GO:0000177
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cytoplasmic exosome (RNase complex)
Cellular Component
Definition (GO:0000177 GONUTS page)
A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. PMID:17174896 PMID:20531386 PMID:26726035
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
prokaryotic exosome multienzyme ribonuclease complex | exact |
cytoplasmic exosome multienzyme ribonuclease complex | exact |
cytoplasmic exosome (ribonuclease complex) | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0000177
Child Term | Relationship to GO:0000177 |
---|---|
bacterial degradosome
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0000177 | cytoplasmic exosome (RNase complex) | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0D1E8X3 | 5270 | A0A0D1E8X3_MYCMD | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A0G2JZ79 | 10116 | SIR1_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1L8G9S0 | 8355 | A0A1L8G9S0_XENLA | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4L3K3 | 6945 | A0A1S4L3K3_IXOSC | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A2K5ATM2 | 6239 | A0A2K5ATM2_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5ATM9 | 6239 | A0A2K5ATM9_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5ATP6 | 6239 | A0A2K5ATP6_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0000177 based on ALL annotations
The top 100 of 323 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cytoplasmic exosome (RNase complex)
|
4,604.13 | 100.00 | 42,340 | 42,340 |
nuclear exosome (RNase complex)
|
3,553.22 | 67.27 | 35,559 | 46,076 |
U4 snRNA 3'-end processing
|
4,046.68 | 65.77 | 30,620 | 34,838 |
exosome (RNase complex)
|
2,814.05 | 55.83 | 36,655 | 59,972 |
nuclear mRNA surveillance
|
4,498.65 | 54.01 | 23,160 | 23,703 |
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
|
3,183.35 | 40.83 | 21,142 | 30,578 |
TRAMP-dependent tRNA surveillance pathway
|
3,169.59 | 40.69 | 21,116 | 30,673 |
nuclear polyadenylation-dependent rRNA catabolic process
|
3,126.16 | 39.51 | 20,568 | 30,292 |
poly(A)-dependent snoRNA 3'-end processing
|
3,097.60 | 35.75 | 18,320 | 27,230 |
rRNA catabolic process
|
1,568.59 | 31.49 | 34,137 | 100,199 |
Totals | 509660 | 58067762 |
No co-occurrence statistics for GO:0000177 based on MANUAL annotations
The top 100 of 129 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cytoplasmic exosome (RNase complex)
|
1,275.22 | 100.00 | 1,013 | 1,013 |
U4 snRNA 3'-end processing
|
1,234.46 | 81.46 | 848 | 876 |
nuclear exosome (RNase complex)
|
971.26 | 73.38 | 965 | 1,267 |
rRNA catabolic process
|
1,075.62 | 67.07 | 776 | 920 |
nuclear mRNA surveillance
|
1,204.89 | 61.94 | 651 | 689 |
TRAMP-dependent tRNA surveillance pathway
|
902.54 | 44.81 | 557 | 787 |
nuclear polyadenylation-dependent rRNA catabolic process
|
894.10 | 44.48 | 556 | 793 |
poly(A)-dependent snoRNA 3'-end processing
|
912.41 | 41.81 | 508 | 710 |
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
|
746.11 | 39.56 | 557 | 952 |
U1 snRNA 3'-end processing
|
1,264.16 | 33.76 | 343 | 346 |
Totals | 9861 | 266107 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2019-09-12 | Deleted | RELATION | is a GO:0044444 (obsolete cytoplasmic part) |
2016-08-10 | Deleted | DEFINITION | Complex of 3'-5' exoribonucleases found in the cytoplasm. |
2016-08-10 | Added | DEFINITION | A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
2015-04-24 | Added | RELATION | part of GO:0005737 (cytoplasm) |
2013-02-02 | Deleted | RELATION | part of GO:0005737 (cytoplasm) |
2012-10-29 | Added | RELATION | part of GO:0005737 (cytoplasm) |
2008-05-23 | Added | SYNONYM | cytoplasmic exosome multienzyme ribonuclease complex |
2008-05-23 | Added | SYNONYM | cytoplasmic exosome (ribonuclease complex) |
2008-05-23 | Added | SYNONYM | prokaryotic exosome multienzyme ribonuclease complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-02-06 | Updated | TERM | cytoplasmic exosome (RNase complex) |
2001-04-03 | Updated | TERM | cytoplasmic exosome (RNase complex) |
2001-03-30 | Added | TERM | cytoplasmic exosome (RNase complex) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-08-10 | Deleted | DEFINITION | Complex of 3'-5' exoribonucleases found in the cytoplasm. |
2016-08-10 | Added | DEFINITION | A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
2008-05-23 | Added | SYNONYM | cytoplasmic exosome multienzyme ribonuclease complex |
2008-05-23 | Added | SYNONYM | cytoplasmic exosome (ribonuclease complex) |
2008-05-23 | Added | SYNONYM | prokaryotic exosome multienzyme ribonuclease complex |
2008-05-13 | Added | DEFINITION | Complex of 3'-5' exoribonucleases found in the cytoplasm. |
2008-05-12 | Deleted | DEFINITION | Complex of 3'-5' exoribonucleases found in the cytoplasm. |
2001-08-06 | Added | DEFINITION | Complex of 3'-5' exoribonucleases found in the cytoplasm. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-09-12 | Deleted | RELATION | is a GO:0044444 (obsolete cytoplasmic part) |
2015-04-24 | Added | RELATION | part of GO:0005737 (cytoplasm) |
2013-02-02 | Deleted | RELATION | part of GO:0005737 (cytoplasm) |
2012-10-29 | Added | RELATION | part of GO:0005737 (cytoplasm) |
2008-04-01 | Updated | RELATION | is a GO:0000178 (exosome (RNase complex)) |
2008-04-01 | Updated | RELATION | is a GO:0044444 (obsolete cytoplasmic part) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
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