This term is obsolete.

GO:0004055 JSON

argininosuccinate synthase activity

Molecular Function

Definition (GO:0004055 GONUTS page)

Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.

45,492 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
argininosuccinic acid synthetase activity related
arginosuccinate synthetase activity related
L-citrulline:L-aspartate ligase (AMP-forming) related
citrulline--aspartate ligase activity related
arginine succinate synthetase activity related
argininosuccinate synthetase activity related

Ancestor Chart

Ancestor chart for GO:0004055
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.3.4.5
InterPro IPR001518 Argininosuccinate synthase
InterPro IPR018223 Argininosuccinate synthase, conserved site
InterPro IPR023434 Argininosuccinate synthase, type 1 subfamily
InterPro IPR023437 Argininosuccinate synthase, type 2 subfamily
InterPro IPR024074 Argininosuccinate synthetase, catalytic/multimerisation domain body
MetaCyc ARGSUCCINSYN-RXN
RHEA 10932
Reactome R-HSA-70577

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57743 L-citrulline zwitterion
has_participant CHEBI CHEBI:33019 diphosphate(3-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:456215 adenosine 5'-monophosphate(2-)
has_participant CHEBI CHEBI:57472 (N(omega)-L-arginino)succinate(1-)
has_participant CHEBI CHEBI:29991 L-aspartate(1-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004055 based on ALL annotations
The top 100 of 271 co-occurring terms
Co-occurring Term PR S% #Together #Compared
argininosuccinate synthase activity
4,372.83 100.00 45,315 45,315
argininosuccinate metabolic process
4,372.73 98.21 44,506 44,507
urea cycle
3,568.17 80.55 44,601 54,659
L-arginine biosynthetic process
487.06 11.13 45,055 404,507
protein homodimerization activity
126.02 2.42 5,971 207,186
ligase activity
62.31 1.42 43,738 3,069,286
ATP binding
10.32 0.24 44,910 19,024,482
cellular response to laminar fluid shear stress
876.70 0.18 82 409
negative regulation of leukocyte cell-cell adhesion
696.26 0.18 82 515
cytoplasm
7.64 0.17 44,567 25,503,657
Totals 320388 70714506
No co-occurrence statistics for GO:0004055 based on MANUAL annotations
The top 56 of 56 co-occurring terms
Co-occurring Term PR S% #Together #Compared
argininosuccinate synthase activity
8,767.29 100.00 161 161
argininosuccinate metabolic process
8,712.49 98.15 159 160
urea cycle
7,508.15 85.64 161 188
L-arginine biosynthetic process
2,840.11 32.39 161 497
negative regulation of leukocyte cell-cell adhesion
1,095.91 1.14 2 16
cellular response to laminar fluid shear stress
797.03 1.10 2 22
citrulline metabolic process
273.98 0.90 2 64
aspartate metabolic process
227.72 0.85 2 77
cellular response to amine stimulus
876.73 0.59 1 10
cellular response to oleic acid
674.41 0.58 1 13
Totals 873 604241

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM citrulline--aspartate ligase activity
2020-10-08 Deleted SYNONYM argininosuccinate synthetase activity
2020-10-08 Deleted SYNONYM citrulline--aspartate ligase activity
2020-10-08 Added SYNONYM L-citrulline:L-aspartate ligase (AMP-forming)
2020-10-08 Added SYNONYM argininosuccinate synthetase activity
2020-10-08 Deleted SYNONYM arginosuccinate synthetase activity
2020-10-08 Deleted SYNONYM argininosuccinic acid synthetase activity
2020-10-08 Deleted SYNONYM L-citrulline:L-aspartate ligase (AMP-forming)
2020-10-08 Deleted SYNONYM arginine succinate synthetase activity
2020-10-08 Added SYNONYM arginine succinate synthetase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM argininosuccinate synthase activity
2002-02-06 Updated TERM argininosuccinate synthase
2001-04-03 Updated TERM argininosuccinate synthase
2001-03-30 Added TERM argininosuccinate synthase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM citrulline--aspartate ligase activity
2020-10-08 Deleted SYNONYM argininosuccinate synthetase activity
2020-10-08 Deleted SYNONYM citrulline--aspartate ligase activity
2020-10-08 Added SYNONYM L-citrulline:L-aspartate ligase (AMP-forming)
2020-10-08 Added SYNONYM argininosuccinate synthetase activity
2020-10-08 Deleted SYNONYM arginosuccinate synthetase activity
2020-10-08 Deleted SYNONYM argininosuccinic acid synthetase activity
2020-10-08 Deleted SYNONYM L-citrulline:L-aspartate ligase (AMP-forming)
2020-10-08 Deleted SYNONYM arginine succinate synthetase activity
2020-10-08 Added SYNONYM arginine succinate synthetase activity
2020-10-08 Added SYNONYM arginosuccinate synthetase activity
2020-10-08 Added SYNONYM argininosuccinic acid synthetase activity
2008-07-27 Added DEFINITION Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.
2008-07-27 Deleted DEFINITION Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (Nw-L-arginino)succinate.
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (Nw-L-arginino)succinate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (Nw-L-arginino)succinate.
2007-11-08 Added SYNONYM arginosuccinate synthetase activity
2007-11-08 Added SYNONYM argininosuccinic acid synthetase activity
2007-11-08 Added SYNONYM L-citrulline:L-aspartate ligase (AMP-forming)
2007-09-06 Added SYNONYM citrulline--aspartate ligase activity
2007-09-06 Added SYNONYM argininosuccinate synthetase activity
2007-09-06 Added SYNONYM arginine succinate synthetase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (Nw-L-arginino)succinate.
Timestamp Action Category Detail
2012-11-07 Deleted RELATION has part GO:0000050 (urea cycle)
2010-10-13 Added RELATION has part GO:0000050 (urea cycle)
2008-04-01 Updated RELATION is a GO:0016879 (ligase activity, forming carbon-nitrogen bonds)
Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-70577
2019-04-01 Added XREF Reactome:R-HSA-70577
2018-12-11 Added XREF reactome:R-HSA-70577
2018-07-13 Added XREF RHEA:10932
2018-07-13 Deleted XREF RHEA:10935
2011-09-16 Added XREF RHEA:10935
2003-10-27 Added XREF MetaCyc:ARGSUCCINSYN-RXN
2001-03-30 Added XREF EC:6.3.4.5
Timestamp Action Category Detail
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