GO:0004076
JSON
biotin synthase activity
Molecular Function
Definition (GO:0004076 GONUTS page)
Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
biotin synthetase activity | related |
dethiobiotin:sulfur sulfurtransferase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.8.1.6 | |
InterPro | IPR002684 | Biotin synthase/Biotin biosynthesis bifunctional protein BioAB |
KEGG_REACTION | R01078 | |
MetaCyc | 2.8.1.6-RXN | |
RHEA | 22060 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:64428 | H group |
has_participant | CHEBI | CHEBI:59789 | S-adenosyl-L-methionine zwitterion |
has_participant | CHEBI | CHEBI:57586 | biotinate |
has_participant | CHEBI | CHEBI:149473 | (4R,5S)-dethiobiotin(1-) |
has_participant | CHEBI | CHEBI:33738 | di-mu-sulfido-diiron(1+) |
has_participant | CHEBI | CHEBI:29917 | thiol group |
has_participant | CHEBI | CHEBI:33737 | di-mu-sulfido-diiron(2+) |
has_participant | CHEBI | CHEBI:57844 | L-methionine zwitterion |
has_participant | CHEBI | CHEBI:17319 | 5'-deoxyadenosine |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004076 based on ALL annotations
The top 100 of 106 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
biotin synthase activity
|
7,009.92 | 100.00 | 27,809 | 27,809 |
water-soluble vitamin biosynthetic process
|
4,726.64 | 64.02 | 25,775 | 38,226 |
sulfur compound biosynthetic process
|
2,131.32 | 29.69 | 25,775 | 84,774 |
biotin biosynthetic process
|
1,488.36 | 21.15 | 27,287 | 128,517 |
2 iron, 2 sulfur cluster binding
|
226.77 | 3.23 | 27,249 | 842,312 |
iron-sulfur cluster binding
|
116.27 | 1.66 | 27,235 | 1,641,943 |
iron ion binding
|
92.06 | 1.31 | 22,716 | 1,729,644 |
4 iron, 4 sulfur cluster binding
|
81.58 | 1.16 | 27,512 | 2,363,962 |
adenosylmethionine-8-amino-7-oxononanoate transaminase activity
|
51.34 | 0.41 | 259 | 35,365 |
transferase activity
|
23.09 | 0.33 | 23,831 | 7,234,614 |
Totals | 266618 | 275113848 |
No co-occurrence statistics for GO:0004076 based on MANUAL annotations
The top 10 of 10 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
biotin synthase activity
|
13,890.31 | 100.00 | 93 | 93 |
biotin biosynthetic process
|
2,778.06 | 20.00 | 93 | 465 |
2 iron, 2 sulfur cluster binding
|
1,176.50 | 8.47 | 93 | 1,098 |
peptidoglycan-based cell wall
|
17.56 | 0.11 | 1 | 791 |
4 iron, 4 sulfur cluster binding
|
9.40 | 0.06 | 1 | 1,477 |
protein homodimerization activity
|
2.61 | 0.02 | 1 | 5,319 |
mitochondrion
|
0.61 | 0.00 | 2 | 45,791 |
protein binding
|
0.33 | 0.00 | 1 | 41,817 |
cellular_component
|
0.22 | 0.00 | 1 | 62,739 |
plasma membrane
|
0.11 | 0.00 | 1 | 131,928 |
Totals | 287 | 291518 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+. |
2020-10-08 | Added | SYNONYM | dethiobiotin:sulfur sulfurtransferase activity |
2020-10-08 | Deleted | SYNONYM | biotin synthetase activity |
2020-10-08 | Deleted | SYNONYM | dethiobiotin:sulfur sulfurtransferase activity |
2020-10-08 | Added | SYNONYM | biotin synthetase activity |
2019-06-20 | Added | XREF | KEGG_REACTION:R01078 |
2019-06-20 | Deleted | XREF | KEGG:R01078 |
2018-07-13 | Deleted | XREF | RHEA:22063 |
2018-07-13 | Deleted | RELATION | is a GO:0070283 (radical SAM enzyme activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | biotin synthase activity |
2002-02-06 | Updated | TERM | biotin synthase |
2001-04-03 | Updated | TERM | biotin synthase |
2001-03-30 | Added | TERM | biotin synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+. |
2020-10-08 | Added | SYNONYM | dethiobiotin:sulfur sulfurtransferase activity |
2020-10-08 | Deleted | SYNONYM | biotin synthetase activity |
2020-10-08 | Deleted | SYNONYM | dethiobiotin:sulfur sulfurtransferase activity |
2020-10-08 | Added | SYNONYM | biotin synthetase activity |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: dethiobiotin + sulfur = biotin. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+). |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: dethiobiotin + sulfur = biotin. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: dethiobiotin + sulfur = biotin. |
2007-11-08 | Added | SYNONYM | dethiobiotin:sulfur sulfurtransferase activity |
2007-09-06 | Added | SYNONYM | biotin synthetase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: dethiobiotin + sulfur = biotin. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-07-13 | Deleted | RELATION | is a GO:0070283 (radical SAM enzyme activity) |
2009-02-05 | Added | RELATION | is a GO:0070283 (radical SAM enzyme activity) |
2008-04-01 | Updated | RELATION | is a GO:0016783 (sulfurtransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Added | XREF | KEGG_REACTION:R01078 |
2019-06-20 | Deleted | XREF | KEGG:R01078 |
2018-07-13 | Deleted | XREF | RHEA:22063 |
2018-07-13 | Added | XREF | RHEA:22060 |
2010-10-11 | Added | XREF | RHEA:22063 |
2010-10-11 | Added | XREF | KEGG:R01078 |
2003-10-27 | Added | XREF | MetaCyc:2.8.1.6-RXN |
2001-03-30 | Added | XREF | EC:2.8.1.6 |
Timestamp | Action | Category | Detail |
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