This term is obsolete.

GO:0004016 JSON

adenylate cyclase activity

Molecular Function

Definition (GO:0004016 GONUTS page)

Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.

212,933 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ATP diphosphate-lyase (cyclizing) activity related
adenylylcyclase activity related
ATP pyrophosphate-lyase activity related
adenyl cyclase activity related
adenylyl cyclase activity exact
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity related
cAMP generating peptide activity related
3',5'-cyclic AMP synthetase activity related

Ancestor Chart

Ancestor chart for GO:0004016
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004016

Child Term Relationship to
GO:0004016
regulation of adenylate cyclase activity
regulates
positive regulation of adenylate cyclase activity
positively_regulates
negative regulation of adenylate cyclase activity
negatively_regulates
adenylate cyclase inhibitor activity
negatively_regulates
adenylate cyclase regulator activity
regulates
calcium- and calmodulin-responsive adenylate cyclase activity
is_a
adenylate cyclase activator activity
positively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P9WQ29 83332 Y1320_MYCTU GO:0004016 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:11431477
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 4.6.1.1
InterPro IPR000274 Adenylate cyclase, class-I
InterPro IPR009398 Adenylate cyclase, conserved domain
InterPro IPR013716 Adenylate cyclase G-alpha binding
InterPro IPR014046 Diadenylate cyclase
InterPro IPR016577 Adenylate cyclase, type 10
InterPro IPR030672 Adenylate cyclase
InterPro IPR034693 Diadenylate cyclase CdaS
InterPro IPR034701 Diadenylate cyclase CdaA
MetaCyc ADENYLATECYC-RXN

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:33019 diphosphate(3-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:58165 3',5'-cyclic AMP(1-)

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0008492 obsolete cAMP generating peptide activity consider GO:0004016

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004016 based on ALL annotations
The top 100 of 1,064 co-occurring terms
Co-occurring Term PR S% #Together #Compared
adenylate cyclase activity
935.13 100.00 211,902 211,902
cyclic nucleotide biosynthetic process
870.02 57.18 126,583 136,055
cAMP biosynthetic process
917.80 41.31 88,228 89,893
intracellular signal transduction
225.80 21.39 138,156 572,152
phosphorus-oxygen lyase activity
791.41 10.61 22,935 27,100
guanylate cyclase activity
644.10 10.57 23,533 34,166
receptor guanylyl cyclase signaling pathway
803.07 10.49 22,629 26,350
cGMP biosynthetic process
588.93 10.43 23,540 37,378
peptide receptor activity
901.57 9.93 21,119 21,905
diadenylate cyclase activity
891.18 8.18 17,401 18,259
Totals 1298285 221123401
No co-occurrence statistics for GO:0004016 based on MANUAL annotations
The top 100 of 344 co-occurring terms
Co-occurring Term PR S% #Together #Compared
adenylate cyclase activity
2,623.67 100.00 538 538
cAMP biosynthetic process
2,052.39 32.77 194 248
adenylate cyclase-activating G protein-coupled receptor signaling pathway
280.60 10.04 334 3,123
cellular response to forskolin
612.19 3.46 21 90
calcium- and calmodulin-responsive adenylate cyclase activity
2,623.67 2.79 15 15
neuroinflammatory response
428.35 1.38 8 49
positive regulation of long-term synaptic potentiation
279.86 1.32 8 75
positive regulation of CREB transcription factor activity
583.04 1.07 6 27
regulation of adaptive immune response
242.93 0.85 5 54
adenylate cyclase binding
76.05 0.81 6 207
Totals 1522 47306

