This term is obsolete.

GO:0004152 JSON

dihydroorotate dehydrogenase activity

Molecular Function

Definition (GO:0004152 GONUTS page)

Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.

86,712 annotations

Ancestor Chart

Ancestor chart for GO:0004152
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004152

Child Term Relationship to
GO:0004152
dihydroorotate dehydrogenase (fumarate) activity
is_a
dihydroorotate dehydrogenase (NAD+) activity
is_a
dihydroorotate dehydrogenase (quinone) activity
is_a
dihydroorotate dehydrogenase (NADP+) activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03878 559292 SCE2_YEAST GO:0004152 To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR005719 Dihydroorotate dehydrogenase, class 2
InterPro IPR012135 Dihydroorotate dehydrogenase, class 1/ 2
InterPro IPR024920 Dihydroorotate dehydrogenase, class 1
InterPro IPR033886 Dihydroorotate dehydrogenase, class 1A
InterPro IPR033888 Dihydroorotate dehydrogenase, class 1B
KEGG_REACTION R01868
MetaCyc DIHYDROOROTATE-DEHYDROGENASE-RXN
RHEA 18073
Reactome R-HSA-73569

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:17499 hydrogen donor
has_participant CHEBI CHEBI:30864 (S)-dihydroorotate
has_participant CHEBI CHEBI:30839 orotate
has_participant CHEBI CHEBI:13193 hydrogen acceptor

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004152 based on ALL annotations
The top 100 of 313 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dihydroorotate dehydrogenase activity
3,366.09 100.00 58,868 58,868
pyrimidine ribonucleotide biosynthetic process
2,594.04 47.07 32,225 41,816
UMP biosynthetic process
1,690.77 40.23 39,382 78,404
dihydroorotate dehydrogenase (quinone) activity
3,358.19 36.10 21,272 21,322
'de novo' pyrimidine nucleobase biosynthetic process
710.83 21.05 57,977 274,547
'de novo' UMP biosynthetic process
575.45 16.64 50,769 296,973
pyrimidine nucleotide biosynthetic process
381.75 11.19 52,439 462,376
dihydroorotate dehydrogenase (NAD+) activity
3,284.69 7.12 4,197 4,301
dihydroorotate dehydrogenase (fumarate) activity
3,026.33 3.09 1,826 2,031
uracil binding
899.25 2.46 1,550 5,802
Totals 512003 178481042
No co-occurrence statistics for GO:0004152 based on MANUAL annotations
The top 35 of 35 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dihydroorotate dehydrogenase activity
8,065.90 100.00 175 175
pyrimidine ribonucleotide biosynthetic process
7,947.29 75.71 134 136
'de novo' pyrimidine nucleobase biosynthetic process
3,230.10 39.86 173 432
dihydroorotate dehydrogenase (quinone) activity
8,065.90 1.71 3 3
'de novo' UMP biosynthetic process
1,152.27 1.55 3 21
mitochondrial inner membrane
117.01 1.44 108 7,445
dihydroorotase activity
129.05 0.67 2 125
fumarate metabolic process
100.20 0.60 2 161
dihydroorotate dehydrogenase (NAD+) activity
8,065.90 0.57 1 1
response to L-arginine
161.32 0.45 1 50
Totals 675 693871

Change Log

Timestamp Action Category Detail
2022-07-30 Deleted SYNONYM DHOdehase activity
2022-07-30 Deleted SYNONYM dihydoorotic acid dehydrogenase activity
2022-07-30 Added RELATION is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
2022-07-30 Deleted RELATION is a GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor)
2022-07-30 Deleted SYNONYM (DHO) dehydrogenase activity
2022-07-30 Deleted SYNONYM (S)-dihydroorotate:quinone oxidoreductase activity
2022-07-30 Deleted XREF EC:1.3.5.2
2022-07-30 Deleted SYNONYM dihydroorotate:ubiquinone oxidoreductase activity
2020-10-08 Added SYNONYM dihydoorotic acid dehydrogenase activity
2020-10-08 Added SYNONYM DHOdehase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM dihydroorotate dehydrogenase activity
2002-02-06 Updated TERM dihydroorotate dehydrogenase
2001-04-03 Updated TERM dihydroorotate dehydrogenase
2001-03-30 Added TERM dihydroorotate dehydrogenase
Timestamp Action Category Detail
2022-07-30 Deleted SYNONYM DHOdehase activity
2022-07-30 Deleted SYNONYM dihydoorotic acid dehydrogenase activity
2022-07-30 Deleted SYNONYM (DHO) dehydrogenase activity
2022-07-30 Deleted SYNONYM (S)-dihydroorotate:quinone oxidoreductase activity
2022-07-30 Deleted SYNONYM dihydroorotate:ubiquinone oxidoreductase activity
2020-10-08 Added SYNONYM dihydoorotic acid dehydrogenase activity
2020-10-08 Added SYNONYM DHOdehase activity
2020-10-08 Deleted SYNONYM dihydoorotic acid dehydrogenase activity
2020-10-08 Deleted SYNONYM DHOdehase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.
2010-10-11 Deleted DEFINITION Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor.
2010-09-03 Added SYNONYM (S)-dihydroorotate:quinone oxidoreductase activity
2010-09-03 Deleted SYNONYM (S)-dihydroorotate:(acceptor) oxidoreductase activity
2010-09-03 Deleted SYNONYM (S)-dihydroorotate:acceptor oxidoreductase activity
2008-06-30 Added SYNONYM (DHO) dehydrogenase activity
2008-06-30 Added SYNONYM DHOdehase activity
2008-06-30 Added SYNONYM dihydoorotic acid dehydrogenase activity
2008-06-30 Added SYNONYM dihydroorotate:ubiquinone oxidoreductase activity
2008-06-30 Deleted SYNONYM dihydroorotate:ubiquinone oxidoreductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor.
2007-11-08 Added SYNONYM (S)-dihydroorotate:acceptor oxidoreductase activity
2007-11-08 Added SYNONYM (S)-dihydroorotate:(acceptor) oxidoreductase activity
2007-11-08 Added SYNONYM dihydroorotate:ubiquinone oxidoreductase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor.
Timestamp Action Category Detail
2022-07-30 Added RELATION is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
2022-07-30 Deleted RELATION is a GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor)
2010-09-03 Added RELATION is a GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor)
2010-09-03 Deleted RELATION is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
2008-04-01 Updated RELATION is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
Timestamp Action Category Detail
2022-07-30 Deleted XREF EC:1.3.5.2
2019-06-20 Added XREF KEGG_REACTION:R01868
2019-06-20 Deleted XREF KEGG:R01868
2019-04-01 Deleted XREF reactome:R-HSA-73569
2019-04-01 Added XREF Reactome:R-HSA-73569
2018-12-11 Added XREF reactome:R-HSA-73569
2018-07-13 Added XREF RHEA:18073
2018-07-13 Deleted XREF RHEA:18076
2010-10-11 Added XREF RHEA:18076
2010-09-03 Added XREF KEGG:R01868
2010-09-03 Deleted XREF EC:1.3.99.11
2010-09-03 Added XREF EC:1.3.5.2
2003-10-27 Added XREF MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN
2001-03-30 Added XREF EC:1.3.99.11
Timestamp Action Category Detail
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