This term is obsolete.

GO:0003684 JSON

damaged DNA binding

Molecular Function

Definition (GO:0003684 GONUTS page)

Binding to damaged DNA.

450,905 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
DNA repair enzyme related
DNA repair protein related

Ancestor Chart

Ancestor chart for GO:0003684
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003684

Child Term Relationship to
GO:0003684
single-strand break-containing DNA binding
is_a
alkylated DNA binding
is_a
DNA-(abasic site) binding
is_a
oxidized DNA binding
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link
Considerations when annotating from ChiP assay results Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein P40999 284812 PMT1M_SCHPO GO:0003677 To remove over-annotation from InterPro entries IPR001525 and IPR018117; for this particular C5-methyltransferase family member, there is a Ser residue in the active site that may be responsible. Reported by InterPro on 19-10-2012
NOT-qualified manual protein A0A0G2K0G0 10116 A0A0G2K0G0_RAT GO:0003677 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GWQ8 10116 A0A1B0GWQ8_RAT GO:0003677 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0003677 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZKC5 10116 A0A8I5ZKC5_RAT GO:0003677 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0003677 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A7B9 10116 A0A8I6A7B9_RAT GO:0003677 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AB42 10116 A0A8I6AB42_RAT GO:0003677 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ASJ7 10116 A0A8I6ASJ7_RAT GO:0003677 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AUW9 10116 A0A8I6AUW9_RAT GO:0003677 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR000465 XPA/RAD14
InterPro IPR002706 DNA-repair protein Xrcc1, N-terminal
InterPro IPR004504 DNA repair protein RadA
InterPro IPR004576 Transcription-repair coupling factor
InterPro IPR004579 ERCC1/RAD10/SWI10 family
InterPro IPR004583 DNA repair protein Rad4
InterPro IPR006165 Ku70
InterPro IPR011938 DNA recombination/repair protein RadA
InterPro IPR011939 DNA repair and recombination protein RadB
InterPro IPR012112 DNA repair protein Rev1

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0003685 obsolete DNA repair protein consider GO:0003684
GO:0003686 obsolete DNA repair enzyme consider GO:0003684
GO:0008845 obsolete endonuclease VIII activity consider GO:0003684

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003684 based on ALL annotations
The top 100 of 2,296 co-occurring terms
Co-occurring Term PR S% #Together #Compared
damaged DNA binding
525.65 100.00 370,855 370,855
ATP-dependent DNA damage sensor activity
203.34 20.08 109,253 282,426
error-prone translesion synthesis
419.75 19.00 74,001 92,670
SOS response
124.57 14.33 98,681 416,388
DNA repair
69.99 13.25 357,169 2,682,566
DNA-(apurinic or apyrimidinic site) endonuclease activity
181.76 11.85 56,650 163,834
base-excision repair
103.84 11.01 73,857 373,869
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
299.14 10.90 44,058 77,419
oxidized purine nucleobase lesion DNA N-glycosylase activity
522.60 10.44 38,744 38,970
DNA damage response
87.47 10.35 79,724 479,118
Totals 3888396 163465932
No co-occurrence statistics for GO:0003684 based on MANUAL annotations
The top 100 of 1,222 co-occurring terms
Co-occurring Term PR S% #Together #Compared
damaged DNA binding
561.90 100.00 2,299 2,299
DNA replication factor A complex
461.81 39.46 992 1,207
single-stranded telomeric DNA binding
473.28 37.38 924 1,097
telomere maintenance via telomerase
409.50 35.06 927 1,272
nucleotide-excision repair
279.86 33.49 1,162 2,333
meiotic cell cycle
297.98 29.71 927 1,748
double-strand break repair via homologous recombination
149.56 22.21 1,317 4,948
5'-3' DNA exonuclease activity
352.46 11.21 276 440
nucleotide-excision repair factor 1 complex
559.56 10.43 240 241
interstrand cross-link repair
176.04 9.94 292 932
Totals 14484 126556

Change Log

Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to damaged DNA.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with damaged DNA.
2021-03-06 Added RELATION has part GO:0140612 (DNA damage sensor activity)
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with damaged DNA.
2009-07-03 Deleted DEFINITION Interacting selectively with damaged DNA.
2008-05-13 Added DEFINITION Interacting selectively with damaged DNA.
2008-05-12 Deleted DEFINITION Interacting selectively with damaged DNA.
2008-04-01 Updated RELATION is a GO:0003677 (DNA binding)
2007-09-26 Deleted SYNONYM endonuclease VIII activity
2007-08-09 Deleted SYNONYM DNA repair enzyme
Timestamp Action Category Detail
2003-06-10 Updated TERM damaged DNA binding
2003-03-19 Updated TERM damaged DNA binding activity
2002-02-06 Updated TERM damaged DNA binding
2001-04-03 Updated TERM damaged DNA binding
2001-03-30 Added TERM damaged DNA binding
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to damaged DNA.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with damaged DNA.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with damaged DNA.
2009-07-03 Deleted DEFINITION Interacting selectively with damaged DNA.
2008-05-13 Added DEFINITION Interacting selectively with damaged DNA.
2008-05-12 Deleted DEFINITION Interacting selectively with damaged DNA.
2007-09-26 Deleted SYNONYM endonuclease VIII activity
2007-08-09 Deleted SYNONYM DNA repair enzyme
2007-08-09 Added SYNONYM endonuclease VIII activity
2007-08-09 Added SYNONYM DNA repair protein
2007-08-09 Added SYNONYM DNA repair enzyme
2007-08-09 Deleted SYNONYM endonuclease VIII activity
2007-08-09 Deleted SYNONYM DNA repair protein
2005-08-10 Added SYNONYM DNA repair protein
2005-08-10 Added SYNONYM endonuclease VIII activity
2005-08-10 Added SYNONYM DNA repair enzyme
2003-03-26 Added DEFINITION Interacting selectively with damaged DNA.
Timestamp Action Category Detail
2021-03-06 Added RELATION has part GO:0140612 (DNA damage sensor activity)
2008-04-01 Updated RELATION is a GO:0003677 (DNA binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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