GO:0004055
JSON
argininosuccinate synthase activity
Molecular Function
Definition (GO:0004055 GONUTS page)
Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
argininosuccinic acid synthetase activity | related |
arginosuccinate synthetase activity | related |
L-citrulline:L-aspartate ligase (AMP-forming) | related |
citrulline--aspartate ligase activity | related |
arginine succinate synthetase activity | related |
argininosuccinate synthetase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.3.4.5 | |
InterPro | IPR001518 | Argininosuccinate synthase |
InterPro | IPR018223 | Argininosuccinate synthase, conserved site |
InterPro | IPR023434 | Argininosuccinate synthase, type 1 subfamily |
InterPro | IPR023437 | Argininosuccinate synthase, type 2 subfamily |
InterPro | IPR024074 | Argininosuccinate synthetase, catalytic/multimerisation domain body |
MetaCyc | ARGSUCCINSYN-RXN | |
RHEA | 10932 | |
Reactome | R-HSA-70577 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57743 | L-citrulline zwitterion |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:456215 | adenosine 5'-monophosphate(2-) |
has_participant | CHEBI | CHEBI:57472 | (N(omega)-L-arginino)succinate(1-) |
has_participant | CHEBI | CHEBI:29991 | L-aspartate(1-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004055 based on ALL annotations
The top 100 of 271 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
argininosuccinate synthase activity
|
4,372.83 | 100.00 | 45,315 | 45,315 |
argininosuccinate metabolic process
|
4,372.73 | 98.21 | 44,506 | 44,507 |
urea cycle
|
3,568.17 | 80.55 | 44,601 | 54,659 |
L-arginine biosynthetic process
|
487.06 | 11.13 | 45,055 | 404,507 |
protein homodimerization activity
|
126.02 | 2.42 | 5,971 | 207,186 |
ligase activity
|
62.31 | 1.42 | 43,738 | 3,069,286 |
ATP binding
|
10.32 | 0.24 | 44,910 | 19,024,482 |
cellular response to laminar fluid shear stress
|
876.70 | 0.18 | 82 | 409 |
negative regulation of leukocyte cell-cell adhesion
|
696.26 | 0.18 | 82 | 515 |
cytoplasm
|
7.64 | 0.17 | 44,567 | 25,503,657 |
Totals | 320388 | 70714506 |
No co-occurrence statistics for GO:0004055 based on MANUAL annotations
The top 56 of 56 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
argininosuccinate synthase activity
|
8,767.29 | 100.00 | 161 | 161 |
argininosuccinate metabolic process
|
8,712.49 | 98.15 | 159 | 160 |
urea cycle
|
7,508.15 | 85.64 | 161 | 188 |
L-arginine biosynthetic process
|
2,840.11 | 32.39 | 161 | 497 |
negative regulation of leukocyte cell-cell adhesion
|
1,095.91 | 1.14 | 2 | 16 |
cellular response to laminar fluid shear stress
|
797.03 | 1.10 | 2 | 22 |
citrulline metabolic process
|
273.98 | 0.90 | 2 | 64 |
aspartate metabolic process
|
227.72 | 0.85 | 2 | 77 |
cellular response to amine stimulus
|
876.73 | 0.59 | 1 | 10 |
cellular response to oleic acid
|
674.41 | 0.58 | 1 | 13 |
Totals | 873 | 604241 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | citrulline--aspartate ligase activity |
2020-10-08 | Deleted | SYNONYM | argininosuccinate synthetase activity |
2020-10-08 | Deleted | SYNONYM | citrulline--aspartate ligase activity |
2020-10-08 | Added | SYNONYM | L-citrulline:L-aspartate ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | argininosuccinate synthetase activity |
2020-10-08 | Deleted | SYNONYM | arginosuccinate synthetase activity |
2020-10-08 | Deleted | SYNONYM | argininosuccinic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | L-citrulline:L-aspartate ligase (AMP-forming) |
2020-10-08 | Deleted | SYNONYM | arginine succinate synthetase activity |
2020-10-08 | Added | SYNONYM | arginine succinate synthetase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | argininosuccinate synthase activity |
2002-02-06 | Updated | TERM | argininosuccinate synthase |
2001-04-03 | Updated | TERM | argininosuccinate synthase |
2001-03-30 | Added | TERM | argininosuccinate synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | citrulline--aspartate ligase activity |
2020-10-08 | Deleted | SYNONYM | argininosuccinate synthetase activity |
2020-10-08 | Deleted | SYNONYM | citrulline--aspartate ligase activity |
2020-10-08 | Added | SYNONYM | L-citrulline:L-aspartate ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | argininosuccinate synthetase activity |
2020-10-08 | Deleted | SYNONYM | arginosuccinate synthetase activity |
2020-10-08 | Deleted | SYNONYM | argininosuccinic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | L-citrulline:L-aspartate ligase (AMP-forming) |
2020-10-08 | Deleted | SYNONYM | arginine succinate synthetase activity |
2020-10-08 | Added | SYNONYM | arginine succinate synthetase activity |
2020-10-08 | Added | SYNONYM | arginosuccinate synthetase activity |
2020-10-08 | Added | SYNONYM | argininosuccinic acid synthetase activity |
2008-07-27 | Added | DEFINITION | Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. |
2008-07-27 | Deleted | DEFINITION | Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (Nw-L-arginino)succinate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (Nw-L-arginino)succinate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (Nw-L-arginino)succinate. |
2007-11-08 | Added | SYNONYM | arginosuccinate synthetase activity |
2007-11-08 | Added | SYNONYM | argininosuccinic acid synthetase activity |
2007-11-08 | Added | SYNONYM | L-citrulline:L-aspartate ligase (AMP-forming) |
2007-09-06 | Added | SYNONYM | citrulline--aspartate ligase activity |
2007-09-06 | Added | SYNONYM | argininosuccinate synthetase activity |
2007-09-06 | Added | SYNONYM | arginine succinate synthetase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (Nw-L-arginino)succinate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-11-07 | Deleted | RELATION | has part GO:0000050 (urea cycle) |
2010-10-13 | Added | RELATION | has part GO:0000050 (urea cycle) |
2008-04-01 | Updated | RELATION | is a GO:0016879 (ligase activity, forming carbon-nitrogen bonds) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-70577 |
2019-04-01 | Added | XREF | Reactome:R-HSA-70577 |
2018-12-11 | Added | XREF | reactome:R-HSA-70577 |
2018-07-13 | Added | XREF | RHEA:10932 |
2018-07-13 | Deleted | XREF | RHEA:10935 |
2011-09-16 | Added | XREF | RHEA:10935 |
2003-10-27 | Added | XREF | MetaCyc:ARGSUCCINSYN-RXN |
2001-03-30 | Added | XREF | EC:6.3.4.5 |
Timestamp | Action | Category | Detail |
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