This term is obsolete.

GO:0004222 JSON

metalloendopeptidase activity

Molecular Function

Definition (GO:0004222 GONUTS page)

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

1,029,854 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
metalloendoprotease activity narrow
metalloendoproteinase activity narrow

Ancestor Chart

Ancestor chart for GO:0004222
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004222

Child Term Relationship to
GO:0004222
negative regulation of metalloendopeptidase activity
negatively_regulates
metalloendopeptidase inhibitor activity
negatively_regulates
metalloendopeptidase activity involved in amyloid precursor protein catabolic process
is_a
regulation of metalloendopeptidase activity
regulates
mitochondrial processing peptidase complex
capable_of
positive regulation of metalloendopeptidase activity
positively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q18581 6239 ACN1_CAEEL GO:0008237 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 17th April 2015. IPR001548
NOT-qualified manual protein A0A0B4JCV5 7227 A0A0B4JCV5_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4JD89 7227 A0A0B4JD89_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K6V8 7227 A0A0B4K6V8_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K7A7 7227 A0A0B4K7A7_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K7P3 7227 A0A0B4K7P3_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KFB1 7227 A0A0B4KFB1_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KFH4 7227 A0A0B4KFH4_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KGE6 7227 A0A0B4KGE6_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4LEH6 7227 A0A0B4LEH6_DROME GO:0008237 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10913309

Cross-references

Database ID Description
EC 3.4.24.-
EC 3.4.24.11
EC 3.4.24.14
EC 3.4.24.17
EC 3.4.24.18
EC 3.4.24.19
EC 3.4.24.21
EC 3.4.24.22
EC 3.4.24.23
EC 3.4.24.24

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0004234 obsolete macrophage elastase activity consider GO:0004222
GO:0004241 obsolete alpha-mitochondrial processing peptidase consider GO:0004222
GO:0004242 obsolete beta-mitochondrial processing peptidase consider GO:0004222
GO:0004228 obsolete gelatinase A activity replaced_by GO:0004222
GO:0004229 obsolete gelatinase B activity replaced_by GO:0004222
GO:0004231 obsolete insulysin activity replaced_by GO:0004222
GO:0004235 obsolete matrilysin activity replaced_by GO:0004222
GO:0004238 obsolete meprin A activity replaced_by GO:0004222
GO:0004240 obsolete mitochondrial processing peptidase activity replaced_by GO:0004222
GO:0004243 obsolete mitochondrial intermediate peptidase activity replaced_by GO:0004222

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004222 based on ALL annotations
The top 100 of 3,722 co-occurring terms
Co-occurring Term PR S% #Together #Compared
metalloendopeptidase activity
190.52 100.00 1,023,208 1,023,208
metallopeptidase activity
89.06 35.89 621,305 1,329,122
protein processing
132.17 15.13 165,918 239,165
proteolysis
26.90 13.35 726,596 5,145,668
endopeptidase activity
95.84 12.35 143,976 286,200
CAAX-box protein processing
190.49 12.32 126,094 126,115
CAAX-box protein maturation
190.35 10.96 112,166 112,264
ATP-dependent peptidase activity
61.66 7.52 91,272 282,025
extracellular matrix
70.43 6.09 69,567 188,172
extracellular matrix organization
90.33 5.28 57,394 121,049
Totals 5873652 225662442
No co-occurrence statistics for GO:0004222 based on MANUAL annotations
The top 100 of 1,140 co-occurring terms
Co-occurring Term PR S% #Together #Compared
metalloendopeptidase activity
283.04 100.00 4,564 4,564
extracellular matrix organization
124.60 20.52 1,267 2,878
collagen catabolic process
272.66 19.42 893 927
protein processing
89.71 10.59 626 1,975
proteolysis
35.18 8.34 923 7,427
peptide metabolic process
155.13 7.06 342 624
mitochondrial protein processing
201.09 6.24 292 411
CAAX-box protein processing
277.16 6.19 283 289
m-AAA complex
283.04 5.24 239 239
extracellular matrix
30.26 5.08 403 3,769
Totals 16088 424837

Change Log

Timestamp Action Category Detail
2024-11-07 Added XREF EC:3.4.24.65
2023-12-26 Added XREF Reactome:R-HSA-9840532
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Timestamp Action Category Detail
2003-03-19 Updated TERM metalloendopeptidase activity
2002-02-06 Updated TERM metalloendopeptidase
2001-04-03 Updated TERM metalloendopeptidase
2001-03-30 Added TERM metalloendopeptidase
Timestamp Action Category Detail
2016-02-14 Deleted SYNONYM metalloendoproteinase activity
2016-02-14 Added SYNONYM metalloendoproteinase activity
2016-02-14 Added SYNONYM metalloendoprotease activity
2016-02-14 Deleted SYNONYM metalloendoprotease activity
2008-11-23 Added SYNONYM metalloendoproteinase activity
2008-11-23 Deleted SYNONYM metalloprotease
2008-11-23 Deleted SYNONYM metalloproteinase
2008-11-23 Added SYNONYM metalloendoprotease activity
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2007-08-09 Added SYNONYM metalloproteinase
2007-08-09 Deleted SYNONYM metalloproteinase
2007-08-09 Deleted SYNONYM metalloprotease
2007-08-09 Added SYNONYM metalloprotease
2004-04-19 Added SYNONYM metalloprotease
2004-04-19 Added SYNONYM metalloproteinase
2004-04-16 Deleted SYNONYM metalloproteinase
2004-04-16 Deleted SYNONYM metalloprotease
2003-07-31 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2003-04-12 Updated DEFINITION Enzymes within subclass EC:3.4, peptide hydrolases, that hydrolyze nonterminal peptide linkages in oligopeptides or polypeptides, and that contain a chelated metal ion as an essential catalytic activity at their active sites.
2002-11-27 Added DEFINITION Enzymes within subclass EC 3.4, peptide hydrolases, that hydrolyze nonterminal peptide linkages in oligopeptides or polypeptides, and that contain a chelated metal ion as an essential catalytic activity at their active sites.
2001-08-28 Added SYNONYM metalloprotease
2001-08-28 Added SYNONYM metalloproteinase
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008237 (metallopeptidase activity)
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)
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