This term is obsolete.

GO:0004326 JSON

tetrahydrofolylpolyglutamate synthase activity

Molecular Function

Definition (GO:0004326 GONUTS page)

Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).

77,303 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity related
tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) related
folylpolyglutamate synthase activity exact
folylpoly(gamma-glutamate) synthase activity related
N10-formyltetrahydropteroyldiglutamate synthetase activity related
formyltetrahydropteroyldiglutamate synthetase activity related
folate polyglutamate synthetase activity related
tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming) related
tetrahydrofolate synthase activity related
FPGS activity related

Ancestor Chart

Ancestor chart for GO:0004326
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.3.2.17
InterPro IPR001645 Folylpolyglutamate synthetase
InterPro IPR018109 Folylpolyglutamate synthetase, conserved site
InterPro IPR023600 Folylpolyglutamate synthase, eukaryota
MetaCyc FOLYLPOLYGLUTAMATESYNTH-RXN
RHEA 10580
Reactome R-HSA-197958
Reactome R-HSA-200681
Reactome R-HSA-200682

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:43474 hydrogenphosphate
has_participant CHEBI CHEBI:141005 (6S)-5,6,7,8-tetrahydrofolyl-poly(gamma-glutamate) macromolecule
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:29985 L-glutamate(1-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004326 based on ALL annotations
The top 100 of 473 co-occurring terms
Co-occurring Term PR S% #Together #Compared
tetrahydrofolylpolyglutamate synthase activity
2,529.57 100.00 77,064 77,064
tetrahydrofolylpolyglutamate biosynthetic process
2,528.26 99.95 77,064 77,104
dihydrofolate synthase activity
2,528.27 60.73 46,815 46,839
dihydrofolate biosynthetic process
2,528.22 60.73 46,815 46,840
folic acid-containing compound biosynthetic process
873.26 34.51 77,003 223,055
acid-amino acid ligase activity
597.93 22.78 66,463 281,173
UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
564.67 8.92 9,964 44,636
folic acid biosynthetic process
211.18 5.75 12,000 143,742
UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity
447.03 5.57 5,795 32,792
tetrahydrofolate biosynthetic process
144.82 4.41 12,462 217,667
Totals 834005 125136923
No co-occurrence statistics for GO:0004326 based on MANUAL annotations
The top 42 of 42 co-occurring terms
Co-occurring Term PR S% #Together #Compared
tetrahydrofolylpolyglutamate synthase activity
5,871.81 100.00 220 220
tetrahydrofolylpolyglutamate biosynthetic process
4,668.81 62.21 163 205
dihydrofolate synthase activity
5,763.08 23.98 53 54
folic acid-containing compound biosynthetic process
1,540.62 14.36 53 202
nucleoside metabolic process
1,957.27 3.39 8 24
glycine metabolic process
939.49 3.05 8 50
glutamate metabolic process
281.53 1.95 7 146
folic acid-containing compound metabolic process
444.83 1.78 5 66
animal organ regeneration
142.35 1.05 4 165
folic acid metabolic process
95.48 0.59 2 123
Totals 1122 701873

