MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
GO:0000165
JSON
MAPK cascade
Biological Process
Definition (GO:0000165 GONUTS page)
An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. PMID:20811974 PMID:9561267
Comments
MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
Secondary IDs
GO:0007255
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
MAP kinase kinase kinase cascade | exact |
mitogen-activated protein kinase cascade | exact |
ERK/MAPK cascade | narrow |
MAP kinase cascade | exact |
MAPKKK cascade | exact |
MAPK signalling | related |
MAPK signaling | related |
MAPK signal transduction | exact |
MAPKKK cascade during sporulation | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0000165
Child Term | Relationship to GO:0000165 |
---|---|
pheromone response MAPK cascade
|
is_a |
regulation of MAPK cascade
|
regulates |
JNK cascade
|
is_a |
ERK1 and ERK2 cascade
|
is_a |
MAP-kinase scaffold activity
|
part_of |
negative regulation of MAPK cascade
|
negatively_regulates |
MAP kinase activity
|
part_of |
MAP kinase kinase activity
|
part_of |
stress-activated MAPK cascade
|
is_a |
p38MAPK cascade
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0000165 | MAPK cascade | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P35465 | 10116 | PAK1_RAT | GO:0000165 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P49762 | 7227 | DOA_DROME | GO:0000165 | 4 NOT-qualified manual annotations exist with evidence code ECO:0000316 from this reference: PMID:11014821 | |
NOT-qualified manual | protein | P70425 | 10090 | RIT2_MOUSE | GO:0000165 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:14662747 | |
NOT-qualified manual | protein | Q13153 | 9606 | PAK1_HUMAN | GO:0000165 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8805275 | |
NOT-qualified manual | protein | Q5BJQ5 | 10116 | RIT2_RAT | GO:0000165 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q99578 | 9606 | RIT2_HUMAN | GO:0000165 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR029546 | Astrocytic phosphoprotein PEA-15, death effector domain |
InterPro | IPR038785 | Mitogen-activated protein kinase 13 |
InterPro | IPR038786 | Mitogen-activated protein kinase 12 |
InterPro | IPR043969 | MAP3K, PH domain |
InterPro | IPR045801 | Mitogen-activated protein kinase kinase kinase, N-terminal |
Wikipedia | MAPK_cascade | |
Wikipedia | Mitogen-activated_protein_kinase |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0000185 | obsolete activation of MAPKKK activity | consider GO:0000165 |
GO:0000186 | obsolete activation of MAPKK activity | consider GO:0000165 |
GO:0000187 | obsolete activation of MAPK activity | consider GO:0000165 |
GO:0000188 | obsolete inactivation of MAPK activity | consider GO:0000165 |
GO:0000197 | obsolete activation of MAPKKK activity involved in cell wall organization or biogenesis | consider GO:0000165 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0000165 based on ALL annotations
The top 100 of 4,229 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
MAPK cascade
|
1,728.24 | 100.00 | 112,796 | 112,796 |
MAP kinase activity
|
1,627.41 | 31.76 | 36,540 | 38,804 |
JNK cascade
|
1,284.01 | 22.73 | 27,826 | 37,453 |
JUN kinase activity
|
1,600.14 | 18.97 | 21,723 | 23,462 |
MAP kinase kinase kinase activity
|
1,439.30 | 17.25 | 20,159 | 24,206 |
MAP kinase kinase activity
|
1,601.77 | 12.88 | 14,679 | 15,838 |
MAP-kinase scaffold activity
|
1,421.86 | 10.64 | 12,289 | 14,937 |
JUN kinase kinase kinase activity
|
1,556.60 | 10.60 | 12,098 | 13,432 |
protein serine kinase activity
|
304.11 | 8.03 | 14,520 | 82,516 |
MAP kinase kinase kinase kinase activity
|
1,706.59 | 6.35 | 7,171 | 7,262 |
Totals | 777980 | 34972871 |
No co-occurrence statistics for GO:0000165 based on MANUAL annotations
The top 100 of 3,182 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
MAPK cascade
|
912.93 | 100.00 | 1,415 | 1,415 |
MAP kinase kinase kinase activity
|
752.55 | 35.84 | 549 | 666 |
MAP kinase kinase activity
|
735.84 | 16.36 | 241 | 299 |
regulation of MAPK cascade
|
234.30 | 8.68 | 164 | 639 |
neuron projection morphogenesis
|
169.54 | 7.43 | 156 | 840 |
p38MAPK cascade
|
288.08 | 4.53 | 71 | 225 |
JNK cascade
|
132.52 | 3.92 | 72 | 496 |
JUN kinase kinase activity
|
639.05 | 3.41 | 49 | 70 |
positive regulation of MAPK cascade
|
48.43 | 3.30 | 114 | 2,149 |
ERK1 and ERK2 cascade
|
184.03 | 3.15 | 51 | 253 |
Totals | 5404 | 77777 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-01-30 | Deleted | DEFINITION | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
2024-01-30 | Added | DEFINITION | An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
2023-12-15 | Deleted | RELATION | is a GO:0035556 (intracellular signal transduction) |
2023-12-15 | Added | RELATION | is a GO:0141124 (intracellular signaling cassette) |
2023-08-04 | Deleted | RELATION | has part GO:0038030 (obsolete non-canonical Wnt signaling pathway via MAPK cascade) |
2023-08-04 | Deleted | RELATION | has part GO:0038029 (obsolete epidermal growth factor receptor signaling pathway via MAPK cascade) |
2021-06-06 | Added | SECONDARY | GO:0007255 (activation of MAP/ERK kinase kinase) |
