PDBsum entry 1v8f

Ligase

PDB id: 1v8f

Contents

Protein chains

276 a.a. *

Ligands

144

P6G

GOL ×8

Metals

_CL ×5

Waters ×724

* Residue conservation analysis

PDB id:

1v8f

Name:

Ligase

Title:

Crystal structure of pantoate-beta-alanine (pantothenate synthetase) from thermus thermophilus hb8

Structure:

Pantoate-beta-alanine ligase. Chain: a, b. Synonym: pantothenate synthetase. Engineered: yes

Source:

Thermus thermophilus. Organism_taxid: 274. Gene: panc. Expressed in: escherichia coli. Expression_system_taxid: 562.

Biol. unit:

Dimer (from PQS)

Resolution:

1.90Å R-factor: 0.205 R-free: 0.257

Authors:

B.Bagautdinov,T.H.Tahirov,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

B.Bagautdinov and t.h.tahirov Crystal structure of pantothenate synthetase from thermus thermophilus hb8. To be published, .

Date:

08-Jan-04 Release date: 20-Jan-04

Protein chains

Q5SHF5  (PANC_THET8) -  Pantothenate synthetase from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)

Seq: 276 a.a.

Struc: 276 a.a.

Enzyme reactions

• Enzyme class: E.C.6.3.2.1 - pantoate--beta-alanine ligase (AMP-forming).
• Pathway: Coenzyme A Biosynthesis (early stages)
• Reaction: (R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H⁺

(R)-pantoate + beta-alanine + ATP (Bound ligand (Het Group name = GOL) matches with 50.00% similarity) = (R)-pantothenate + AMP + diphosphate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site