This term is obsolete.

GO:0004413 JSON

homoserine kinase activity

Molecular Function

Definition (GO:0004413 GONUTS page)

Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+.

38,100 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ATP:L-homoserine O-phosphotransferase activity related
HSK related
homoserine kinase (phosphorylating) related

Ancestor Chart

Ancestor chart for GO:0004413
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3Q0M1 9615 A0A8I3Q0M1_CANLF GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I6AKN3 10116 A0A8I6AKN3_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ALM9 10116 A0A8I6ALM9_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GLX5 10116 A0A8I6GLX5_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J0TR01 8355 A0A8J0TR01_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8J0TZJ2 8355 A0A8J0TZJ2_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8M2B232 7955 A0A8M2B232_DANRE GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 2.7.1.39
InterPro IPR000870 Homoserine kinase
InterPro IPR005280 Homoserine kinase, type II
KEGG_REACTION R01771
MetaCyc HOMOSERKIN-RXN
RHEA 13985

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57476 L-homoserine zwitterion
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:57590 O-phosphonato-L-homoserine(2-)
has_participant CHEBI CHEBI:456216 ADP(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004413 based on ALL annotations
The top 100 of 211 co-occurring terms
Co-occurring Term PR S% #Together #Compared
homoserine kinase activity
5,202.69 100.00 38,087 38,087
threonine metabolic process
5,179.43 60.63 23,155 23,259
threonine biosynthetic process
874.15 16.76 37,534 223,392
sterol biosynthetic process
83.78 0.99 945 58,683
amino acid kinase activity
224.20 0.77 351 8,145
kinase activity
32.91 0.63 33,832 5,349,025
phosphoribosylformylglycinamidine cyclo-ligase activity
22.21 0.24 203 47,548
adenine biosynthetic process
22.12 0.24 202 47,509
ATP binding
8.61 0.17 31,469 19,024,482
phosphoribosylamine-glycine ligase activity
11.10 0.15 202 94,678
Totals 190440 94101378
No co-occurrence statistics for GO:0004413 based on MANUAL annotations
The top 20 of 20 co-occurring terms
Co-occurring Term PR S% #Together #Compared
homoserine kinase activity
78,418.50 100.00 18 18
threonine biosynthetic process
9,870.86 12.59 18 143
phosphoserine:homoserine phosphotransferase activity
78,418.50 5.56 1 1
homoserine metabolic process
19,604.63 4.76 1 4
photoperiodism, flowering
1,568.37 1.49 1 50
4-amino-4-deoxychorismate synthase activity
732.88 0.81 1 107
dephosphorylation
533.46 0.61 1 147
L-phosphoserine phosphatase activity
458.59 0.53 1 171
response to fungus
423.88 0.50 1 185
methionine metabolic process
321.39 0.38 1 244
Totals 57 370325

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+).
2022-09-01 Added DEFINITION Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+.
2020-10-08 Added SYNONYM ATP:L-homoserine O-phosphotransferase activity
2020-10-08 Added SYNONYM homoserine kinase (phosphorylating)
2020-10-08 Deleted SYNONYM ATP:L-homoserine O-phosphotransferase activity
2020-10-08 Deleted SYNONYM homoserine kinase (phosphorylating)
2019-06-20 Deleted XREF KEGG:R01771
2019-06-20 Added XREF KEGG_REACTION:R01771
2018-07-13 Deleted XREF RHEA:13988
2018-07-13 Added XREF RHEA:13985
Timestamp Action Category Detail
2003-03-19 Updated TERM homoserine kinase activity
2002-02-06 Updated TERM homoserine kinase
2001-04-03 Updated TERM homoserine kinase
2001-03-30 Added TERM homoserine kinase
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+).
2022-09-01 Added DEFINITION Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+.
2020-10-08 Added SYNONYM ATP:L-homoserine O-phosphotransferase activity
2020-10-08 Added SYNONYM homoserine kinase (phosphorylating)
2020-10-08 Deleted SYNONYM ATP:L-homoserine O-phosphotransferase activity
2020-10-08 Deleted SYNONYM homoserine kinase (phosphorylating)
2010-10-11 Deleted DEFINITION Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine.
2010-10-11 Added DEFINITION Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+).
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine.
2007-11-08 Added SYNONYM HSK
2007-11-08 Added SYNONYM ATP:L-homoserine O-phosphotransferase activity
2007-11-08 Added SYNONYM homoserine kinase (phosphorylating)
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0019202 (amino acid kinase activity)
2008-04-01 Updated RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R01771
2019-06-20 Added XREF KEGG_REACTION:R01771
2018-07-13 Deleted XREF RHEA:13988
2018-07-13 Added XREF RHEA:13985
2010-10-11 Added XREF RHEA:13988
2010-10-11 Added XREF KEGG:R01771
2003-10-27 Added XREF MetaCyc:HOMOSERKIN-RXN
2001-03-30 Added XREF EC:2.7.1.39
Timestamp Action Category Detail
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