GO:0004222
JSON
metalloendopeptidase activity
Molecular Function
Definition (GO:0004222 GONUTS page)
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
metalloendoprotease activity | narrow |
metalloendoproteinase activity | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004222
Child Term | Relationship to GO:0004222 |
---|---|
negative regulation of metalloendopeptidase activity
|
negatively_regulates |
metalloendopeptidase inhibitor activity
|
negatively_regulates |
metalloendopeptidase activity involved in amyloid precursor protein catabolic process
|
is_a |
regulation of metalloendopeptidase activity
|
regulates |
mitochondrial processing peptidase complex
|
capable_of |
positive regulation of metalloendopeptidase activity
|
positively_regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q18581 | 6239 | ACN1_CAEEL | GO:0008237 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 17th April 2015. | IPR001548 |
NOT-qualified manual | protein | A0A0B4JCV5 | 7227 | A0A0B4JCV5_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4JD89 | 7227 | A0A0B4JD89_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K6V8 | 7227 | A0A0B4K6V8_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K7A7 | 7227 | A0A0B4K7A7_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K7P3 | 7227 | A0A0B4K7P3_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KFB1 | 7227 | A0A0B4KFB1_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KFH4 | 7227 | A0A0B4KFH4_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KGE6 | 7227 | A0A0B4KGE6_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4LEH6 | 7227 | A0A0B4LEH6_DROME | GO:0008237 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10913309 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.4.24.- | |
EC | 3.4.24.11 | |
EC | 3.4.24.14 | |
EC | 3.4.24.17 | |
EC | 3.4.24.18 | |
EC | 3.4.24.19 | |
EC | 3.4.24.21 | |
EC | 3.4.24.22 | |
EC | 3.4.24.23 | |
EC | 3.4.24.24 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0004234 | obsolete macrophage elastase activity | consider GO:0004222 |
GO:0004241 | obsolete alpha-mitochondrial processing peptidase | consider GO:0004222 |
GO:0004242 | obsolete beta-mitochondrial processing peptidase | consider GO:0004222 |
GO:0004228 | obsolete gelatinase A activity | replaced_by GO:0004222 |
GO:0004229 | obsolete gelatinase B activity | replaced_by GO:0004222 |
GO:0004231 | obsolete insulysin activity | replaced_by GO:0004222 |
GO:0004235 | obsolete matrilysin activity | replaced_by GO:0004222 |
GO:0004238 | obsolete meprin A activity | replaced_by GO:0004222 |
GO:0004240 | obsolete mitochondrial processing peptidase activity | replaced_by GO:0004222 |
GO:0004243 | obsolete mitochondrial intermediate peptidase activity | replaced_by GO:0004222 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004222 based on ALL annotations
The top 100 of 3,722 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
metalloendopeptidase activity
|
190.52 | 100.00 | 1,023,208 | 1,023,208 |
metallopeptidase activity
|
89.06 | 35.89 | 621,305 | 1,329,122 |
protein processing
|
132.17 | 15.13 | 165,918 | 239,165 |
proteolysis
|
26.90 | 13.35 | 726,596 | 5,145,668 |
endopeptidase activity
|
95.84 | 12.35 | 143,976 | 286,200 |
CAAX-box protein processing
|
190.49 | 12.32 | 126,094 | 126,115 |
CAAX-box protein maturation
|
190.35 | 10.96 | 112,166 | 112,264 |
ATP-dependent peptidase activity
|
61.66 | 7.52 | 91,272 | 282,025 |
extracellular matrix
|
70.43 | 6.09 | 69,567 | 188,172 |
extracellular matrix organization
|
90.33 | 5.28 | 57,394 | 121,049 |
Totals | 5873652 | 225662442 |
No co-occurrence statistics for GO:0004222 based on MANUAL annotations
The top 100 of 1,140 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
metalloendopeptidase activity
|
283.04 | 100.00 | 4,564 | 4,564 |
extracellular matrix organization
|
124.60 | 20.52 | 1,267 | 2,878 |
collagen catabolic process
|
272.66 | 19.42 | 893 | 927 |
protein processing
|
89.71 | 10.59 | 626 | 1,975 |
proteolysis
|
35.18 | 8.34 | 923 | 7,427 |
peptide metabolic process
|
155.13 | 7.06 | 342 | 624 |
mitochondrial protein processing
|
201.09 | 6.24 | 292 | 411 |
CAAX-box protein processing
|
277.16 | 6.19 | 283 | 289 |
m-AAA complex
|
283.04 | 5.24 | 239 | 239 |
extracellular matrix
|
30.26 | 5.08 | 403 | 3,769 |
Totals | 16088 | 424837 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-07 | Added | XREF | EC:3.4.24.65 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9840532 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9844241 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9840408 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9840564 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9824402 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9822532 |
2023-11-01 | Added | XREF | Reactome:R-HSA-8874122 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-8874122 |
2023-10-23 | Added | XREF | Reactome:R-HSA-8874122 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | metalloendopeptidase activity |
2002-02-06 | Updated | TERM | metalloendopeptidase |
2001-04-03 | Updated | TERM | metalloendopeptidase |
2001-03-30 | Added | TERM | metalloendopeptidase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-02-14 | Deleted | SYNONYM | metalloendoproteinase activity |
2016-02-14 | Added | SYNONYM | metalloendoproteinase activity |
2016-02-14 | Added | SYNONYM | metalloendoprotease activity |
2016-02-14 | Deleted | SYNONYM | metalloendoprotease activity |
