   
Solution NMR
Released: 21 Oct 2008
Model geometry
Fit model/data
Data not deposited
2jsh
2jsh
2jsh
Entries 1 to 7 of 7
Entries 1 to 7 of 7