This term is obsolete.

GO:0000177 JSON

cytoplasmic exosome (RNase complex)

Cellular Component

Definition (GO:0000177 GONUTS page)

A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. PMID:17174896 PMID:20531386 PMID:26726035

42,481 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
prokaryotic exosome multienzyme ribonuclease complex exact
cytoplasmic exosome multienzyme ribonuclease complex exact
cytoplasmic exosome (ribonuclease complex) exact

Ancestor Chart

Ancestor chart for GO:0000177
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000177

Child Term Relationship to
GO:0000177
bacterial degradosome
is_a

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0000177 cytoplasmic exosome (RNase complex) Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0D1E8X3 5270 A0A0D1E8X3_MYCMD GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A0G2JZ79 10116 SIR1_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1L8G9S0 8355 A0A1L8G9S0_XENLA GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4L3K3 6945 A0A1S4L3K3_IXOSC GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A2K5ATM2 6239 A0A2K5ATM2_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5ATM9 6239 A0A2K5ATM9_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5ATP6 6239 A0A2K5ATP6_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000177 based on ALL annotations
The top 100 of 323 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cytoplasmic exosome (RNase complex)
4,604.13 100.00 42,340 42,340
nuclear exosome (RNase complex)
3,553.22 67.27 35,559 46,076
U4 snRNA 3'-end processing
4,046.68 65.77 30,620 34,838
exosome (RNase complex)
2,814.05 55.83 36,655 59,972
nuclear mRNA surveillance
4,498.65 54.01 23,160 23,703
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
3,183.35 40.83 21,142 30,578
TRAMP-dependent tRNA surveillance pathway
3,169.59 40.69 21,116 30,673
nuclear polyadenylation-dependent rRNA catabolic process
3,126.16 39.51 20,568 30,292
poly(A)-dependent snoRNA 3'-end processing
3,097.60 35.75 18,320 27,230
rRNA catabolic process
1,568.59 31.49 34,137 100,199
Totals 509660 58067762
No co-occurrence statistics for GO:0000177 based on MANUAL annotations
The top 100 of 129 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cytoplasmic exosome (RNase complex)
1,275.22 100.00 1,013 1,013
U4 snRNA 3'-end processing
1,234.46 81.46 848 876
nuclear exosome (RNase complex)
971.26 73.38 965 1,267
rRNA catabolic process
1,075.62 67.07 776 920
nuclear mRNA surveillance
1,204.89 61.94 651 689
TRAMP-dependent tRNA surveillance pathway
902.54 44.81 557 787
nuclear polyadenylation-dependent rRNA catabolic process
894.10 44.48 556 793
poly(A)-dependent snoRNA 3'-end processing
912.41 41.81 508 710
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
746.11 39.56 557 952
U1 snRNA 3'-end processing
1,264.16 33.76 343 346
Totals 9861 266107

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2019-09-12 Deleted RELATION is a GO:0044444 (obsolete cytoplasmic part)
2016-08-10 Deleted DEFINITION Complex of 3'-5' exoribonucleases found in the cytoplasm.
2016-08-10 Added DEFINITION A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
2015-04-24 Added RELATION part of GO:0005737 (cytoplasm)
2013-02-02 Deleted RELATION part of GO:0005737 (cytoplasm)
2012-10-29 Added RELATION part of GO:0005737 (cytoplasm)
2008-05-23 Added SYNONYM cytoplasmic exosome multienzyme ribonuclease complex
2008-05-23 Added SYNONYM cytoplasmic exosome (ribonuclease complex)
2008-05-23 Added SYNONYM prokaryotic exosome multienzyme ribonuclease complex
Timestamp Action Category Detail
2002-02-06 Updated TERM cytoplasmic exosome (RNase complex)
2001-04-03 Updated TERM cytoplasmic exosome (RNase complex)
2001-03-30 Added TERM cytoplasmic exosome (RNase complex)
Timestamp Action Category Detail
2016-08-10 Deleted DEFINITION Complex of 3'-5' exoribonucleases found in the cytoplasm.
2016-08-10 Added DEFINITION A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
2008-05-23 Added SYNONYM cytoplasmic exosome multienzyme ribonuclease complex
2008-05-23 Added SYNONYM cytoplasmic exosome (ribonuclease complex)
2008-05-23 Added SYNONYM prokaryotic exosome multienzyme ribonuclease complex
2008-05-13 Added DEFINITION Complex of 3'-5' exoribonucleases found in the cytoplasm.
2008-05-12 Deleted DEFINITION Complex of 3'-5' exoribonucleases found in the cytoplasm.
2001-08-06 Added DEFINITION Complex of 3'-5' exoribonucleases found in the cytoplasm.
Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0044444 (obsolete cytoplasmic part)
2015-04-24 Added RELATION part of GO:0005737 (cytoplasm)
2013-02-02 Deleted RELATION part of GO:0005737 (cytoplasm)
2012-10-29 Added RELATION part of GO:0005737 (cytoplasm)
2008-04-01 Updated RELATION is a GO:0000178 (exosome (RNase complex))
2008-04-01 Updated RELATION is a GO:0044444 (obsolete cytoplasmic part)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
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