This term is obsolete.

GO:0004076 JSON

biotin synthase activity

Molecular Function

Definition (GO:0004076 GONUTS page)

Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+.

27,906 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
biotin synthetase activity related
dethiobiotin:sulfur sulfurtransferase activity related

Ancestor Chart

Ancestor chart for GO:0004076
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.8.1.6
InterPro IPR002684 Biotin synthase/Biotin biosynthesis bifunctional protein BioAB
KEGG_REACTION R01078
MetaCyc 2.8.1.6-RXN
RHEA 22060

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:64428 H group
has_participant CHEBI CHEBI:59789 S-adenosyl-L-methionine zwitterion
has_participant CHEBI CHEBI:57586 biotinate
has_participant CHEBI CHEBI:149473 (4R,5S)-dethiobiotin(1-)
has_participant CHEBI CHEBI:33738 di-mu-sulfido-diiron(1+)
has_participant CHEBI CHEBI:29917 thiol group
has_participant CHEBI CHEBI:33737 di-mu-sulfido-diiron(2+)
has_participant CHEBI CHEBI:57844 L-methionine zwitterion
has_participant CHEBI CHEBI:17319 5'-deoxyadenosine

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004076 based on ALL annotations
The top 100 of 106 co-occurring terms
Co-occurring Term PR S% #Together #Compared
biotin synthase activity
7,009.92 100.00 27,809 27,809
water-soluble vitamin biosynthetic process
4,726.64 64.02 25,775 38,226
sulfur compound biosynthetic process
2,131.32 29.69 25,775 84,774
biotin biosynthetic process
1,488.36 21.15 27,287 128,517
2 iron, 2 sulfur cluster binding
226.77 3.23 27,249 842,312
iron-sulfur cluster binding
116.27 1.66 27,235 1,641,943
iron ion binding
92.06 1.31 22,716 1,729,644
4 iron, 4 sulfur cluster binding
81.58 1.16 27,512 2,363,962
adenosylmethionine-8-amino-7-oxononanoate transaminase activity
51.34 0.41 259 35,365
transferase activity
23.09 0.33 23,831 7,234,614
Totals 266618 275113848
No co-occurrence statistics for GO:0004076 based on MANUAL annotations
The top 10 of 10 co-occurring terms
Co-occurring Term PR S% #Together #Compared
biotin synthase activity
13,890.31 100.00 93 93
biotin biosynthetic process
2,778.06 20.00 93 465
2 iron, 2 sulfur cluster binding
1,176.50 8.47 93 1,098
peptidoglycan-based cell wall
17.56 0.11 1 791
4 iron, 4 sulfur cluster binding
9.40 0.06 1 1,477
protein homodimerization activity
2.61 0.02 1 5,319
mitochondrion
0.61 0.00 2 45,791
protein binding
0.33 0.00 1 41,817
cellular_component
0.22 0.00 1 62,739
plasma membrane
0.11 0.00 1 131,928
Totals 287 291518

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+).
2022-09-01 Added DEFINITION Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+.
2020-10-08 Added SYNONYM dethiobiotin:sulfur sulfurtransferase activity
2020-10-08 Deleted SYNONYM biotin synthetase activity
2020-10-08 Deleted SYNONYM dethiobiotin:sulfur sulfurtransferase activity
2020-10-08 Added SYNONYM biotin synthetase activity
2019-06-20 Added XREF KEGG_REACTION:R01078
2019-06-20 Deleted XREF KEGG:R01078
2018-07-13 Deleted XREF RHEA:22063
2018-07-13 Deleted RELATION is a GO:0070283 (radical SAM enzyme activity)
Timestamp Action Category Detail
2003-03-19 Updated TERM biotin synthase activity
2002-02-06 Updated TERM biotin synthase
2001-04-03 Updated TERM biotin synthase
2001-03-30 Added TERM biotin synthase
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+).
2022-09-01 Added DEFINITION Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+.
2020-10-08 Added SYNONYM dethiobiotin:sulfur sulfurtransferase activity
2020-10-08 Deleted SYNONYM biotin synthetase activity
2020-10-08 Deleted SYNONYM dethiobiotin:sulfur sulfurtransferase activity
2020-10-08 Added SYNONYM biotin synthetase activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: dethiobiotin + sulfur = biotin.
2010-10-11 Added DEFINITION Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+).
2008-05-13 Added DEFINITION Catalysis of the reaction: dethiobiotin + sulfur = biotin.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: dethiobiotin + sulfur = biotin.
2007-11-08 Added SYNONYM dethiobiotin:sulfur sulfurtransferase activity
2007-09-06 Added SYNONYM biotin synthetase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: dethiobiotin + sulfur = biotin.
Timestamp Action Category Detail
2018-07-13 Deleted RELATION is a GO:0070283 (radical SAM enzyme activity)
2009-02-05 Added RELATION is a GO:0070283 (radical SAM enzyme activity)
2008-04-01 Updated RELATION is a GO:0016783 (sulfurtransferase activity)
Timestamp Action Category Detail
2019-06-20 Added XREF KEGG_REACTION:R01078
2019-06-20 Deleted XREF KEGG:R01078
2018-07-13 Deleted XREF RHEA:22063
2018-07-13 Added XREF RHEA:22060
2010-10-11 Added XREF RHEA:22063
2010-10-11 Added XREF KEGG:R01078
2003-10-27 Added XREF MetaCyc:2.8.1.6-RXN
2001-03-30 Added XREF EC:2.8.1.6
Timestamp Action Category Detail
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