GO:0003938
JSON
IMP dehydrogenase activity
Molecular Function
Definition (GO:0003938 GONUTS page)
Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
inosine monophosphate dehydrogenase activity | related |
inosine monophosphate oxidoreductase activity | related |
inosine-5'-phosphate dehydrogenase activity | related |
IMP:NAD+ oxidoreductase activity | related |
inosinate dehydrogenase activity | related |
inosinic acid dehydrogenase activity | related |
inosine 5'-monophosphate dehydrogenase activity | related |
IMP oxidoreductase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4KZV0 | 6945 | A0A1S4KZV0_IXOSC | GO:0016616 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.1.1.205 | |
InterPro | IPR005990 | Inosine-5'-monophosphate dehydrogenase |
MetaCyc | IMP-DEHYDROG-RXN | |
RHEA | 11708 | |
Reactome | R-HSA-73794 | |
Reactome | R-HSA-9748945 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57464 | 5'-xanthylate(2-) |
has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:58053 | IMP(2-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003938 based on ALL annotations
The top 100 of 258 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
IMP dehydrogenase activity
|
3,158.90 | 100.00 | 61,711 | 61,711 |
GTP biosynthetic process
|
1,622.09 | 48.57 | 55,520 | 108,121 |
GMP biosynthetic process
|
1,364.62 | 36.64 | 43,640 | 101,020 |
purine nucleotide biosynthetic process
|
253.15 | 7.99 | 59,894 | 747,372 |
GMP reductase activity
|
1,003.79 | 5.54 | 3,878 | 12,204 |
IMP salvage
|
198.24 | 3.20 | 3,773 | 60,121 |
nucleotide binding
|
64.31 | 2.01 | 37,497 | 1,841,736 |
purine ribonucleoside salvage
|
80.21 | 1.86 | 3,983 | 156,866 |
oxidoreductase activity
|
12.98 | 0.41 | 48,937 | 11,906,003 |
metal ion binding
|
5.80 | 0.18 | 43,670 | 23,771,070 |
Totals | 381121 | 111420320 |
No co-occurrence statistics for GO:0003938 based on MANUAL annotations
The top 54 of 54 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
IMP dehydrogenase activity
|
6,871.27 | 100.00 | 188 | 188 |
GTP biosynthetic process
|
6,327.01 | 91.18 | 186 | 202 |
'de novo' XMP biosynthetic process
|
916.17 | 1.87 | 4 | 30 |
lymphocyte proliferation
|
549.70 | 1.71 | 4 | 50 |
nucleotide binding
|
240.25 | 1.53 | 5 | 143 |
GMP biosynthetic process
|
179.25 | 1.46 | 6 | 230 |
GMP reductase activity
|
1,145.21 | 1.01 | 2 | 12 |
cellular response to interleukin-4
|
176.19 | 0.76 | 2 | 78 |
glycosome
|
89.24 | 0.72 | 3 | 231 |
ficolin-1-rich granule lumen
|
110.83 | 0.65 | 2 | 124 |
Totals | 637 | 883681 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9748945 |
2020-10-08 | Added | SYNONYM | inosine 5'-monophosphate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | IMP oxidoreductase activity |
2020-10-08 | Added | SYNONYM | inosine monophosphate oxidoreductase activity |
2020-10-08 | Added | SYNONYM | IMP oxidoreductase activity |
2020-10-08 | Added | SYNONYM | inosine monophosphate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | inosine-5'-phosphate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | IMP:NAD+ oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | inosine-5'-phosphate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | inosine monophosphate dehydrogenase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | IMP dehydrogenase activity |
2002-02-06 | Updated | TERM | IMP dehydrogenase |
2001-04-03 | Updated | TERM | IMP dehydrogenase |
2001-03-30 | Added | TERM | IMP dehydrogenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | inosine 5'-monophosphate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | IMP oxidoreductase activity |
2020-10-08 | Added | SYNONYM | inosine monophosphate oxidoreductase activity |
2020-10-08 | Added | SYNONYM | IMP oxidoreductase activity |
2020-10-08 | Added | SYNONYM | inosine monophosphate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | inosine-5'-phosphate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | IMP:NAD+ oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | inosine-5'-phosphate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | inosine monophosphate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | IMP:NAD+ oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | inosine monophosphate oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | inosine 5'-monophosphate dehydrogenase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. |
2007-11-08 | Added | SYNONYM | inosine-5'-phosphate dehydrogenase activity |
2007-11-08 | Added | SYNONYM | inosine monophosphate dehydrogenase activity |
2007-11-08 | Added | SYNONYM | IMP:NAD+ oxidoreductase activity |
2007-09-06 | Added | SYNONYM | inosinic acid dehydrogenase activity |
2007-09-06 | Added | SYNONYM | inosine monophosphate oxidoreductase activity |
2007-09-06 | Added | SYNONYM | inosine 5'-monophosphate dehydrogenase activity |
2007-09-06 | Added | SYNONYM | inosinate dehydrogenase activity |
2007-09-06 | Added | SYNONYM | IMP oxidoreductase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9748945 |
2019-04-01 | Added | XREF | Reactome:R-HSA-73794 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-73794 |
2018-12-11 | Added | XREF | reactome:R-HSA-73794 |
2018-07-13 | Added | XREF | RHEA:11708 |
2018-07-13 | Deleted | XREF | RHEA:11711 |
2011-09-16 | Added | XREF | RHEA:11711 |
2003-10-27 | Added | XREF | MetaCyc:IMP-DEHYDROG-RXN |
2001-03-30 | Added | XREF | EC:1.1.1.205 |
Timestamp | Action | Category | Detail |
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