GO:0000213
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tRNA-intron endonuclease activity
Molecular Function
Definition (GO:0000213 GONUTS page)
Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
tRNA splicing endonuclease activity | related |
tRNA-intron endoribonuclease activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0000213
Child Term | Relationship to GO:0000213 |
---|---|
tRNA-intron endonuclease complex
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4KFF6 | 7227 | A0A0B4KFF6_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | A0A0G2K5G5 | 10116 | A0A0G2K5G5_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y871 | 10116 | A0A8I5Y871_RAT | GO:0004521 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZP12 | 10116 | A0A8I5ZP12_RAT | GO:0004521 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A3V5 | 10116 | A0A8I6A3V5_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A4X4 | 10116 | A0A8I6A4X4_RAT | GO:0004521 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ACW3 | 10116 | A0A8I6ACW3_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6G551 | 10116 | A0A8I6G551_RAT | GO:0004521 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6ISA8 | 10116 | A6ISA8_RAT | GO:0004521 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J211 | 10116 | A6J211_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 4.6.1.16 | |
InterPro | IPR006676 | tRNA-splicing endonuclease |
InterPro | IPR006677 | tRNA intron endonuclease, catalytic domain-like |
InterPro | IPR006678 | tRNA intron endonuclease, N-terminal |
InterPro | IPR016589 | tRNA-splicing endonuclease, SEN2 subunit |
InterPro | IPR016690 | tRNA-splicing endonuclease, SEN34 subunit |
InterPro | IPR023516 | tRNA-splicing endonuclease, archaeal long subfamily |
InterPro | IPR036740 | tRNA intron endonuclease, N-terminal domain superfamily |
MetaCyc | 3.1.27.9-RXN |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0000213 based on ALL annotations
The top 100 of 358 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
tRNA-intron endonuclease activity
|
15,067.67 | 100.00 | 13,151 | 13,151 |
tRNA-type intron splice site recognition and cleavage
|
10,326.10 | 51.11 | 8,783 | 12,816 |
tRNA-intron endonuclease complex
|
9,295.38 | 41.08 | 7,253 | 11,757 |
tRNA splicing, via endonucleolytic cleavage and ligation
|
4,990.63 | 33.02 | 13,027 | 39,331 |
tRNA processing
|
97.27 | 0.64 | 11,478 | 1,777,988 |
nucleic acid binding
|
53.51 | 0.36 | 11,803 | 3,323,383 |
endonuclease activity
|
41.33 | 0.27 | 6,184 | 2,254,459 |
lyase activity
|
29.34 | 0.19 | 8,808 | 4,523,172 |
antibiotic catabolic process
|
31.74 | 0.12 | 40 | 18,989 |
Lsm1-7-Pat1 complex
|
30.30 | 0.11 | 31 | 15,417 |
Totals | 97223 | 54105511 |
No co-occurrence statistics for GO:0000213 based on MANUAL annotations
The top 19 of 19 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
tRNA-intron endonuclease activity
|
7,974.76 | 100.00 | 177 | 177 |
tRNA-type intron splice site recognition and cleavage
|
4,790.30 | 59.86 | 176 | 293 |
tRNA-intron endonuclease complex
|
3,898.11 | 41.72 | 131 | 268 |
tRNA processing
|
1,130.75 | 13.15 | 114 | 804 |
tRNA splicing, via endonucleolytic cleavage and ligation
|
48.63 | 0.45 | 3 | 492 |
mitochondrial outer membrane
|
11.16 | 0.13 | 5 | 3,574 |
mitochondrial membrane
|
6.91 | 0.08 | 1 | 1,154 |
tRNA binding
|
6.13 | 0.07 | 2 | 2,604 |
cytoplasm
|
4.56 | 0.06 | 113 | 197,513 |
peroxisome
|
1.75 | 0.02 | 1 | 4,568 |
Totals | 745 | 822368 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Deleted | SYNONYM | transfer ribonucleate intron endoribonuclease activity |
2022-12-18 | Deleted | SYNONYM | tRNATRPintron endonuclease activity |
2022-12-18 | Deleted | SYNONYM | transfer splicing endonuclease activity |
