PDBsum entry 7lxu

Hydrolase

PDB id: 7lxu

Contents

Protein chains

251 a.a.

229 a.a.

242 a.a.

233 a.a.

236 a.a.

235 a.a.

242 a.a.

229 a.a.

219 a.a.

215 a.a.

195 a.a.

209 a.a.

213 a.a.

234 a.a.

Ligands

YHD ×2

PDB id:

7lxu

Name:

Hydrolase

Title:

Structure of plasmodium falciparum 20s proteasome with bound mpi-5

Structure:

20s proteasome alpha-1 subunit. Chain: a, o. 20s proteasome alpha-2 subunit. Chain: b, p. 20s proteasome alpha-3 subunit. Chain: c, q. 20s proteasome alpha-4 subunit. Chain: d, r. 20s proteasome alpha-5 subunit.

Source:

Plasmodium falciparum (isolate 3d7). Organism_taxid: 36329. Strain: isolate 3d7. Strain: isolate 3d7

Authors:

R.D.Metcalfe,C.J.Morton,S.C.Xie,B.Liu,E.Hanssen,A.P.Leis,L.Tilley, M.D.W.Griffin

Key ref:

s.c.xie and l.tilley (2021). Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proc.Natl.Acad.Sci.USA, 118, . PubMed id: 34548400

Date:

05-Mar-21 Release date: 22-Sep-21

Protein chains

Q8IAR3  (Q8IAR3_PLAF7) -  Proteasome subunit alpha type-6, putative from Plasmodium falciparum (isolate 3D7)

Seq: 260 a.a.

Struc: 251 a.a.

Protein chains

C6KST3  (C6KST3_PLAF7) -  Proteasome subunit alpha type-2, putative from Plasmodium falciparum (isolate 3D7)

Seq: 235 a.a.

Struc: 229 a.a.

Protein chains

Q8IDG3  (Q8IDG3_PLAF7) -  Proteasome subunit alpha type from Plasmodium falciparum (isolate 3D7)

Seq: 246 a.a.

Struc: 242 a.a.

Protein chains

Q8IDG2  (Q8IDG2_PLAF7) -  Proteasome subunit alpha type from Plasmodium falciparum (isolate 3D7)

Seq: 241 a.a.

Struc: 233 a.a.

Protein chains

Q8IBI3  (Q8IBI3_PLAF7) -  Proteasome subunit alpha type from Plasmodium falciparum (isolate 3D7)

Seq: 256 a.a.

Struc: 236 a.a.

Protein chains

Q8IK90  (Q8IK90_PLAF7) -  Proteasome subunit alpha type-1, putative from Plasmodium falciparum (isolate 3D7)

Seq: 254 a.a.

Struc: 235 a.a.

Protein chains

O77396  (O77396_PLAF7) -  Proteasome subunit alpha type-3, putative from Plasmodium falciparum (isolate 3D7)

Seq: 252 a.a.

Struc: 242 a.a.

Protein chains

Q8I0U7  (Q8I0U7_PLAF7) -  Proteasome subunit beta type-6, putative from Plasmodium falciparum (isolate 3D7)

Seq: 282 a.a.

Struc: 229 a.a.

Protein chains

Q8I6T3  (Q8I6T3_PLAF7) -  Proteasome subunit beta from Plasmodium falciparum (isolate 3D7)

Seq: 270 a.a.

Struc: 219 a.a.

Protein chains

Q8I261  (Q8I261_PLAF7) -  Proteasome subunit beta from Plasmodium falciparum (isolate 3D7)

Seq: 218 a.a.

Struc: 215 a.a.

Protein chains

Q8IKC9  (Q8IKC9_PLAF7) -  Proteasome subunit beta from Plasmodium falciparum (isolate 3D7)

Seq: 195 a.a.

Struc: 195 a.a.

Protein chains

Q8IJT1  (Q8IJT1_PLAF7) -  Proteasome subunit beta from Plasmodium falciparum (isolate 3D7)

Seq: 271 a.a.

Struc: 209 a.a.

Protein chains

A0A5K1K7U1  (A0A5K1K7U1_PLAF7) -  Proteasome subunit beta from Plasmodium falciparum (isolate 3D7)

Seq: 240 a.a.

Struc: 213 a.a.

Protein chains

Q7K6A9  (Q7K6A9_PLAF7) -  Proteasome subunit beta from Plasmodium falciparum (isolate 3D7)

Seq: 265 a.a.

Struc: 234 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b: E.C.3.4.25.1 - proteasome endopeptidase complex.
• Reaction: Cleavage at peptide bonds with very broad specificity.

Proc.Natl.Acad.Sci.USA 118: (2021)

PubMed id: 34548400

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.

s.c.xie, l.tilley.

ABSTRACT

No abstract given.