GO:0004326
JSON
tetrahydrofolylpolyglutamate synthase activity
Molecular Function
Definition (GO:0004326 GONUTS page)
Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity | related |
tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) | related |
folylpolyglutamate synthase activity | exact |
folylpoly(gamma-glutamate) synthase activity | related |
N10-formyltetrahydropteroyldiglutamate synthetase activity | related |
formyltetrahydropteroyldiglutamate synthetase activity | related |
folate polyglutamate synthetase activity | related |
tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming) | related |
tetrahydrofolate synthase activity | related |
FPGS activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.3.2.17 | |
InterPro | IPR001645 | Folylpolyglutamate synthetase |
InterPro | IPR018109 | Folylpolyglutamate synthetase, conserved site |
InterPro | IPR023600 | Folylpolyglutamate synthase, eukaryota |
MetaCyc | FOLYLPOLYGLUTAMATESYNTH-RXN | |
RHEA | 10580 | |
Reactome | R-HSA-197958 | |
Reactome | R-HSA-200681 | |
Reactome | R-HSA-200682 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
has_participant | CHEBI | CHEBI:141005 | (6S)-5,6,7,8-tetrahydrofolyl-poly(gamma-glutamate) macromolecule |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
has_participant | CHEBI | CHEBI:29985 | L-glutamate(1-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004326 based on ALL annotations
The top 100 of 473 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
tetrahydrofolylpolyglutamate synthase activity
|
2,529.57 | 100.00 | 77,064 | 77,064 |
tetrahydrofolylpolyglutamate biosynthetic process
|
2,528.26 | 99.95 | 77,064 | 77,104 |
dihydrofolate synthase activity
|
2,528.27 | 60.73 | 46,815 | 46,839 |
dihydrofolate biosynthetic process
|
2,528.22 | 60.73 | 46,815 | 46,840 |
folic acid-containing compound biosynthetic process
|
873.26 | 34.51 | 77,003 | 223,055 |
acid-amino acid ligase activity
|
597.93 | 22.78 | 66,463 | 281,173 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
|
564.67 | 8.92 | 9,964 | 44,636 |
folic acid biosynthetic process
|
211.18 | 5.75 | 12,000 | 143,742 |
UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity
|
447.03 | 5.57 | 5,795 | 32,792 |
tetrahydrofolate biosynthetic process
|
144.82 | 4.41 | 12,462 | 217,667 |
Totals | 834005 | 125136923 |
No co-occurrence statistics for GO:0004326 based on MANUAL annotations
The top 42 of 42 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
tetrahydrofolylpolyglutamate synthase activity
|
5,871.81 | 100.00 | 220 | 220 |
tetrahydrofolylpolyglutamate biosynthetic process
|
4,668.81 | 62.21 | 163 | 205 |
dihydrofolate synthase activity
|
5,763.08 | 23.98 | 53 | 54 |
folic acid-containing compound biosynthetic process
|
1,540.62 | 14.36 | 53 | 202 |
nucleoside metabolic process
|
1,957.27 | 3.39 | 8 | 24 |
glycine metabolic process
|
939.49 | 3.05 | 8 | 50 |
glutamate metabolic process
|
281.53 | 1.95 | 7 | 146 |
folic acid-containing compound metabolic process
|
444.83 | 1.78 | 5 | 66 |
animal organ regeneration
|
142.35 | 1.05 | 4 | 165 |
folic acid metabolic process
|
95.48 | 0.59 | 2 | 123 |
Totals | 1122 | 701873 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | FPGS activity |
2020-10-08 | Deleted | SYNONYM | tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming) |
2020-10-08 | Added | SYNONYM | tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming) |
2020-10-08 | Added | SYNONYM | folylpoly-gamma-glutamate synthase activity |
2020-10-08 | Added | SYNONYM | tetrahydrofolate synthase activity |
2020-10-08 | Added | SYNONYM | folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity |
2020-10-08 | Added | SYNONYM | folylpolyglutamyl synthetase activity |
2020-10-08 | Added | SYNONYM | folylpoly(gamma-glutamate) synthase activity |
2020-10-08 | Added | SYNONYM | folylpolyglutamate synthetase activity |
2020-10-08 | Added | SYNONYM | N(10)-formyltetrahydropteroyldiglutamate synthetase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-06 | Updated | TERM | tetrahydrofolylpolyglutamate synthase activity |
2003-03-19 | Updated | TERM | folylpolyglutamate synthase activity |
2002-02-06 | Updated | TERM | folylpolyglutamate synthase |
2001-04-03 | Updated | TERM | folylpolyglutamate synthase |
2001-03-30 | Added | TERM | folylpolyglutamate synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | FPGS activity |
2020-10-08 | Deleted | SYNONYM | tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming) |
2020-10-08 | Added | SYNONYM | tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming) |
2020-10-08 | Added | SYNONYM | folylpoly-gamma-glutamate synthase activity |
2020-10-08 | Added | SYNONYM | tetrahydrofolate synthase activity |
