This term is obsolete.

GO:0004152 JSON

dihydroorotate dehydrogenase activity

Molecular Function

Definition (GO:0004152 GONUTS page)

Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.

86,186 annotations

Ancestor Chart

Ancestor chart for GO:0004152
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004152

Child Term Relationship to
GO:0004152
dihydroorotate dehydrogenase (fumarate) activity
is_a
dihydroorotate dehydrogenase (NAD+) activity
is_a
dihydroorotate dehydrogenase (quinone) activity
is_a
dihydroorotate dehydrogenase (NADP+) activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03878 559292 SCE2_YEAST GO:0004152 To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR005719 Dihydroorotate dehydrogenase, class 2
InterPro IPR012135 Dihydroorotate dehydrogenase, class 1/ 2
InterPro IPR024920 Dihydroorotate dehydrogenase, class 1
InterPro IPR033886 Dihydroorotate dehydrogenase, class 1A
InterPro IPR033888 Dihydroorotate dehydrogenase, class 1B
KEGG_REACTION R01868
MetaCyc DIHYDROOROTATE-DEHYDROGENASE-RXN
RHEA 18073
Reactome R-HSA-73569

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:17499 hydrogen donor
has_participant CHEBI CHEBI:30864 (S)-dihydroorotate
has_participant CHEBI CHEBI:30839 orotate
has_participant CHEBI CHEBI:13193 hydrogen acceptor

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004152 based on ALL annotations
The top 100 of 296 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dihydroorotate dehydrogenase activity
3,352.86 100.00 58,141 58,141
pyrimidine ribonucleotide biosynthetic process
2,583.70 46.96 31,740 41,189
UMP biosynthetic process
1,688.33 40.38 39,012 77,474
dihydroorotate dehydrogenase (quinone) activity
3,345.12 37.14 21,614 21,664
'de novo' pyrimidine nucleobase biosynthetic process
708.36 21.06 57,260 271,028
'de novo' UMP biosynthetic process
575.30 16.72 50,449 294,019
pyrimidine nucleotide biosynthetic process
362.57 10.67 51,870 479,672
dihydroorotate dehydrogenase (NAD+) activity
3,281.46 6.94 4,044 4,132
dihydroorotate dehydrogenase (fumarate) activity
3,020.49 3.19 1,863 2,068
uracil binding
902.24 2.43 1,515 5,630
Totals 506245 177204947
No co-occurrence statistics for GO:0004152 based on MANUAL annotations
The top 35 of 35 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dihydroorotate dehydrogenase activity
7,781.92 100.00 166 166
pyrimidine ribonucleotide biosynthetic process
7,659.37 74.40 125 127
'de novo' pyrimidine nucleobase biosynthetic process
3,174.71 40.59 164 402
dihydroorotate dehydrogenase (quinone) activity
7,781.92 1.81 3 3
'de novo' UMP biosynthetic process
1,111.70 1.63 3 21
mitochondrial inner membrane
110.14 1.40 99 6,995
dihydroorotase activity
128.63 0.70 2 121
fumarate metabolic process
103.76 0.64 2 150
dihydroorotate dehydrogenase (NAD+) activity
7,781.92 0.60 1 1
response to L-arginine
155.64 0.47 1 50
Totals 639 647041

Change Log

Timestamp Action Category Detail
2022-07-30 Deleted XREF EC:1.3.5.2
2022-07-30 Added RELATION is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
2022-07-30 Deleted RELATION is a GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor)
2022-07-30 Deleted SYNONYM (S)-dihydroorotate:quinone oxidoreductase activity
2022-07-30 Deleted SYNONYM dihydroorotate:ubiquinone oxidoreductase activity
2022-07-30 Deleted SYNONYM (DHO) dehydrogenase activity
2022-07-30 Deleted SYNONYM DHOdehase activity
2022-07-30 Deleted SYNONYM dihydoorotic acid dehydrogenase activity
2020-10-08 Deleted SYNONYM dihydoorotic acid dehydrogenase activity
2020-10-08 Added SYNONYM DHOdehase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM dihydroorotate dehydrogenase activity
2002-02-06 Updated TERM dihydroorotate dehydrogenase
2001-04-03 Updated TERM dihydroorotate dehydrogenase
2001-03-30 Added TERM dihydroorotate dehydrogenase
Timestamp Action Category Detail
2022-07-30 Deleted SYNONYM (S)-dihydroorotate:quinone oxidoreductase activity
2022-07-30 Deleted SYNONYM dihydroorotate:ubiquinone oxidoreductase activity
2022-07-30 Deleted SYNONYM (DHO) dehydrogenase activity
2022-07-30 Deleted SYNONYM DHOdehase activity
2022-07-30 Deleted SYNONYM dihydoorotic acid dehydrogenase activity
2020-10-08 Deleted SYNONYM dihydoorotic acid dehydrogenase activity
2020-10-08 Added SYNONYM DHOdehase activity
2020-10-08 Deleted SYNONYM DHOdehase activity
2020-10-08 Added SYNONYM dihydoorotic acid dehydrogenase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.
2010-10-11 Deleted DEFINITION Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor.
2010-09-03 Deleted SYNONYM (S)-dihydroorotate:acceptor oxidoreductase activity
2010-09-03 Added SYNONYM (S)-dihydroorotate:quinone oxidoreductase activity
2010-09-03 Deleted SYNONYM (S)-dihydroorotate:(acceptor) oxidoreductase activity
2008-06-30 Added SYNONYM dihydroorotate:ubiquinone oxidoreductase activity
2008-06-30 Deleted SYNONYM dihydroorotate:ubiquinone oxidoreductase activity
2008-06-30 Added SYNONYM DHOdehase activity
2008-06-30 Added SYNONYM dihydoorotic acid dehydrogenase activity
2008-06-30 Added SYNONYM (DHO) dehydrogenase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor.
2007-11-08 Added SYNONYM (S)-dihydroorotate:(acceptor) oxidoreductase activity
2007-11-08 Added SYNONYM (S)-dihydroorotate:acceptor oxidoreductase activity
2007-11-08 Added SYNONYM dihydroorotate:ubiquinone oxidoreductase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor.
Timestamp Action Category Detail
2022-07-30 Added RELATION is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
2022-07-30 Deleted RELATION is a GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor)
2010-09-03 Added RELATION is a GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor)
2010-09-03 Deleted RELATION is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
2008-04-01 Updated RELATION is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
Timestamp Action Category Detail
2022-07-30 Deleted XREF EC:1.3.5.2
2019-06-20 Deleted XREF KEGG:R01868
2019-06-20 Added XREF KEGG_REACTION:R01868
2019-04-01 Added XREF Reactome:R-HSA-73569
2019-04-01 Deleted XREF reactome:R-HSA-73569
2018-12-11 Added XREF reactome:R-HSA-73569
2018-07-13 Added XREF RHEA:18073
2018-07-13 Deleted XREF RHEA:18076
2010-10-11 Added XREF RHEA:18076
2010-09-03 Added XREF EC:1.3.5.2
2010-09-03 Deleted XREF EC:1.3.99.11
2010-09-03 Added XREF KEGG:R01868
2003-10-27 Added XREF MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN
2001-03-30 Added XREF EC:1.3.99.11
Timestamp Action Category Detail
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