This term is obsolete.

GO:0003954 JSON

NADH dehydrogenase activity

Molecular Function

Definition (GO:0003954 GONUTS page)

Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.

1,553,736 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
type 1 dehydrogenase activity related
diaphorase activity broad
cytochrome c reductase activity related
diphosphopyridine diaphorase activity related
diphosphopyrinase activity related
dihydronicotinamide adenine dinucleotide dehydrogenase activity related
reduced diphosphopyridine nucleotide diaphorase activity related
NADH:(acceptor) oxidoreductase activity related
beta-NADH dehydrogenase dinucleotide activity related
NADH oxidoreductase activity related

Ancestor Chart

Ancestor chart for GO:0003954
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003954

Child Term Relationship to
GO:0003954
NADH:ubiquinone reductase (non-electrogenic) activity
is_a
NADH:menaquinone oxidoreductase activity
is_a
NADH dehydrogenase complex
capable_of
NADH dehydrogenase (ubiquinone) activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
InterPro IPR045024 Alternative NADH dehydrogenase
RHEA 11356

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57945 NADH(2-)
has_participant CHEBI CHEBI:17499 hydrogen donor
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:13193 hydrogen acceptor

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003954 based on ALL annotations
The top 100 of 524 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NADH dehydrogenase activity
403.10 100.00 491,581 491,581
ATP synthesis coupled electron transport
191.19 33.26 258,913 545,890
NADH dehydrogenase (ubiquinone) activity
148.38 30.49 314,555 854,540
ubiquinone binding
327.63 21.55 111,451 137,123
quinone binding
88.42 13.96 136,444 622,018
electron transport coupled proton transport
47.01 10.44 245,139 2,101,926
aerobic respiration
42.83 9.54 237,543 2,235,733
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
107.75 8.56 54,964 205,632
mitochondrial membrane
71.69 7.37 54,913 308,745
NADH oxidation
306.45 6.90 34,689 45,629
Totals 3723674 164696926
No co-occurrence statistics for GO:0003954 based on MANUAL annotations
The top 100 of 131 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NADH dehydrogenase activity
1,826.05 100.00 773 773
aerobic respiration
536.09 22.63 384 1,308
ubiquinone binding
1,132.43 18.37 160 258
mitochondrial electron transport, NADH to ubiquinone
434.56 17.23 297 1,248
electron transport coupled proton transport
536.00 14.76 177 603
respiratory chain complex I
227.97 11.66 493 3,949
mitochondrial respiratory chain complex I assembly
185.40 7.59 179 1,763
NADH dehydrogenase (ubiquinone) activity
148.10 5.18 97 1,196
respiratory electron transport chain
156.01 4.28 61 714
cytochrome-b5 reductase activity, acting on NAD(P)H
247.19 3.19 31 229
Totals 3128 113475

