This term is obsolete.

GO:0003995 JSON

acyl-CoA dehydrogenase activity

Molecular Function

Definition (GO:0003995 GONUTS page)

Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].

Secondary IDs

GO:0019109

445,570 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
general acyl CoA dehydrogenase activity related
acyl CoA dehydrogenase activity exact
fatty-acyl-CoA dehydrogenase activity related
fatty acyl coenzyme A dehydrogenase activity related
acyl coenzyme A dehydrogenase activity exact
acyl-CoA reductase activity exact

Ancestor Chart

Ancestor chart for GO:0003995
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003995

Child Term Relationship to
GO:0003995
very-long-chain fatty acyl-CoA dehydrogenase activity
is_a
medium-chain fatty acyl-CoA dehydrogenase activity
is_a
long-chain fatty acyl-CoA dehydrogenase activity
is_a
glutaryl-CoA dehydrogenase activity
is_a
short-chain fatty acyl-CoA dehydrogenase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
InterPro IPR006089 Acyl-CoA dehydrogenase, conserved site
InterPro IPR008670 Long-chain-fatty-acyl-CoA reductase, LuxC
InterPro IPR015396 Acyl-CoA dehydrogenase, C-terminal, bacterial-type
InterPro IPR034178 Isobutyryl-CoA dehydrogenase
InterPro IPR034183 Isovaleryl-CoA dehydrogenase
InterPro IPR045008 Acyl-coenzyme A oxidase 4-like
InterPro IPR047634 Acyl-CoA dehydrogenase FadE
MetaCyc ACYLCOADEHYDROG-RXN
RHEA 44704
Reactome R-HSA-109341

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:58307 FADH2(2-)
has_participant CHEBI CHEBI:65111 3-substituted propionyl-CoA(4-)
has_participant CHEBI CHEBI:58856 2,3-trans-enoyl CoA(4-)
has_participant CHEBI CHEBI:57692 FAD(3-)

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0102393 obsolete decanoyl-[acp] 2-dehydrogenase activity replaced_by GO:0003995

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003995 based on ALL annotations
The top 100 of 786 co-occurring terms
Co-occurring Term PR S% #Together #Compared
acyl-CoA dehydrogenase activity
542.69 100.00 365,134 365,134
oxidoreductase activity, acting on the CH-CH group of donors
265.35 38.73 237,582 485,901
fatty acid beta-oxidation using acyl-CoA dehydrogenase
337.52 25.15 108,388 174,277
flavin adenine dinucleotide binding
103.80 18.68 324,573 1,696,922
fatty-acyl-CoA binding
169.44 4.33 17,496 56,036
glutaryl-CoA dehydrogenase activity
358.67 4.28 15,986 24,188
fatty-acyl-CoA biosynthetic process
322.81 4.20 15,781 26,530
short-chain fatty acyl-CoA dehydrogenase activity
512.09 4.05 14,811 15,696
L-leucine catabolic process
93.29 3.41 14,882 86,573
cellular catabolic process
542.04 2.97 10,832 10,845
Totals 1656365 164975854
No co-occurrence statistics for GO:0003995 based on MANUAL annotations
The top 93 of 93 co-occurring terms
Co-occurring Term PR S% #Together #Compared
acyl-CoA dehydrogenase activity
2,880.68 100.00 490 490
fatty acid beta-oxidation using acyl-CoA dehydrogenase
1,187.19 30.98 272 660
short-chain fatty acyl-CoA dehydrogenase activity
733.26 2.64 14 55
medium-chain fatty acyl-CoA dehydrogenase activity
411.53 1.65 9 63
very-long-chain fatty acyl-CoA dehydrogenase activity
458.29 1.33 7 44
butyrate catabolic process
448.11 1.33 7 45
long-chain fatty acyl-CoA dehydrogenase activity
508.36 1.16 6 34
medium-chain fatty acid metabolic process
900.21 1.00 5 16
flavin adenine dinucleotide binding
27.60 0.85 36 3,757
short-chain 2-methyl fatty acyl-CoA dehydrogenase activity
1,646.10 0.81 4 7
Totals 1450 1023665

