PDBsum entry 6bpy

Oxidoreductase

PDB id: 6bpy

Contents

Protein chains

324 a.a.

Ligands

FAD ×2

MLI ×5

FMT ×7

NAP ×2

ACT

MLT

Waters ×45

PDB id:

6bpy

Name:

Oxidoreductase

Title:

Aspergillus fumigatus thioredoxin reductase

Structure:

Thioredoxin reductase. Chain: a, b. Engineered: yes

Source:

Neosartorya fumigata. Aspergillus fumigatus. Organism_taxid: 746128. Gene: cdv57_04819, cdv58_04527. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

3.20Å R-factor: 0.233 R-free: 0.261

Authors:

A.C.Marshall,J.B.Bruning

Key ref:

a.c.marshall and j.b.bruning (2019). Structure, Mechanism, and Inhibition ofAspergillus fumigatusThioredoxin Reductase. Antimicrob.Agents Chemother., 63, . PubMed id: 30642940

Date:

27-Nov-17 Release date: 09-Jan-19

Protein chains

A0A229Y1X4  (A0A229Y1X4_ASPFM) -  Thioredoxin reductase from Aspergillus fumigatus

Seq: 373 a.a.

Struc: 324 a.a.

Enzyme reactions

• Enzyme class: E.C.1.8.1.9 - thioredoxin-disulfide reductase (NADPH).
• Reaction: [thioredoxin]-dithiol + NADP⁺ = [thioredoxin]-disulfide + NADPH + H⁺

[thioredoxin]-dithiol + NADP(+) (Bound ligand (Het Group name = FAD) matches with 71.19% similarity) = [thioredoxin]-disulfide + NADPH + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Antimicrob.Agents Chemother. 63: (2019)

PubMed id: 30642940

Structure, Mechanism, and Inhibition ofAspergillus fumigatusThioredoxin Reductase.

a.c.marshall, j.b.bruning.

ABSTRACT

No abstract given.