This term is obsolete.

GO:0000050 JSON

urea cycle

Biological Process

Definition (GO:0000050 GONUTS page)

The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.

Secondary IDs

GO:0006594, GO:0006871

54,730 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
urea biosynthetic process exact
urea biosynthesis exact
ornithine cycle exact

Ancestor Chart

Ancestor chart for GO:0000050
Chart options
Ancestor chart

Cross-references

Database ID Description
Reactome R-HSA-70635
UniProtKB-KW KW-0835 Urea cycle
Wikipedia Urea_cycle

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_output CHEBI CHEBI:16199 urea

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000050 based on ALL annotations
The top 100 of 578 co-occurring terms
Co-occurring Term PR S% #Together #Compared
urea cycle
3,625.29 100.00 54,659 54,659
argininosuccinate metabolic process
3,625.29 81.43 44,507 44,507
argininosuccinate synthase activity
3,568.17 80.55 44,601 45,315
arginase activity
1,597.31 13.21 8,675 19,689
arginine catabolic process to ornithine
1,081.25 11.39 8,507 28,523
L-arginine biosynthetic process
403.34 10.87 45,004 404,507
arginine metabolic process
252.98 5.12 8,808 126,223
protein homodimerization activity
103.52 2.31 5,916 207,186
manganese ion binding
64.13 1.61 8,505 480,768
ligase activity
51.34 1.41 43,469 3,069,286
Totals 390445 63504371
No co-occurrence statistics for GO:0000050 based on MANUAL annotations
The top 100 of 318 co-occurring terms
Co-occurring Term PR S% #Together #Compared
urea cycle
7,508.15 100.00 188 188
argininosuccinate synthase activity
7,508.15 85.64 161 161
argininosuccinate metabolic process
7,508.15 85.11 160 160
L-arginine biosynthetic process
2,522.86 32.24 167 497
cellular response to ammonium ion
1,668.48 1.98 4 18
arginine metabolic process
463.47 1.89 5 81
cellular response to glucagon stimulus
910.08 1.84 4 33
arginine biosynthetic process via ornithine
213.17 1.81 9 317
carbamoyl-phosphate synthase (ammonia) activity
403.66 1.81 5 93
response to amine
732.50 1.78 4 41
Totals 914 11229

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-70635
2024-07-13 Deleted RELATION is a GO:1901566 (obsolete organonitrogen compound biosynthetic process)
2020-02-28 Deleted XREF MIPS_funcat:01.01.05
2020-02-28 Deleted XREF MIPS_funcat:01.01.05.03
2019-05-04 Added XREF MIPS_funcat:01.01.05
2019-05-04 Added XREF MIPS_funcat:01.01.05.03
2017-08-13 Deleted RELATION is a GO:0044711 (obsolete single-organism biosynthetic process)
2013-11-28 Added RELATION is a GO:0044711 (obsolete single-organism biosynthetic process)
2013-03-11 Deleted RELATION is a GO:1901576 (obsolete organic substance biosynthetic process)
2013-03-11 Added RELATION is a GO:1901566 (obsolete organonitrogen compound biosynthetic process)
Timestamp Action Category Detail
2002-02-06 Updated TERM urea cycle
2001-04-03 Updated TERM urea cycle
2001-03-30 Added TERM urea cycle
Timestamp Action Category Detail
2010-10-13 Deleted DEFINITION A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.
2010-10-13 Added DEFINITION The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
2008-05-13 Added DEFINITION A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.
2008-05-12 Deleted DEFINITION A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.
2007-08-09 Deleted SYNONYM ornithine cycle
2007-08-09 Deleted SYNONYM urea biosynthetic process
2007-08-09 Added SYNONYM urea biosynthetic process
2007-08-09 Added SYNONYM urea biosynthesis
2007-08-09 Added SYNONYM ornithine cycle
2007-08-09 Deleted SYNONYM urea biosynthesis
2007-01-15 Added SYNONYM urea biosynthetic process
2005-07-16 Added SYNONYM urea biosynthesis
2004-10-08 Updated DEFINITION A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.
2004-04-19 Added SYNONYM ornithine cycle
2004-04-16 Deleted SYNONYM ornithine cycle
2001-08-06 Added DEFINITION A cyclic metabolic pathway that converts waste nitrogen, in the form of ammonium to urea.
2001-04-03 Added SYNONYM ornithine cycle
Timestamp Action Category Detail
2024-07-13 Deleted RELATION is a GO:1901566 (obsolete organonitrogen compound biosynthetic process)
2017-08-13 Deleted RELATION is a GO:0044711 (obsolete single-organism biosynthetic process)
2013-11-28 Added RELATION is a GO:0044711 (obsolete single-organism biosynthetic process)
2013-03-11 Deleted RELATION is a GO:1901576 (obsolete organic substance biosynthetic process)
2013-03-11 Added RELATION is a GO:1901566 (obsolete organonitrogen compound biosynthetic process)
2012-11-07 Added RELATION is a GO:1901576 (obsolete organic substance biosynthetic process)
2009-07-12 Deleted RELATION is a GO:0009058 (biosynthetic process)
2009-07-12 Added RELATION is a GO:0043604 (amide biosynthetic process)
2009-07-06 Added RELATION is a GO:0009058 (biosynthetic process)
2008-04-01 Updated RELATION is a GO:0019627 (urea metabolic process)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-70635
2020-02-28 Deleted XREF MIPS_funcat:01.01.05
2020-02-28 Deleted XREF MIPS_funcat:01.01.05.03
2019-05-04 Added XREF MIPS_funcat:01.01.05
2019-05-04 Added XREF MIPS_funcat:01.01.05.03
2009-02-25 Added XREF Wikipedia:Urea_cycle
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.