Change Log

Timestamp Action Category Detail
2024-08-07 Deleted XREF MetaCyc:RXN-13624
2023-12-15 Added XREF MetaCyc:RXN-13624
2023-08-08 Added DEFINITION Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].
2023-08-08 Added XREF RHEA:44704
2023-08-08 Deleted XREF MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN
2023-08-08 Deleted XREF EC:1.3.-.-
2023-08-08 Deleted DEFINITION Catalysis of the reaction: acyl-CoA + oxidized [electron-transfer flavoprotein]= 2,3-dehydroacyl-CoA + reduced [electron-transfer flavoprotein] + H+.
2022-06-20 Deleted SYNONYM long-chain acyl coenzyme A dehydrogenase activity
2022-06-20 Deleted SYNONYM acyl coenzyme A dehydrogenase activity
2022-06-20 Added SYNONYM acyl coenzyme A dehydrogenase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM acyl-CoA dehydrogenase activity
2002-02-06 Updated TERM acyl-CoA dehydrogenase
2001-04-03 Updated TERM acyl-CoA dehydrogenase
2001-03-30 Added TERM acyl-CoA dehydrogenase
Timestamp Action Category Detail
2023-08-08 Added DEFINITION Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].
2023-08-08 Deleted DEFINITION Catalysis of the reaction: acyl-CoA + oxidized [electron-transfer flavoprotein]= 2,3-dehydroacyl-CoA + reduced [electron-transfer flavoprotein] + H+.
2022-06-20 Deleted SYNONYM long-chain acyl coenzyme A dehydrogenase activity
2022-06-20 Deleted SYNONYM acyl coenzyme A dehydrogenase activity
2022-06-20 Added SYNONYM acyl coenzyme A dehydrogenase activity
2022-06-20 Added SYNONYM acyl CoA dehydrogenase activity
2022-06-20 Deleted SYNONYM medium-chain acyl-coenzyme A dehydrogenase activity
2022-06-20 Deleted SYNONYM acyl-CoA:(acceptor) 2,3-oxidoreductase activity
2022-06-20 Deleted SYNONYM acyl dehydrogenase activity
2022-06-20 Deleted SYNONYM acyl CoA dehydrogenase activity
2022-06-20 Deleted SYNONYM acyl-CoA:acceptor 2,3-oxidoreductase activity
2022-06-20 Deleted SYNONYM long-chain acyl-CoA dehydrogenase activity
2022-06-20 Deleted SYNONYM medium-chain acyl-CoA dehydrogenase activity
2022-06-20 Deleted DEFINITION Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
2022-06-20 Added DEFINITION Catalysis of the reaction: acyl-CoA + oxidized [electron-transfer flavoprotein]= 2,3-dehydroacyl-CoA + reduced [electron-transfer flavoprotein] + H+.
2020-10-08 Added SYNONYM acyl coenzyme A dehydrogenase activity
2020-10-08 Added SYNONYM fatty-acyl-CoA dehydrogenase activity
2020-10-08 Added SYNONYM fatty acyl coenzyme A dehydrogenase activity
2020-10-08 Added SYNONYM acyl dehydrogenase activity
2020-10-08 Added SYNONYM acyl CoA dehydrogenase activity
2020-10-08 Added SYNONYM long-chain acyl-CoA dehydrogenase activity
2020-10-08 Added SYNONYM acyl-CoA:acceptor 2,3-oxidoreductase activity
2020-10-08 Added SYNONYM medium-chain acyl-coenzyme A dehydrogenase activity
2020-10-08 Added SYNONYM acyl-CoA:(acceptor) 2,3-oxidoreductase activity
2020-10-08 Added SYNONYM general acyl CoA dehydrogenase activity
2020-10-08 Added SYNONYM long-chain acyl coenzyme A dehydrogenase activity
2020-10-08 Deleted SYNONYM acyl CoA dehydrogenase activity
2020-10-08 Deleted SYNONYM acyl coenzyme A dehydrogenase activity
2020-10-08 Deleted SYNONYM acyl-CoA:(acceptor) 2,3-oxidoreductase activity
2020-10-08 Deleted SYNONYM acyl-CoA:acceptor 2,3-oxidoreductase activity
2020-10-08 Deleted SYNONYM fatty acyl coenzyme A dehydrogenase activity
2020-10-08 Deleted SYNONYM fatty-acyl-CoA dehydrogenase activity
2020-10-08 Deleted SYNONYM general acyl CoA dehydrogenase activity
2020-10-08 Deleted SYNONYM long-chain acyl coenzyme A dehydrogenase activity
2020-10-08 Deleted SYNONYM long-chain acyl-CoA dehydrogenase activity
2020-10-08 Deleted SYNONYM medium-chain acyl-coenzyme A dehydrogenase activity
