Uniprot accession / id : Q9UK05  OR   Uniprot accession / id : Q9WV56  OR   Uniprot accession / id : P34822
 
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Entry Information
Entry status  (1)
REL
(20)
 
Experimental methods  (1)
X-ray diffraction
(20)
 
Authors  (67)
Calero G
(12)
Demeler B
(12)
Henrickson A
(12)
Hinck AP
(12)
Hinck CS
(12)
Lin G
(12)
Morosky SA
(12)
Olsen SK
(12)
Roman BL
(12)
Rosato TL
(12)
Schwartze TA
(12)
Taylor AB
(12)
Bokhove M
(2)
Brown CT
(2)
Croci R
(2)
Gao Y
(2)
Han L
(2)
Jovine L
(2)
Le V
(2)
Le VQ
(2)
Letarte M
(2)
Li W
(2)
Mi LZ
(2)
Morrell NW
(2)
Saito T
(2)
Salmon RM
(2)
Springer TA
(2)
Tian Y
(2)
Walz T
(2)
Zamora-Caballero S
(2)
de Sanctis D
(2)
Baker KA
(1)
Beech JS
(1)
Brown MA
(1)
Chen C
(1)
Choe S
(1)
Grainger DJ
(1)
Greppi C
(1)
Grinberg AV
(1)
Guo J
(1)
Kumar R
(1)
Lawera A
(1)
Liharska K
(1)
Liu J
(1)
Lowden P
(1)
Mahoney A
(1)
Martinez-Hackert E
(1)
Mi L-Z
(1)
Naik C
(1)
Parice Y
(1)
Pukac L
(1)
Reckless J
(1)
Roschke V
(1)
Sako D
(1)
Sanyal I
(1)
Seehra J
(1)
Singh M
(1)
Tong Z
(1)
Townson SA
(1)
Tsareva T
(1)
Ucran JA
(1)
Underwood KW
(1)
Upton PD
(1)
Wei Z
(1)
Wood JH
(1)
Yu M
(1)
Zhao Q
(1)
 
Homo / hetero assembly  (2)
homo
(15)
hetero
(5)
 
Assembly composition  (2)
protein structure
(15)
protein/protein complex
(5)
 
Assembly polymer count  (4)
dimer
(14)
tetramer
(3)
hexamer
(2)
monomer
(1)
 
Resolution distribution
1.5 - 2
(4)
2.0 - 2.5
(9)
2.5 - 3
(2)
3.0 - 3.5
(4)
4.0 - 4.5
(1)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(1)
2010 - 2015
(4)
2015 - 2020
(5)
2020 - 2025
(13)
2025 - 2030
(12)
 
Journal  (5)
J Mol Biol
(12)
J Biol Chem
(3)
Cell Rep
(2)
Proc Natl Acad Sci U S A
(2)
Nat Commun
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(20)
 
Organism name  (2)
Homo sapiens
(20)
Mus musculus
(2)
 
Molecule name  (4)
BMP-9
(20)
Bone morphogenetic protein 9
(20)
GDF-2
(20)
Growth/differentiation factor 2
(20)
 
Molecule type  (1)
Protein
(20)
 
Gene names  (4)
BMP9
(20)
GDF2
(20)
Bmp9
(2)
Gdf2
(2)
 
Interacting Molecules  (5)
Growth/differentiation factor 2
(3)
Activin receptor type-1-like
(2)
Activin receptor type-2B
(1)
Endoglin
(1)
Maltose/maltodextrin-binding periplasmic protein
(1)
 
Interacting ligands  (6)
CL : CHLORIDE ION
(12)
GOL : GLYCEROL
(12)
NA : SODIUM ION
(12)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(3)
ZN : ZINC ION
(2)
CYS : CYSTEINE
(1)
 
Function and Biology
Biological function  (1)
growth factor activity
(8)
 
Biological cell component  (1)
extracellular region
(8)
 
Sequence and Structure classification
CATH class  (1)
Mainly Beta
(5)
 
CATH topology  (1)
Cystine Knot Cytokines, subunit B
(5)
 
Pfam accession / name  (2)
PF00019 : TGF_beta
(20)
PF00688 : TGFb_propeptide
(3)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(20)
 
Diffraction radiation source type  (2)
Synchrotron
(19)
Rotating anode
(1)
 
Diffraction source  (9)
APS BEAMLINE 22-ID
(11)
DIAMOND BEAMLINE I02
(2)
APS BEAMLINE 23-ID-D
(1)
APS BEAMLINE 24-ID-C
(1)
DIAMOND BEAMLINE I04
(1)
DIAMOND BEAMLINE I04-1
(1)
RIGAKU FR-E+ SUPERBRIGHT
(1)
SSRL BEAMLINE BL12-2
(1)
SSRL BEAMLINE BL9-2
(1)
 
Synchrotron site  (3)
APS
(13)
Diamond
(4)
SSRL
(2)
 
Diffraction detector type  (2)
Pixel
(17)
CCD
(3)
 
