GO:0003684
JSON
damaged DNA binding
Molecular Function
Definition (GO:0003684 GONUTS page)
Binding to damaged DNA.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
DNA repair enzyme | related |
DNA repair protein | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0003684
Child Term | Relationship to GO:0003684 |
---|---|
single-strand break-containing DNA binding
|
is_a |
alkylated DNA binding
|
is_a |
DNA-(abasic site) binding
|
is_a |
oxidized DNA binding
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Considerations when annotating from ChiP assay results | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | P40999 | 284812 | PMT1M_SCHPO | GO:0003677 | To remove over-annotation from InterPro entries IPR001525 and IPR018117; for this particular C5-methyltransferase family member, there is a Ser residue in the active site that may be responsible. Reported by InterPro on 19-10-2012 | |
NOT-qualified manual | protein | A0A0G2K0G0 | 10116 | A0A0G2K0G0_RAT | GO:0003677 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GWQ8 | 10116 | A0A1B0GWQ8_RAT | GO:0003677 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0003677 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZKC5 | 10116 | A0A8I5ZKC5_RAT | GO:0003677 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0003677 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A7B9 | 10116 | A0A8I6A7B9_RAT | GO:0003677 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AB42 | 10116 | A0A8I6AB42_RAT | GO:0003677 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ASJ7 | 10116 | A0A8I6ASJ7_RAT | GO:0003677 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AUW9 | 10116 | A0A8I6AUW9_RAT | GO:0003677 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000465 | XPA/RAD14 |
InterPro | IPR002706 | DNA-repair protein Xrcc1, N-terminal |
InterPro | IPR004504 | DNA repair protein RadA |
InterPro | IPR004576 | Transcription-repair coupling factor |
InterPro | IPR004579 | ERCC1/RAD10/SWI10 family |
InterPro | IPR004583 | DNA repair protein Rad4 |
InterPro | IPR006165 | Ku70 |
InterPro | IPR011938 | DNA recombination/repair protein RadA |
InterPro | IPR011939 | DNA repair and recombination protein RadB |
InterPro | IPR012112 | DNA repair protein Rev1 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0003685 | obsolete DNA repair protein | consider GO:0003684 |
GO:0003686 | obsolete DNA repair enzyme | consider GO:0003684 |
GO:0008845 | obsolete endonuclease VIII activity | consider GO:0003684 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003684 based on ALL annotations
The top 100 of 2,296 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
damaged DNA binding
|
525.65 | 100.00 | 370,855 | 370,855 |
ATP-dependent DNA damage sensor activity
|
203.34 | 20.08 | 109,253 | 282,426 |
error-prone translesion synthesis
|
419.75 | 19.00 | 74,001 | 92,670 |
SOS response
|
124.57 | 14.33 | 98,681 | 416,388 |
DNA repair
|
69.99 | 13.25 | 357,169 | 2,682,566 |
DNA-(apurinic or apyrimidinic site) endonuclease activity
|
181.76 | 11.85 | 56,650 | 163,834 |
base-excision repair
|
103.84 | 11.01 | 73,857 | 373,869 |
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
|
299.14 | 10.90 | 44,058 | 77,419 |
oxidized purine nucleobase lesion DNA N-glycosylase activity
|
522.60 | 10.44 | 38,744 | 38,970 |
DNA damage response
|
87.47 | 10.35 | 79,724 | 479,118 |
Totals | 3888396 | 163465932 |
No co-occurrence statistics for GO:0003684 based on MANUAL annotations
The top 100 of 1,222 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
damaged DNA binding
|
561.90 | 100.00 | 2,299 | 2,299 |
DNA replication factor A complex
|
461.81 | 39.46 | 992 | 1,207 |
single-stranded telomeric DNA binding
|
473.28 | 37.38 | 924 | 1,097 |
telomere maintenance via telomerase
|
409.50 | 35.06 | 927 | 1,272 |
nucleotide-excision repair
|
279.86 | 33.49 | 1,162 | 2,333 |
meiotic cell cycle
|
297.98 | 29.71 | 927 | 1,748 |
double-strand break repair via homologous recombination
|
149.56 | 22.21 | 1,317 | 4,948 |
5'-3' DNA exonuclease activity
|
352.46 | 11.21 | 276 | 440 |
nucleotide-excision repair factor 1 complex
|
559.56 | 10.43 | 240 | 241 |
interstrand cross-link repair
|
176.04 | 9.94 | 292 | 932 |
Totals | 14484 | 126556 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to damaged DNA. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with damaged DNA. |
2021-03-06 | Added | RELATION | has part GO:0140612 (DNA damage sensor activity) |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with damaged DNA. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with damaged DNA. |
2008-05-13 | Added | DEFINITION | Interacting selectively with damaged DNA. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with damaged DNA. |
2008-04-01 | Updated | RELATION | is a GO:0003677 (DNA binding) |
2007-09-26 | Deleted | SYNONYM | endonuclease VIII activity |
2007-08-09 | Deleted | SYNONYM | DNA repair enzyme |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-06-10 | Updated | TERM | damaged DNA binding |
2003-03-19 | Updated | TERM | damaged DNA binding activity |
2002-02-06 | Updated | TERM | damaged DNA binding |
2001-04-03 | Updated | TERM | damaged DNA binding |
2001-03-30 | Added | TERM | damaged DNA binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to damaged DNA. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with damaged DNA. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with damaged DNA. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with damaged DNA. |
2008-05-13 | Added | DEFINITION | Interacting selectively with damaged DNA. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with damaged DNA. |
2007-09-26 | Deleted | SYNONYM | endonuclease VIII activity |
2007-08-09 | Deleted | SYNONYM | DNA repair enzyme |
2007-08-09 | Added | SYNONYM | endonuclease VIII activity |
2007-08-09 | Added | SYNONYM | DNA repair protein |
2007-08-09 | Added | SYNONYM | DNA repair enzyme |
2007-08-09 | Deleted | SYNONYM | endonuclease VIII activity |
2007-08-09 | Deleted | SYNONYM | DNA repair protein |
2005-08-10 | Added | SYNONYM | DNA repair protein |
2005-08-10 | Added | SYNONYM | endonuclease VIII activity |
2005-08-10 | Added | SYNONYM | DNA repair enzyme |
2003-03-26 | Added | DEFINITION | Interacting selectively with damaged DNA. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-03-06 | Added | RELATION | has part GO:0140612 (DNA damage sensor activity) |
2008-04-01 | Updated | RELATION | is a GO:0003677 (DNA binding) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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