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM FPGS activity
2020-10-08 Deleted SYNONYM tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)
2020-10-08 Added SYNONYM tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)
2020-10-08 Added SYNONYM folylpoly-gamma-glutamate synthase activity
2020-10-08 Added SYNONYM tetrahydrofolate synthase activity
2020-10-08 Added SYNONYM folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity
2020-10-08 Added SYNONYM folylpolyglutamyl synthetase activity
2020-10-08 Added SYNONYM folylpoly(gamma-glutamate) synthase activity
2020-10-08 Added SYNONYM folylpolyglutamate synthetase activity
2020-10-08 Added SYNONYM N(10)-formyltetrahydropteroyldiglutamate synthetase activity
Timestamp Action Category Detail
2003-09-06 Updated TERM tetrahydrofolylpolyglutamate synthase activity
2003-03-19 Updated TERM folylpolyglutamate synthase activity
2002-02-06 Updated TERM folylpolyglutamate synthase
2001-04-03 Updated TERM folylpolyglutamate synthase
2001-03-30 Added TERM folylpolyglutamate synthase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM FPGS activity
2020-10-08 Deleted SYNONYM tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)
2020-10-08 Added SYNONYM tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)
2020-10-08 Added SYNONYM folylpoly-gamma-glutamate synthase activity
2020-10-08 Added SYNONYM tetrahydrofolate synthase activity
2020-10-08 Added SYNONYM folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity
2020-10-08 Added SYNONYM folylpolyglutamyl synthetase activity
2020-10-08 Added SYNONYM folylpoly(gamma-glutamate) synthase activity
2020-10-08 Added SYNONYM folylpolyglutamate synthetase activity
2020-10-08 Added SYNONYM N(10)-formyltetrahydropteroyldiglutamate synthetase activity
2020-10-08 Added SYNONYM folate polyglutamate synthetase activity
2020-10-08 Added SYNONYM tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)
2020-10-08 Added SYNONYM tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity
2020-10-08 Added SYNONYM formyltetrahydropteroyldiglutamate synthetase activity
2020-10-08 Added SYNONYM N10-formyltetrahydropteroyldiglutamate synthetase activity
2020-10-08 Deleted SYNONYM FPGS activity
2020-10-08 Deleted SYNONYM N(10)-formyltetrahydropteroyldiglutamate synthetase activity
2020-10-08 Deleted SYNONYM folate polyglutamate synthetase activity
2020-10-08 Deleted SYNONYM folylpoly(gamma-glutamate) synthase activity
2020-10-08 Deleted SYNONYM folylpoly-gamma-glutamate synthase activity
2020-10-08 Deleted SYNONYM folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity
2020-10-08 Deleted SYNONYM folylpolyglutamate synthetase activity
2020-10-08 Deleted SYNONYM folylpolyglutamyl synthetase activity
2020-10-08 Deleted SYNONYM formyltetrahydropteroyldiglutamate synthetase activity
2020-10-08 Deleted SYNONYM tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity
2020-10-08 Deleted SYNONYM N10-formyltetrahydropteroyldiglutamate synthetase activity
2020-10-08 Deleted SYNONYM tetrahydrofolate synthase activity
2020-10-08 Deleted SYNONYM tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).
2007-11-08 Added SYNONYM tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)
2007-11-08 Added SYNONYM tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)
2007-11-08 Added SYNONYM tetrahydrofolate synthase activity
2007-11-08 Added SYNONYM N10-formyltetrahydropteroyldiglutamate synthetase activity
2007-10-18 Deleted SYNONYM tetrahydrofolylpolyglutamate synthase activity
2007-09-06 Added SYNONYM folylpolyglutamyl synthetase activity
2007-09-06 Added SYNONYM formyltetrahydropteroyldiglutamate synthetase activity
2007-09-06 Added SYNONYM folylpolyglutamate synthetase activity
2007-09-06 Added SYNONYM folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity
2007-09-06 Added SYNONYM folylpoly-gamma-glutamate synthase activity
2007-09-06 Added SYNONYM folylpoly(gamma-glutamate) synthase activity
2007-09-06 Added SYNONYM tetrahydrofolylpolyglutamate synthase activity
2007-09-06 Added SYNONYM tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity
2007-09-06 Added SYNONYM FPGS activity
2007-09-06 Added SYNONYM N(10)-formyltetrahydropteroyldiglutamate synthetase activity
2007-09-06 Added SYNONYM folate polyglutamate synthetase activity
2007-08-09 Deleted SYNONYM folylpolyglutamate synthase activity
2007-08-09 Added SYNONYM folylpolyglutamate synthase activity
2004-04-19 Added SYNONYM folylpolyglutamate synthase activity
2004-04-16 Deleted SYNONYM folylpolyglutamate synthase activity
2003-10-27 Added SYNONYM folylpolyglutamate synthase activity
2003-04-24 Updated DEFINITION Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + tetrahydrofolyl-[Glu](n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-[Glu](n+1).
Timestamp Action Category Detail
2011-05-15 Added RELATION part of GO:0046901 (tetrahydrofolylpolyglutamate biosynthetic process)
2008-04-01 Updated RELATION is a GO:0016881 (acid-amino acid ligase activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:10580
2019-04-01 Deleted XREF reactome:R-HSA-197958
2019-04-01 Deleted XREF reactome:R-HSA-200681
2019-04-01 Added XREF Reactome:R-HSA-197958
2019-04-01 Added XREF Reactome:R-HSA-200682
2019-04-01 Added XREF Reactome:R-HSA-200681
2019-04-01 Deleted XREF reactome:R-HSA-200682
2018-12-11 Added XREF reactome:R-HSA-200682
2018-12-11 Added XREF reactome:R-HSA-197958
2018-12-11 Added XREF reactome:R-HSA-200681
2003-10-27 Added XREF MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN
2001-03-30 Added XREF EC:6.3.2.17
Timestamp Action Category Detail
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