2022-12-18 | Deleted | SYNONYM | tRNA-splicing endonuclease activity |
2022-12-18 | Added | XREF | EC:4.6.1.16 |
2022-12-18 | Deleted | SYNONYM | splicing endonuclease activity |
2022-12-18 | Deleted | XREF | EC:3.1.27.9 |
2020-10-08 | Added | SYNONYM | tRNATRPintron endonuclease activity |
2020-10-08 | Deleted | SYNONYM | tRNA-splicing endonuclease activity |
2020-10-08 | Deleted | SYNONYM | transfer splicing endonuclease activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | tRNA-intron endonuclease activity |
2002-02-06 | Updated | TERM | tRNA-intron endonuclease |
2001-04-03 | Updated | TERM | tRNA-intron endonuclease |
2001-03-30 | Added | TERM | tRNA-intron endonuclease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Deleted | SYNONYM | transfer ribonucleate intron endoribonuclease activity |
2022-12-18 | Deleted | SYNONYM | tRNATRPintron endonuclease activity |
2022-12-18 | Deleted | SYNONYM | transfer splicing endonuclease activity |
2022-12-18 | Deleted | SYNONYM | tRNA-splicing endonuclease activity |
2022-12-18 | Deleted | SYNONYM | splicing endonuclease activity |
2020-10-08 | Added | SYNONYM | tRNATRPintron endonuclease activity |
2020-10-08 | Deleted | SYNONYM | tRNA-splicing endonuclease activity |
2020-10-08 | Deleted | SYNONYM | transfer splicing endonuclease activity |
2020-10-08 | Deleted | SYNONYM | transfer ribonucleate intron endoribonuclease activity |
2020-10-08 | Added | SYNONYM | transfer splicing endonuclease activity |
2020-10-08 | Added | SYNONYM | tRNA-splicing endonuclease activity |
2020-10-08 | Added | SYNONYM | tRNA splicing endonuclease activity |
2020-10-08 | Added | SYNONYM | splicing endonuclease activity |
2020-10-08 | Added | SYNONYM | transfer ribonucleate intron endoribonuclease activity |
2020-10-08 | Deleted | SYNONYM | tRNATRPintron endonuclease activity |
2020-10-08 | Deleted | SYNONYM | splicing endonuclease activity |
2020-10-08 | Deleted | SYNONYM | tRNA splicing endonuclease activity |
2008-05-23 | Added | SYNONYM | tRNA-intron endoribonuclease activity |
2008-05-13 | Added | DEFINITION | Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. |
2007-12-14 | Added | SYNONYM | splicing endonuclease activity |
2007-12-14 | Added | SYNONYM | transfer ribonucleate intron endoribonuclease activity |
2007-12-14 | Added | SYNONYM | transfer splicing endonuclease activity |
2007-12-14 | Added | SYNONYM | tRNA splicing endonuclease activity |
2007-12-14 | Added | SYNONYM | tRNATRPintron endonuclease activity |
2007-09-06 | Deleted | SYNONYM | tRNA-splicing endonuclease |
2007-09-06 | Added | SYNONYM | tRNA-splicing endonuclease activity |
2007-08-09 | Deleted | SYNONYM | tRNA-splicing endonuclease |
2007-08-09 | Added | SYNONYM | tRNA-splicing endonuclease |
2004-04-19 | Added | SYNONYM | tRNA-splicing endonuclease |
2004-04-16 | Deleted | SYNONYM | tRNA-splicing endonuclease |
2003-10-27 | Added | SYNONYM | tRNA-splicing endonuclease |
2003-08-18 | Deleted | SYNONYM | tRNA-splicing endonuclease |
2002-11-27 | Updated | DEFINITION | Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. |
2001-08-06 | Added | DEFINITION | Enzyme that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. |
2001-03-30 | Added | SYNONYM | tRNA-splicing endonuclease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0004549 (tRNA-specific ribonuclease activity) |
2008-04-01 | Updated | RELATION | is a GO:0016892 (RNA endonuclease activity, producing 3'-phosphomonoesters) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Added | XREF | EC:4.6.1.16 |
2022-12-18 | Deleted | XREF | EC:3.1.27.9 |
2003-10-27 | Added | XREF | MetaCyc:3.1.27.9-RXN |
2001-03-30 | Added | XREF | EC:3.1.27.9 |
Timestamp | Action | Category | Detail |
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