This term is obsolete.
MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.

GO:0000165 JSON

MAPK cascade

Biological Process

Definition (GO:0000165 GONUTS page)

An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. PMID:20811974 PMID:9561267

Comments

MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.

Secondary IDs

GO:0007255

311,157 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
mitogen-activated protein kinase cascade exact
MAPK signal transduction exact
MAP kinase kinase kinase cascade exact
MAP kinase cascade exact
MAPKKK cascade during sporulation narrow
MAPKKK cascade exact
MAPK signaling related
MAPK signalling related
ERK/MAPK cascade narrow

Ancestor Chart

Ancestor chart for GO:0000165
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000165

Child Term Relationship to
GO:0000165
negative regulation of MAPK cascade
negatively_regulates
pheromone response MAPK cascade
is_a
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
positively_regulates
MAP-kinase scaffold activity
part_of
ERK1 and ERK2 cascade
is_a
MAP kinase kinase activity
part_of
MAP kinase kinase kinase activity
part_of
ERK5 cascade
is_a
positive regulation of MAPK cascade
positively_regulates
MAP kinase activity
part_of

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0000165 MAPK cascade Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P35465 10116 PAK1_RAT GO:0000165 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P49762 7227 DOA_DROME GO:0000165 4 NOT-qualified manual annotations exist with evidence code ECO:0000316 from this reference: PMID:11014821
NOT-qualified manual protein P70425 10090 RIT2_MOUSE GO:0000165 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:14662747
NOT-qualified manual protein Q13153 9606 PAK1_HUMAN GO:0000165 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8805275
NOT-qualified manual protein Q5BJQ5 10116 RIT2_RAT GO:0000165 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q99578 9606 RIT2_HUMAN GO:0000165 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-references

Database ID Description
InterPro IPR029546 Astrocytic phosphoprotein PEA-15, death effector domain
InterPro IPR038785 Mitogen-activated protein kinase 13
InterPro IPR038786 Mitogen-activated protein kinase 12
InterPro IPR043969 MAP3K, PH domain
InterPro IPR045801 Mitogen-activated protein kinase kinase kinase, N-terminal
Reactome R-HSA-169893
Reactome R-HSA-5673001
Wikipedia MAPK_cascade
Wikipedia Mitogen-activated_protein_kinase

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0000185 obsolete activation of MAPKKK activity consider GO:0000165
GO:0000186 obsolete activation of MAPKK activity consider GO:0000165
GO:0000187 obsolete activation of MAPK activity consider GO:0000165
GO:0000188 obsolete inactivation of MAPK activity consider GO:0000165
GO:0000197 obsolete activation of MAPKKK activity involved in cell wall organization or biogenesis consider GO:0000165

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000165 based on ALL annotations
The top 100 of 4,240 co-occurring terms
Co-occurring Term PR S% #Together #Compared
MAPK cascade
1,661.83 100.00 119,239 119,239
MAP kinase activity
1,562.33 30.93 37,623 40,019
JNK cascade
1,124.46 17.61 22,930 33,888
MAP kinase kinase kinase activity
1,337.11 17.32 21,556 26,791
JUN kinase activity
1,597.28 15.71 18,857 19,619
MAP kinase kinase activity
1,493.96 12.64 15,289 17,007
MAP-kinase scaffold activity
1,363.90 10.31 12,580 15,328
JUN kinase kinase kinase activity
1,322.98 8.04 9,792 12,300
protein serine kinase activity
306.67 7.53 13,454 72,906
MAP kinase kinase kinase kinase activity
1,642.37 6.15 7,341 7,428
Totals 782549 34590786
No co-occurrence statistics for GO:0000165 based on MANUAL annotations
The top 100 of 3,191 co-occurring terms
Co-occurring Term PR S% #Together #Compared
MAPK cascade
860.69 100.00 1,640 1,640
MAP kinase kinase kinase activity
711.73 34.09 602 728
MAP kinase kinase activity
772.30 19.79 332 370
regulation of MAPK cascade
283.09 12.43 273 830
neuron projection morphogenesis
224.49 11.08 265 1,016
p38MAPK cascade
246.89 3.96 72 251
JNK cascade
111.80 3.43 73 562
positive regulation of MAPK cascade
42.70 2.91 108 2,177
ERK1 and ERK2 cascade
171.48 2.81 52 261
phosphotyrosine residue binding
117.26 2.55 50 367
Totals 6316 120778

