This term is obsolete.

GO:0000213 JSON

tRNA-intron endonuclease activity

Molecular Function

Definition (GO:0000213 GONUTS page)

Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.

13,318 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
tRNA splicing endonuclease activity related
tRNA-intron endoribonuclease activity exact

Ancestor Chart

Ancestor chart for GO:0000213
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000213

Child Term Relationship to
GO:0000213
tRNA-intron endonuclease complex
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A0A0G2K5G5 10116 A0A0G2K5G5_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y871 10116 A0A8I5Y871_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZP12 10116 A0A8I5ZP12_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A3V5 10116 A0A8I6A3V5_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A4X4 10116 A0A8I6A4X4_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ACW3 10116 A0A8I6ACW3_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6G551 10116 A0A8I6G551_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6ISA8 10116 A6ISA8_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J211 10116 A6J211_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 4.6.1.16
InterPro IPR006676 tRNA-splicing endonuclease
InterPro IPR006677 tRNA intron endonuclease, catalytic domain-like
InterPro IPR006678 tRNA intron endonuclease, N-terminal
InterPro IPR016589 tRNA-splicing endonuclease, SEN2 subunit
InterPro IPR016690 tRNA-splicing endonuclease, SEN34 subunit
InterPro IPR023516 tRNA-splicing endonuclease, archaeal long subfamily
InterPro IPR036740 tRNA intron endonuclease, N-terminal domain superfamily
MetaCyc 3.1.27.9-RXN

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000213 based on ALL annotations
The top 100 of 358 co-occurring terms
Co-occurring Term PR S% #Together #Compared
tRNA-intron endonuclease activity
15,067.67 100.00 13,151 13,151
tRNA-type intron splice site recognition and cleavage
10,326.10 51.11 8,783 12,816
tRNA-intron endonuclease complex
9,295.38 41.08 7,253 11,757
tRNA splicing, via endonucleolytic cleavage and ligation
4,990.63 33.02 13,027 39,331
tRNA processing
97.27 0.64 11,478 1,777,988
nucleic acid binding
53.51 0.36 11,803 3,323,383
endonuclease activity
41.33 0.27 6,184 2,254,459
lyase activity
29.34 0.19 8,808 4,523,172
antibiotic catabolic process
31.74 0.12 40 18,989
Lsm1-7-Pat1 complex
30.30 0.11 31 15,417
Totals 97223 54105511
No co-occurrence statistics for GO:0000213 based on MANUAL annotations
The top 19 of 19 co-occurring terms
Co-occurring Term PR S% #Together #Compared
tRNA-intron endonuclease activity
7,974.76 100.00 177 177
tRNA-type intron splice site recognition and cleavage
4,790.30 59.86 176 293
tRNA-intron endonuclease complex
3,898.11 41.72 131 268
tRNA processing
1,130.75 13.15 114 804
tRNA splicing, via endonucleolytic cleavage and ligation
48.63 0.45 3 492
mitochondrial outer membrane
11.16 0.13 5 3,574
mitochondrial membrane
6.91 0.08 1 1,154
tRNA binding
6.13 0.07 2 2,604
cytoplasm
4.56 0.06 113 197,513
peroxisome
1.75 0.02 1 4,568
Totals 745 822368

Change Log

Timestamp Action Category Detail
2022-12-18 Deleted SYNONYM transfer ribonucleate intron endoribonuclease activity
2022-12-18 Deleted SYNONYM tRNATRPintron endonuclease activity
2022-12-18 Deleted SYNONYM transfer splicing endonuclease activity
2022-12-18 Deleted SYNONYM tRNA-splicing endonuclease activity
2022-12-18 Added XREF EC:4.6.1.16
2022-12-18 Deleted SYNONYM splicing endonuclease activity
2022-12-18 Deleted XREF EC:3.1.27.9
2020-10-08 Added SYNONYM tRNATRPintron endonuclease activity
2020-10-08 Deleted SYNONYM tRNA-splicing endonuclease activity
2020-10-08 Deleted SYNONYM transfer splicing endonuclease activity
Timestamp Action Category Detail
2003-03-19 Updated TERM tRNA-intron endonuclease activity
2002-02-06 Updated TERM tRNA-intron endonuclease
2001-04-03 Updated TERM tRNA-intron endonuclease
2001-03-30 Added TERM tRNA-intron endonuclease
Timestamp Action Category Detail
2022-12-18 Deleted SYNONYM transfer ribonucleate intron endoribonuclease activity
2022-12-18 Deleted SYNONYM tRNATRPintron endonuclease activity
2022-12-18 Deleted SYNONYM transfer splicing endonuclease activity
2022-12-18 Deleted SYNONYM tRNA-splicing endonuclease activity
2022-12-18 Deleted SYNONYM splicing endonuclease activity
2020-10-08 Added SYNONYM tRNATRPintron endonuclease activity
2020-10-08 Deleted SYNONYM tRNA-splicing endonuclease activity
2020-10-08 Deleted SYNONYM transfer splicing endonuclease activity
2020-10-08 Deleted SYNONYM transfer ribonucleate intron endoribonuclease activity
2020-10-08 Added SYNONYM transfer splicing endonuclease activity
2020-10-08 Added SYNONYM tRNA-splicing endonuclease activity
2020-10-08 Added SYNONYM tRNA splicing endonuclease activity
2020-10-08 Added SYNONYM splicing endonuclease activity
2020-10-08 Added SYNONYM transfer ribonucleate intron endoribonuclease activity
2020-10-08 Deleted SYNONYM tRNATRPintron endonuclease activity
2020-10-08 Deleted SYNONYM splicing endonuclease activity
2020-10-08 Deleted SYNONYM tRNA splicing endonuclease activity
2008-05-23 Added SYNONYM tRNA-intron endoribonuclease activity
2008-05-13 Added DEFINITION Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
2008-05-12 Deleted DEFINITION Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
2007-12-14 Added SYNONYM splicing endonuclease activity
2007-12-14 Added SYNONYM transfer ribonucleate intron endoribonuclease activity
2007-12-14 Added SYNONYM transfer splicing endonuclease activity
2007-12-14 Added SYNONYM tRNA splicing endonuclease activity
2007-12-14 Added SYNONYM tRNATRPintron endonuclease activity
2007-09-06 Deleted SYNONYM tRNA-splicing endonuclease
2007-09-06 Added SYNONYM tRNA-splicing endonuclease activity
2007-08-09 Deleted SYNONYM tRNA-splicing endonuclease
2007-08-09 Added SYNONYM tRNA-splicing endonuclease
2004-04-19 Added SYNONYM tRNA-splicing endonuclease
2004-04-16 Deleted SYNONYM tRNA-splicing endonuclease
2003-10-27 Added SYNONYM tRNA-splicing endonuclease
2003-08-18 Deleted SYNONYM tRNA-splicing endonuclease
2002-11-27 Updated DEFINITION Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
2001-08-06 Added DEFINITION Enzyme that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
2001-03-30 Added SYNONYM tRNA-splicing endonuclease
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004549 (tRNA-specific ribonuclease activity)
2008-04-01 Updated RELATION is a GO:0016892 (RNA endonuclease activity, producing 3'-phosphomonoesters)
Timestamp Action Category Detail
2022-12-18 Added XREF EC:4.6.1.16
2022-12-18 Deleted XREF EC:3.1.27.9
2003-10-27 Added XREF MetaCyc:3.1.27.9-RXN
2001-03-30 Added XREF EC:3.1.27.9
Timestamp Action Category Detail
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