GO:0003910
JSON
DNA ligase (ATP) activity
Molecular Function
Definition (GO:0003910 GONUTS page)
Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
polydeoxyribonucleotide synthase (ATP) activity | related |
polynucleotide ligase | broad |
DNA joinase activity | broad |
DNA repair enzyme activity | related |
sealase activity | related |
poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming) | related |
DNA-joining enzyme | related |
deoxyribonucleate ligase | broad |
deoxyribonucleic acid joinase | broad |
deoxyribonucleic acid ligase | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.5.1.1 | |
InterPro | IPR000977 | DNA ligase, ATP-dependent |
InterPro | IPR012308 | DNA ligase, ATP-dependent, N-terminal |
InterPro | IPR012309 | DNA ligase, ATP-dependent, C-terminal |
InterPro | IPR012310 | DNA ligase, ATP-dependent, central |
InterPro | IPR016306 | DNA ligase, bacteriophage T7-type |
InterPro | IPR021536 | DNA ligase IV domain |
InterPro | IPR022865 | DNA ligase, ATP-dependent, bacterial/archaeal |
InterPro | IPR029710 | DNA ligase 4 |
InterPro | IPR036599 | DNA ligase, ATP-dependent, N-terminal domain superfamily |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0018329 | obsolete enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine | consider GO:0003910 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003910 based on ALL annotations
The top 100 of 645 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA ligase (ATP) activity
|
2,857.98 | 100.00 | 69,334 | 69,334 |
lagging strand elongation
|
2,046.07 | 19.91 | 14,992 | 20,941 |
DNA ligase IV complex
|
1,637.56 | 8.23 | 6,077 | 10,606 |
nucleotide-excision repair, DNA gap filling
|
728.25 | 7.30 | 6,430 | 25,234 |
Okazaki fragment processing involved in mitotic DNA replication
|
2,751.42 | 5.61 | 3,899 | 4,050 |
double-strand break repair via nonhomologous end joining
|
242.88 | 4.70 | 6,587 | 77,511 |
DNA biosynthetic process
|
129.31 | 4.28 | 30,330 | 670,341 |
DNA recombination
|
105.38 | 3.68 | 68,235 | 1,850,625 |
DNA-dependent protein kinase-DNA ligase 4 complex
|
1,342.09 | 3.14 | 2,255 | 4,802 |
DNA ligase III-XRCC1 complex
|
2,857.98 | 3.01 | 2,088 | 2,088 |
Totals | 575838 | 109220127 |
No co-occurrence statistics for GO:0003910 based on MANUAL annotations
The top 100 of 105 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA ligase (ATP) activity
|
4,411.04 | 100.00 | 320 | 320 |
lagging strand elongation
|
2,731.91 | 45.96 | 205 | 331 |
DNA ligase IV complex
|
2,003.18 | 22.55 | 99 | 218 |
Okazaki fragment processing involved in mitotic DNA replication
|
3,954.73 | 15.95 | 52 | 58 |
nucleotide-excision repair, DNA gap filling
|
1,008.53 | 15.14 | 99 | 433 |
DNA-dependent protein kinase-DNA ligase 4 complex
|
1,200.28 | 9.37 | 40 | 147 |
double-strand break repair via nonhomologous end joining
|
372.47 | 7.24 | 108 | 1,279 |
double-strand break repair via classical nonhomologous end joining
|
1,366.80 | 5.96 | 22 | 71 |
immunoglobulin V(D)J recombination
|
1,078.25 | 5.67 | 22 | 90 |
DNA ligase activity
|
3,632.62 | 4.33 | 14 | 17 |
Totals | 1675 | 430145 |
Change Log
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- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-28 | Deleted | XREF | Reactome:R-HSA-9914903 |
2024-12-27 | Added | XREF | Reactome:R-HSA-9914903 |
2024-12-13 | Deleted | XREF | Reactome:R-HSA-9914903 |
2024-12-12 | Added | XREF | Reactome:R-HSA-9914903 |
2020-10-08 | Added | SYNONYM | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming) |
2020-10-08 | Deleted | SYNONYM | polydeoxyribonucleotide synthase (ATP) activity |
2020-10-08 | Added | SYNONYM | polydeoxyribonucleotide synthase (ATP) activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (ATP) activity |
2020-10-08 | Deleted | SYNONYM | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming) |
2020-10-08 | Deleted | SYNONYM | polynucleotide ligase (ATP) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | DNA ligase (ATP) activity |
2002-02-06 | Updated | TERM | DNA ligase (ATP) |
2001-04-03 | Updated | TERM | DNA ligase (ATP) |
2001-03-30 | Added | TERM | DNA ligase (ATP) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming) |
2020-10-08 | Deleted | SYNONYM | polydeoxyribonucleotide synthase (ATP) activity |
2020-10-08 | Added | SYNONYM | polydeoxyribonucleotide synthase (ATP) activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (ATP) activity |
2020-10-08 | Deleted | SYNONYM | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming) |
2020-10-08 | Deleted | SYNONYM | polynucleotide ligase (ATP) activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). |
2007-11-08 | Added | SYNONYM | deoxyribonucleic ligase |
2007-11-08 | Added | SYNONYM | DNA-joining enzyme |
2007-11-08 | Added | SYNONYM | deoxyribonucleic-joining enzyme |
2007-11-08 | Added | SYNONYM | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming) |
2007-11-08 | Added | SYNONYM | deoxyribonucleic acid repair enzyme |
2007-11-08 | Added | SYNONYM | deoxyribonucleic acid ligase |
2007-11-08 | Added | SYNONYM | deoxyribonucleic acid joinase |
2007-11-08 | Added | SYNONYM | deoxyribonucleate ligase |
2007-11-08 | Added | SYNONYM | deoxyribonucleic acid-joining enzyme |
2007-11-08 | Added | SYNONYM | deoxyribonucleic joinase |
2007-11-08 | Added | SYNONYM | deoxyribonucleic repair enzyme |
2007-11-08 | Added | SYNONYM | polynucleotide ligase |
2007-09-06 | Added | SYNONYM | DNA joinase activity |
2007-09-06 | Added | SYNONYM | DNA repair enzyme activity |
2007-09-06 | Added | SYNONYM | polynucleotide ligase (ATP) activity |
2007-09-06 | Added | SYNONYM | polydeoxyribonucleotide synthase (ATP) activity |
2007-09-06 | Added | SYNONYM | sealase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0003909 (DNA ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-28 | Deleted | XREF | Reactome:R-HSA-9914903 |
2024-12-27 | Added | XREF | Reactome:R-HSA-9914903 |
2024-12-13 | Deleted | XREF | Reactome:R-HSA-9914903 |
2024-12-12 | Added | XREF | Reactome:R-HSA-9914903 |
2009-05-21 | Deleted | XREF | MetaCyc:DNA-LIGASE-(ATP)-RXN |
2009-05-21 | Added | XREF | MetaCyc:DNA-LIGASE-ATP-RXN |
2003-10-27 | Added | XREF | MetaCyc:DNA-LIGASE-(ATP)-RXN |
2001-03-30 | Added | XREF | EC:6.5.1.1 |
Timestamp | Action | Category | Detail |
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