Change Log

Timestamp Action Category Detail
2023-08-11 Deleted XREF MetaCyc:NADH-DEHYDROGENASE-RXN
2021-02-28 Deleted XREF EC:1.6.99.3
2020-10-08 Added SYNONYM diphosphopyrinase activity
2020-10-08 Added SYNONYM beta-NADH dehydrogenase dinucleotide activity
2020-10-08 Added SYNONYM NADH diaphorase activity
2020-10-08 Added SYNONYM diphosphopyridine diaphorase activity
2020-10-08 Added SYNONYM reduced diphosphopyridine nucleotide diaphorase activity
2020-10-08 Added SYNONYM dihydrocodehydrogenase I dehydrogenase activity
2020-10-08 Added SYNONYM NADH:acceptor oxidoreductase activity
2020-10-08 Added SYNONYM dihydronicotinamide adenine dinucleotide dehydrogenase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM NADH dehydrogenase activity
2002-05-21 Updated TERM NADH dehydrogenase
2002-03-31 Updated TERM NADH2 dehydrogenase
2002-02-06 Updated TERM NADH dehydrogenase
2001-08-21 Updated TERM NADH dehydrogenase
2001-04-03 Updated TERM NADH2 dehydrogenase
2001-03-30 Added TERM NADH2 dehydrogenase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM diphosphopyrinase activity
2020-10-08 Added SYNONYM beta-NADH dehydrogenase dinucleotide activity
2020-10-08 Added SYNONYM NADH diaphorase activity
2020-10-08 Added SYNONYM diphosphopyridine diaphorase activity
2020-10-08 Added SYNONYM reduced diphosphopyridine nucleotide diaphorase activity
2020-10-08 Added SYNONYM dihydrocodehydrogenase I dehydrogenase activity
2020-10-08 Added SYNONYM NADH:acceptor oxidoreductase activity
2020-10-08 Added SYNONYM dihydronicotinamide adenine dinucleotide dehydrogenase activity
2020-10-08 Added SYNONYM NADH2 dehydrogenase activity
2020-10-08 Added SYNONYM DPNH diaphorase activity
2020-10-08 Added SYNONYM NADH hydrogenase activity
2020-10-08 Deleted SYNONYM NADH hydrogenase activity
2020-10-08 Deleted SYNONYM NADH oxidoreductase activity
2020-10-08 Deleted SYNONYM DPNH diaphorase activity
2020-10-08 Deleted SYNONYM NADH diaphorase activity
2020-10-08 Deleted SYNONYM NADH2 dehydrogenase activity
2020-10-08 Deleted SYNONYM NADH:(acceptor) oxidoreductase activity
2020-10-08 Deleted SYNONYM NADH:acceptor oxidoreductase activity
2020-10-08 Deleted SYNONYM diphosphopyridine diaphorase activity
2020-10-08 Added SYNONYM NADH oxidoreductase activity
2020-10-08 Deleted SYNONYM beta-NADH dehydrogenase dinucleotide activity
2020-10-08 Deleted SYNONYM dihydrocodehydrogenase I dehydrogenase activity
2020-10-08 Deleted SYNONYM dihydronicotinamide adenine dinucleotide dehydrogenase activity
2020-10-08 Deleted SYNONYM diphosphopyrinase activity
2020-10-08 Deleted SYNONYM reduced diphosphopyridine nucleotide diaphorase activity
2020-10-08 Added SYNONYM NADH:(acceptor) oxidoreductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
2007-11-08 Added SYNONYM diphosphopyridine diaphorase activity
2007-11-08 Added SYNONYM NADH:(acceptor) oxidoreductase activity
2007-11-08 Added SYNONYM NADH2 dehydrogenase activity
2007-11-08 Added SYNONYM NADH:acceptor oxidoreductase activity
2007-09-06 Added SYNONYM reduced diphosphopyridine nucleotide diaphorase activity
2007-09-06 Added SYNONYM diphosphopyrinase activity
2007-09-06 Added SYNONYM dihydronicotinamide adenine dinucleotide dehydrogenase activity
2007-09-06 Added SYNONYM NADH-menadione oxidoreductase activity
2007-09-06 Added SYNONYM type 1 dehydrogenase activity
2007-09-06 Added SYNONYM type I dehydrogenase activity
2007-09-06 Deleted SYNONYM cytochrome c reductase
2007-09-06 Added SYNONYM DPNH diaphorase activity
2007-09-06 Added SYNONYM NADH diaphorase activity
2007-09-06 Added SYNONYM NADH hydrogenase activity
2007-09-06 Added SYNONYM NADH oxidoreductase activity
2007-09-06 Added SYNONYM diaphorase activity
2007-09-06 Added SYNONYM dihydrocodehydrogenase I dehydrogenase activity
2007-09-06 Added SYNONYM NADH:cytochrome c oxidoreductase activity
2007-09-06 Added SYNONYM cytochrome c reductase activity
2007-09-06 Added SYNONYM beta-NADH dehydrogenase dinucleotide activity
2007-08-09 Added SYNONYM cytochrome c reductase
2007-08-09 Deleted SYNONYM cytochrome c reductase
2004-04-19 Added SYNONYM cytochrome c reductase
2004-04-16 Deleted SYNONYM cytochrome c reductase
2003-10-27 Added SYNONYM cytochrome c reductase
2003-08-21 Deleted SYNONYM cytochrome c reductase
2002-11-27 Added DEFINITION Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
2002-04-24 Added SYNONYM cytochrome c reductase
Timestamp Action Category Detail
2008-06-30 Deleted RELATION is a GO:0009055 (electron transfer activity)
2008-04-01 Updated RELATION is a GO:0016651 (oxidoreductase activity, acting on NAD(P)H)
2008-04-01 Updated RELATION is a GO:0009055 (electron transfer activity)
Timestamp Action Category Detail
2023-08-11 Deleted XREF MetaCyc:NADH-DEHYDROGENASE-RXN
2021-02-28 Deleted XREF EC:1.6.99.3
2018-07-13 Added XREF RHEA:11356
2018-07-13 Deleted XREF RHEA:11359
2011-09-16 Added XREF RHEA:11359
2003-10-27 Added XREF MetaCyc:NADH-DEHYDROGENASE-RXN
2001-03-30 Added XREF EC:1.6.99.3
Timestamp Action Category Detail
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