2020-11-24 | Deleted | RELATION | is a GO:0023014 (signal transduction by protein phosphorylation) |
2020-02-28 | Deleted | XREF | MIPS_funcat:30.01.05.01.03 |
2019-05-04 | Added | XREF | MIPS_funcat:30.01.05.01.03 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-01-27 | Updated | TERM | MAPK cascade |
2002-02-06 | Updated | TERM | MAPKKK cascade |
2001-04-03 | Updated | TERM | MAPKKK cascade |
2001-03-30 | Added | TERM | MAPKKK cascade |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-01-30 | Deleted | DEFINITION | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
2024-01-30 | Added | DEFINITION | An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
2018-02-09 | Deleted | DEFINITION | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
2018-02-09 | Added | DEFINITION | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
2013-12-14 | Added | SYNONYM | MAPK signal transduction |
2012-01-29 | Added | SYNONYM | mitogen-activated protein kinase cascade |
2012-01-27 | Added | SYNONYM | ERK/MAPK cascade |
2012-01-27 | Deleted | SYNONYM | ERK/MAPK cascade |
2012-01-27 | Deleted | SYNONYM | MAPK cascade |
2012-01-27 | Added | SYNONYM | MAPKKK cascade |
2012-01-27 | Added | DEFINITION | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
2012-01-27 | Deleted | DEFINITION | A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK. |
2011-05-12 | Added | DEFINITION | A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK. |
2011-05-12 | Deleted | DEFINITION | A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. |
2010-01-07 | Added | DEFINITION | A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. |
2010-01-07 | Deleted | DEFINITION | Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. |
2009-07-06 | Deleted | SYNONYM | MAPKKK cascade during sporulation (sensu Saccharomyces) |
2009-07-06 | Deleted | SYNONYM | MAPKKK cascade during sporulation (sensu Fungi) |
2009-07-06 | Added | SYNONYM | MAPKKK cascade during sporulation |
2008-05-13 | Added | DEFINITION | Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. |
2008-05-12 | Deleted | DEFINITION | Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. |
2008-04-18 | Added | SYNONYM | MAPK signaling |
2008-04-18 | Added | SYNONYM | MAPK signalling |
2007-08-09 | Deleted | SYNONYM | MAPKKK cascade during sporulation (sensu Saccharomyces) |
2007-08-09 | Deleted | SYNONYM | MAP kinase cascade |
2007-08-09 | Deleted | SYNONYM | MAP kinase kinase kinase cascade |
2007-08-09 | Deleted | SYNONYM | MAPK cascade |
2007-08-09 | Deleted | SYNONYM | MAPKKK cascade during sporulation (sensu Fungi) |
2007-08-09 | Added | SYNONYM | MAPKKK cascade during sporulation (sensu Saccharomyces) |
2007-08-09 | Added | SYNONYM | MAPKKK cascade during sporulation (sensu Fungi) |
2007-08-09 | Added | SYNONYM | MAPK cascade |
2007-08-09 | Added | SYNONYM | MAP kinase kinase kinase cascade |
2007-08-09 | Added | SYNONYM | MAP kinase cascade |
2007-08-09 | Added | SYNONYM | ERK/MAPK cascade |
2007-08-09 | Deleted | SYNONYM | ERK/MAPK cascade |
2007-04-21 | Added | SYNONYM | MAPKKK cascade during sporulation (sensu Saccharomyces) |
2007-04-21 | Added | SYNONYM | MAPKKK cascade during sporulation (sensu Fungi) |
2006-03-25 | Added | SYNONYM | ERK/MAPK cascade |
2005-06-27 | Added | SYNONYM | MAP kinase kinase kinase cascade |
2005-06-27 | Added | SYNONYM | MAP kinase cascade |
2005-06-27 | Added | SYNONYM | MAPK cascade |
2001-08-06 | Added | DEFINITION | Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Deleted | RELATION | is a GO:0035556 (intracellular signal transduction) |
2023-12-15 | Added | RELATION | is a GO:0141124 (intracellular signaling cassette) |
2023-08-04 | Deleted | RELATION | has part GO:0038030 (obsolete non-canonical Wnt signaling pathway via MAPK cascade) |
2023-08-04 | Deleted | RELATION | has part GO:0038029 (obsolete epidermal growth factor receptor signaling pathway via MAPK cascade) |
2020-11-24 | Deleted | RELATION | is a GO:0023014 (signal transduction by protein phosphorylation) |
2013-12-04 | Deleted | RELATION | is a GO:0007243 (intracellular protein kinase cascade) |
2013-12-04 | Added | RELATION | is a GO:0035556 (intracellular signal transduction) |
2013-11-15 | Added | RELATION | is a GO:0023014 (signal transduction by protein phosphorylation) |
2011-09-11 | Added | RELATION | has part GO:0038029 (obsolete epidermal growth factor receptor signaling pathway via MAPK cascade) |
2011-09-11 | Added | RELATION | has part GO:0038030 (obsolete non-canonical Wnt signaling pathway via MAPK cascade) |
2008-04-01 | Updated | RELATION | is a GO:0007243 (intracellular protein kinase cascade) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-02-28 | Deleted | XREF | MIPS_funcat:30.01.05.01.03 |
2019-05-04 | Added | XREF | MIPS_funcat:30.01.05.01.03 |
2009-02-25 | Added | XREF | Wikipedia:MAPK_cascade |
2009-02-25 | Added | XREF | Wikipedia:Mitogen-activated_protein_kinase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-06-06 | Added | SECONDARY | GO:0007255 (activation of MAP/ERK kinase kinase) |
2015-12-09 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
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