GO:0003746
JSON
translation elongation factor activity
Molecular Function
Definition (GO:0003746 GONUTS page)
Functions in chain elongation during polypeptide synthesis at the ribosome.
Secondary IDs
GO:0008182, GO:0008183
Ancestor Chart
Ancestor chart for GO:0003746
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0003746 | translation elongation factor activity | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2K9J3 | 10116 | A0A0G2K9J3_RAT | GO:0003746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZWL9 | 10116 | A0A8I5ZWL9_RAT | GO:0003746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AJA2 | 10116 | A0A8I6AJA2_RAT | GO:0003746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JIT1 | 10116 | A6JIT1_RAT | GO:0003746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JIT2 | 10116 | A6JIT2_RAT | GO:0003746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JIT3 | 10116 | A6JIT3_RAT | GO:0003746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4ABV1 | 10116 | D4ABV1_RAT | GO:0003746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q5BJP6 | 10116 | RRF2M_RAT | GO:0003746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q5M809 | 10116 | Q5M809_RAT | GO:0003746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q969S9 | 9606 | RRF2M_HUMAN | GO:0003746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:19716793 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001059 | Translation elongation factor P/YeiP, central |
InterPro | IPR001326 | Translation elongation factor EF1B, beta/delta chains, conserved site |
InterPro | IPR001662 | Elongation factor 1B gamma, C-terminal |
InterPro | IPR001816 | Translation elongation factor EFTs/EF1B |
InterPro | IPR001884 | Translation elongation factor IF5A-like |
InterPro | IPR004535 | Translation elongation factor, selenocysteine-specific |
InterPro | IPR004539 | Translation elongation factor EF1A, eukaryotic/archaeal |
InterPro | IPR004540 | Translation elongation factor EFG/EF2 |
InterPro | IPR004541 | Translation elongation factor EFTu/EF1A, bacterial/organelle |
InterPro | IPR004542 | Translation elongation factor EF1B, beta chain, archaeal |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0016147 | obsolete protein-synthesizing GTPase activity, elongation | consider GO:0003746 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003746 based on ALL annotations
The top 100 of 2,034 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
translation elongation factor activity
|
340.98 | 100.00 | 581,134 | 581,134 |
translational elongation
|
335.05 | 97.53 | 576,714 | 586,925 |
GTPase activity
|
66.65 | 16.66 | 308,300 | 1,577,317 |
GTP binding
|
46.09 | 12.34 | 341,129 | 2,523,530 |
ribosome disassembly
|
171.60 | 10.77 | 70,030 | 139,154 |
regulation of DNA-templated transcription elongation
|
170.57 | 9.34 | 59,842 | 119,626 |
RNA polymerase binding
|
257.87 | 9.33 | 55,871 | 73,877 |
DNA-templated transcription elongation
|
157.06 | 9.18 | 59,750 | 129,716 |
peptide biosynthetic process
|
338.24 | 8.07 | 46,937 | 47,317 |
positive regulation of translation
|
167.32 | 6.79 | 42,433 | 86,472 |
Totals | 3381757 | 181436644 |
No co-occurrence statistics for GO:0003746 based on MANUAL annotations
The top 100 of 228 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
translation elongation factor activity
|
774.72 | 100.00 | 1,822 | 1,822 |
translational elongation
|
576.74 | 50.27 | 1,107 | 1,487 |
mitochondrial translational elongation
|
690.74 | 27.07 | 510 | 572 |
ribosome binding
|
62.20 | 5.10 | 224 | 2,790 |
GTPase activity
|
37.93 | 4.58 | 761 | 15,544 |
translation
|
41.34 | 4.36 | 351 | 6,577 |
ribonucleoprotein complex
|
39.93 | 3.81 | 232 | 4,501 |
selenocysteine incorporation
|
245.41 | 2.64 | 51 | 161 |
eukaryotic translation elongation factor 1 complex
|
659.94 | 1.26 | 23 | 27 |
cytoplasmic translational elongation
|
130.40 | 0.89 | 17 | 101 |
Totals | 6393 | 540091 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2019-04-01 | Added | XREF | Reactome:R-HSA-192841 |
2019-04-01 | Added | XREF | Reactome:R-HSA-192704 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-192841 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-192704 |
2018-12-11 | Added | XREF | reactome:R-HSA-192841 |
2018-12-11 | Added | XREF | reactome:R-HSA-192704 |
2010-06-15 | Added | RELATION | part of GO:0006414 (translational elongation) |
2010-06-14 | Deleted | RELATION | part of GO:0006414 (translational elongation) |
2010-06-08 | Added | RELATION | part of GO:0006414 (translational elongation) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | translation elongation factor activity |
2002-02-06 | Updated | TERM | translation elongation factor |
2001-04-03 | Updated | TERM | translation elongation factor |
2001-03-30 | Added | TERM | translation elongation factor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Functions in chain elongation during polypeptide synthesis at the ribosome. |
2008-05-12 | Deleted | DEFINITION | Functions in chain elongation during polypeptide synthesis at the ribosome. |
2007-07-11 | Deleted | SYNONYM | protein-synthesizing GTPase activity, elongation |
2005-08-10 | Added | SYNONYM | protein-synthesizing GTPase activity, elongation |
2003-07-24 | Updated | DEFINITION | Functions in chain elongation during polypeptide synthesis at the ribosome. |
2002-11-27 | Updated | DEFINITION | Any of a group of soluble proteins required for chain elongation during polypeptide synthesis at the ribosome. |
2001-08-06 | Added | DEFINITION | any member of a group of soluble proteins required for chain elongation during polypeptide synthesis at the ribosome. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-06-15 | Added | RELATION | part of GO:0006414 (translational elongation) |
2010-06-14 | Deleted | RELATION | part of GO:0006414 (translational elongation) |
2010-06-08 | Added | RELATION | part of GO:0006414 (translational elongation) |
2008-04-01 | Updated | RELATION | is a GO:0008135 (translation factor activity, RNA binding) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-192841 |
2019-04-01 | Added | XREF | Reactome:R-HSA-192704 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-192841 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-192704 |
2018-12-11 | Added | XREF | reactome:R-HSA-192841 |
2018-12-11 | Added | XREF | reactome:R-HSA-192704 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
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