GO:0004152
JSON
dihydroorotate dehydrogenase activity
Molecular Function
Definition (GO:0004152 GONUTS page)
Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.
Ancestor Chart
Ancestor chart for GO:0004152
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004152
Child Term | Relationship to GO:0004152 |
---|---|
dihydroorotate dehydrogenase (fumarate) activity
|
is_a |
dihydroorotate dehydrogenase (NAD+) activity
|
is_a |
dihydroorotate dehydrogenase (quinone) activity
|
is_a |
dihydroorotate dehydrogenase (NADP+) activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03878 | 559292 | SCE2_YEAST | GO:0004152 | To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012 | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR005719 | Dihydroorotate dehydrogenase, class 2 |
InterPro | IPR012135 | Dihydroorotate dehydrogenase, class 1/ 2 |
InterPro | IPR024920 | Dihydroorotate dehydrogenase, class 1 |
InterPro | IPR033886 | Dihydroorotate dehydrogenase, class 1A |
InterPro | IPR033888 | Dihydroorotate dehydrogenase, class 1B |
KEGG_REACTION | R01868 | |
MetaCyc | DIHYDROOROTATE-DEHYDROGENASE-RXN | |
RHEA | 18073 | |
Reactome | R-HSA-73569 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:17499 | hydrogen donor |
has_participant | CHEBI | CHEBI:30864 | (S)-dihydroorotate |
has_participant | CHEBI | CHEBI:30839 | orotate |
has_participant | CHEBI | CHEBI:13193 | hydrogen acceptor |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004152 based on ALL annotations
The top 100 of 296 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dihydroorotate dehydrogenase activity
|
3,352.86 | 100.00 | 58,141 | 58,141 |
pyrimidine ribonucleotide biosynthetic process
|
2,583.70 | 46.96 | 31,740 | 41,189 |
UMP biosynthetic process
|
1,688.33 | 40.38 | 39,012 | 77,474 |
dihydroorotate dehydrogenase (quinone) activity
|
3,345.12 | 37.14 | 21,614 | 21,664 |
'de novo' pyrimidine nucleobase biosynthetic process
|
708.36 | 21.06 | 57,260 | 271,028 |
'de novo' UMP biosynthetic process
|
575.30 | 16.72 | 50,449 | 294,019 |
pyrimidine nucleotide biosynthetic process
|
362.57 | 10.67 | 51,870 | 479,672 |
dihydroorotate dehydrogenase (NAD+) activity
|
3,281.46 | 6.94 | 4,044 | 4,132 |
dihydroorotate dehydrogenase (fumarate) activity
|
3,020.49 | 3.19 | 1,863 | 2,068 |
uracil binding
|
902.24 | 2.43 | 1,515 | 5,630 |
Totals | 506245 | 177204947 |
No co-occurrence statistics for GO:0004152 based on MANUAL annotations
The top 35 of 35 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dihydroorotate dehydrogenase activity
|
7,781.92 | 100.00 | 166 | 166 |
pyrimidine ribonucleotide biosynthetic process
|
7,659.37 | 74.40 | 125 | 127 |
'de novo' pyrimidine nucleobase biosynthetic process
|
3,174.71 | 40.59 | 164 | 402 |
dihydroorotate dehydrogenase (quinone) activity
|
7,781.92 | 1.81 | 3 | 3 |
'de novo' UMP biosynthetic process
|
1,111.70 | 1.63 | 3 | 21 |
mitochondrial inner membrane
|
110.14 | 1.40 | 99 | 6,995 |
dihydroorotase activity
|
128.63 | 0.70 | 2 | 121 |
fumarate metabolic process
|
103.76 | 0.64 | 2 | 150 |
dihydroorotate dehydrogenase (NAD+) activity
|
7,781.92 | 0.60 | 1 | 1 |
response to L-arginine
|
155.64 | 0.47 | 1 | 50 |
Totals | 639 | 647041 |
Change Log
- All changes
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-30 | Deleted | XREF | EC:1.3.5.2 |
2022-07-30 | Added | RELATION | is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors) |
2022-07-30 | Deleted | RELATION | is a GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor) |
2022-07-30 | Deleted | SYNONYM | (S)-dihydroorotate:quinone oxidoreductase activity |
