PDBsum entry 7ut0

Hydrolase

PDB id: 7ut0

Contents

Protein chains

284 a.a.

Ligands

EDO ×2

Waters ×390

PDB id:

7ut0

Name:

Hydrolase

Title:

Human ddah-1, apo form

Structure:

N(g),n(g)-dimethylarginine dimethylaminohydrolase 1. Chain: a, b. Synonym: ddah-1,dimethylarginine dimethylaminohydrolase 1,ddahi, dimethylargininase-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ddah1, ddah. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.68Å R-factor: 0.154 R-free: 0.208

Authors:

C.A.Smith,Y.T.Ghebre

Key ref:

C.A.Smith et al. (2022). Esomeprazole covalently interacts with the cardiovasc enzyme dimethylarginine dimethylaminohydrolase: insig into the cardiovascular risk of proton pump inhibitor. Biochim biophys acta gen, 1866, 30149. PubMed id: 35472493

Date:

26-Apr-22 Release date: 18-May-22

Protein chains

O94760  (DDAH1_HUMAN) -  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 from Homo sapiens

Seq: 285 a.a.

Struc: 284 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.5.3.18 - dimethylargininase.
• Reaction: N(omega),N(omega)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

Molecule diagrams generated from .mol files obtained from the KEGG ftp site