PDBsum entry 7d8s

Transcription

PDB id: 7d8s

Contents

Protein chains

185 a.a.

175 a.a.

Ligands

SO4 ×3

Waters ×312

PDB id:

7d8s

Name:

Transcription

Title:

Mitf bhlhlz apo structure

Structure:

Microphthalmia-associated transcription factor,methionyl- tRNA synthetase beta subunit. Chain: a, b, c, d. Engineered: yes. Mutation: yes. Other_details: fusion protein of microphthalmia-associated transcription factor and methionyl-tRNA synthetase beta subunit

Source:

Homo sapiens, aquifex aeolicus vf5. Human. Organism_taxid: 9606, 224324. Strain: vf5. Gene: mitf, bhlhe32, metg', aq_422. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.28Å R-factor: 0.233 R-free: 0.271

Authors:

M.Guo,P.Fang,J.Wang

Key ref:

Z.Liu et al. Targeting the lineage-Specific dynamic microphthalmia-Associated transcription factor (mitf) melanoma treatment. To be published, . PubMed id: 36588115

Date:

09-Oct-20 Release date: 13-Oct-21

Protein chains

O66738  (O66738_AQUAE) -  Methionyl-tRNA synthetase beta subunit from Aquifex aeolicus (strain VF5)

Seq: 111 a.a.

Struc: 185 a.a.*

Protein chains

O75030  (MITF_HUMAN) -  Microphthalmia-associated transcription factor from Homo sapiens

Seq: 526 a.a.

Struc: 185 a.a.*

Protein chain

O66738  (O66738_AQUAE) -  Methionyl-tRNA synthetase beta subunit from Aquifex aeolicus (strain VF5)

Seq: 111 a.a.

Struc: 175 a.a.*

Protein chain

O75030  (MITF_HUMAN) -  Microphthalmia-associated transcription factor from Homo sapiens

Seq: 526 a.a.

Struc: 175 a.a.*

* PDB and UniProt seqs differ at 228 residue positions (black crosses)