GO:0003755
JSON
peptidyl-prolyl cis-trans isomerase activity
Molecular Function
Definition (GO:0003755 GONUTS page)
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
Secondary IDs
GO:0004752, GO:0042028
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cyclophilin-type peptidyl-prolyl cis-trans isomerase activity | narrow |
juglone-sensitive cis-trans proline isomerase activity | narrow |
cyclophilin activity | related |
peptide bond isomerase activity | related |
peptidylprolyl isomerase activity | related |
peptidyl-prolyl isomerase B reaction | related |
parvulin | related |
immunophilin | related |
PPIase activity | related |
peptidylprolyl cis-trans isomerase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0003755
Child Term | Relationship to GO:0003755 |
---|---|
RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5YC36 | 10116 | A0A8I5YC36_RAT | GO:0003755 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZXY2 | 10116 | A0A8I5ZXY2_RAT | GO:0003755 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A7U0 | 10116 | A0A8I6A7U0_RAT | GO:0003755 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AIX4 | 10116 | A0A8I6AIX4_RAT | GO:0003755 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ARD8 | 10116 | A0A8I6ARD8_RAT | GO:0003755 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J7T8 | 10116 | A6J7T8_RAT | GO:0003755 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JSN3 | 10116 | A6JSN3_RAT | GO:0003755 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JSN4 | 10116 | A6JSN4_RAT | GO:0003755 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JSN5 | 10116 | A6JSN5_RAT | GO:0003755 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JSN6 | 10116 | A6JSN6_RAT | GO:0003755 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 5.2.1.8 | |
InterPro | IPR000297 | Peptidyl-prolyl cis-trans isomerase, PpiC-type |
InterPro | IPR001179 | FKBP-type peptidyl-prolyl cis-trans isomerase domain |
InterPro | IPR002130 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
InterPro | IPR008104 | Macrophage infectivity potentiator |
InterPro | IPR016304 | Peptidyl-prolyl cis-trans isomerase E |
InterPro | IPR020892 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site |
InterPro | IPR023034 | Peptidyl-prolyl isomerase SurA |
InterPro | IPR023059 | Foldase protein PrsA |
InterPro | IPR023566 | Peptidyl-prolyl cis-trans isomerase Fpr3/Fpr4-like |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:83833 | peptidylproline (omega=0) residue |
has_participant | CHEBI | CHEBI:83834 | peptidylproline (omega=180) residue |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0004600 | obsolete cyclophilin | consider GO:0003755 |
GO:0006460 | obsolete peptidyl-prolyl isomerase B reaction | consider GO:0003755 |
GO:0030051 | obsolete FK506-sensitive peptidyl-prolyl cis-trans isomerase | consider GO:0003755 |
GO:0030053 | obsolete immunophilin | consider GO:0003755 |
GO:0042027 | obsolete cyclophilin-type peptidyl-prolyl cis-trans isomerase activity | consider GO:0003755 |
GO:0030052 | obsolete parvulin | replaced_by GO:0003755 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003755 based on ALL annotations
The top 100 of 2,910 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
peptidyl-prolyl cis-trans isomerase activity
|
423.23 | 100.00 | 468,194 | 468,194 |
RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
|
421.23 | 47.63 | 223,527 | 224,589 |
RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
|
421.23 | 47.63 | 223,527 | 224,589 |
protein folding
|
87.11 | 16.41 | 209,284 | 1,016,795 |
chaperone-mediated protein folding
|
161.68 | 9.01 | 49,381 | 129,263 |
regulation of transcription by RNA polymerase II
|
40.85 | 8.73 | 223,444 | 2,314,777 |
cyclosporin A binding
|
423.22 | 8.49 | 39,760 | 39,761 |
