GO:0003954
JSON
NADH dehydrogenase activity
Molecular Function
Definition (GO:0003954 GONUTS page)
Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
type 1 dehydrogenase activity | related |
diaphorase activity | broad |
cytochrome c reductase activity | related |
diphosphopyridine diaphorase activity | related |
diphosphopyrinase activity | related |
dihydronicotinamide adenine dinucleotide dehydrogenase activity | related |
reduced diphosphopyridine nucleotide diaphorase activity | related |
NADH:(acceptor) oxidoreductase activity | related |
beta-NADH dehydrogenase dinucleotide activity | related |
NADH oxidoreductase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0003954
Child Term | Relationship to GO:0003954 |
---|---|
NADH:ubiquinone reductase (non-electrogenic) activity
|
is_a |
NADH:menaquinone oxidoreductase activity
|
is_a |
NADH dehydrogenase complex
|
capable_of |
NADH dehydrogenase (ubiquinone) activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR045024 | Alternative NADH dehydrogenase |
RHEA | 11356 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
has_participant | CHEBI | CHEBI:17499 | hydrogen donor |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:13193 | hydrogen acceptor |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003954 based on ALL annotations
The top 100 of 524 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NADH dehydrogenase activity
|
403.10 | 100.00 | 491,581 | 491,581 |
ATP synthesis coupled electron transport
|
191.19 | 33.26 | 258,913 | 545,890 |
NADH dehydrogenase (ubiquinone) activity
|
148.38 | 30.49 | 314,555 | 854,540 |
ubiquinone binding
|
327.63 | 21.55 | 111,451 | 137,123 |
quinone binding
|
88.42 | 13.96 | 136,444 | 622,018 |
electron transport coupled proton transport
|
47.01 | 10.44 | 245,139 | 2,101,926 |
aerobic respiration
|
42.83 | 9.54 | 237,543 | 2,235,733 |
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
|
107.75 | 8.56 | 54,964 | 205,632 |
mitochondrial membrane
|
71.69 | 7.37 | 54,913 | 308,745 |
NADH oxidation
|
306.45 | 6.90 | 34,689 | 45,629 |
Totals | 3723674 | 164696926 |
No co-occurrence statistics for GO:0003954 based on MANUAL annotations
The top 100 of 131 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NADH dehydrogenase activity
|
1,826.05 | 100.00 | 773 | 773 |
aerobic respiration
|
536.09 | 22.63 | 384 | 1,308 |
ubiquinone binding
|
1,132.43 | 18.37 | 160 | 258 |
mitochondrial electron transport, NADH to ubiquinone
|
434.56 | 17.23 | 297 | 1,248 |
electron transport coupled proton transport
|
536.00 | 14.76 | 177 | 603 |
respiratory chain complex I
|
227.97 | 11.66 | 493 | 3,949 |
mitochondrial respiratory chain complex I assembly
|
185.40 | 7.59 | 179 | 1,763 |
NADH dehydrogenase (ubiquinone) activity
|
148.10 | 5.18 | 97 | 1,196 |
respiratory electron transport chain
|
156.01 | 4.28 | 61 | 714 |
cytochrome-b5 reductase activity, acting on NAD(P)H
|
247.19 | 3.19 | 31 | 229 |
Totals | 3128 | 113475 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-11 | Deleted | XREF | MetaCyc:NADH-DEHYDROGENASE-RXN |
2021-02-28 | Deleted | XREF | EC:1.6.99.3 |
2020-10-08 | Added | SYNONYM | diphosphopyrinase activity |
2020-10-08 | Added | SYNONYM | beta-NADH dehydrogenase dinucleotide activity |
2020-10-08 | Added | SYNONYM | NADH diaphorase activity |
2020-10-08 | Added | SYNONYM | diphosphopyridine diaphorase activity |
2020-10-08 | Added | SYNONYM | reduced diphosphopyridine nucleotide diaphorase activity |
2020-10-08 | Added | SYNONYM | dihydrocodehydrogenase I dehydrogenase activity |
2020-10-08 | Added | SYNONYM | NADH:acceptor oxidoreductase activity |
2020-10-08 | Added | SYNONYM | dihydronicotinamide adenine dinucleotide dehydrogenase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | NADH dehydrogenase activity |
2002-05-21 | Updated | TERM | NADH dehydrogenase |
2002-03-31 | Updated | TERM | NADH2 dehydrogenase |
2002-02-06 | Updated | TERM | NADH dehydrogenase |
2001-08-21 | Updated | TERM | NADH dehydrogenase |
2001-04-03 | Updated | TERM | NADH2 dehydrogenase |
2001-03-30 | Added | TERM | NADH2 dehydrogenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | diphosphopyrinase activity |
2020-10-08 | Added | SYNONYM | beta-NADH dehydrogenase dinucleotide activity |