Refinement software  (2)
PHENIX
(19)
REFMAC
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 20
Entries 1 to 10 of 20
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Crystal structure of human BMP9 at 1.87 A resolution
Saito T, Bokhove M, Jovine L
Cell Rep (2017) [PMID: 28564608  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL   
Assembly name: Growth/differentiation factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-193830 (Preferred)   search this ID
PDBe-KB: Q9UK05   
X-ray diffraction
1.87Å resolution
Released: 7 Jun 2017
Model geometry
Fit model/data
5i05
5i05
5i05
Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9
Bokhove M, Saito T, Jovine L
Cell Rep (2017) [PMID: 28564608  ]
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Carbohydrate polymer components:
Molecule 1 - GLC(2)
Assembly name: Growth/differentiation factor 2 and Endoglin, Maltose/maltodextrin-binding periplasmic protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-142520 (Preferred)   search this ID
PDBe-KB: Q9UK05    P0AEX9    P17813   
X-ray diffraction
4.451Å resolution
Released: 7 Jun 2017
Model geometry
Fit model/data
5hzw
5hzw
5hzw
BMP-9 Wild-Type Dimer With Radiation Damage in Neutral pH
Schwartze TA, Hinck AP
J Mol Biol (2025) [PMID: 39793884  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    NA    CL    NA   
Assembly name: Growth/differentiation factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-193830 (Preferred)   search this ID
PDBe-KB: Q9UK05   
X-ray diffraction
2.34Å resolution
Released: 5 Mar 2025
Model geometry
Fit model/data
9dpo
9dpo
9dpo
BMP-9 Wild-Type Dimer in Acidic pH
Schwartze TA, Hinck AP
J Mol Biol (2025) [PMID: 39793884  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    NA    CL    NA   
Assembly name: Growth/differentiation factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-193830 (Preferred)   search this ID
PDBe-KB: Q9UK05   
X-ray diffraction
2.12Å resolution
Released: 5 Mar 2025
Model geometry
Data not analysed
Fit model/data
Data not analysed
9dpp
9dpp
9dpp
BMP-9 G389S Dimer Without Radiation Damage in Neutral pH
Schwartze TA, Hinck AP
J Mol Biol (2025) [PMID: 39793884  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    NA    CL    NA   
Assembly name: Growth/differentiation factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-193830 (Preferred)   search this ID
PDBe-KB: Q9UK05   
X-ray diffraction
2.06Å resolution
Released: 5 Mar 2025
Model geometry
Data not analysed
Fit model/data
Data not analysed
9dps
9dps
9dps
BMP-9 Monomer Growth Factor with Cysteinylation
Schwartze TA, Hinck AP
J Mol Biol (2025) [PMID: 39793884  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CYS    CYS    NA    CL    NA   
Assembly name: Growth/differentiation factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-285036 (Preferred)   search this ID
PDBe-KB: Q9UK05   
X-ray diffraction
1.9Å resolution
Released: 22 Jan 2025
Model geometry
Fit model/data
9dpm
9dpm
9dpm
BMP-9 K357R G389S Dimer With Radiation Damage in Neutral pH
Schwartze TA, Hinck AP
J Mol Biol (2025) [PMID: 39793884  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    NA    CL    NA   
Assembly name: Growth/differentiation factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-193830 (Preferred)   search this ID
PDBe-KB: Q9UK05   
X-ray diffraction
2.71Å resolution
Released: 5 Mar 2025
Model geometry
Data not analysed
Fit model/data
Data not analysed
9dpw
9dpw
9dpw
BMP-9 G389S Dimer in Acidic pH
Schwartze TA, Hinck AP
J Mol Biol (2025) [PMID: 39793884  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    NA    CL    NA   
Assembly name: Growth/differentiation factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-193830 (Preferred)   search this ID
PDBe-KB: Q9UK05   
X-ray diffraction
2.1Å resolution
Released: 5 Mar 2025
Model geometry
Data not analysed
Fit model/data
Data not analysed
9dpu
9dpu
9dpu
BMP-9 Wild-Type Dimer Without Radiation Damage in Neutral pH
Schwartze TA, Hinck AP
J Mol Biol (2025) [PMID: 39793884  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    NA    CL    NA   
Assembly name: Growth/differentiation factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-193830 (Preferred)   search this ID
PDBe-KB: Q9UK05   
X-ray diffraction
2.24Å resolution
Released: 5 Mar 2025
Model geometry
Data not analysed
Fit model/data
Data not analysed
9dpn
9dpn
9dpn
BMP-9 Wild-Type Dimer without Radiation Damage in Acidic pH
Schwartze TA, Hinck AP
J Mol Biol (2025) [PMID: 39793884  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    NA    CL    NA   
Assembly name: Growth/differentiation factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-193830 (Preferred)   search this ID
PDBe-KB: Q9UK05   
X-ray diffraction
2.35Å resolution
Released: 5 Mar 2025
Model geometry
Data not analysed
Fit model/data
Data not analysed
9dpq
9dpq
9dpq
Entries 1 to 10 of 20
Entries 1 to 10 of 20