'de novo' cotranslational protein folding
|
338.44 | 8.19 | 39,141 | 48,947 |
protein unfolding
|
217.85 | 7.75 | 39,141 | 76,043 |
protein folding chaperone
|
114.82 | 7.14 | 41,380 | 152,527 |
Totals | 2327166 | 172033984 |
No co-occurrence statistics for GO:0003755 based on MANUAL annotations
The top 100 of 540 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
peptidyl-prolyl cis-trans isomerase activity
|
430.21 | 100.00 | 3,281 | 3,281 |
cyclosporin A binding
|
430.21 | 39.80 | 1,306 | 1,306 |
protein folding
|
74.14 | 14.94 | 1,734 | 10,062 |
chaperone-mediated protein folding
|
179.37 | 13.42 | 542 | 1,300 |
protein unfolding
|
167.36 | 4.61 | 163 | 419 |
'de novo' cotranslational protein folding
|
154.46 | 4.56 | 163 | 454 |
protein tyrosine phosphatase activator activity
|
366.48 | 4.18 | 138 | 162 |
catalytic step 2 spliceosome
|
24.08 | 3.52 | 285 | 5,091 |
protein phosphatase type 2A complex
|
53.78 | 3.25 | 138 | 1,104 |
intracellular membrane-bounded organelle
|
15.80 | 2.99 | 455 | 12,391 |
Totals | 13089 | 691996 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Deleted | RELATION | part of GO:0000413 (protein peptidyl-prolyl isomerization) |
2020-10-08 | Deleted | SYNONYM | peptide bond isomerase activity |
2020-10-08 | Deleted | SYNONYM | peptidylproline cis-trans-isomerase activity |
2020-10-08 | Deleted | SYNONYM | peptidylprolyl isomerase activity |
2020-10-08 | Added | SYNONYM | rotamase activity |
2020-10-08 | Added | SYNONYM | peptidylprolyl isomerase activity |
2020-10-08 | Deleted | SYNONYM | peptidylprolyl cis-trans isomerase activity |
2020-10-08 | Deleted | SYNONYM | rotamase activity |
2020-10-08 | Added | SYNONYM | peptidylproline cis-trans-isomerase activity |
2020-10-08 | Added | SYNONYM | PPIase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | peptidyl-prolyl cis-trans isomerase activity |
2002-06-05 | Added | TERM | peptidyl-prolyl cis-trans isomerase |
2002-05-30 | Deleted | TERM | peptidylprolyl cis-trans isomerase |
2002-02-13 | Updated | TERM | peptidylprolyl cis-trans isomerase |
2002-02-06 | Updated | TERM | peptidyl-prolyl isomerase |
2001-11-07 | Updated | TERM | peptidyl-prolyl isomerase |
2001-04-03 | Updated | TERM | peptidylprolyl isomerase |
2001-03-30 | Added | TERM | peptidylprolyl isomerase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | peptide bond isomerase activity |
2020-10-08 | Deleted | SYNONYM | peptidylproline cis-trans-isomerase activity |
2020-10-08 | Deleted | SYNONYM | peptidylprolyl isomerase activity |
2020-10-08 | Added | SYNONYM | rotamase activity |
2020-10-08 | Added | SYNONYM | peptidylprolyl isomerase activity |
2020-10-08 | Deleted | SYNONYM | peptidylprolyl cis-trans isomerase activity |
2020-10-08 | Deleted | SYNONYM | rotamase activity |
2020-10-08 | Added | SYNONYM | peptidylproline cis-trans-isomerase activity |
2020-10-08 | Added | SYNONYM | PPIase activity |
2020-10-08 | Added | SYNONYM | peptide bond isomerase activity |
2020-10-08 | Added | SYNONYM | peptidylprolyl cis-trans isomerase activity |
2020-10-08 | Deleted | SYNONYM | PPIase activity |
2009-04-29 | Added | SYNONYM | juglone-sensitive cis-trans proline isomerase activity |
2009-04-29 | Added | SYNONYM | juglone-sensitive peptidyl-prolyl cis-trans isomerase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). |
2007-12-14 | Added | SYNONYM | peptide bond isomerase activity |
2007-12-14 | Added | SYNONYM | peptidylproline cis-trans-isomerase activity |
2007-12-14 | Added | SYNONYM | peptidylprolyl isomerase activity |
2007-09-06 | Deleted | SYNONYM | rotamase |
2007-09-06 | Added | SYNONYM | PPIase activity |
2007-09-06 | Added | SYNONYM | peptidylprolyl cis-trans isomerase activity |
2007-09-06 | Added | SYNONYM | rotamase activity |
