This term is obsolete.

GO:0004298 JSON

threonine-type endopeptidase activity

Molecular Function

Definition (GO:0004298 GONUTS page)

Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.

57,158 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
threonine endopeptidase activity exact
26S protease related
MCP related
alkaline protease related
ingensin related
large multicatalytic protease narrow
lens neutral proteinase narrow
multicatalytic endopeptidase complex related
multicatalytic proteinase narrow
multicatalytic proteinase (complex) narrow

Ancestor Chart

Ancestor chart for GO:0004298
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4JCV5 7227 A0A0B4JCV5_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4JD89 7227 A0A0B4JD89_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K6V8 7227 A0A0B4K6V8_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K7A7 7227 A0A0B4K7A7_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K7P3 7227 A0A0B4K7P3_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KFB1 7227 A0A0B4KFB1_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KFH4 7227 A0A0B4KFH4_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KGE6 7227 A0A0B4KGE6_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4LEH6 7227 A0A0B4LEH6_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10913309
NOT-qualified manual protein A0A0B4LG43 7227 A0A0B4LG43_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047

Cross-references

Database ID Description
EC 3.4.25.-
InterPro IPR000243 Peptidase T1A, proteasome beta-subunit
InterPro IPR019982 Proteasome alpha subunit, archaeal
InterPro IPR022281 ATP-dependent protease, HslV subunit
InterPro IPR022296 Proteasome, alpha subunit, bacterial
InterPro IPR022483 Proteasome subunit beta, actinobacteria
InterPro IPR037464 Threonine aspartase 1
Reactome R-HSA-9818574
Reactome R-HSA-9818577
UniProtKB-KW KW-0888 Threonine protease

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004298 based on ALL annotations
The top 100 of 535 co-occurring terms
Co-occurring Term PR S% #Together #Compared
threonine-type endopeptidase activity
3,473.48 100.00 57,048 57,048
proteasome core complex
1,554.27 43.13 52,640 117,640
proteasome core complex, beta-subunit complex
2,035.57 20.63 13,780 23,514
proteolysis involved in protein catabolic process
722.40 20.19 49,877 239,821
proteasome complex
634.74 17.66 47,878 262,002
HslUV protease complex
846.86 16.95 20,397 83,660
proteasomal protein catabolic process
971.64 15.06 14,028 50,148
modification-dependent protein catabolic process
770.23 8.26 6,634 29,917
proteasome core complex, alpha-subunit complex
567.69 7.52 6,971 42,653
protein catabolic process
266.56 6.62 18,515 241,268
Totals 464785 101718823
No co-occurrence statistics for GO:0004298 based on MANUAL annotations
The top 65 of 65 co-occurring terms
Co-occurring Term PR S% #Together #Compared
threonine-type endopeptidase activity
11,665.56 100.00 121 121
protein maturation
919.04 7.65 88 1,117
proteasomal protein catabolic process
378.75 2.39 10 308
CD8-positive, alpha-beta T cell homeostasis
3,333.02 1.59 2 7
symbiont-mediated perturbation of host defenses
1,666.51 1.50 2 14
protein denaturation
2,916.39 0.81 1 4
cellular response to type I interferon
777.70 0.74 1 15
thymic T cell selection
648.09 0.72 1 18
proteasomal ubiquitin-independent protein catabolic process
135.65 0.69 2 172
T-helper 17 cell differentiation
416.63 0.68 1 28
Totals 445 962242

