This term is obsolete.

GO:0003755 JSON

peptidyl-prolyl cis-trans isomerase activity

Molecular Function

Definition (GO:0003755 GONUTS page)

Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

Secondary IDs

GO:0004752, GO:0042028

920,757 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cyclophilin-type peptidyl-prolyl cis-trans isomerase activity narrow
juglone-sensitive cis-trans proline isomerase activity narrow
cyclophilin activity related
peptide bond isomerase activity related
peptidylprolyl isomerase activity related
peptidyl-prolyl isomerase B reaction related
parvulin related
immunophilin related
PPIase activity related
peptidylprolyl cis-trans isomerase activity related

Ancestor Chart

Ancestor chart for GO:0003755
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003755

Child Term Relationship to
GO:0003755
RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5YC36 10116 A0A8I5YC36_RAT GO:0003755 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZXY2 10116 A0A8I5ZXY2_RAT GO:0003755 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A7U0 10116 A0A8I6A7U0_RAT GO:0003755 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AIX4 10116 A0A8I6AIX4_RAT GO:0003755 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ARD8 10116 A0A8I6ARD8_RAT GO:0003755 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J7T8 10116 A6J7T8_RAT GO:0003755 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JSN3 10116 A6JSN3_RAT GO:0003755 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JSN4 10116 A6JSN4_RAT GO:0003755 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JSN5 10116 A6JSN5_RAT GO:0003755 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JSN6 10116 A6JSN6_RAT GO:0003755 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 5.2.1.8
InterPro IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type
InterPro IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
InterPro IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
InterPro IPR008104 Macrophage infectivity potentiator
InterPro IPR016304 Peptidyl-prolyl cis-trans isomerase E
InterPro IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
InterPro IPR023034 Peptidyl-prolyl isomerase SurA
InterPro IPR023059 Foldase protein PrsA
InterPro IPR023566 Peptidyl-prolyl cis-trans isomerase Fpr3/Fpr4-like

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:83833 peptidylproline (omega=0) residue
has_participant CHEBI CHEBI:83834 peptidylproline (omega=180) residue

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0004600 obsolete cyclophilin consider GO:0003755
GO:0006460 obsolete peptidyl-prolyl isomerase B reaction consider GO:0003755
GO:0030051 obsolete FK506-sensitive peptidyl-prolyl cis-trans isomerase consider GO:0003755
GO:0030053 obsolete immunophilin consider GO:0003755
GO:0042027 obsolete cyclophilin-type peptidyl-prolyl cis-trans isomerase activity consider GO:0003755
GO:0030052 obsolete parvulin replaced_by GO:0003755

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003755 based on ALL annotations
The top 100 of 2,910 co-occurring terms
Co-occurring Term PR S% #Together #Compared
peptidyl-prolyl cis-trans isomerase activity
423.23 100.00 468,194 468,194
RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
421.23 47.63 223,527 224,589
RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
421.23 47.63 223,527 224,589
protein folding
87.11 16.41 209,284 1,016,795
chaperone-mediated protein folding
161.68 9.01 49,381 129,263
regulation of transcription by RNA polymerase II
40.85 8.73 223,444 2,314,777
cyclosporin A binding
423.22 8.49 39,760 39,761
'de novo' cotranslational protein folding
338.44 8.19 39,141 48,947
protein unfolding
217.85 7.75 39,141 76,043
protein folding chaperone
114.82 7.14 41,380 152,527
Totals 2327166 172033984
No co-occurrence statistics for GO:0003755 based on MANUAL annotations
The top 100 of 540 co-occurring terms
Co-occurring Term PR S% #Together #Compared
peptidyl-prolyl cis-trans isomerase activity
430.21 100.00 3,281 3,281
cyclosporin A binding
430.21 39.80 1,306 1,306
protein folding
74.14 14.94 1,734 10,062
chaperone-mediated protein folding
179.37 13.42 542 1,300
protein unfolding
167.36 4.61 163 419
'de novo' cotranslational protein folding
154.46 4.56 163 454
protein tyrosine phosphatase activator activity
366.48 4.18 138 162
catalytic step 2 spliceosome
24.08 3.52 285 5,091
protein phosphatase type 2A complex
53.78 3.25 138 1,104
intracellular membrane-bounded organelle
15.80 2.99 455 12,391
Totals 13089 691996