2007-09-06 | Deleted | SYNONYM | PPIase |
2007-09-06 | Deleted | SYNONYM | cyclophilin |
2007-09-06 | Added | SYNONYM | cyclophilin activity |
2007-08-09 | Added | SYNONYM | FK506-sensitive peptidyl-prolyl cis-trans isomerase |
2007-08-09 | Added | SYNONYM | PPIase |
2007-08-09 | Added | SYNONYM | cis-trans proline isomerase activity |
2007-08-09 | Added | SYNONYM | cyclophilin |
2007-08-09 | Added | SYNONYM | cyclophilin-type peptidyl-prolyl cis-trans isomerase activity |
2007-08-09 | Added | SYNONYM | immunophilin |
2007-08-09 | Added | SYNONYM | parvulin |
2007-08-09 | Added | SYNONYM | peptidyl-prolyl isomerase B reaction |
2007-08-09 | Added | SYNONYM | rotamase |
2007-08-09 | Deleted | SYNONYM | FK506-sensitive peptidyl-prolyl cis-trans isomerase |
2007-08-09 | Deleted | SYNONYM | PPIase |
2007-08-09 | Deleted | SYNONYM | cis-trans proline isomerase activity |
2007-08-09 | Deleted | SYNONYM | cyclophilin |
2007-08-09 | Deleted | SYNONYM | cyclophilin-type peptidyl-prolyl cis-trans isomerase activity |
2007-08-09 | Deleted | SYNONYM | immunophilin |
2007-08-09 | Deleted | SYNONYM | parvulin |
2007-08-09 | Deleted | SYNONYM | peptidyl-prolyl isomerase B reaction |
2007-08-09 | Deleted | SYNONYM | rotamase |
2006-09-29 | Added | SYNONYM | cis-trans proline isomerase activity |
2005-08-10 | Added | SYNONYM | cyclophilin |
2005-08-10 | Added | SYNONYM | FK506-sensitive peptidyl-prolyl cis-trans isomerase |
2005-08-10 | Added | SYNONYM | immunophilin |
2005-08-10 | Added | SYNONYM | parvulin |
2005-08-10 | Added | SYNONYM | peptidyl-prolyl isomerase B reaction |
2005-08-10 | Added | SYNONYM | cyclophilin-type peptidyl-prolyl cis-trans isomerase activity |
2004-04-19 | Added | SYNONYM | rotamase |
2004-04-19 | Added | SYNONYM | PPIase |
2004-04-16 | Deleted | SYNONYM | PPIase |
2004-04-16 | Deleted | SYNONYM | rotamase |
2003-10-27 | Added | SYNONYM | PPIase |
2003-10-27 | Added | SYNONYM | rotamase |
2003-08-21 | Deleted | SYNONYM | rotamase |
2003-08-21 | Deleted | SYNONYM | PPIase |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). |
2002-06-05 | Added | SYNONYM | PPIase |
2002-06-05 | Added | SYNONYM | rotamase |
2002-05-30 | Deleted | SYNONYM | rotamase |
2002-05-30 | Deleted | SYNONYM | PPIase |
2001-06-21 | Added | SYNONYM | PPIase |
2001-06-21 | Added | SYNONYM | rotamase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Deleted | RELATION | part of GO:0000413 (protein peptidyl-prolyl isomerization) |
2017-09-19 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2011-04-07 | Added | RELATION | part of GO:0000413 (protein peptidyl-prolyl isomerization) |
2008-04-01 | Updated | RELATION | is a GO:0016859 (cis-trans isomerase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:16237 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-9626816 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2022073 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2022073 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9626816 |
2019-02-09 | Added | XREF | reactome:R-HSA-9626816 |
2019-01-29 | Deleted | XREF | reactome:R-HSA-9626816 |
2019-01-26 | Added | XREF | reactome:R-HSA-9626816 |
2018-12-11 | Added | XREF | reactome:R-HSA-2022073 |
2003-10-27 | Added | XREF | MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN |
2002-06-05 | Added | XREF | EC:5.2.1.8 |
2002-05-30 | Deleted | XREF | EC:5.2.1.8 |
2001-03-30 | Added | XREF | EC:5.2.1.8 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-04-29 | Added | SECONDARY | GO:0042028 (juglone-sensitive peptidyl-prolyl cis-trans isomerase activity) |
2002-06-05 | Added | SECONDARY | GO:0004752 (rotamase) |
2002-05-30 | Deleted | SECONDARY | GO:0004752 (rotamase) |
2001-06-21 | Added | SECONDARY | GO:0004752 (rotamase) |
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