GO:0003972
JSON
RNA ligase (ATP) activity
Molecular Function
Definition (GO:0003972 GONUTS page)
Catalysis of the reaction: ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
polyribonucleotide synthase (ATP) activity | related |
ribonucleic ligase activity | broad |
polyribonucleotide ligase activity | related |
poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming) | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.5.1.3 | |
InterPro | IPR012387 | tRNA ligase Trl1, fungi |
InterPro | IPR012647 | RNA ligase, Rnl2 |
InterPro | IPR012648 | T4 RNA ligase 1 |
InterPro | IPR015965 | tRNA ligase, phosphodiesterase |
InterPro | IPR015966 | tRNA ligase, kinase domain, fungi |
InterPro | IPR038837 | tRNA ligase 1 |
InterPro | IPR041211 | RNA ligase 1 |
InterPro | IPR044263 | RNA ligase 2, viral |
MetaCyc | RNA-LIGASE-ATP-RXN |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003972 based on ALL annotations
The top 100 of 235 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
RNA ligase (ATP) activity
|
9,379.22 | 100.00 | 21,127 | 21,127 |
RNA ligase (GTP) activity
|
4,772.23 | 32.92 | 10,195 | 20,037 |
RNA repair
|
1,952.41 | 17.09 | 10,322 | 49,586 |
tRNA-splicing ligase complex
|
2,698.18 | 10.27 | 2,911 | 10,119 |
tRNA splicing, via endonucleolytic cleavage and ligation
|
1,197.11 | 9.06 | 5,020 | 39,331 |
GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
|
9,379.22 | 5.79 | 1,224 | 1,224 |
ligase activity, forming phosphoric ester bonds
|
8,754.46 | 5.29 | 1,121 | 1,201 |
intron homing
|
2,921.30 | 2.12 | 470 | 1,509 |
response to reactive oxygen species
|
279.46 | 1.80 | 916 | 30,743 |
RNA processing
|
118.87 | 1.26 | 13,496 | 1,064,849 |
Totals | 131884 | 71323662 |
No co-occurrence statistics for GO:0003972 based on MANUAL annotations
The top 35 of 35 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
RNA ligase (ATP) activity
|
54,289.73 | 100.00 | 26 | 26 |
GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
|
54,289.73 | 11.54 | 3 | 3 |
mRNA editing complex
|
6,032.19 | 4.76 | 2 | 18 |
tRNA splicing, via endonucleolytic cleavage and ligation
|
2,096.55 | 3.81 | 19 | 492 |
virus tail fiber assembly
|
10,857.95 | 3.33 | 1 | 5 |
RNA splicing, via endonucleolytic cleavage and ligation
|
10,857.95 | 3.33 | 1 | 5 |
positive regulation of translation in response to stress
|
6,786.22 | 3.03 | 1 | 8 |
RNA ligase (GTP) activity
|
5,428.97 | 2.86 | 1 | 10 |
mitochondrial mRNA editing complex
|
1,962.28 | 2.83 | 3 | 83 |
GMP binding
|
3,016.10 | 2.33 | 1 | 18 |
Totals | 112 | 634477 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-28 | Added | DEFINITION | Catalysis of the reaction: ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate. |
2024-03-28 | Deleted | DEFINITION | Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m). |
2020-10-08 | Deleted | SYNONYM | poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | polyribonucleotide ligase activity |
2020-10-08 | Added | SYNONYM | polyribonucleotide synthase (ATP) activity |
2020-10-08 | Deleted | SYNONYM | polyribonucleotide synthase (ATP) activity |
2020-10-08 | Deleted | SYNONYM | polyribonucleotide ligase activity |
2019-04-01 | Added | XREF | Reactome:R-HSA-5696816 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5696816 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | RNA ligase (ATP) activity |
2002-02-06 | Updated | TERM | RNA ligase (ATP) |
2001-04-03 | Updated | TERM | RNA ligase (ATP) |
2001-03-30 | Added | TERM | RNA ligase (ATP) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-28 | Added | DEFINITION | Catalysis of the reaction: ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate. |
2024-03-28 | Deleted | DEFINITION | Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m). |
2020-10-08 | Deleted | SYNONYM | poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | polyribonucleotide ligase activity |
2020-10-08 | Added | SYNONYM | polyribonucleotide synthase (ATP) activity |
2020-10-08 | Deleted | SYNONYM | polyribonucleotide synthase (ATP) activity |
2020-10-08 | Deleted | SYNONYM | polyribonucleotide ligase activity |
2010-09-03 | Deleted | DEFINITION | Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m). |
2010-09-03 | Added | DEFINITION | Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m). |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m). |
2007-11-08 | Added | SYNONYM | poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming) |
2007-11-08 | Added | SYNONYM | polyribonucleotide ligase activity |
2007-09-06 | Added | SYNONYM | polyribonucleotide synthase (ATP) activity |
2007-09-06 | Added | SYNONYM | ribonucleic ligase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0008452 (RNA ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-5696816 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5696816 |
2018-12-11 | Added | XREF | reactome:R-HSA-5696816 |
2009-05-21 | Added | XREF | MetaCyc:RNA-LIGASE-ATP-RXN |
2009-05-21 | Deleted | XREF | MetaCyc:RNA-LIGASE-(ATP)-RXN |
2003-10-27 | Added | XREF | MetaCyc:RNA-LIGASE-(ATP)-RXN |
2001-03-30 | Added | XREF | EC:6.5.1.3 |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link