This term is obsolete.

GO:0003848 JSON

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity

Molecular Function

Definition (GO:0003848 GONUTS page)

Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+.

47,039 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity related
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity related
ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity related
H2-pteridine-CH2OH pyrophosphokinase activity related
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity exact
hydroxymethyldihydropteridine pyrophosphokinase activity related
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity related
HPPK related
7,8-dihydroxymethylpterin-pyrophosphokinase activity related
6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity related

Ancestor Chart

Ancestor chart for GO:0003848
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.7.6.3
InterPro IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK
InterPro IPR016261 Folic acid synthesis protein FOL1
InterPro IPR027510 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, MptE
KEGG_REACTION R03503
MetaCyc H2PTERIDINEPYROPHOSPHOKIN-RXN
RHEA 11412

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:456215 adenosine 5'-monophosphate(2-)
has_participant CHEBI CHEBI:72950 (7,8-dihydropterin-6-yl)methyl diphosphate(3-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:44841 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-one

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003848 based on ALL annotations
The top 100 of 290 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
4,144.72 100.00 47,033 47,033
folic acid biosynthetic process
1,301.13 30.98 45,124 143,742
folic acid-containing compound biosynthetic process
827.72 19.75 44,545 223,055
tetrahydrofolate biosynthetic process
717.26 16.59 37,668 217,667
dihydroneopterin aldolase activity
291.67 3.30 2,752 39,107
dihydropteroate synthase activity
248.82 3.21 3,028 50,438
mitochondrial envelope
287.56 2.62 1,895 27,313
thiamine diphosphokinase activity
201.85 1.64 1,138 23,367
tetrahydromethanopterin biosynthetic process
895.67 0.93 451 2,087
kinase activity
36.87 0.89 46,434 5,220,332
Totals 287755 129697634
No co-occurrence statistics for GO:0003848 based on MANUAL annotations
The top 11 of 11 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
258,359.80 100.00 5 5
folic acid biosynthetic process
20,668.79 7.14 2 25
dihydropteroate synthase activity
8,908.96 3.42 4 116
dihydroneopterin aldolase activity
5,016.70 1.89 2 103
tetrahydrofolate biosynthetic process
3,312.31 1.27 3 234
mitochondrial envelope
2,425.91 0.93 2 213
magnesium ion binding
176.29 0.07 2 2,931
response to oxidative stress
141.80 0.05 1 1,822
mitochondrion
11.28 0.00 2 45,791
cytosol
6.14 0.00 2 84,217
Totals 27 314846

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+).
2022-09-01 Added DEFINITION Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+.
2020-10-08 Added SYNONYM 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity
2020-10-08 Added SYNONYM H2-pteridine-CH2OH pyrophosphokinase activity
2020-10-08 Added SYNONYM ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity
2020-10-08 Deleted SYNONYM hydroxymethyldihydropteridine pyrophosphokinase activity
2020-10-08 Deleted SYNONYM H2-pteridine-CH2OH pyrophosphokinase activity
2020-10-08 Deleted SYNONYM ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity
2020-10-08 Deleted SYNONYM 7,8-dihydroxymethylpterin-pyrophosphokinase activity
2020-10-08 Deleted SYNONYM 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity
Timestamp Action Category Detail
2003-09-09 Updated TERM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
2003-03-19 Updated TERM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity
2002-02-06 Updated TERM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
2001-04-03 Updated TERM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
2001-03-30 Added TERM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+).
2022-09-01 Added DEFINITION Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+.
2020-10-08 Added SYNONYM 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity
2020-10-08 Added SYNONYM H2-pteridine-CH2OH pyrophosphokinase activity
2020-10-08 Added SYNONYM ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity
2020-10-08 Deleted SYNONYM hydroxymethyldihydropteridine pyrophosphokinase activity
2020-10-08 Deleted SYNONYM H2-pteridine-CH2OH pyrophosphokinase activity
2020-10-08 Deleted SYNONYM ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity
2020-10-08 Deleted SYNONYM 7,8-dihydroxymethylpterin-pyrophosphokinase activity
2020-10-08 Deleted SYNONYM 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity
2020-10-08 Deleted SYNONYM 7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity
2020-10-08 Deleted SYNONYM 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity
2020-10-08 Deleted SYNONYM 6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity
2020-10-08 Added SYNONYM hydroxymethyldihydropteridine pyrophosphokinase activity
2020-10-08 Added SYNONYM 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity
2020-10-08 Added SYNONYM 6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity
2020-10-08 Added SYNONYM 7,8-dihydroxymethylpterin-pyrophosphokinase activity
2020-10-08 Added SYNONYM 7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine.
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine.
2007-11-08 Added SYNONYM HPPK
2007-11-08 Added SYNONYM hydroxymethyldihydropteridine pyrophosphokinase activity
2007-11-08 Added SYNONYM 7,8-dihydroxymethylpterin-pyrophosphokinase activity
2007-11-08 Added SYNONYM ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity
2007-11-08 Added SYNONYM H2-pteridine-CH2OH pyrophosphokinase activity
2007-09-06 Added SYNONYM 6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity
2007-09-06 Added SYNONYM 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity
2007-09-06 Added SYNONYM 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity
2007-09-06 Added SYNONYM 7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity
2007-08-09 Added SYNONYM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity
2007-08-09 Deleted SYNONYM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity
2004-04-19 Added SYNONYM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity
2004-04-16 Deleted SYNONYM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity
2003-10-27 Added SYNONYM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine.
Timestamp Action Category Detail
2008-06-20 Deleted RELATION is a GO:0016301 (kinase activity)
2008-04-01 Updated RELATION is a GO:0016778 (diphosphotransferase activity)
2008-04-01 Updated RELATION is a GO:0016301 (kinase activity)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R03503
2019-06-20 Added XREF KEGG_REACTION:R03503
2018-07-13 Added XREF RHEA:11412
2018-07-13 Deleted XREF RHEA:11415
2010-10-11 Added XREF KEGG:R03503
2010-10-11 Added XREF RHEA:11415
2003-10-27 Added XREF MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN
2001-03-30 Added XREF EC:2.7.6.3
Timestamp Action Category Detail
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
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