GO:0000050
JSON
urea cycle
Biological Process
Definition (GO:0000050 GONUTS page)
The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
Secondary IDs
GO:0006594, GO:0006871
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
urea biosynthetic process | exact |
urea biosynthesis | exact |
ornithine cycle | exact |
Ancestor Chart
Ancestor chart for GO:0000050
Cross-references
Database | ID | Description |
---|---|---|
Reactome | R-HSA-70635 | |
UniProtKB-KW | KW-0835 | Urea cycle |
Wikipedia | Urea_cycle |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_output | CHEBI | CHEBI:16199 | urea |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0000050 based on ALL annotations
The top 100 of 578 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
urea cycle
|
3,625.29 | 100.00 | 54,659 | 54,659 |
argininosuccinate metabolic process
|
3,625.29 | 81.43 | 44,507 | 44,507 |
argininosuccinate synthase activity
|
3,568.17 | 80.55 | 44,601 | 45,315 |
arginase activity
|
1,597.31 | 13.21 | 8,675 | 19,689 |
arginine catabolic process to ornithine
|
1,081.25 | 11.39 | 8,507 | 28,523 |
L-arginine biosynthetic process
|
403.34 | 10.87 | 45,004 | 404,507 |
arginine metabolic process
|
252.98 | 5.12 | 8,808 | 126,223 |
protein homodimerization activity
|
103.52 | 2.31 | 5,916 | 207,186 |
manganese ion binding
|
64.13 | 1.61 | 8,505 | 480,768 |
ligase activity
|
51.34 | 1.41 | 43,469 | 3,069,286 |
Totals | 390445 | 63504371 |
No co-occurrence statistics for GO:0000050 based on MANUAL annotations
The top 100 of 318 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
urea cycle
|
7,508.15 | 100.00 | 188 | 188 |
argininosuccinate synthase activity
|
7,508.15 | 85.64 | 161 | 161 |
argininosuccinate metabolic process
|
7,508.15 | 85.11 | 160 | 160 |
L-arginine biosynthetic process
|
2,522.86 | 32.24 | 167 | 497 |
cellular response to ammonium ion
|
1,668.48 | 1.98 | 4 | 18 |
arginine metabolic process
|
463.47 | 1.89 | 5 | 81 |
cellular response to glucagon stimulus
|
910.08 | 1.84 | 4 | 33 |
arginine biosynthetic process via ornithine
|
213.17 | 1.81 | 9 | 317 |
carbamoyl-phosphate synthase (ammonia) activity
|
403.66 | 1.81 | 5 | 93 |
response to amine
|
732.50 | 1.78 | 4 | 41 |
Totals | 914 | 11229 |
Change Log
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- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-70635 |
2024-07-13 | Deleted | RELATION | is a GO:1901566 (obsolete organonitrogen compound biosynthetic process) |
2020-02-28 | Deleted | XREF | MIPS_funcat:01.01.05 |
2020-02-28 | Deleted | XREF | MIPS_funcat:01.01.05.03 |
2019-05-04 | Added | XREF | MIPS_funcat:01.01.05 |
2019-05-04 | Added | XREF | MIPS_funcat:01.01.05.03 |
2017-08-13 | Deleted | RELATION | is a GO:0044711 (obsolete single-organism biosynthetic process) |
2013-11-28 | Added | RELATION | is a GO:0044711 (obsolete single-organism biosynthetic process) |
2013-03-11 | Deleted | RELATION | is a GO:1901576 (obsolete organic substance biosynthetic process) |
2013-03-11 | Added | RELATION | is a GO:1901566 (obsolete organonitrogen compound biosynthetic process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-02-06 | Updated | TERM | urea cycle |
2001-04-03 | Updated | TERM | urea cycle |
2001-03-30 | Added | TERM | urea cycle |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-13 | Deleted | DEFINITION | A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. |
2010-10-13 | Added | DEFINITION | The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate. |
2008-05-13 | Added | DEFINITION | A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. |
2008-05-12 | Deleted | DEFINITION | A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. |
2007-08-09 | Deleted | SYNONYM | ornithine cycle |
2007-08-09 | Deleted | SYNONYM | urea biosynthetic process |
2007-08-09 | Added | SYNONYM | urea biosynthetic process |
2007-08-09 | Added | SYNONYM | urea biosynthesis |
2007-08-09 | Added | SYNONYM | ornithine cycle |
2007-08-09 | Deleted | SYNONYM | urea biosynthesis |
2007-01-15 | Added | SYNONYM | urea biosynthetic process |
2005-07-16 | Added | SYNONYM | urea biosynthesis |
2004-10-08 | Updated | DEFINITION | A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. |
2004-04-19 | Added | SYNONYM | ornithine cycle |
2004-04-16 | Deleted | SYNONYM | ornithine cycle |
2001-08-06 | Added | DEFINITION | A cyclic metabolic pathway that converts waste nitrogen, in the form of ammonium to urea. |
2001-04-03 | Added | SYNONYM | ornithine cycle |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-07-13 | Deleted | RELATION | is a GO:1901566 (obsolete organonitrogen compound biosynthetic process) |
2017-08-13 | Deleted | RELATION | is a GO:0044711 (obsolete single-organism biosynthetic process) |
2013-11-28 | Added | RELATION | is a GO:0044711 (obsolete single-organism biosynthetic process) |
2013-03-11 | Deleted | RELATION | is a GO:1901576 (obsolete organic substance biosynthetic process) |
2013-03-11 | Added | RELATION | is a GO:1901566 (obsolete organonitrogen compound biosynthetic process) |
2012-11-07 | Added | RELATION | is a GO:1901576 (obsolete organic substance biosynthetic process) |
2009-07-12 | Deleted | RELATION | is a GO:0009058 (biosynthetic process) |
2009-07-12 | Added | RELATION | is a GO:0043604 (amide biosynthetic process) |
2009-07-06 | Added | RELATION | is a GO:0009058 (biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0019627 (urea metabolic process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-70635 |
2020-02-28 | Deleted | XREF | MIPS_funcat:01.01.05 |
2020-02-28 | Deleted | XREF | MIPS_funcat:01.01.05.03 |
2019-05-04 | Added | XREF | MIPS_funcat:01.01.05 |
2019-05-04 | Added | XREF | MIPS_funcat:01.01.05.03 |
2009-02-25 | Added | XREF | Wikipedia:Urea_cycle |
Timestamp | Action | Category | Detail |
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