This term is obsolete.

GO:0003910 JSON

DNA ligase (ATP) activity

Molecular Function

Definition (GO:0003910 GONUTS page)

Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).

69,691 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
polydeoxyribonucleotide synthase (ATP) activity related
polynucleotide ligase broad
DNA joinase activity broad
DNA repair enzyme activity related
sealase activity related
poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming) related
DNA-joining enzyme related
deoxyribonucleate ligase broad
deoxyribonucleic acid joinase broad
deoxyribonucleic acid ligase broad

Ancestor Chart

Ancestor chart for GO:0003910
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.5.1.1
InterPro IPR000977 DNA ligase, ATP-dependent
InterPro IPR012308 DNA ligase, ATP-dependent, N-terminal
InterPro IPR012309 DNA ligase, ATP-dependent, C-terminal
InterPro IPR012310 DNA ligase, ATP-dependent, central
InterPro IPR016306 DNA ligase, bacteriophage T7-type
InterPro IPR021536 DNA ligase IV domain
InterPro IPR022865 DNA ligase, ATP-dependent, bacterial/archaeal
InterPro IPR029710 DNA ligase 4
InterPro IPR036599 DNA ligase, ATP-dependent, N-terminal domain superfamily

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0018329 obsolete enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine consider GO:0003910

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003910 based on ALL annotations
The top 100 of 645 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA ligase (ATP) activity
2,857.98 100.00 69,334 69,334
lagging strand elongation
2,046.07 19.91 14,992 20,941
DNA ligase IV complex
1,637.56 8.23 6,077 10,606
nucleotide-excision repair, DNA gap filling
728.25 7.30 6,430 25,234
Okazaki fragment processing involved in mitotic DNA replication
2,751.42 5.61 3,899 4,050
double-strand break repair via nonhomologous end joining
242.88 4.70 6,587 77,511
DNA biosynthetic process
129.31 4.28 30,330 670,341
DNA recombination
105.38 3.68 68,235 1,850,625
DNA-dependent protein kinase-DNA ligase 4 complex
1,342.09 3.14 2,255 4,802
DNA ligase III-XRCC1 complex
2,857.98 3.01 2,088 2,088
Totals 575838 109220127
No co-occurrence statistics for GO:0003910 based on MANUAL annotations
The top 100 of 105 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA ligase (ATP) activity
4,411.04 100.00 320 320
lagging strand elongation
2,731.91 45.96 205 331
DNA ligase IV complex
2,003.18 22.55 99 218
Okazaki fragment processing involved in mitotic DNA replication
3,954.73 15.95 52 58
nucleotide-excision repair, DNA gap filling
1,008.53 15.14 99 433
DNA-dependent protein kinase-DNA ligase 4 complex
1,200.28 9.37 40 147
double-strand break repair via nonhomologous end joining
372.47 7.24 108 1,279
double-strand break repair via classical nonhomologous end joining
1,366.80 5.96 22 71
immunoglobulin V(D)J recombination
1,078.25 5.67 22 90
DNA ligase activity
3,632.62 4.33 14 17
Totals 1675 430145

Change Log

Timestamp Action Category Detail
2024-12-28 Deleted XREF Reactome:R-HSA-9914903
2024-12-27 Added XREF Reactome:R-HSA-9914903
2024-12-13 Deleted XREF Reactome:R-HSA-9914903
2024-12-12 Added XREF Reactome:R-HSA-9914903
2020-10-08 Added SYNONYM poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
2020-10-08 Deleted SYNONYM polydeoxyribonucleotide synthase (ATP) activity
2020-10-08 Added SYNONYM polydeoxyribonucleotide synthase (ATP) activity
2020-10-08 Added SYNONYM polynucleotide ligase (ATP) activity
2020-10-08 Deleted SYNONYM poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
2020-10-08 Deleted SYNONYM polynucleotide ligase (ATP) activity
Timestamp Action Category Detail
2003-03-19 Updated TERM DNA ligase (ATP) activity
2002-02-06 Updated TERM DNA ligase (ATP)
2001-04-03 Updated TERM DNA ligase (ATP)
2001-03-30 Added TERM DNA ligase (ATP)
Timestamp Action Category Detail
2020-10-08 Added SYNONYM poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
2020-10-08 Deleted SYNONYM polydeoxyribonucleotide synthase (ATP) activity
2020-10-08 Added SYNONYM polydeoxyribonucleotide synthase (ATP) activity
2020-10-08 Added SYNONYM polynucleotide ligase (ATP) activity
2020-10-08 Deleted SYNONYM poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
2020-10-08 Deleted SYNONYM polynucleotide ligase (ATP) activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
2007-11-08 Added SYNONYM deoxyribonucleic ligase
2007-11-08 Added SYNONYM DNA-joining enzyme
2007-11-08 Added SYNONYM deoxyribonucleic-joining enzyme
2007-11-08 Added SYNONYM poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
2007-11-08 Added SYNONYM deoxyribonucleic acid repair enzyme
2007-11-08 Added SYNONYM deoxyribonucleic acid ligase
2007-11-08 Added SYNONYM deoxyribonucleic acid joinase
2007-11-08 Added SYNONYM deoxyribonucleate ligase
2007-11-08 Added SYNONYM deoxyribonucleic acid-joining enzyme
2007-11-08 Added SYNONYM deoxyribonucleic joinase
2007-11-08 Added SYNONYM deoxyribonucleic repair enzyme
2007-11-08 Added SYNONYM polynucleotide ligase
2007-09-06 Added SYNONYM DNA joinase activity
2007-09-06 Added SYNONYM DNA repair enzyme activity
2007-09-06 Added SYNONYM polynucleotide ligase (ATP) activity
2007-09-06 Added SYNONYM polydeoxyribonucleotide synthase (ATP) activity
2007-09-06 Added SYNONYM sealase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0003909 (DNA ligase activity)
Timestamp Action Category Detail
2024-12-28 Deleted XREF Reactome:R-HSA-9914903
2024-12-27 Added XREF Reactome:R-HSA-9914903
2024-12-13 Deleted XREF Reactome:R-HSA-9914903
2024-12-12 Added XREF Reactome:R-HSA-9914903
2009-05-21 Deleted XREF MetaCyc:DNA-LIGASE-(ATP)-RXN
2009-05-21 Added XREF MetaCyc:DNA-LIGASE-ATP-RXN
2003-10-27 Added XREF MetaCyc:DNA-LIGASE-(ATP)-RXN
2001-03-30 Added XREF EC:6.5.1.1
Timestamp Action Category Detail
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