GO:0004016
JSON
adenylate cyclase activity
Molecular Function
Definition (GO:0004016 GONUTS page)
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cAMP generating peptide activity | related |
ATP diphosphate-lyase (cyclizing) activity | related |
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity | related |
ATP pyrophosphate-lyase activity | related |
3',5'-cyclic AMP synthetase activity | related |
adenylyl cyclase activity | exact |
adenylylcyclase activity | related |
adenyl cyclase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004016
Child Term | Relationship to GO:0004016 |
---|---|
calcium- and calmodulin-responsive adenylate cyclase activity
|
is_a |
negative regulation of adenylate cyclase activity
|
negatively_regulates |
adenylate cyclase regulator activity
|
regulates |
adenylate cyclase activator activity
|
positively_regulates |
regulation of adenylate cyclase activity
|
regulates |
positive regulation of adenylate cyclase activity
|
positively_regulates |
adenylate cyclase inhibitor activity
|
negatively_regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P9WQ29 | 83332 | Y1320_MYCTU | GO:0004016 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:11431477 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 4.6.1.1 | |
InterPro | IPR000274 | Adenylate cyclase, class-I |
InterPro | IPR009398 | Adenylate cyclase, conserved domain |
InterPro | IPR013716 | Adenylate cyclase G-alpha binding |
InterPro | IPR014046 | Diadenylate cyclase |
InterPro | IPR016577 | Adenylate cyclase, type 10 |
InterPro | IPR030672 | Adenylate cyclase |
InterPro | IPR034693 | Diadenylate cyclase CdaS |
InterPro | IPR034701 | Diadenylate cyclase CdaA |
MetaCyc | ADENYLATECYC-RXN |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:58165 | 3',5'-cyclic AMP(1-) |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0008492 | obsolete cAMP generating peptide activity | consider GO:0004016 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004016 based on ALL annotations
The top 100 of 1,069 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
adenylate cyclase activity
|
940.59 | 100.00 | 207,251 | 207,251 |
cyclic nucleotide biosynthetic process
|
876.48 | 57.75 | 124,968 | 134,109 |
cAMP biosynthetic process
|
919.99 | 41.73 | 87,292 | 89,247 |
intracellular signal transduction
|
229.18 | 21.61 | 136,053 | 558,389 |
phosphorus-oxygen lyase activity
|
729.09 | 10.53 | 22,513 | 29,044 |
guanylate cyclase activity
|
646.80 | 10.43 | 22,696 | 33,005 |
receptor guanylyl cyclase signaling pathway
|
806.83 | 10.33 | 21,787 | 25,399 |
cGMP biosynthetic process
|
590.57 | 10.29 | 22,702 | 36,157 |
peptide receptor activity
|
908.29 | 9.76 | 20,299 | 21,021 |
diadenylate cyclase activity
|
896.64 | 8.44 | 17,566 | 18,427 |
Totals | 1257915 | 209943313 |
No co-occurrence statistics for GO:0004016 based on MANUAL annotations
The top 100 of 341 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
adenylate cyclase activity
|
2,518.13 | 100.00 | 513 | 513 |
cAMP biosynthetic process
|
2,077.24 | 43.36 | 245 | 297 |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
|
760.97 | 14.34 | 110 | 364 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway
|
270.31 | 10.08 | 320 | 2,981 |
cellular response to forskolin
|
372.40 | 3.31 | 21 | 142 |
calcium- and calmodulin-responsive adenylate cyclase activity
|
2,518.13 | 2.92 | 15 | 15 |
neuroinflammatory response
|
411.12 | 1.44 | 8 | 49 |
positive regulation of long-term synaptic potentiation
|
268.60 | 1.38 | 8 | 75 |
positive regulation of CREB transcription factor activity
|
559.58 | 1.12 | 6 | 27 |
regulation of adaptive immune response
|
233.16 | 0.89 | 5 | 54 |
Totals | 1643 | 45059 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | RELATION | has part GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway) |
2024-02-24 | Deleted | RELATION | has part GO:0140676 (oscillatory cAMP signaling) |
2023-04-02 | Added | XREF | Reactome:R-HSA-9712183 |
2021-07-04 | Added | RELATION | has part GO:0140676 (oscillatory cAMP signaling) |
2020-10-08 | Added | SYNONYM | ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity |
2020-10-08 | Added | SYNONYM | ATP pyrophosphate-lyase activity |
2020-10-08 | Added | SYNONYM | 3',5'-cyclic AMP synthetase activity |
2020-10-08 | Added | SYNONYM | adenylylcyclase activity |