2020-10-08 | Added | SYNONYM | folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity |
2020-10-08 | Added | SYNONYM | folylpolyglutamyl synthetase activity |
2020-10-08 | Added | SYNONYM | folylpoly(gamma-glutamate) synthase activity |
2020-10-08 | Added | SYNONYM | folylpolyglutamate synthetase activity |
2020-10-08 | Added | SYNONYM | N(10)-formyltetrahydropteroyldiglutamate synthetase activity |
2020-10-08 | Added | SYNONYM | folate polyglutamate synthetase activity |
2020-10-08 | Added | SYNONYM | tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) |
2020-10-08 | Added | SYNONYM | tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity |
2020-10-08 | Added | SYNONYM | formyltetrahydropteroyldiglutamate synthetase activity |
2020-10-08 | Added | SYNONYM | N10-formyltetrahydropteroyldiglutamate synthetase activity |
2020-10-08 | Deleted | SYNONYM | FPGS activity |
2020-10-08 | Deleted | SYNONYM | N(10)-formyltetrahydropteroyldiglutamate synthetase activity |
2020-10-08 | Deleted | SYNONYM | folate polyglutamate synthetase activity |
2020-10-08 | Deleted | SYNONYM | folylpoly(gamma-glutamate) synthase activity |
2020-10-08 | Deleted | SYNONYM | folylpoly-gamma-glutamate synthase activity |
2020-10-08 | Deleted | SYNONYM | folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity |
2020-10-08 | Deleted | SYNONYM | folylpolyglutamate synthetase activity |
2020-10-08 | Deleted | SYNONYM | folylpolyglutamyl synthetase activity |
2020-10-08 | Deleted | SYNONYM | formyltetrahydropteroyldiglutamate synthetase activity |
2020-10-08 | Deleted | SYNONYM | tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity |
2020-10-08 | Deleted | SYNONYM | N10-formyltetrahydropteroyldiglutamate synthetase activity |
2020-10-08 | Deleted | SYNONYM | tetrahydrofolate synthase activity |
2020-10-08 | Deleted | SYNONYM | tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). |
2007-11-08 | Added | SYNONYM | tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming) |
2007-11-08 | Added | SYNONYM | tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) |
2007-11-08 | Added | SYNONYM | tetrahydrofolate synthase activity |
2007-11-08 | Added | SYNONYM | N10-formyltetrahydropteroyldiglutamate synthetase activity |
2007-10-18 | Deleted | SYNONYM | tetrahydrofolylpolyglutamate synthase activity |
2007-09-06 | Added | SYNONYM | folylpolyglutamyl synthetase activity |
2007-09-06 | Added | SYNONYM | formyltetrahydropteroyldiglutamate synthetase activity |
2007-09-06 | Added | SYNONYM | folylpolyglutamate synthetase activity |
2007-09-06 | Added | SYNONYM | folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity |
2007-09-06 | Added | SYNONYM | folylpoly-gamma-glutamate synthase activity |
2007-09-06 | Added | SYNONYM | folylpoly(gamma-glutamate) synthase activity |
2007-09-06 | Added | SYNONYM | tetrahydrofolylpolyglutamate synthase activity |
2007-09-06 | Added | SYNONYM | tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity |
2007-09-06 | Added | SYNONYM | FPGS activity |
2007-09-06 | Added | SYNONYM | N(10)-formyltetrahydropteroyldiglutamate synthetase activity |
2007-09-06 | Added | SYNONYM | folate polyglutamate synthetase activity |
2007-08-09 | Deleted | SYNONYM | folylpolyglutamate synthase activity |
2007-08-09 | Added | SYNONYM | folylpolyglutamate synthase activity |
2004-04-19 | Added | SYNONYM | folylpolyglutamate synthase activity |
2004-04-16 | Deleted | SYNONYM | folylpolyglutamate synthase activity |
2003-10-27 | Added | SYNONYM | folylpolyglutamate synthase activity |
2003-04-24 | Updated | DEFINITION | Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + tetrahydrofolyl-[Glu](n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-[Glu](n+1). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-05-15 | Added | RELATION | part of GO:0046901 (tetrahydrofolylpolyglutamate biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0016881 (acid-amino acid ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:10580 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-197958 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-200681 |
2019-04-01 | Added | XREF | Reactome:R-HSA-197958 |
2019-04-01 | Added | XREF | Reactome:R-HSA-200682 |
2019-04-01 | Added | XREF | Reactome:R-HSA-200681 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-200682 |
2018-12-11 | Added | XREF | reactome:R-HSA-200682 |
2018-12-11 | Added | XREF | reactome:R-HSA-197958 |
2018-12-11 | Added | XREF | reactome:R-HSA-200681 |
2003-10-27 | Added | XREF | MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN |
2001-03-30 | Added | XREF | EC:6.3.2.17 |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link