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-169893
2024-12-05 Added XREF Reactome:R-HSA-5673001
2024-01-30 Deleted DEFINITION An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
2024-01-30 Added DEFINITION An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
2023-12-15 Added RELATION is a GO:0141124 (intracellular signaling cassette)
2023-12-15 Deleted RELATION is a GO:0035556 (intracellular signal transduction)
2023-08-04 Deleted RELATION has part GO:0038030 (obsolete non-canonical Wnt signaling pathway via MAPK cascade)
2023-08-04 Deleted RELATION has part GO:0038029 (obsolete epidermal growth factor receptor signaling pathway via MAPK cascade)
2021-06-06 Added SECONDARY GO:0007255 (activation of MAP/ERK kinase kinase)
2020-11-24 Deleted RELATION is a GO:0023014 (signal transduction by protein phosphorylation)
Timestamp Action Category Detail
2012-01-27 Updated TERM MAPK cascade
2002-02-06 Updated TERM MAPKKK cascade
2001-04-03 Updated TERM MAPKKK cascade
2001-03-30 Added TERM MAPKKK cascade
Timestamp Action Category Detail
2024-01-30 Deleted DEFINITION An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
2024-01-30 Added DEFINITION An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
2018-02-09 Deleted DEFINITION An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
2018-02-09 Added DEFINITION An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
2013-12-14 Added SYNONYM MAPK signal transduction
2012-01-29 Added SYNONYM mitogen-activated protein kinase cascade
2012-01-27 Deleted DEFINITION A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK.
2012-01-27 Added SYNONYM MAPKKK cascade
2012-01-27 Added SYNONYM ERK/MAPK cascade
2012-01-27 Deleted SYNONYM ERK/MAPK cascade
2012-01-27 Deleted SYNONYM MAPK cascade
2012-01-27 Added DEFINITION An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
2011-05-12 Deleted DEFINITION A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2011-05-12 Added DEFINITION A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK.
2010-01-07 Deleted DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2010-01-07 Added DEFINITION A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2009-07-06 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2009-07-06 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2009-07-06 Added SYNONYM MAPKKK cascade during sporulation
2008-05-13 Added DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2008-05-12 Deleted DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2008-04-18 Added SYNONYM MAPK signaling
2008-04-18 Added SYNONYM MAPK signalling
2007-08-09 Deleted SYNONYM MAPK cascade
2007-08-09 Deleted SYNONYM MAP kinase kinase kinase cascade
2007-08-09 Deleted SYNONYM MAP kinase cascade
2007-08-09 Deleted SYNONYM ERK/MAPK cascade
2007-08-09 Added SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-08-09 Added SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-08-09 Added SYNONYM MAPK cascade
2007-08-09 Added SYNONYM MAP kinase kinase kinase cascade
2007-08-09 Added SYNONYM MAP kinase cascade
2007-08-09 Added SYNONYM ERK/MAPK cascade
2007-08-09 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-08-09 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-04-21 Added SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-04-21 Added SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2006-03-25 Added SYNONYM ERK/MAPK cascade
2005-06-27 Added SYNONYM MAP kinase kinase kinase cascade
2005-06-27 Added SYNONYM MAP kinase cascade
2005-06-27 Added SYNONYM MAPK cascade
2001-08-06 Added DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
Timestamp Action Category Detail
2023-12-15 Added RELATION is a GO:0141124 (intracellular signaling cassette)
2023-12-15 Deleted RELATION is a GO:0035556 (intracellular signal transduction)
2023-08-04 Deleted RELATION has part GO:0038030 (obsolete non-canonical Wnt signaling pathway via MAPK cascade)
2023-08-04 Deleted RELATION has part GO:0038029 (obsolete epidermal growth factor receptor signaling pathway via MAPK cascade)
2020-11-24 Deleted RELATION is a GO:0023014 (signal transduction by protein phosphorylation)
2013-12-04 Added RELATION is a GO:0035556 (intracellular signal transduction)
2013-12-04 Deleted RELATION is a GO:0007243 (intracellular protein kinase cascade)
2013-11-15 Added RELATION is a GO:0023014 (signal transduction by protein phosphorylation)
2011-09-11 Added RELATION has part GO:0038029 (obsolete epidermal growth factor receptor signaling pathway via MAPK cascade)
2011-09-11 Added RELATION has part GO:0038030 (obsolete non-canonical Wnt signaling pathway via MAPK cascade)
2008-04-01 Updated RELATION is a GO:0007243 (intracellular protein kinase cascade)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-169893
2024-12-05 Added XREF Reactome:R-HSA-5673001
2020-02-28 Deleted XREF MIPS_funcat:30.01.05.01.03
2019-05-04 Added XREF MIPS_funcat:30.01.05.01.03
2009-02-25 Added XREF Wikipedia:MAPK_cascade
2009-02-25 Added XREF Wikipedia:Mitogen-activated_protein_kinase
Timestamp Action Category Detail
2021-06-06 Added SECONDARY GO:0007255 (activation of MAP/ERK kinase kinase)
2015-12-09 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
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