2020-10-08 Deleted SYNONYM acyl dehydrogenase activity
2009-11-11 Added SYNONYM acyl-CoA reductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
2007-11-08 Added SYNONYM general acyl CoA dehydrogenase activity
2007-11-08 Added SYNONYM long-chain acyl coenzyme A dehydrogenase activity
2007-11-08 Added SYNONYM long-chain acyl-CoA dehydrogenase activity
2007-11-08 Added SYNONYM medium-chain acyl-coenzyme A dehydrogenase activity
2007-11-08 Added SYNONYM fatty-acyl-CoA dehydrogenase activity
2007-11-08 Added SYNONYM acyl CoA dehydrogenase activity
2007-11-08 Added SYNONYM fatty acyl coenzyme A dehydrogenase activity
2007-11-08 Added SYNONYM acyl-CoA:acceptor 2,3-oxidoreductase activity
2007-11-08 Added SYNONYM acyl-CoA:(acceptor) 2,3-oxidoreductase activity
2007-11-08 Added SYNONYM acyl coenzyme A dehydrogenase activity
2007-09-06 Added SYNONYM acyl dehydrogenase activity
2007-09-06 Added SYNONYM medium-chain acyl-CoA dehydrogenase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
Timestamp Action Category Detail
2022-06-20 Deleted RELATION is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
2022-06-20 Added RELATION is a GO:0052890 (oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor)
2014-04-03 Added RELATION has part GO:0033539 (fatty acid beta-oxidation using acyl-CoA dehydrogenase)
2008-04-01 Updated RELATION is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
Timestamp Action Category Detail
2024-08-07 Deleted XREF MetaCyc:RXN-13624
2023-12-15 Added XREF MetaCyc:RXN-13624
2023-08-08 Added XREF RHEA:44704
2023-08-08 Deleted XREF MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN
2023-08-08 Deleted XREF EC:1.3.-.-
2022-06-20 Deleted XREF EC:1.3.99.3
2022-06-20 Added XREF EC:1.3.-.-
2019-04-01 Deleted XREF reactome:R-HSA-77299
2019-04-01 Deleted XREF reactome:R-HSA-77338
2019-04-01 Deleted XREF reactome:R-HSA-77263
2019-04-01 Added XREF Reactome:R-HSA-77338
2019-04-01 Added XREF Reactome:R-HSA-77274
2019-04-01 Added XREF Reactome:R-HSA-70859
2019-04-01 Added XREF Reactome:R-HSA-77319
2019-04-01 Added XREF Reactome:R-HSA-70800
2019-04-01 Added XREF Reactome:R-HSA-5695980
2019-04-01 Added XREF Reactome:R-HSA-109341
2019-04-01 Added XREF Reactome:R-HSA-77345
2019-04-01 Added XREF Reactome:R-HSA-77263
2019-04-01 Added XREF Reactome:R-HSA-77327
2019-04-01 Added XREF Reactome:R-HSA-77299
2019-04-01 Added XREF Reactome:R-HSA-5695989
2019-04-01 Deleted XREF reactome:R-HSA-70800
2019-04-01 Deleted XREF reactome:R-HSA-77327
2019-04-01 Deleted XREF reactome:R-HSA-77274
2019-04-01 Deleted XREF reactome:R-HSA-5695989
2019-04-01 Deleted XREF reactome:R-HSA-77345
2019-04-01 Deleted XREF reactome:R-HSA-5695980
2019-04-01 Deleted XREF reactome:R-HSA-77319
2019-04-01 Deleted XREF reactome:R-HSA-70859
2019-04-01 Deleted XREF reactome:R-HSA-109341
2018-12-11 Added XREF reactome:R-HSA-70859
2018-12-11 Added XREF reactome:R-HSA-109341
2018-12-11 Added XREF reactome:R-HSA-5695980
2018-12-11 Added XREF reactome:R-HSA-70800
2018-12-11 Added XREF reactome:R-HSA-77299
2018-12-11 Added XREF reactome:R-HSA-77263
2018-12-11 Added XREF reactome:R-HSA-77338
2018-12-11 Added XREF reactome:R-HSA-77319
2018-12-11 Added XREF reactome:R-HSA-77345
2018-12-11 Added XREF reactome:R-HSA-5695989
2018-12-11 Added XREF reactome:R-HSA-77274
2018-12-11 Added XREF reactome:R-HSA-77327
2011-05-03 Deleted XREF EC:1.3.99.-
2009-11-11 Added XREF MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN
2009-11-11 Added XREF EC:1.3.99.-
2003-10-27 Added XREF MetaCyc:ACYLCOADEHYDROG-RXN
2001-03-30 Added XREF EC:1.3.99.3
Timestamp Action Category Detail
2009-11-11 Added SECONDARY GO:0019109 (acyl-CoA reductase activity)
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