2008-11-23 | Added | SYNONYM | metalloendoproteinase activity |
2008-11-23 | Deleted | SYNONYM | metalloprotease |
2008-11-23 | Deleted | SYNONYM | metalloproteinase |
2008-11-23 | Added | SYNONYM | metalloendoprotease activity |
2008-08-18 | Added | DEFINITION | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
2008-08-18 | Deleted | DEFINITION | Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. |
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. |
2007-08-09 | Added | SYNONYM | metalloproteinase |
2007-08-09 | Deleted | SYNONYM | metalloproteinase |
2007-08-09 | Deleted | SYNONYM | metalloprotease |
2007-08-09 | Added | SYNONYM | metalloprotease |
2004-04-19 | Added | SYNONYM | metalloprotease |
2004-04-19 | Added | SYNONYM | metalloproteinase |
2004-04-16 | Deleted | SYNONYM | metalloproteinase |
2004-04-16 | Deleted | SYNONYM | metalloprotease |
2003-07-31 | Updated | DEFINITION | Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. |
2003-04-12 | Updated | DEFINITION | Enzymes within subclass EC:3.4, peptide hydrolases, that hydrolyze nonterminal peptide linkages in oligopeptides or polypeptides, and that contain a chelated metal ion as an essential catalytic activity at their active sites. |
2002-11-27 | Added | DEFINITION | Enzymes within subclass EC 3.4, peptide hydrolases, that hydrolyze nonterminal peptide linkages in oligopeptides or polypeptides, and that contain a chelated metal ion as an essential catalytic activity at their active sites. |
2001-08-28 | Added | SYNONYM | metalloprotease |
2001-08-28 | Added | SYNONYM | metalloproteinase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0008237 (metallopeptidase activity) |
2008-04-01 | Updated | RELATION | is a GO:0004175 (endopeptidase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-07 | Added | XREF | EC:3.4.24.65 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9840532 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9844241 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9840408 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9840564 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9824402 |
2023-12-26 | Added | XREF | Reactome:R-HSA-9822532 |
2023-11-01 | Added | XREF | Reactome:R-HSA-8874122 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-8874122 |
2023-10-23 | Added | XREF | Reactome:R-HSA-8874122 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-8874122 |
2023-08-28 | Added | XREF | Reactome:R-HSA-8874122 |
2023-08-14 | Deleted | XREF | Reactome:R-HSA-8874122 |
2023-08-12 | Added | XREF | Reactome:R-HSA-8874122 |
2023-08-11 | Deleted | XREF | Reactome:R-HSA-8874122 |
2023-07-26 | Added | XREF | Reactome:R-HSA-8874122 |
2023-07-24 | Deleted | XREF | Reactome:R-HSA-8874122 |
2023-07-14 | Added | XREF | Reactome:R-HSA-8874122 |
2023-07-12 | Deleted | XREF | Reactome:R-HSA-8874122 |
2023-07-10 | Added | XREF | EC:3.4.24.34 |
2023-07-10 | Added | XREF | EC:3.4.24.3 |
2023-07-10 | Added | XREF | EC:3.4.24.7 |
2023-07-10 | Added | XREF | Reactome:R-HSA-8874122 |
2023-07-08 | Deleted | XREF | Reactome:R-HSA-8874122 |
2023-06-24 | Added | XREF | Reactome:R-HSA-8874122 |
2023-06-18 | Deleted | XREF | Reactome:R-HSA-8874122 |
2023-06-13 | Added | XREF | Reactome:R-HSA-8874122 |
2021-01-04 | Deleted | XREF | EC:3.4.24 |
2021-01-04 | Added | XREF | EC:3.4.24.- |
2020-10-22 | Added | XREF | EC:3.4.24.69 |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.55-RXN |
2020-10-22 | Added | XREF | EC:3.4.24.14 |
2020-10-22 | Added | XREF | EC:3.4.24.59 |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.11-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.23-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.24-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.56-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.70-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.72-RXN |
2020-10-22 | Added | XREF | EC:3.4.24.18 |
2020-10-22 | Added | XREF | EC:3.4.24.70 |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.18-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.64-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.71-RXN |
2020-10-22 | Added | XREF | EC:3.4.24.17 |
2020-10-22 | Added | XREF | EC:3.4.24.22 |
2020-10-22 | Added | XREF | EC:3.4.24.37 |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.14-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.17-RXN |
2020-10-22 | Added | XREF | EC:3.4.24.11 |
2020-10-22 | Added | XREF | EC:3.4.24.21 |
2020-10-22 | Added | XREF | EC:3.4.24.23 |
2020-10-22 | Added | XREF | EC:3.4.24.55 |
2020-10-22 | Added | XREF | EC:3.4.24.72 |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.21-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.61-RXN |
2020-10-22 | Added | XREF | EC:3.4.24.35 |
2020-10-22 | Added | XREF | EC:3.4.24.56 |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.57-RXN |
2020-10-22 | Added | XREF | EC:3.4.24.24 |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.19-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.35-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.59-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.69-RXN |
2020-10-22 | Added | XREF | EC:3.4.24.19 |
2020-10-22 | Added | XREF | EC:3.4.24.57 |
2020-10-22 | Added | XREF | EC:3.4.24.61 |
2020-10-22 | Added | XREF | EC:3.4.24.64 |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.22-RXN |
2020-10-22 | Added | XREF | MetaCyc:3.4.24.37-RXN |
2020-10-22 | Added | XREF | EC:3.4.24.71 |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.21-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.61-RXN |
