GO:0004298
JSON
threonine-type endopeptidase activity
Molecular Function
Definition (GO:0004298 GONUTS page)
Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
26S protease | related |
threonine endopeptidase activity | exact |
tricorn proteinase | narrow |
tricorn protease | narrow |
MCP | related |
alkaline protease | related |
ingensin | related |
large multicatalytic protease | narrow |
lens neutral proteinase | narrow |
multicatalytic endopeptidase complex | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4JCV5 | 7227 | A0A0B4JCV5_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4JD89 | 7227 | A0A0B4JD89_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K6V8 | 7227 | A0A0B4K6V8_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K7A7 | 7227 | A0A0B4K7A7_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K7P3 | 7227 | A0A0B4K7P3_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KFB1 | 7227 | A0A0B4KFB1_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KFH4 | 7227 | A0A0B4KFH4_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KGE6 | 7227 | A0A0B4KGE6_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4LEH6 | 7227 | A0A0B4LEH6_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10913309 | |
NOT-qualified manual | protein | A0A0B4LG43 | 7227 | A0A0B4LG43_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.4.25.- | |
InterPro | IPR000243 | Peptidase T1A, proteasome beta-subunit |
InterPro | IPR019982 | Proteasome alpha subunit, archaeal |
InterPro | IPR022281 | ATP-dependent protease, HslV subunit |
InterPro | IPR022296 | Proteasome, alpha subunit, bacterial |
InterPro | IPR022483 | Proteasome subunit beta, actinobacteria |
InterPro | IPR037464 | Threonine aspartase 1 |
Reactome | R-HSA-9818574 | |
Reactome | R-HSA-9818577 | |
UniProtKB-KW | KW-0888 | Threonine protease |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004298 based on ALL annotations
The top 100 of 546 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
threonine-type endopeptidase activity
|
3,494.53 | 100.00 | 55,784 | 55,784 |
proteasome core complex
|
1,578.47 | 43.54 | 51,521 | 114,061 |
proteolysis involved in protein catabolic process
|
709.23 | 19.72 | 48,782 | 240,359 |
proteasome complex
|
623.05 | 17.24 | 46,760 | 262,266 |
HslUV protease complex
|
852.58 | 17.06 | 20,195 | 82,775 |
proteasome core complex, beta-subunit complex
|
1,878.55 | 16.78 | 10,939 | 20,349 |
proteasomal protein catabolic process
|
976.23 | 14.95 | 13,573 | 48,586 |
modification-dependent protein catabolic process
|
760.94 | 7.96 | 6,222 | 28,574 |
proteasome core complex, alpha-subunit complex
|
572.42 | 7.48 | 6,744 | 41,171 |
protein catabolic process
|
265.40 | 6.58 | 18,349 | 241,599 |
Totals | 452556 | 102170617 |
No co-occurrence statistics for GO:0004298 based on MANUAL annotations
The top 67 of 67 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
threonine-type endopeptidase activity
|
12,186.78 | 100.00 | 106 | 106 |
protein maturation
|
980.40 | 7.83 | 79 | 982 |
proteasomal protein catabolic process
|
407.58 | 2.53 | 10 | 299 |
CD8-positive, alpha-beta T cell homeostasis
|
3,481.94 | 1.80 | 2 | 7 |
symbiont-mediated perturbation of host defenses
|
1,740.97 | 1.69 | 2 | 14 |
protein denaturation
|
3,046.70 | 0.92 | 1 | 4 |
cellular response to type I interferon
|
812.45 | 0.83 | 1 | 15 |
thymic T cell selection
|
677.04 | 0.81 | 1 | 18 |
proteasomal ubiquitin-independent protein catabolic process
|
152.33 | 0.76 | 2 | 160 |
T-helper 17 cell differentiation
|
435.24 | 0.75 | 1 | 28 |
Totals | 412 | 915664 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-11-01 | Added | XREF | Reactome:R-HSA-9818577 |
2023-11-01 | Added | XREF | Reactome:R-HSA-9818574 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-9818574 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-9818577 |
2023-10-23 | Added | XREF | Reactome:R-HSA-9818574 |
2023-10-23 | Added | XREF | Reactome:R-HSA-9818577 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-9818577 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-9818574 |
