Uniprot accession / id : Q9Y2W6  OR   Uniprot accession / id : A5PJM9  OR   Uniprot accession / id : Q80VL1  OR   Uniprot accession / id : G3V8T7  OR   Uniprot accession / id : Q58EP5  OR   Uniprot accession / id : Q9VQ91  OR   Uniprot accession / id : Q7Q0T6
 
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Entry Information
Entry status  (1)
REL
(10)
 
Experimental methods  (2)
X-ray diffraction
(8)
Solution NMR
(2)
 
Authors  (55)
Gu J
(4)
Huang Y
(4)
Li R
(4)
Liu W
(4)
Ma J
(4)
Min J
(4)
Peng C
(4)
Structural Genomics Consortium (SGC)
(4)
Wu L
(4)
Wu P
(4)
Yu Y
(4)
Zhang Y
(4)
Zhang YH
(4)
Arrowsmith CH
(3)
Bountra C
(3)
Chen C
(3)
Edwards AM
(3)
Liu K
(3)
Ding D
(2)
Huang H
(2)
Inoue M
(2)
Izumi N
(2)
Kigawa T
(2)
Muto Y
(2)
Ni Z
(2)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(2)
Shirouzu M
(2)
Sidhu SS
(2)
Tempel W
(2)
Terada T
(2)
Tomari Y
(2)
Yokoyama S
(2)
Zhang H
(2)
Adams MA
(1)
Adams-Cioaba MA
(1)
Amaya MF
(1)
Bochkarev A
(1)
Chen S
(1)
Dang W
(1)
Dong A
(1)
Gish G
(1)
Guo Y
(1)
Hayashi F
(1)
He F
(1)
James DA
(1)
Jin J
(1)
Kozieradzki I
(1)
Li Y
(1)
Min JR
(1)
Park JG
(1)
Pawson T
(1)
Tenaglia E
(1)
Weigelt J
(1)
Xu C
(1)
Zhang W
(1)
 
Homo / hetero assembly  (2)
homo
(7)
hetero
(3)
 
Assembly composition  (2)
protein structure
(7)
protein/protein complex
(3)
 
Assembly polymer count  (3)
monomer
(7)
dimer
(2)
tetramer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(6)
2.5 - 3
(1)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(2)
2015 - 2020
(7)
 
Journal  (3)
Proc Natl Acad Sci U S A
(7)
To be published
(2)
Methods
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(10)
 
Organism name  (3)
Homo sapiens
(5)
Drosophila melanogaster
(4)
Mus musculus
(1)
 
Molecule name  (4)
Tudor and KH domain-containing protein
(6)
Tudor domain-containing protein 2
(6)
Partner of PIWIs protein
(4)
Tudor and KH domain-containing protein homolog
(4)
 
Molecule type  (1)
Protein
(10)
 
Gene names  (6)
TDRD2
(5)
TDRKH
(5)
Tdrd2
(5)
CG7082
(4)
papi
(4)
Tdrkh
(1)
 
Interacting Molecules  (4)
Protein piwi
(2)
Fab antigen-binding fragment
(1)
Piwi-like protein 1
(1)
Uncharacterized protein
(1)
 
Interacting ligands  (1)
CAC : CACODYLATE ION
(1)
 
Function and Biology
Biological function  (4)
RNA binding
(1)
flavin adenine dinucleotide binding
(1)
nucleic acid binding
(1)
oxidoreductase activity, acting on the CH-CH group of donors
(1)
 