2020-10-19 | Deleted | XREF | EC:3.4.24.17 |
2020-10-19 | Deleted | XREF | EC:3.4.24.22 |
2020-10-19 | Deleted | XREF | EC:3.4.24.37 |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.14-RXN |
2020-10-19 | Deleted | XREF | EC:3.4.24.35 |
2020-10-19 | Deleted | XREF | EC:3.4.24.56 |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.57-RXN |
2020-10-19 | Deleted | XREF | EC:3.4.24.24 |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.19-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.35-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.59-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.69-RXN |
2020-10-19 | Deleted | XREF | EC:3.4.24.19 |
2020-10-19 | Deleted | XREF | EC:3.4.24.57 |
2020-10-19 | Deleted | XREF | EC:3.4.24.61 |
2020-10-19 | Deleted | XREF | EC:3.4.24.64 |
2020-10-19 | Deleted | XREF | EC:3.4.24.59 |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.11-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.23-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.24-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.56-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.70-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.72-RXN |
2020-10-19 | Deleted | XREF | EC:3.4.24.18 |
2020-10-19 | Deleted | XREF | EC:3.4.24.70 |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.18-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.64-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.71-RXN |
2020-10-19 | Deleted | XREF | EC:3.4.24.69 |
2020-10-19 | Deleted | XREF | EC:3.4.24.71 |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.17-RXN |
2020-10-19 | Deleted | XREF | EC:3.4.24.11 |
2020-10-19 | Deleted | XREF | EC:3.4.24.21 |
2020-10-19 | Deleted | XREF | EC:3.4.24.23 |
2020-10-19 | Deleted | XREF | EC:3.4.24.55 |
2020-10-19 | Deleted | XREF | EC:3.4.24.72 |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.22-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.37-RXN |
2020-10-19 | Deleted | XREF | MetaCyc:3.4.24.55-RXN |
2020-10-19 | Deleted | XREF | EC:3.4.24.14 |
2020-07-19 | Added | XREF | EC:3.4.24.17 |
2020-07-19 | Added | XREF | EC:3.4.24.55 |
2020-07-19 | Added | XREF | EC:3.4.24.23 |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.17-RXN |
2020-07-19 | Added | XREF | EC:3.4.24.71 |
2020-07-19 | Added | XREF | EC:3.4.24.69 |
2020-07-19 | Added | XREF | EC:3.4.24.72 |
2020-07-19 | Added | XREF | EC:3.4.24.22 |
2020-07-19 | Added | XREF | EC:3.4.24.37 |
2020-07-19 | Added | XREF | EC:3.4.24.11 |
2020-07-19 | Added | XREF | EC:3.4.24.21 |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.21-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.61-RXN |
2020-07-19 | Added | XREF | EC:3.4.24.35 |
2020-07-19 | Added | XREF | EC:3.4.24.56 |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.57-RXN |
2020-07-19 | Added | XREF | EC:3.4.24.24 |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.19-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.35-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.59-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.69-RXN |
2020-07-19 | Added | XREF | EC:3.4.24.19 |
2020-07-19 | Added | XREF | EC:3.4.24.57 |
2020-07-19 | Added | XREF | EC:3.4.24.61 |
2020-07-19 | Added | XREF | EC:3.4.24.64 |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.22-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.37-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.55-RXN |
2020-07-19 | Added | XREF | EC:3.4.24.14 |
2020-07-19 | Added | XREF | EC:3.4.24.59 |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.11-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.23-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.24-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.56-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.70-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.72-RXN |
2020-07-19 | Added | XREF | EC:3.4.24.18 |
2020-07-19 | Added | XREF | EC:3.4.24.70 |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.18-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.64-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.71-RXN |
2020-07-19 | Added | XREF | MetaCyc:3.4.24.14-RXN |
2019-05-04 | Added | XREF | Reactome:R-HSA-9624272 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-9624272 |
2019-04-29 | Added | XREF | Reactome:R-HSA-9624272 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-9624272 |
2019-04-27 | Added | XREF | Reactome:R-HSA-9624272 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-9624272 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-4086205 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5228578 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5694082 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2473584 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2533970 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3371385 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3827958 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1564143 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2485148 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3791149 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1168777 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1474210 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1564112 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1592310 |
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