PDBsum entry 8c0c

Nuclear protein

PDB id: 8c0c

Contents

Protein chains

257 a.a.

228 a.a.

Ligands

T0C

Waters ×120

PDB id:

8c0c

Name:

Nuclear protein

Title:

X-ray crystal structure of ppar gamma ligand binding domain in complex with cz46

Structure:

Peroxisome proliferator-activated receptor gamma. Chain: a, b. Synonym: ppar-gamma,nuclear receptor subfamily 1 group c member 3. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pparg, nr1c3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

2.20Å R-factor: 0.227 R-free: 0.272

Authors:

D.Capelli,R.Montanari,G.Pochetti,S.Villa,F.Meneghetti

Key ref:

D.Capelli et al. (2023). Biological screening and crystallographic studies of gamma-Lactone derivatives to investigate ppar gamma phosphorylation inhibition. Biomolecules, 13, . PubMed id: 37189440

Date:

16-Dec-22 Release date: 26-Apr-23

Protein chain

P37231  (PPARG_HUMAN) -  Peroxisome proliferator-activated receptor gamma from Homo sapiens

Seq: 505 a.a.

Struc: 257 a.a.

Protein chain

P37231  (PPARG_HUMAN) -  Peroxisome proliferator-activated receptor gamma from Homo sapiens

Seq: 505 a.a.

Struc: 228 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.?