GO:0004413
JSON
homoserine kinase activity
Molecular Function
Definition (GO:0004413 GONUTS page)
Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ATP:L-homoserine O-phosphotransferase activity | related |
HSK | related |
homoserine kinase (phosphorylating) | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A1L8END5 | 8355 | A0A1L8END5_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8EV37 | 8355 | A0A1L8EV37_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I3Q0M1 | 9615 | A0A8I3Q0M1_CANLF | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I6AKN3 | 10116 | A0A8I6AKN3_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ALM9 | 10116 | A0A8I6ALM9_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6GLX5 | 10116 | A0A8I6GLX5_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8J0TR01 | 8355 | A0A8J0TR01_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8J0TZJ2 | 8355 | A0A8J0TZJ2_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8M2B232 | 7955 | A0A8M2B232_DANRE | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.1.39 | |
InterPro | IPR000870 | Homoserine kinase |
InterPro | IPR005280 | Homoserine kinase, type II |
KEGG_REACTION | R01771 | |
MetaCyc | HOMOSERKIN-RXN | |
RHEA | 13985 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57476 | L-homoserine zwitterion |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:57590 | O-phosphonato-L-homoserine(2-) |
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004413 based on ALL annotations
The top 100 of 211 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
homoserine kinase activity
|
5,202.69 | 100.00 | 38,087 | 38,087 |
threonine metabolic process
|
5,179.43 | 60.63 | 23,155 | 23,259 |
threonine biosynthetic process
|
874.15 | 16.76 | 37,534 | 223,392 |
sterol biosynthetic process
|
83.78 | 0.99 | 945 | 58,683 |
amino acid kinase activity
|
224.20 | 0.77 | 351 | 8,145 |
kinase activity
|
32.91 | 0.63 | 33,832 | 5,349,025 |
phosphoribosylformylglycinamidine cyclo-ligase activity
|
22.21 | 0.24 | 203 | 47,548 |
adenine biosynthetic process
|
22.12 | 0.24 | 202 | 47,509 |
ATP binding
|
8.61 | 0.17 | 31,469 | 19,024,482 |
phosphoribosylamine-glycine ligase activity
|
11.10 | 0.15 | 202 | 94,678 |
Totals | 190440 | 94101378 |
No co-occurrence statistics for GO:0004413 based on MANUAL annotations
The top 20 of 20 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
homoserine kinase activity
|
78,418.50 | 100.00 | 18 | 18 |
threonine biosynthetic process
|
9,870.86 | 12.59 | 18 | 143 |
phosphoserine:homoserine phosphotransferase activity
|
78,418.50 | 5.56 | 1 | 1 |
homoserine metabolic process
|
19,604.63 | 4.76 | 1 | 4 |
photoperiodism, flowering
|
1,568.37 | 1.49 | 1 | 50 |
4-amino-4-deoxychorismate synthase activity
|
732.88 | 0.81 | 1 | 107 |
dephosphorylation
|
533.46 | 0.61 | 1 | 147 |
L-phosphoserine phosphatase activity
|
458.59 | 0.53 | 1 | 171 |
response to fungus
|
423.88 | 0.50 | 1 | 185 |
methionine metabolic process
|
321.39 | 0.38 | 1 | 244 |
Totals | 57 | 370325 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+. |
2020-10-08 | Added | SYNONYM | ATP:L-homoserine O-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | homoserine kinase (phosphorylating) |
2020-10-08 | Deleted | SYNONYM | ATP:L-homoserine O-phosphotransferase activity |
2020-10-08 | Deleted | SYNONYM | homoserine kinase (phosphorylating) |
2019-06-20 | Deleted | XREF | KEGG:R01771 |
2019-06-20 | Added | XREF | KEGG_REACTION:R01771 |
2018-07-13 | Deleted | XREF | RHEA:13988 |
2018-07-13 | Added | XREF | RHEA:13985 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | homoserine kinase activity |
2002-02-06 | Updated | TERM | homoserine kinase |
2001-04-03 | Updated | TERM | homoserine kinase |
2001-03-30 | Added | TERM | homoserine kinase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+. |
2020-10-08 | Added | SYNONYM | ATP:L-homoserine O-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | homoserine kinase (phosphorylating) |
2020-10-08 | Deleted | SYNONYM | ATP:L-homoserine O-phosphotransferase activity |
2020-10-08 | Deleted | SYNONYM | homoserine kinase (phosphorylating) |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+). |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. |
2007-11-08 | Added | SYNONYM | HSK |
2007-11-08 | Added | SYNONYM | ATP:L-homoserine O-phosphotransferase activity |
2007-11-08 | Added | SYNONYM | homoserine kinase (phosphorylating) |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0019202 (amino acid kinase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R01771 |
2019-06-20 | Added | XREF | KEGG_REACTION:R01771 |
2018-07-13 | Deleted | XREF | RHEA:13988 |
2018-07-13 | Added | XREF | RHEA:13985 |
2010-10-11 | Added | XREF | RHEA:13988 |
2010-10-11 | Added | XREF | KEGG:R01771 |
2003-10-27 | Added | XREF | MetaCyc:HOMOSERKIN-RXN |
2001-03-30 | Added | XREF | EC:2.7.1.39 |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link