This term is obsolete.

GO:0001664 JSON

G protein-coupled receptor binding

Molecular Function

Definition (GO:0001664 GONUTS page)

Binding to a G protein-coupled receptor.

250,173 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
G-protein-coupled receptor ligand narrow
G-protein coupled receptor binding exact
G protein coupled receptor ligand narrow
G protein coupled receptor binding exact

Ancestor Chart

Ancestor chart for GO:0001664
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0001664

Child Term Relationship to
GO:0001664
GO:0031762
follicle-stimulating hormone receptor binding
is_a
GO:0031784
melatonin receptor binding
is_a
GO:0031806
G protein-coupled histamine receptor binding
is_a
GO:0071855
neuropeptide receptor binding
is_a
GO:0031761
fMet-Leu-Phe receptor binding
is_a
GO:0031849
olfactory receptor binding
is_a
GO:0031789
G protein-coupled acetylcholine receptor binding
is_a
GO:0031767
gastric inhibitory polypeptide receptor binding
is_a
GO:0031788
motilin receptor binding
is_a
GO:0031531
thyrotropin-releasing hormone receptor binding
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O95970 9606 LGI1_HUMAN GO:0005102 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20463223
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein Q8K4Y5 10116 LGI1_RAT GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR000469 G-protein alpha subunit, group 12/13
InterPro IPR000654 G-protein alpha subunit, group Q
InterPro IPR002975 Fungal G-protein, alpha subunit
InterPro IPR002976 Plant G-protein, alpha subunit
InterPro IPR013297 Neuropeptide B/W precursor family
InterPro IPR031713 G-protein coupled receptor ligand 15
InterPro IPR034441 Bursicon subunit beta
InterPro IPR037884 LARG, RGS domain
InterPro IPR037887 p115RhoGEF, RGS domain
InterPro IPR037889 Rho guanine nucleotide exchange factor 11, RGS domain

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0001664 based on ALL annotations
The top 100 of 2,096 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0001664
G protein-coupled receptor binding
2,934.71 100.00 67,521 67,521
GO:0031683
G-protein beta/gamma-subunit complex binding
2,419.51 44.27 33,005 40,033
GO:0005834
heterotrimeric G-protein complex
1,937.74 38.98 32,927 49,868
GO:0019001
guanyl nucleotide binding
2,604.55 26.05 18,191 20,497
GO:0007188
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
1,418.59 23.97 21,759 45,014
GO:0004703
G protein-coupled receptor kinase activity
1,581.85 10.97 8,172 15,161
GO:0002031
G protein-coupled receptor internalization
2,409.03 9.93 6,851 8,346
GO:2000852
regulation of corticosterone secretion
2,894.26 7.09 4,793 4,860
GO:0005179
hormone activity
257.58 5.19 7,606 86,659
GO:0030141
secretory granule
465.20 5.16 4,794 30,243
Totals 497247 19640047
No co-occurrence statistics for GO:0001664 based on MANUAL annotations
The top 100 of 1,717 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0001664
G protein-coupled receptor binding
1,100.18 100.00 1,283 1,283
GO:0031683
G-protein beta/gamma-subunit complex binding
918.75 50.14 714 855
GO:0005834
heterotrimeric G-protein complex
574.15 36.93 716 1,372
GO:0007188
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
567.80 32.25 593 1,149
GO:0002031
G protein-coupled receptor internalization
821.15 7.81 103 138
GO:0060158
phospholipase C-activating dopamine receptor signaling pathway
542.56 5.31 72 146
GO:0003924
GTPase activity
50.82 4.46 718 15,544
GO:0004703
G protein-coupled receptor kinase activity
779.88 4.29 56 79
GO:0007603
phototransduction, visible light
355.75 3.87 54 167
GO:0007191
adenylate cyclase-activating dopamine receptor signaling pathway
518.35 3.66 49 104
Totals 6349 94047

Change Log

Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a G protein-coupled receptor.
2021-05-24 Added DEFINITION Binding to a G protein-coupled receptor.
2019-04-01 Deleted XREF reactome:R-HSA-500717
2019-04-01 Added XREF Reactome:R-HSA-500717
2018-12-11 Added XREF reactome:R-HSA-500717
2018-09-08 Deleted SYNONYM G-protein-coupled receptor binding
2018-09-08 Deleted DEFINITION Interacting selectively and non-covalently with a G-protein coupled receptor.
2018-09-08 Added DEFINITION Interacting selectively and non-covalently with a G protein-coupled receptor.
2018-09-08 Added SYNONYM G-protein coupled receptor binding
2018-09-08 Updated TERM G protein-coupled receptor binding
Timestamp Action Category Detail
2018-09-08 Updated TERM G protein-coupled receptor binding
2011-10-24 Updated TERM G-protein coupled receptor binding
2003-06-10 Updated TERM G-protein-coupled receptor binding
2003-03-19 Updated TERM G-protein-coupled receptor binding activity
2002-07-23 Updated TERM G-protein-coupled receptor binding
2002-02-15 Added TERM G-protein coupled receptor ligand
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a G protein-coupled receptor.
2021-05-24 Added DEFINITION Binding to a G protein-coupled receptor.
2018-09-08 Deleted SYNONYM G-protein-coupled receptor binding
2018-09-08 Deleted DEFINITION Interacting selectively and non-covalently with a G-protein coupled receptor.
2018-09-08 Added DEFINITION Interacting selectively and non-covalently with a G protein-coupled receptor.
2018-09-08 Added SYNONYM G-protein coupled receptor binding
2011-10-24 Added DEFINITION Interacting selectively and non-covalently with a G-protein coupled receptor.
2011-10-24 Added SYNONYM G-protein-coupled receptor binding
2011-10-24 Deleted DEFINITION Interacting selectively and non-covalently with a G-protein-coupled receptor.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with a G-protein-coupled receptor.
2009-07-03 Deleted DEFINITION Interacting selectively with a G-protein-coupled receptor.
2008-05-13 Added DEFINITION Interacting selectively with a G-protein-coupled receptor.
2008-05-12 Deleted DEFINITION Interacting selectively with a G-protein-coupled receptor.
2007-08-09 Added SYNONYM G protein coupled receptor binding
2007-08-09 Deleted SYNONYM G protein coupled receptor ligand
2007-08-09 Deleted SYNONYM G-protein-coupled receptor ligand
2007-08-09 Deleted SYNONYM G protein coupled receptor binding
2007-08-09 Added SYNONYM G-protein-coupled receptor ligand
2007-08-09 Added SYNONYM G protein coupled receptor ligand
2005-06-27 Added SYNONYM G protein coupled receptor ligand
2005-06-27 Added SYNONYM G protein coupled receptor binding
2003-03-26 Updated DEFINITION Interacting selectively with a G-protein-coupled receptor.
2002-11-27 Added DEFINITION Interacting selectively and stoichiometrically with a G-protein-coupled receptor.
2002-07-26 Added SYNONYM G-protein-coupled receptor ligand
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0005102 (signaling receptor binding)
Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-500717
2019-04-01 Added XREF Reactome:R-HSA-500717
2018-12-11 Added XREF reactome:R-HSA-500717
Timestamp Action Category Detail
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