2020-10-08 | Added | SYNONYM | NADH diaphorase activity |
2020-10-08 | Added | SYNONYM | diphosphopyridine diaphorase activity |
2020-10-08 | Added | SYNONYM | reduced diphosphopyridine nucleotide diaphorase activity |
2020-10-08 | Added | SYNONYM | dihydrocodehydrogenase I dehydrogenase activity |
2020-10-08 | Added | SYNONYM | NADH:acceptor oxidoreductase activity |
2020-10-08 | Added | SYNONYM | dihydronicotinamide adenine dinucleotide dehydrogenase activity |
2020-10-08 | Added | SYNONYM | NADH2 dehydrogenase activity |
2020-10-08 | Added | SYNONYM | DPNH diaphorase activity |
2020-10-08 | Added | SYNONYM | NADH hydrogenase activity |
2020-10-08 | Deleted | SYNONYM | NADH hydrogenase activity |
2020-10-08 | Deleted | SYNONYM | NADH oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | DPNH diaphorase activity |
2020-10-08 | Deleted | SYNONYM | NADH diaphorase activity |
2020-10-08 | Deleted | SYNONYM | NADH2 dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | NADH:(acceptor) oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | NADH:acceptor oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | diphosphopyridine diaphorase activity |
2020-10-08 | Added | SYNONYM | NADH oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | beta-NADH dehydrogenase dinucleotide activity |
2020-10-08 | Deleted | SYNONYM | dihydrocodehydrogenase I dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | dihydronicotinamide adenine dinucleotide dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | diphosphopyrinase activity |
2020-10-08 | Deleted | SYNONYM | reduced diphosphopyridine nucleotide diaphorase activity |
2020-10-08 | Added | SYNONYM | NADH:(acceptor) oxidoreductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. |
2007-11-08 | Added | SYNONYM | diphosphopyridine diaphorase activity |
2007-11-08 | Added | SYNONYM | NADH:(acceptor) oxidoreductase activity |
2007-11-08 | Added | SYNONYM | NADH2 dehydrogenase activity |
2007-11-08 | Added | SYNONYM | NADH:acceptor oxidoreductase activity |
2007-09-06 | Added | SYNONYM | reduced diphosphopyridine nucleotide diaphorase activity |
2007-09-06 | Added | SYNONYM | diphosphopyrinase activity |
2007-09-06 | Added | SYNONYM | dihydronicotinamide adenine dinucleotide dehydrogenase activity |
2007-09-06 | Added | SYNONYM | NADH-menadione oxidoreductase activity |
2007-09-06 | Added | SYNONYM | type 1 dehydrogenase activity |
2007-09-06 | Added | SYNONYM | type I dehydrogenase activity |
2007-09-06 | Deleted | SYNONYM | cytochrome c reductase |
2007-09-06 | Added | SYNONYM | DPNH diaphorase activity |
2007-09-06 | Added | SYNONYM | NADH diaphorase activity |
2007-09-06 | Added | SYNONYM | NADH hydrogenase activity |
2007-09-06 | Added | SYNONYM | NADH oxidoreductase activity |
2007-09-06 | Added | SYNONYM | diaphorase activity |
2007-09-06 | Added | SYNONYM | dihydrocodehydrogenase I dehydrogenase activity |
2007-09-06 | Added | SYNONYM | NADH:cytochrome c oxidoreductase activity |
2007-09-06 | Added | SYNONYM | cytochrome c reductase activity |
2007-09-06 | Added | SYNONYM | beta-NADH dehydrogenase dinucleotide activity |
2007-08-09 | Added | SYNONYM | cytochrome c reductase |
2007-08-09 | Deleted | SYNONYM | cytochrome c reductase |
2004-04-19 | Added | SYNONYM | cytochrome c reductase |
2004-04-16 | Deleted | SYNONYM | cytochrome c reductase |
2003-10-27 | Added | SYNONYM | cytochrome c reductase |
2003-08-21 | Deleted | SYNONYM | cytochrome c reductase |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. |
2002-04-24 | Added | SYNONYM | cytochrome c reductase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-06-30 | Deleted | RELATION | is a GO:0009055 (electron transfer activity) |
2008-04-01 | Updated | RELATION | is a GO:0016651 (oxidoreductase activity, acting on NAD(P)H) |
2008-04-01 | Updated | RELATION | is a GO:0009055 (electron transfer activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-11 | Deleted | XREF | MetaCyc:NADH-DEHYDROGENASE-RXN |
2021-02-28 | Deleted | XREF | EC:1.6.99.3 |
2018-07-13 | Added | XREF | RHEA:11356 |
2018-07-13 | Deleted | XREF | RHEA:11359 |
2011-09-16 | Added | XREF | RHEA:11359 |
2003-10-27 | Added | XREF | MetaCyc:NADH-DEHYDROGENASE-RXN |
2001-03-30 | Added | XREF | EC:1.6.99.3 |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link