2020-10-08 | Deleted | SYNONYM | ATP diphosphate-lyase (cyclizing) activity |
2020-10-08 | Deleted | SYNONYM | ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | adenylate cyclase activity |
2002-02-06 | Updated | TERM | adenylate cyclase |
2001-04-03 | Updated | TERM | adenylate cyclase |
2001-03-30 | Added | TERM | adenylate cyclase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity |
2020-10-08 | Added | SYNONYM | ATP pyrophosphate-lyase activity |
2020-10-08 | Added | SYNONYM | 3',5'-cyclic AMP synthetase activity |
2020-10-08 | Added | SYNONYM | adenylylcyclase activity |
2020-10-08 | Deleted | SYNONYM | ATP diphosphate-lyase (cyclizing) activity |
2020-10-08 | Deleted | SYNONYM | ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity |
2020-10-08 | Deleted | SYNONYM | adenylylcyclase activity |
2020-10-08 | Added | SYNONYM | ATP diphosphate-lyase (cyclizing) activity |
2020-10-08 | Deleted | SYNONYM | adenyl cyclase activity |
2020-10-08 | Deleted | SYNONYM | ATP pyrophosphate-lyase activity |
2020-10-08 | Added | SYNONYM | adenyl cyclase activity |
2020-10-08 | Deleted | SYNONYM | 3',5'-cyclic AMP synthetase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. |
2007-12-14 | Added | SYNONYM | ATP diphosphate-lyase (cyclizing) activity |
2007-12-14 | Added | SYNONYM | ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity |
2007-12-14 | Added | SYNONYM | adenylylcyclase activity |
2007-09-06 | Added | SYNONYM | 3',5'-cyclic AMP synthetase activity |
2007-09-06 | Added | SYNONYM | ATP pyrophosphate-lyase activity |
2007-09-06 | Added | SYNONYM | adenyl cyclase activity |
2007-08-09 | Deleted | SYNONYM | cAMP generating peptide activity |
2007-08-09 | Deleted | SYNONYM | adenylyl cyclase activity |
2007-08-09 | Added | SYNONYM | cAMP generating peptide activity |
2007-08-09 | Added | SYNONYM | adenylyl cyclase activity |
2005-08-10 | Added | SYNONYM | cAMP generating peptide activity |
2004-09-03 | Added | SYNONYM | adenylyl cyclase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | RELATION | has part GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway) |
2024-02-24 | Deleted | RELATION | has part GO:0140676 (oscillatory cAMP signaling) |
2021-07-04 | Added | RELATION | has part GO:0140676 (oscillatory cAMP signaling) |
2018-05-16 | Deleted | RELATION | part of GO:0006171 (cAMP biosynthetic process) |
2010-06-15 | Added | RELATION | part of GO:0006171 (cAMP biosynthetic process) |
2010-06-14 | Deleted | RELATION | part of GO:0006171 (cAMP biosynthetic process) |
2010-06-08 | Added | RELATION | part of GO:0006171 (cAMP biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0016849 (phosphorus-oxygen lyase activity) |
2008-04-01 | Updated | RELATION | is a GO:0009975 (cyclase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9712183 |
2019-04-01 | Added | XREF | Reactome:R-HSA-392129 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-170676 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5610727 |
2019-04-01 | Added | XREF | Reactome:R-HSA-381607 |
2019-04-01 | Added | XREF | Reactome:R-HSA-170676 |
2019-04-01 | Added | XREF | Reactome:R-HSA-164377 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5610727 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5211224 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-392129 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-164377 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-381607 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5211224 |
2019-02-09 | Deleted | XREF | reactome:R-HSA-442715 |
2019-01-29 | Added | XREF | reactome:R-HSA-442715 |
2019-01-26 | Deleted | XREF | reactome:R-HSA-442715 |
2018-12-11 | Added | XREF | reactome:R-HSA-5610727 |
2018-12-11 | Added | XREF | reactome:R-HSA-442715 |
2018-12-11 | Added | XREF | reactome:R-HSA-170676 |
2018-12-11 | Added | XREF | reactome:R-HSA-392129 |
2018-12-11 | Added | XREF | reactome:R-HSA-164377 |
2018-12-11 | Added | XREF | reactome:R-HSA-381607 |
2018-12-11 | Added | XREF | reactome:R-HSA-5211224 |
2018-07-13 | Deleted | XREF | RHEA:15392 |
2018-07-13 | Added | XREF | RHEA:15389 |
2011-09-16 | Added | XREF | RHEA:15392 |
2003-10-27 | Added | XREF | MetaCyc:ADENYLATECYC-RXN |
2001-03-30 | Added | XREF | EC:4.6.1.1 |
Timestamp | Action | Category | Detail |
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