GO:0003848
JSON
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
Molecular Function
Definition (GO:0003848 GONUTS page)
Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity | related |
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity | related |
ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity | related |
H2-pteridine-CH2OH pyrophosphokinase activity | related |
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity | exact |
hydroxymethyldihydropteridine pyrophosphokinase activity | related |
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity | related |
HPPK | related |
7,8-dihydroxymethylpterin-pyrophosphokinase activity | related |
6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.6.3 | |
InterPro | IPR000550 | 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK |
InterPro | IPR016261 | Folic acid synthesis protein FOL1 |
InterPro | IPR027510 | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, MptE |
KEGG_REACTION | R03503 | |
MetaCyc | H2PTERIDINEPYROPHOSPHOKIN-RXN | |
RHEA | 11412 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:456215 | adenosine 5'-monophosphate(2-) |
has_participant | CHEBI | CHEBI:72950 | (7,8-dihydropterin-6-yl)methyl diphosphate(3-) |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:44841 | 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-one |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003848 based on ALL annotations
The top 100 of 290 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
|
4,144.72 | 100.00 | 47,033 | 47,033 |
folic acid biosynthetic process
|
1,301.13 | 30.98 | 45,124 | 143,742 |
folic acid-containing compound biosynthetic process
|
827.72 | 19.75 | 44,545 | 223,055 |
tetrahydrofolate biosynthetic process
|
717.26 | 16.59 | 37,668 | 217,667 |
dihydroneopterin aldolase activity
|
291.67 | 3.30 | 2,752 | 39,107 |
dihydropteroate synthase activity
|
248.82 | 3.21 | 3,028 | 50,438 |
mitochondrial envelope
|
287.56 | 2.62 | 1,895 | 27,313 |
thiamine diphosphokinase activity
|
201.85 | 1.64 | 1,138 | 23,367 |
tetrahydromethanopterin biosynthetic process
|
895.67 | 0.93 | 451 | 2,087 |
kinase activity
|
36.87 | 0.89 | 46,434 | 5,220,332 |
Totals | 287755 | 129697634 |
No co-occurrence statistics for GO:0003848 based on MANUAL annotations
The top 11 of 11 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
|
258,359.80 | 100.00 | 5 | 5 |
folic acid biosynthetic process
|
20,668.79 | 7.14 | 2 | 25 |
dihydropteroate synthase activity
|
8,908.96 | 3.42 | 4 | 116 |
dihydroneopterin aldolase activity
|
5,016.70 | 1.89 | 2 | 103 |
tetrahydrofolate biosynthetic process
|
3,312.31 | 1.27 | 3 | 234 |
mitochondrial envelope
|
2,425.91 | 0.93 | 2 | 213 |
magnesium ion binding
|
176.29 | 0.07 | 2 | 2,931 |
response to oxidative stress
|
141.80 | 0.05 | 1 | 1,822 |
mitochondrion
|
11.28 | 0.00 | 2 | 45,791 |
cytosol
|
6.14 | 0.00 | 2 | 84,217 |
Totals | 27 | 314846 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+. |
2020-10-08 | Added | SYNONYM | 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity |
2020-10-08 | Added | SYNONYM | H2-pteridine-CH2OH pyrophosphokinase activity |
2020-10-08 | Added | SYNONYM | ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity |
2020-10-08 | Deleted | SYNONYM | hydroxymethyldihydropteridine pyrophosphokinase activity |
2020-10-08 | Deleted | SYNONYM | H2-pteridine-CH2OH pyrophosphokinase activity |
2020-10-08 | Deleted | SYNONYM | ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity |
2020-10-08 | Deleted | SYNONYM | 7,8-dihydroxymethylpterin-pyrophosphokinase activity |
2020-10-08 | Deleted | SYNONYM | 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-09 | Updated | TERM | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
2003-03-19 | Updated | TERM | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity |
2002-02-06 | Updated | TERM | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase |
2001-04-03 | Updated | TERM | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase |
2001-03-30 | Added | TERM | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+. |
2020-10-08 | Added | SYNONYM | 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity |
2020-10-08 | Added | SYNONYM | H2-pteridine-CH2OH pyrophosphokinase activity |
2020-10-08 | Added | SYNONYM | ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity |
2020-10-08 | Deleted | SYNONYM | hydroxymethyldihydropteridine pyrophosphokinase activity |
2020-10-08 | Deleted | SYNONYM | H2-pteridine-CH2OH pyrophosphokinase activity |
2020-10-08 | Deleted | SYNONYM | ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity |
2020-10-08 | Deleted | SYNONYM | 7,8-dihydroxymethylpterin-pyrophosphokinase activity |
2020-10-08 | Deleted | SYNONYM | 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity |
2020-10-08 | Deleted | SYNONYM | 7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity |
2020-10-08 | Deleted | SYNONYM | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity |
2020-10-08 | Deleted | SYNONYM | 6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity |
2020-10-08 | Added | SYNONYM | hydroxymethyldihydropteridine pyrophosphokinase activity |
2020-10-08 | Added | SYNONYM | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity |
2020-10-08 | Added | SYNONYM | 6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity |
2020-10-08 | Added | SYNONYM | 7,8-dihydroxymethylpterin-pyrophosphokinase activity |
2020-10-08 | Added | SYNONYM | 7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+). |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine. |
2007-11-08 | Added | SYNONYM | HPPK |
2007-11-08 | Added | SYNONYM | hydroxymethyldihydropteridine pyrophosphokinase activity |
2007-11-08 | Added | SYNONYM | 7,8-dihydroxymethylpterin-pyrophosphokinase activity |
2007-11-08 | Added | SYNONYM | ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity |
2007-11-08 | Added | SYNONYM | H2-pteridine-CH2OH pyrophosphokinase activity |
2007-09-06 | Added | SYNONYM | 6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity |
2007-09-06 | Added | SYNONYM | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity |
2007-09-06 | Added | SYNONYM | 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity |
2007-09-06 | Added | SYNONYM | 7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity |
2007-08-09 | Added | SYNONYM | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity |
2007-08-09 | Deleted | SYNONYM | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity |
2004-04-19 | Added | SYNONYM | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity |
2004-04-16 | Deleted | SYNONYM | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity |
2003-10-27 | Added | SYNONYM | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-06-20 | Deleted | RELATION | is a GO:0016301 (kinase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016778 (diphosphotransferase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016301 (kinase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R03503 |
2019-06-20 | Added | XREF | KEGG_REACTION:R03503 |
2018-07-13 | Added | XREF | RHEA:11412 |
2018-07-13 | Deleted | XREF | RHEA:11415 |
2010-10-11 | Added | XREF | KEGG:R03503 |
2010-10-11 | Added | XREF | RHEA:11415 |
2003-10-27 | Added | XREF | MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN |
2001-03-30 | Added | XREF | EC:2.7.6.3 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
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