Change Log

Timestamp Action Category Detail
2024-02-24 Deleted RELATION has part GO:0140676 (oscillatory cAMP signaling)
2024-02-24 Added RELATION has part GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway)
2023-04-02 Added XREF Reactome:R-HSA-9712183
2021-07-04 Added RELATION has part GO:0140676 (oscillatory cAMP signaling)
2020-10-08 Added SYNONYM ATP pyrophosphate-lyase activity
2020-10-08 Added SYNONYM 3',5'-cyclic AMP synthetase activity
2020-10-08 Added SYNONYM adenylylcyclase activity
2020-10-08 Added SYNONYM ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity
2020-10-08 Added SYNONYM ATP diphosphate-lyase (cyclizing) activity
2020-10-08 Deleted SYNONYM adenyl cyclase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM adenylate cyclase activity
2002-02-06 Updated TERM adenylate cyclase
2001-04-03 Updated TERM adenylate cyclase
2001-03-30 Added TERM adenylate cyclase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM ATP pyrophosphate-lyase activity
2020-10-08 Added SYNONYM 3',5'-cyclic AMP synthetase activity
2020-10-08 Added SYNONYM adenylylcyclase activity
2020-10-08 Added SYNONYM ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity
2020-10-08 Added SYNONYM ATP diphosphate-lyase (cyclizing) activity
2020-10-08 Deleted SYNONYM adenyl cyclase activity
2020-10-08 Deleted SYNONYM ATP pyrophosphate-lyase activity
2020-10-08 Deleted SYNONYM 3',5'-cyclic AMP synthetase activity
2020-10-08 Added SYNONYM adenyl cyclase activity
2020-10-08 Deleted SYNONYM adenylylcyclase activity
2020-10-08 Deleted SYNONYM ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity
2020-10-08 Deleted SYNONYM ATP diphosphate-lyase (cyclizing) activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
2007-12-14 Added SYNONYM ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity
2007-12-14 Added SYNONYM ATP diphosphate-lyase (cyclizing) activity
2007-12-14 Added SYNONYM adenylylcyclase activity
2007-09-06 Added SYNONYM adenyl cyclase activity
2007-09-06 Added SYNONYM ATP pyrophosphate-lyase activity
2007-09-06 Added SYNONYM 3',5'-cyclic AMP synthetase activity
2007-08-09 Added SYNONYM adenylyl cyclase activity
2007-08-09 Added SYNONYM cAMP generating peptide activity
2007-08-09 Deleted SYNONYM cAMP generating peptide activity
2007-08-09 Deleted SYNONYM adenylyl cyclase activity
2005-08-10 Added SYNONYM cAMP generating peptide activity
2004-09-03 Added SYNONYM adenylyl cyclase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
Timestamp Action Category Detail
2024-02-24 Deleted RELATION has part GO:0140676 (oscillatory cAMP signaling)
2024-02-24 Added RELATION has part GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway)
2021-07-04 Added RELATION has part GO:0140676 (oscillatory cAMP signaling)
2018-05-16 Deleted RELATION part of GO:0006171 (cAMP biosynthetic process)
2010-06-15 Added RELATION part of GO:0006171 (cAMP biosynthetic process)
2010-06-14 Deleted RELATION part of GO:0006171 (cAMP biosynthetic process)
2010-06-08 Added RELATION part of GO:0006171 (cAMP biosynthetic process)
2008-04-01 Updated RELATION is a GO:0009975 (cyclase activity)
2008-04-01 Updated RELATION is a GO:0016849 (phosphorus-oxygen lyase activity)
Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9712183
2019-04-01 Added XREF Reactome:R-HSA-170676
2019-04-01 Deleted XREF reactome:R-HSA-5610727
2019-04-01 Added XREF Reactome:R-HSA-5610727
2019-04-01 Added XREF Reactome:R-HSA-5211224
2019-04-01 Added XREF Reactome:R-HSA-381607
2019-04-01 Added XREF Reactome:R-HSA-392129
2019-04-01 Added XREF Reactome:R-HSA-164377
2019-04-01 Deleted XREF reactome:R-HSA-392129
2019-04-01 Deleted XREF reactome:R-HSA-5211224
2019-04-01 Deleted XREF reactome:R-HSA-170676
2019-04-01 Deleted XREF reactome:R-HSA-164377
2019-04-01 Deleted XREF reactome:R-HSA-381607
2019-02-09 Deleted XREF reactome:R-HSA-442715
2019-01-29 Added XREF reactome:R-HSA-442715
2019-01-26 Deleted XREF reactome:R-HSA-442715
2018-12-11 Added XREF reactome:R-HSA-442715
2018-12-11 Added XREF reactome:R-HSA-170676
2018-12-11 Added XREF reactome:R-HSA-392129
2018-12-11 Added XREF reactome:R-HSA-5211224
2018-12-11 Added XREF reactome:R-HSA-381607
2018-12-11 Added XREF reactome:R-HSA-5610727
2018-12-11 Added XREF reactome:R-HSA-164377
2018-07-13 Deleted XREF RHEA:15392
2018-07-13 Added XREF RHEA:15389
2011-09-16 Added XREF RHEA:15392
2003-10-27 Added XREF MetaCyc:ADENYLATECYC-RXN
2001-03-30 Added XREF EC:4.6.1.1
Timestamp Action Category Detail
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