Change Log

Timestamp Action Category Detail
2022-02-17 Deleted RELATION part of GO:0000413 (protein peptidyl-prolyl isomerization)
2020-10-08 Deleted SYNONYM peptide bond isomerase activity
2020-10-08 Deleted SYNONYM peptidylproline cis-trans-isomerase activity
2020-10-08 Deleted SYNONYM peptidylprolyl isomerase activity
2020-10-08 Added SYNONYM rotamase activity
2020-10-08 Added SYNONYM peptidylprolyl isomerase activity
2020-10-08 Deleted SYNONYM peptidylprolyl cis-trans isomerase activity
2020-10-08 Deleted SYNONYM rotamase activity
2020-10-08 Added SYNONYM peptidylproline cis-trans-isomerase activity
2020-10-08 Added SYNONYM PPIase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM peptidyl-prolyl cis-trans isomerase activity
2002-06-05 Added TERM peptidyl-prolyl cis-trans isomerase
2002-05-30 Deleted TERM peptidylprolyl cis-trans isomerase
2002-02-13 Updated TERM peptidylprolyl cis-trans isomerase
2002-02-06 Updated TERM peptidyl-prolyl isomerase
2001-11-07 Updated TERM peptidyl-prolyl isomerase
2001-04-03 Updated TERM peptidylprolyl isomerase
2001-03-30 Added TERM peptidylprolyl isomerase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM peptide bond isomerase activity
2020-10-08 Deleted SYNONYM peptidylproline cis-trans-isomerase activity
2020-10-08 Deleted SYNONYM peptidylprolyl isomerase activity
2020-10-08 Added SYNONYM rotamase activity
2020-10-08 Added SYNONYM peptidylprolyl isomerase activity
2020-10-08 Deleted SYNONYM peptidylprolyl cis-trans isomerase activity
2020-10-08 Deleted SYNONYM rotamase activity
2020-10-08 Added SYNONYM peptidylproline cis-trans-isomerase activity
2020-10-08 Added SYNONYM PPIase activity
2020-10-08 Added SYNONYM peptide bond isomerase activity
2020-10-08 Added SYNONYM peptidylprolyl cis-trans isomerase activity
2020-10-08 Deleted SYNONYM PPIase activity
2009-04-29 Added SYNONYM juglone-sensitive cis-trans proline isomerase activity
2009-04-29 Added SYNONYM juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
2007-12-14 Added SYNONYM peptide bond isomerase activity
2007-12-14 Added SYNONYM peptidylproline cis-trans-isomerase activity
2007-12-14 Added SYNONYM peptidylprolyl isomerase activity
2007-09-06 Deleted SYNONYM rotamase
2007-09-06 Added SYNONYM PPIase activity
2007-09-06 Added SYNONYM peptidylprolyl cis-trans isomerase activity
2007-09-06 Added SYNONYM rotamase activity
2007-09-06 Deleted SYNONYM PPIase
2007-09-06 Deleted SYNONYM cyclophilin
2007-09-06 Added SYNONYM cyclophilin activity
2007-08-09 Added SYNONYM FK506-sensitive peptidyl-prolyl cis-trans isomerase
2007-08-09 Added SYNONYM PPIase
2007-08-09 Added SYNONYM cis-trans proline isomerase activity
2007-08-09 Added SYNONYM cyclophilin
2007-08-09 Added SYNONYM cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
2007-08-09 Added SYNONYM immunophilin
2007-08-09 Added SYNONYM parvulin
2007-08-09 Added SYNONYM peptidyl-prolyl isomerase B reaction
2007-08-09 Added SYNONYM rotamase
2007-08-09 Deleted SYNONYM FK506-sensitive peptidyl-prolyl cis-trans isomerase
2007-08-09 Deleted SYNONYM PPIase
2007-08-09 Deleted SYNONYM cis-trans proline isomerase activity
2007-08-09 Deleted SYNONYM cyclophilin
2007-08-09 Deleted SYNONYM cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
2007-08-09 Deleted SYNONYM immunophilin
2007-08-09 Deleted SYNONYM parvulin
2007-08-09 Deleted SYNONYM peptidyl-prolyl isomerase B reaction
2007-08-09 Deleted SYNONYM rotamase
2006-09-29 Added SYNONYM cis-trans proline isomerase activity
2005-08-10 Added SYNONYM cyclophilin
2005-08-10 Added SYNONYM FK506-sensitive peptidyl-prolyl cis-trans isomerase
2005-08-10 Added SYNONYM immunophilin
2005-08-10 Added SYNONYM parvulin
2005-08-10 Added SYNONYM peptidyl-prolyl isomerase B reaction
2005-08-10 Added SYNONYM cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
2004-04-19 Added SYNONYM rotamase
2004-04-19 Added SYNONYM PPIase
2004-04-16 Deleted SYNONYM PPIase
2004-04-16 Deleted SYNONYM rotamase
2003-10-27 Added SYNONYM PPIase
2003-10-27 Added SYNONYM rotamase
2003-08-21 Deleted SYNONYM rotamase
2003-08-21 Deleted SYNONYM PPIase
2002-11-27 Added DEFINITION Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
2002-06-05 Added SYNONYM PPIase
2002-06-05 Added SYNONYM rotamase
2002-05-30 Deleted SYNONYM rotamase
2002-05-30 Deleted SYNONYM PPIase
2001-06-21 Added SYNONYM PPIase
2001-06-21 Added SYNONYM rotamase
Timestamp Action Category Detail
2022-02-17 Deleted RELATION part of GO:0000413 (protein peptidyl-prolyl isomerization)
2017-09-19 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2011-04-07 Added RELATION part of GO:0000413 (protein peptidyl-prolyl isomerization)
2008-04-01 Updated RELATION is a GO:0016859 (cis-trans isomerase activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:16237
2019-04-01 Deleted XREF reactome:R-HSA-9626816
2019-04-01 Deleted XREF reactome:R-HSA-2022073
2019-04-01 Added XREF Reactome:R-HSA-2022073
2019-04-01 Added XREF Reactome:R-HSA-9626816
2019-02-09 Added XREF reactome:R-HSA-9626816
2019-01-29 Deleted XREF reactome:R-HSA-9626816
2019-01-26 Added XREF reactome:R-HSA-9626816
2018-12-11 Added XREF reactome:R-HSA-2022073
2003-10-27 Added XREF MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN
2002-06-05 Added XREF EC:5.2.1.8
2002-05-30 Deleted XREF EC:5.2.1.8
2001-03-30 Added XREF EC:5.2.1.8
Timestamp Action Category Detail
2009-04-29 Added SECONDARY GO:0042028 (juglone-sensitive peptidyl-prolyl cis-trans isomerase activity)
2002-06-05 Added SECONDARY GO:0004752 (rotamase)
2002-05-30 Deleted SECONDARY GO:0004752 (rotamase)
2001-06-21 Added SECONDARY GO:0004752 (rotamase)
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