This term is obsolete.

GO:0000160 JSON

phosphorelay signal transduction system

Biological Process

Definition (GO:0000160 GONUTS page)

A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. PMID:9191038

5,413,570 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
histidyl-aspartyl phosphorelay exact

Ancestor Chart

Ancestor chart for GO:0000160
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000160

Child Term Relationship to
GO:0000160
phosphorelay sensor kinase activity
part_of
phosphorelay response regulator activity
part_of
regulation of phosphorelay signal transduction system
regulates
positive regulation of phosphorelay signal transduction system
positively_regulates
ethylene-activated signaling pathway
is_a
osmosensory signaling via phosphorelay pathway
is_a
negative regulation of phosphorelay signal transduction system
negatively_regulates

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O14283 284812 PRR1_SCHPO GO:0000160 They shouldn't match this GO term. Reported by InterPro (Typhaine Paysan-Lafosse) on 08/01/2020 IPR001789
IEA Review protein Q8TFG6 284812 PPK18_SCHPO GO:0000160 They shouldn't match this GO term. Reported by InterPro (Typhaine Paysan-Lafosse) on 08/01/2020 IPR001789

Cross-references

Database ID Description
InterPro IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase
InterPro IPR001789 Signal transduction response regulator, receiver domain
InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
InterPro IPR003755 HPr(Ser) kinase/phosphorylase
InterPro IPR003852 Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal
InterPro IPR004105 Histidine kinase CheA-like, homodimeric domain
InterPro IPR006290 Heavy metal sensor kinase
InterPro IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain
InterPro IPR008248 Protein-glutamate methylesterase/protein-glutamine glutaminase, CheB type
InterPro IPR008358 Signal transduction histidine kinase/phosphatase, lantibiotic regulatory protein MprB

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000160 based on ALL annotations
The top 100 of 2,624 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphorelay signal transduction system
61.68 100.00 3,160,480 3,160,480
phosphorelay sensor kinase activity
59.96 44.74 1,432,236 1,473,219
phosphorelay response regulator activity
57.60 19.69 631,107 675,816
kinase activity
15.12 18.03 1,280,018 5,220,332
signal transduction
18.24 14.50 700,348 2,368,833
protein-DNA complex
43.96 13.74 459,791 645,092
transcription cis-regulatory region binding
16.36 10.38 460,781 1,737,394
regulation of DNA-templated transcription
7.41 9.90 1,138,197 9,472,174
DNA binding
4.24 6.05 1,062,540 15,456,294
protein dimerization activity
12.22 4.33 166,077 838,193
Totals 15135492 296437670
No co-occurrence statistics for GO:0000160 based on MANUAL annotations
The top 100 of 188 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphorelay signal transduction system
1,414.89 100.00 913 913
histidine phosphotransfer kinase activity
1,407.60 84.19 772 776
protein histidine kinase binding
1,359.34 44.73 416 433
cytokinin-activated signaling pathway
932.54 36.15 406 616
phosphorelay sensor kinase activity
862.13 32.79 379 622
phosphorelay response regulator activity
76.36 2.25 34 630
protein histidine kinase activity
332.92 1.26 12 51
osmosensory signaling via phosphorelay pathway
110.97 0.79 8 102
response to cytokinin
106.78 0.79 8 106
protein-DNA complex
11.90 0.48 10 1,189
Totals 4452 575604

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_metagenomics 111

Change Log

Timestamp Action Category Detail
2021-09-14 Deleted SYNONYM phosphorelay signal transduction system
2020-02-28 Deleted XREF MIPS_funcat:30.01.05.07
2020-02-28 Deleted XREF MIPS_funcat:30.05.01.10
2019-05-04 Added XREF MIPS_funcat:30.05.01.10
2019-05-04 Added XREF MIPS_funcat:30.01.05.07
2014-08-29 Added RELATION is a GO:0035556 (intracellular signal transduction)
2014-08-29 Deleted RELATION is a GO:0007165 (signal transduction)
2013-04-18 Updated SUBSET goslim_metagenomics
2012-12-07 Updated TERM phosphorelay signal transduction system
2012-12-07 Added SYNONYM phosphorelay signal transduction system
Timestamp Action Category Detail
2012-12-07 Updated TERM phosphorelay signal transduction system
2002-02-06 Updated TERM two-component signal transduction system (phosphorelay)
2001-04-03 Updated TERM two-component signal transduction system (phosphorelay)
2001-03-30 Added TERM two-component signal transduction system (phosphorelay)
Timestamp Action Category Detail
2021-09-14 Deleted SYNONYM phosphorelay signal transduction system
2012-12-07 Added SYNONYM phosphorelay signal transduction system
2008-05-13 Added DEFINITION A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
2008-05-12 Deleted DEFINITION A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
2007-08-09 Deleted SYNONYM histidyl-aspartyl phosphorelay
2007-08-09 Added SYNONYM histidyl-aspartyl phosphorelay
2005-07-29 Added SYNONYM histidyl-aspartyl phosphorelay
2005-07-28 Updated DEFINITION A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
2005-07-27 Updated DEFINITION A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
2004-08-20 Updated DEFINITION A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase that then acts as a phospho-donor to response regulator proteins; also known as histidyl-aspartyl phosphorelay.
2001-08-06 Added DEFINITION A conserved signal transduction system found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase that then acts as a phospho-donor to response regulator proteins; also known as histidyl-aspartyl phosphorelay.
Timestamp Action Category Detail
2014-08-29 Added RELATION is a GO:0035556 (intracellular signal transduction)
2014-08-29 Deleted RELATION is a GO:0007165 (signal transduction)
2011-01-16 Deleted RELATION is a GO:0023060 (obsolete signal transmission)
2011-01-16 Added RELATION is a GO:0007165 (signal transduction)
2010-02-20 Deleted RELATION is a GO:0007165 (signal transduction)
2010-02-20 Added RELATION is a GO:0023060 (obsolete signal transmission)
2008-04-01 Updated RELATION is a GO:0007165 (signal transduction)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:30.01.05.07
2020-02-28 Deleted XREF MIPS_funcat:30.05.01.10
2019-05-04 Added XREF MIPS_funcat:30.05.01.10
2019-05-04 Added XREF MIPS_funcat:30.01.05.07
Timestamp Action Category Detail
2013-04-18 Updated SUBSET goslim_metagenomics
2012-02-17 Added SUBSET goslim_metagenomics
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