Sequence and Structure classification
SCOP fold  (2)
Eukaryotic type KH-domain (KH-domain type I)
(1)
SH3-like barrel
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 10
Entries 1 to 10 of 10
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tudor in complex with ligand
Zhang H, Tempel W, Bountra C, Arrowsmith CH, Edwards AM, Min J, Structural Genomics Consortium (SGC)
Proc Natl Acad Sci U S A (2017) [PMID: 29118143  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Tudor and KH domain-containing protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-195169 (Preferred)   search this ID
PDBe-KB: Q9Y2W6   
X-ray diffraction
1.93Å resolution
Released: 1 Nov 2017
Model geometry
Fit model/data
6b57
6b57
6b57
Crystal structure of Drosophila melanogaster Papi extended Tudor domain
Zhang YH, Huang Y
Proc Natl Acad Sci U S A (2018) [PMID: 29531043  ]
Assembly composition: protein only structure
Assembly name: Tudor and KH domain-containing protein homolog (Preferred)   search this complex
PDBe complex ID: PDB-CPX-194291 (Preferred)   search this ID
PDBe-KB: Q9VQ91   
X-ray diffraction
2Å resolution
Released: 14 Mar 2018
Model geometry
Fit model/data
5ygc
5ygc
5ygc
Crystal structure of the TDRD2 extended Tudor domain in complex with an antibody fragment and the PIWIL1 peptide
Liu K, Min JR, Structural Genomics Consortium (SGC)
Methods (2020) [PMID: 31288074  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-232168 (Preferred)   search this ID
PDBe-KB: Q9Y2W6    Q96J94   
X-ray diffraction
2.8Å resolution
Released: 24 Jul 2019
Model geometry
Fit model/data
6pi7
6pi7
6pi7
Crystal structure of Drosophila melanogaster Papi extended Tudor domain (D287A) in complex with Piwi N-terminal R10me2s peptide
Zhang YH, Huang Y
Proc Natl Acad Sci U S A (2018) [PMID: 29531043  ]
Assembly composition: protein/protein complex
Modified residues: 2MR    2MR   
Assembly name: Protein piwi and Tudor and KH domain-containing protein homolog (Preferred)   search this complex
PDBe complex ID: PDB-CPX-194276 (Preferred)   search this ID
PDBe-KB: Q9VQ91    Q9VKM1   
X-ray diffraction
1.551Å resolution
Released: 14 Mar 2018
Model geometry
Fit model/data
5ygd
5ygd
5ygd
Crystal structure of drosophila melanogaster Papi extended Tudor domain mutant - D287A
Zhang YH, Huang Y
Proc Natl Acad Sci U S A (2018) [PMID: 29531043  ]
Assembly composition: protein only structure
Assembly name: Tudor and KH domain-containing protein homolog (Preferred)   search this complex
PDBe complex ID: PDB-CPX-194291 (Preferred)   search this ID
PDBe-KB: Q9VQ91   
X-ray diffraction
1.4Å resolution
Released: 14 Mar 2018
Model geometry
Fit model/data
5ygb
5ygb
5ygb
Crystal structure of Drosophila melanogaster Papi extended Tudor domain (D287A) in complex with Piwi N-terminal R10-unme peptide
Zhang YH, Huang Y
Proc Natl Acad Sci U S A (2018) [PMID: 29531043  ]
Assembly composition: protein/protein complex
Assembly name: Protein piwi and Tudor and KH domain-containing protein homolog (Preferred)   search this complex
PDBe complex ID: PDB-CPX-194276 (Preferred)   search this ID
PDBe-KB: Q9VQ91    Q9VKM1   
X-ray diffraction
1.698Å resolution
Released: 14 Mar 2018
Model geometry
Fit model/data
5ygf
5ygf
5ygf
Crystal Structure of the extended TUDOR domain from TDRD2
Zhang H, Tempel W, Dong A, Bountra C, Arrowsmith CH, Edwards AM, Min J, Structural Genomics Consortium (SGC)
Proc Natl Acad Sci U S A (2017) [PMID: 29118143  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CAC   
Assembly name: Tudor and KH domain-containing protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-195169 (Preferred)   search this ID
PDBe-KB: Q9Y2W6   
X-ray diffraction
1.95Å resolution
Released: 13 Apr 2016
Model geometry
Fit model/data
5j39
5j39
5j39
Solution structure of the TUDOR domain of Tudor and KH domain containing protein
Dang W, Muto Y, Inoue M, Kigawa T, Shirouzu M, Terada T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Tudor and KH domain-containing protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-195169 (Preferred)   search this ID
PDBe-KB: Q9Y2W6   
Solution NMR
Released: 30 Sep 2006
Model geometry
Fit model/data
Data not analysed
2diq
2diq
2diq
Crystal structure of TDRD2
Amaya MF, Adams MA, Guo Y, Li Y, Kozieradzki I, Edwards AM, Arrowsmith CH, Weigelt J, Bountra C, Bochkarev A, Min J, Structural Genomics Consortium (SGC)
Proc Natl Acad Sci U S A (2009) [PMID: 19918066  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Tudor and KH domain-containing protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-195169 (Preferred)   search this ID
PDBe-KB: Q9Y2W6   
X-ray diffraction
1.75Å resolution
Released: 6 Jan 2009
Model geometry
Fit model/data
3fdr
3fdr
3fdr
Solution structure of KH domain in protein BAB28342
He F, Muto Y, Inoue M, Kigawa T, Shirouzu M, Terada T, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
To be published
Source organism: Mus musculus  
Assembly composition: protein only structure
Assembly name: Tudor and KH domain-containing protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-182381 (Preferred)   search this ID
PDBe-KB: Q80VL1   
Solution NMR
Released: 24 Nov 2004
Model geometry
Fit model/data
Data not analysed
1we8
1we8
1we8
Entries 1 to 10 of 10
Entries 1 to 10 of 10