2023-08-28 | Added | XREF | Reactome:R-HSA-9818574 |
2023-08-28 | Added | XREF | Reactome:R-HSA-9818577 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-08-18 | Updated | TERM | threonine-type endopeptidase activity |
2003-03-19 | Updated | TERM | threonine endopeptidase activity |
2002-02-06 | Updated | TERM | threonine endopeptidase |
2001-04-03 | Updated | TERM | threonine endopeptidase |
2001-03-30 | Added | TERM | threonine endopeptidase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-04-10 | Added | SYNONYM | 26S protease |
2011-04-10 | Deleted | SYNONYM | 26S protease |
2008-08-18 | Added | DEFINITION | Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. |
2008-08-18 | Deleted | DEFINITION | Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles. |
2008-08-18 | Added | SYNONYM | threonine endopeptidase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles. |
2007-12-14 | Added | SYNONYM | prosome |
2007-12-14 | Added | SYNONYM | multicatalytic proteinase (complex) |
2007-12-14 | Added | SYNONYM | multicatalytic proteinase |
2007-12-14 | Added | SYNONYM | multicatalytic endopeptidase complex |
2007-12-14 | Added | SYNONYM | lens neutral proteinase |
2007-12-14 | Added | SYNONYM | large multicatalytic protease |
2007-12-14 | Added | SYNONYM | ingensin |
2007-12-14 | Added | SYNONYM | alkaline protease |
2007-12-14 | Added | SYNONYM | proteasome endopeptidase complex |
2007-12-14 | Added | SYNONYM | tricorn protease |
2007-12-14 | Added | SYNONYM | tricorn proteinase |
2007-12-14 | Added | SYNONYM | 26S protease |
2007-12-14 | Added | SYNONYM | MCP |
2004-09-11 | Added | DEFINITION | Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-08-18 | Added | RELATION | is a GO:0070003 (threonine-type peptidase activity) |
2008-04-01 | Updated | RELATION | is a GO:0004175 (endopeptidase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-11-01 | Added | XREF | Reactome:R-HSA-9818577 |
2023-11-01 | Added | XREF | Reactome:R-HSA-9818574 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-9818574 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-9818577 |
2023-10-23 | Added | XREF | Reactome:R-HSA-9818574 |
2023-10-23 | Added | XREF | Reactome:R-HSA-9818577 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-9818577 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-9818574 |
2023-08-28 | Added | XREF | Reactome:R-HSA-9818574 |
2023-08-28 | Added | XREF | Reactome:R-HSA-9818577 |
2023-08-14 | Deleted | XREF | Reactome:R-HSA-9818577 |
2023-08-14 | Deleted | XREF | Reactome:R-HSA-9818574 |
2023-08-12 | Added | XREF | Reactome:R-HSA-9818574 |
2023-08-12 | Added | XREF | Reactome:R-HSA-9818577 |
2023-08-11 | Deleted | XREF | Reactome:R-HSA-9818577 |
2023-08-11 | Deleted | XREF | Reactome:R-HSA-9818574 |
2023-07-26 | Added | XREF | Reactome:R-HSA-9818574 |
2023-07-26 | Added | XREF | Reactome:R-HSA-9818577 |
2023-07-24 | Deleted | XREF | Reactome:R-HSA-9818574 |
2023-07-24 | Deleted | XREF | Reactome:R-HSA-9818577 |
2023-07-14 | Added | XREF | Reactome:R-HSA-9818577 |
2023-07-14 | Added | XREF | Reactome:R-HSA-9818574 |
2023-07-12 | Deleted | XREF | Reactome:R-HSA-9818574 |
2023-07-12 | Deleted | XREF | Reactome:R-HSA-9818577 |
2023-07-10 | Added | XREF | Reactome:R-HSA-9818577 |
2023-07-10 | Added | XREF | Reactome:R-HSA-9818574 |
2023-07-08 | Deleted | XREF | Reactome:R-HSA-9818577 |
2023-07-08 | Deleted | XREF | Reactome:R-HSA-9818574 |
2023-06-24 | Added | XREF | Reactome:R-HSA-9818577 |
2023-06-24 | Added | XREF | Reactome:R-HSA-9818574 |
2023-06-18 | Deleted | XREF | Reactome:R-HSA-9818574 |
2023-06-18 | Deleted | XREF | Reactome:R-HSA-9818577 |
2023-06-13 | Added | XREF | Reactome:R-HSA-9818574 |
2023-06-13 | Added | XREF | Reactome:R-HSA-9818577 |
2021-01-04 | Deleted | XREF | EC:3.4.25 |
2021-01-04 | Added | XREF | EC:3.4.25.- |
2006-02-09 | Deleted | XREF | EC:3.4.25.- |
2006-02-09 | Added | XREF | EC:3.4.25 |
2001-03-30 | Added | XREF | EC:3.4.25.- |
Timestamp | Action | Category | Detail |
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