2022-07-30 | Deleted | SYNONYM | dihydroorotate:ubiquinone oxidoreductase activity |
2022-07-30 | Deleted | SYNONYM | (DHO) dehydrogenase activity |
2022-07-30 | Deleted | SYNONYM | DHOdehase activity |
2022-07-30 | Deleted | SYNONYM | dihydoorotic acid dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | dihydoorotic acid dehydrogenase activity |
2020-10-08 | Added | SYNONYM | DHOdehase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | dihydroorotate dehydrogenase activity |
2002-02-06 | Updated | TERM | dihydroorotate dehydrogenase |
2001-04-03 | Updated | TERM | dihydroorotate dehydrogenase |
2001-03-30 | Added | TERM | dihydroorotate dehydrogenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-30 | Deleted | SYNONYM | (S)-dihydroorotate:quinone oxidoreductase activity |
2022-07-30 | Deleted | SYNONYM | dihydroorotate:ubiquinone oxidoreductase activity |
2022-07-30 | Deleted | SYNONYM | (DHO) dehydrogenase activity |
2022-07-30 | Deleted | SYNONYM | DHOdehase activity |
2022-07-30 | Deleted | SYNONYM | dihydoorotic acid dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | dihydoorotic acid dehydrogenase activity |
2020-10-08 | Added | SYNONYM | DHOdehase activity |
2020-10-08 | Deleted | SYNONYM | DHOdehase activity |
2020-10-08 | Added | SYNONYM | dihydoorotic acid dehydrogenase activity |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate. |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. |
2010-09-03 | Deleted | SYNONYM | (S)-dihydroorotate:acceptor oxidoreductase activity |
2010-09-03 | Added | SYNONYM | (S)-dihydroorotate:quinone oxidoreductase activity |
2010-09-03 | Deleted | SYNONYM | (S)-dihydroorotate:(acceptor) oxidoreductase activity |
2008-06-30 | Added | SYNONYM | dihydroorotate:ubiquinone oxidoreductase activity |
2008-06-30 | Deleted | SYNONYM | dihydroorotate:ubiquinone oxidoreductase activity |
2008-06-30 | Added | SYNONYM | DHOdehase activity |
2008-06-30 | Added | SYNONYM | dihydoorotic acid dehydrogenase activity |
2008-06-30 | Added | SYNONYM | (DHO) dehydrogenase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. |
2007-11-08 | Added | SYNONYM | (S)-dihydroorotate:(acceptor) oxidoreductase activity |
2007-11-08 | Added | SYNONYM | (S)-dihydroorotate:acceptor oxidoreductase activity |
2007-11-08 | Added | SYNONYM | dihydroorotate:ubiquinone oxidoreductase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-30 | Added | RELATION | is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors) |
2022-07-30 | Deleted | RELATION | is a GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor) |
2010-09-03 | Added | RELATION | is a GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor) |
2010-09-03 | Deleted | RELATION | is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors) |
2008-04-01 | Updated | RELATION | is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-30 | Deleted | XREF | EC:1.3.5.2 |
2019-06-20 | Deleted | XREF | KEGG:R01868 |
2019-06-20 | Added | XREF | KEGG_REACTION:R01868 |
2019-04-01 | Added | XREF | Reactome:R-HSA-73569 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-73569 |
2018-12-11 | Added | XREF | reactome:R-HSA-73569 |
2018-07-13 | Added | XREF | RHEA:18073 |
2018-07-13 | Deleted | XREF | RHEA:18076 |
2010-10-11 | Added | XREF | RHEA:18076 |
2010-09-03 | Added | XREF | EC:1.3.5.2 |
2010-09-03 | Deleted | XREF | EC:1.3.99.11 |
2010-09-03 | Added | XREF | KEGG:R01868 |
2003-10-27 | Added | XREF | MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN |
2001-03-30 | Added | XREF | EC:1.3.99.11 |
Timestamp | Action | Category | Detail |
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