Change Log

Timestamp Action Category Detail
2023-11-01 Added XREF Reactome:R-HSA-9818577
2023-11-01 Added XREF Reactome:R-HSA-9818574
2023-10-28 Deleted XREF Reactome:R-HSA-9818574
2023-10-28 Deleted XREF Reactome:R-HSA-9818577
2023-10-23 Added XREF Reactome:R-HSA-9818574
2023-10-23 Added XREF Reactome:R-HSA-9818577
2023-10-10 Deleted XREF Reactome:R-HSA-9818574
2023-10-10 Deleted XREF Reactome:R-HSA-9818577
2023-08-28 Added XREF Reactome:R-HSA-9818574
2023-08-28 Added XREF Reactome:R-HSA-9818577
Timestamp Action Category Detail
2008-08-18 Updated TERM threonine-type endopeptidase activity
2003-03-19 Updated TERM threonine endopeptidase activity
2002-02-06 Updated TERM threonine endopeptidase
2001-04-03 Updated TERM threonine endopeptidase
2001-03-30 Added TERM threonine endopeptidase
Timestamp Action Category Detail
2011-04-10 Deleted SYNONYM 26S protease
2011-04-10 Added SYNONYM 26S protease
2008-08-18 Added SYNONYM threonine endopeptidase activity
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2007-12-14 Added SYNONYM multicatalytic endopeptidase complex
2007-12-14 Added SYNONYM lens neutral proteinase
2007-12-14 Added SYNONYM large multicatalytic protease
2007-12-14 Added SYNONYM ingensin
2007-12-14 Added SYNONYM alkaline protease
2007-12-14 Added SYNONYM MCP
2007-12-14 Added SYNONYM 26S protease
2007-12-14 Added SYNONYM multicatalytic proteinase
2007-12-14 Added SYNONYM prosome
2007-12-14 Added SYNONYM tricorn proteinase
2007-12-14 Added SYNONYM multicatalytic proteinase (complex)
2007-12-14 Added SYNONYM proteasome endopeptidase complex
2007-12-14 Added SYNONYM tricorn protease
2004-09-11 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
Timestamp Action Category Detail
2008-08-18 Added RELATION is a GO:0070003 (threonine-type peptidase activity)
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)
Timestamp Action Category Detail
2023-11-01 Added XREF Reactome:R-HSA-9818577
2023-11-01 Added XREF Reactome:R-HSA-9818574
2023-10-28 Deleted XREF Reactome:R-HSA-9818574
2023-10-28 Deleted XREF Reactome:R-HSA-9818577
2023-10-23 Added XREF Reactome:R-HSA-9818574
2023-10-23 Added XREF Reactome:R-HSA-9818577
2023-10-10 Deleted XREF Reactome:R-HSA-9818574
2023-10-10 Deleted XREF Reactome:R-HSA-9818577
2023-08-28 Added XREF Reactome:R-HSA-9818574
2023-08-28 Added XREF Reactome:R-HSA-9818577
2023-08-14 Deleted XREF Reactome:R-HSA-9818577
2023-08-14 Deleted XREF Reactome:R-HSA-9818574
2023-08-12 Added XREF Reactome:R-HSA-9818577
2023-08-12 Added XREF Reactome:R-HSA-9818574
2023-08-11 Deleted XREF Reactome:R-HSA-9818577
2023-08-11 Deleted XREF Reactome:R-HSA-9818574
2023-07-26 Added XREF Reactome:R-HSA-9818574
2023-07-26 Added XREF Reactome:R-HSA-9818577
2023-07-24 Deleted XREF Reactome:R-HSA-9818577
2023-07-24 Deleted XREF Reactome:R-HSA-9818574
2023-07-14 Added XREF Reactome:R-HSA-9818574
2023-07-14 Added XREF Reactome:R-HSA-9818577
2023-07-12 Deleted XREF Reactome:R-HSA-9818577
2023-07-12 Deleted XREF Reactome:R-HSA-9818574
2023-07-10 Added XREF Reactome:R-HSA-9818577
2023-07-10 Added XREF Reactome:R-HSA-9818574
2023-07-08 Deleted XREF Reactome:R-HSA-9818574
2023-07-08 Deleted XREF Reactome:R-HSA-9818577
2023-06-24 Added XREF Reactome:R-HSA-9818574
2023-06-24 Added XREF Reactome:R-HSA-9818577
2023-06-18 Deleted XREF Reactome:R-HSA-9818574
2023-06-18 Deleted XREF Reactome:R-HSA-9818577
2023-06-13 Added XREF Reactome:R-HSA-9818577
2023-06-13 Added XREF Reactome:R-HSA-9818574
2021-01-04 Added XREF EC:3.4.25.-
2021-01-04 Deleted XREF EC:3.4.25
2006-02-09 Deleted XREF EC:3.4.25.-
2006-02-09 Added XREF EC:3.4.25
2001-03-30 Added XREF EC:3.4.25.-
Timestamp Action Category Detail
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